{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:59:59Z","timestamp":1790841599148,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","translationalres.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.trsl.2020.04.007","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T11:25:53Z","timestamp":1586949953000},"page":"1-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1846,"special_numbering":"C","title":["Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases"],"prefix":"10.1016","volume":"220","author":[{"given":"Cynthia","family":"Magro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Justin","family":"Mulvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Berlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Nuovo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Salvatore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Harp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Baxter-Stoltzfus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Laurence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2020.04.007_bib0001","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China. 2019","author":"Zhu","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.trsl.2020.04.007_bib0002","article-title":"WHO declares COVID-19 a Pandemic","author":"Cucinotta","year":"2020","journal-title":"Acta Biomed"},{"key":"10.1016\/j.trsl.2020.04.007_bib0003","unstructured":"cdc.gov\/coronavirus\/2019.ncov"},{"key":"10.1016\/j.trsl.2020.04.007_bib0004","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China","author":"Wang","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.trsl.2020.04.007_bib0005","doi-asserted-by":"crossref","DOI":"10.1111\/jth.14768","article-title":"Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia","author":"Tang","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.04.007_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2020.104211","article-title":"Novel coronavirus: from discovery to clinical diagnostics","volume":"79","author":"Phan","year":"2020","journal-title":"Infect Genet Evol"},{"key":"10.1016\/j.trsl.2020.04.007_bib0007","doi-asserted-by":"crossref","first-page":"e01753","DOI":"10.1128\/mBio.01753-18","article-title":"Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis","volume":"9","author":"Gralinski","year":"2018","journal-title":"mBio."},{"key":"10.1016\/j.trsl.2020.04.007_bib0008","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S2213-2600(20)30076-X","article-title":"Pathologic findings of COVID-19 associated with acute respiratory distress syndrome","volume":"8","author":"Xu","year":"2020","journal-title":"Lancet Respiratory Med"},{"key":"10.1016\/j.trsl.2020.04.007_bib0009","doi-asserted-by":"crossref","DOI":"10.7326\/L20-0895","article-title":"Histopathologic changes and SARS-Cov-2 immunostaining in the lung of a patient with COVID-19","author":"Zhang","year":"2020","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.trsl.2020.04.007_bib0010","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.trsl.2020.04.007_bib0011","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.202003-0817LE","article-title":"Covid-19 does not lead to a \u201cTypical\u201d acute respiratory distress syndrome","author":"Gattinoni","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.trsl.2020.04.007_bib0012","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1309\/AJCP66QIMFARLZKI","article-title":"Degos disease: a C5b-9\/interferon-\u03b1-mediated endotheliopathy syndrome","volume":"135","author":"Magro","year":"2011","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.trsl.2020.04.007_bib0013","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/DAD.0000000000000234","article-title":"The role of the skin biopsy in the diagnosis of atypical hemolytic uremic syndrome","volume":"37","author":"Magro","year":"2015","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.trsl.2020.04.007_bib0014","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1034\/j.1600-6143.2003.00152.x","article-title":"Use of C4d as a diagnostic adjunct in lung allograft biopsies","volume":"3","author":"Magro","year":"2003","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trsl.2020.04.007_bib0015","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1097\/00007890-200211150-00013","article-title":"Humorally mediated posttransplantation septal capillary injury syndrome as a common form of pulmonary allograft rejection: a hypothesis","volume":"74","author":"Magro","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.trsl.2020.04.007_bib0016","article-title":"A pathological report of three COVID-19 cases by minimally invasive autopsies","author":"Yao","year":"2020","journal-title":"Zhonghua bing li xue za zhi\u202f=\u202fChinese J Pathol"},{"key":"10.1016\/j.trsl.2020.04.007_bib0017","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2019003863","article-title":"Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS","author":"Chaturvedi","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.trsl.2020.04.007_bib0018","doi-asserted-by":"crossref","DOI":"10.1309\/AJCP66QIMFARLZKI","article-title":"Degos disease: a C5b-9\/interferon-\u03b1-mediated endotheliopathy syndrome","author":"Magro","year":"2011","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.trsl.2020.04.007_bib0019","article-title":"Insights into the pathogenesis of catastrophic antiphospholipid syndrome. A case report of relapsing catastrophic antiphospholipid syndrome and review of the literature on ischemic colitis","author":"Ruffatti","year":"2019","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.trsl.2020.04.007_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccc.2019.11.004","article-title":"Typical and atypical hemolytic uremic syndrome in the critically Ill","author":"Manrique-Caballero","year":"2020","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.trsl.2020.04.007_bib0021","doi-asserted-by":"crossref","first-page":"554","DOI":"10.2215\/CJN.04760512","article-title":"Genetics and outcome of atypical hemolytic uremic syndrome: a nationwide French series comparing children and adults","volume":"8","author":"Fremeaux-Bacchi","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.trsl.2020.04.007_bib0022","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1172-8-185","article-title":"The effects of Eculizumab on the pathology of malignant atrophic papulosis","author":"Magro","year":"2013","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.trsl.2020.04.007_bib0023","series-title":"Purpura fulminans","author":"Perera","year":"2020"},{"key":"10.1016\/j.trsl.2020.04.007_bib0024","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.4049\/jimmunol.177.7.4794","article-title":"Anovel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways","volume":"177","author":"Rits","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2020.04.007_bib0025","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1128\/JVI.80.6.2684-2693.2006","article-title":"Modeling the early events of severe acute respiratory syndrome coronavirus infection in vitro","volume":"80","author":"Yen","year":"2006","journal-title":"J Virol"},{"key":"10.1016\/j.trsl.2020.04.007_bib0026","article-title":"Hematologic parameters in patients with COVID-19 infection","author":"Fan","year":"2020","journal-title":"Am J Hematol"},{"key":"10.1016\/j.trsl.2020.04.007_bib0027","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2004500","article-title":"Covid-19 in critically ill patients in the Seattle region\u2013case series","author":"Bhatraju","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.trsl.2020.04.007_bib0028","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1529-8019.2011.01392.x","article-title":"An approach to the patient with retiform purpura","volume":"24","author":"Wysong","year":"2011","journal-title":"Dermatologic Ther"},{"issue":"11S1","key":"10.1016\/j.trsl.2020.04.007_bib0029","first-page":"1","article-title":"Atypical hemolytic uremic syndrome (aHUS): essential aspects of an accurate diagnosis","volume":"14","author":"Laurence","year":"2016","journal-title":"Clin Adv Hematol Oncol"},{"key":"10.1016\/j.trsl.2020.04.007_bib0030","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1055\/s-2006-939768","article-title":"Terminal complement complex (C5b-9) in children with recurrent hemolytic uremic syndrome","volume":"32","author":"Prufer","year":"2006","journal-title":"Sem Thromb Hemost"},{"key":"10.1016\/j.trsl.2020.04.007_bib0031","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1182\/blood-2014-02-558296","article-title":"Dynamics of complement activation in aHUS and how to monitor eculizumab therapy","volume":"124","author":"Noris","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.trsl.2020.04.007_bib0032","doi-asserted-by":"crossref","first-page":"8753","DOI":"10.1128\/JVI.00554-10","article-title":"A single asparagine-linked glycosylation site of the severe acute respiratory syndrome coronavirus spike glycoprotein facilitates inhibition by mannose-binding lectin through multiple mechanisms","volume":"84","author":"Zhou","year":"2010","journal-title":"J Virol"},{"key":"10.1016\/j.trsl.2020.04.007_bib0033","first-page":"1","article-title":"The lectin pathway of complement and rheumatic heart disease","volume":"2","author":"Beltrame","year":"2015","journal-title":"Front Ped"},{"key":"10.1016\/j.trsl.2020.04.007_bib0034","doi-asserted-by":"crossref","first-page":"e623","DOI":"10.1371\/journal.pone.0000623","article-title":"Simultaneous activation of complement and coagulation by MBL-associated serine protease 2","volume":"7","author":"Krarup","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2020.04.007_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.11.032","article-title":"Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein","author":"Walls","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.trsl.2020.04.007_bib0036","first-page":"1","article-title":"Be on target: strategies of targeting alternative and lectin pathway components in complement-mediated diseases","volume":"9","author":"Dodo","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.trsl.2020.04.007_bib0037","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1016\/j.dsx.2019.04.042","article-title":"Imbalance between Angiotensin II - Angiotensin (1-7) system is associated with vascular endothelial dysfunction and inflammation in type 2 diabetes with newly diagnosed hypertension","volume":"13","author":"Srivastava","year":"2019","journal-title":"Diabetes Metab Syndr"},{"key":"10.1016\/j.trsl.2020.04.007_bib0038","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1161\/01.RES.0000182677.89816.38","article-title":"Complement activation in angiotensin II-induced organ damage","volume":"97","author":"Shagdarsuren","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.trsl.2020.04.007_bib0039","series-title":"Improved survival following OMS721 treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy (HCT-TMA)","author":"Rambaldi","year":"2018"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524420300700?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524420300700?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:39:58Z","timestamp":1761827998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524420300700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":39,"alternative-id":["S1931524420300700"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2020.04.007","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases","name":"articletitle","label":"Article Title"},{"value":"Translational Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trsl.2020.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}