{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T03:51:03Z","timestamp":1787197863107,"version":"build-2736575974"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","translationalres.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.trsl.2020.04.012","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T10:11:57Z","timestamp":1589191917000},"page":"54-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Venous thrombosis of the liver: current and emerging concepts in management"],"prefix":"10.1016","volume":"225","author":[{"given":"Leonard","family":"Naymagon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.trsl.2020.04.012_bib0001","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/hep.22772","article-title":"Vascular disorders of the liver","volume":"49","author":"DeLeve","year":"2009","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.trsl.2020.04.012_bib0002","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.suc.2010.04.017","article-title":"Liver anatomy","volume":"90","author":"Abdel-Misih","year":"2010","journal-title":"Surg Clin North Am"},{"issue":"6","key":"10.1016\/j.trsl.2020.04.012_bib0003","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2019.01.265","article-title":"Diagnosis, Development, and Treatment of Portal Vein Thrombosis in Patients With and Without Cirrhosis","volume":"156","author":"Intagliata","year":"2019","journal-title":"Gastroenterology"},{"issue":"18","key":"10.1016\/j.trsl.2020.04.012_bib0004","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.3748\/wjg.v13.i18.2535","article-title":"Portal hypertension due to portal venous thrombosis: etiology, clinical outcomes","volume":"13","author":"Harmanci","year":"2007","journal-title":"World J Gastroenterol"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0005","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2214\/AJR.18.19548","article-title":"Portal Vein Thrombosis: Imaging the Spectrum of Disease With an Emphasis on MRI Features","volume":"211","author":"Jha","year":"2018","journal-title":"AJR Am J Roentgenol"},{"issue":"3","key":"10.1016\/j.trsl.2020.04.012_bib0006","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1053\/jhep.2000.16597","article-title":"Recent portal or mesenteric venous thrombosis: increased recognition and frequent recanalization on anticoagulant therapy","volume":"32","author":"Condat","year":"2000","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.trsl.2020.04.012_bib0007","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1053\/gast.2001.21209","article-title":"Current outcome of portal vein thrombosis in adults: risk and benefit of anticoagulant therapy","volume":"120","author":"Condat","year":"2001","journal-title":"Gastroenterology"},{"issue":"12","key":"10.1016\/j.trsl.2020.04.012_bib0008","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.cgh.2008.07.031","article-title":"Portal hypertension-related complications after acute portal vein thrombosis: impact of early anticoagulation","volume":"6","author":"Turnes","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0009","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/MEG.0000000000001237","article-title":"A prediction model for successful anticoagulation in cirrhotic portal vein thrombosis","volume":"31","author":"Rodriguez-Castro","year":"2019","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.trsl.2020.04.012_bib0010","first-page":"315","article-title":"Portal vein thrombosis in cirrhosis: diagnosis, natural history, and therapeutic challenges","volume":"31","author":"Mantaka","year":"2018","journal-title":"Ann Gastroenterol"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0011","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12916-018-1069-8","article-title":"Transient portal vein thrombosis in liver cirrhosis","volume":"16","author":"Qi","year":"2018","journal-title":"BMC Med"},{"issue":"2","key":"10.1016\/j.trsl.2020.04.012_bib0012","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/hep.27546","article-title":"Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: results of a longitudinal study","volume":"61","author":"Nery","year":"2015","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.trsl.2020.04.012_bib0013","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/ajg.2012.452","article-title":"De novo portal vein thrombosis in virus-related cirrhosis: predictive factors and long-term outcomes","volume":"108","author":"Maruyama","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.trsl.2020.04.012_bib0014","doi-asserted-by":"crossref","DOI":"10.1177\/1756284818793561","article-title":"Anticoagulant therapy in patients with liver cirrhosis and portal vein thrombosis: insights for the clinician","volume":"11","author":"Basili","year":"2018","journal-title":"Therap Adv Gastroenterol"},{"issue":"2","key":"10.1016\/j.trsl.2020.04.012_bib0015","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2017.04.042","article-title":"Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis: A Systematic Review and Meta-analysis","volume":"153","author":"Loffredo","year":"2017","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.trsl.2020.04.012_bib0016","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41395-018-0421-0","article-title":"Clinical Impact and Safety of Anticoagulants for Portal Vein Thrombosis in Cirrhosis","volume":"114","author":"Pettinari","year":"2019","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"10.1016\/j.trsl.2020.04.012_bib0017","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/cld.713","article-title":"CON: Anticoagulation for Portal Vein Thrombosis in Advanced Cirrhosis","volume":"12","author":"Rank","year":"2018","journal-title":"Clin Liver Dis (Hoboken)"},{"issue":"3","key":"10.1016\/j.trsl.2020.04.012_bib0018","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/lt.24387","article-title":"Nontumoral portal vein thrombosis in patients awaiting liver transplantation","volume":"22","author":"Chen","year":"2016","journal-title":"Liver Transpl"},{"issue":"8","key":"10.1016\/j.trsl.2020.04.012_bib0019","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/lt.22105","article-title":"Portal vein thrombosis and liver transplant survival benefit","volume":"16","author":"Englesbe","year":"2010","journal-title":"Liver Transpl"},{"issue":"4","key":"10.1016\/j.trsl.2020.04.012_bib0020","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1097\/SLA.0000000000000252","article-title":"When and why portal vein thrombosis matters in liver transplantation: a critical audit of 174 cases","volume":"259","author":"Hibi","year":"2014","journal-title":"Ann Surg"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0021","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jhep.2015.07.040","article-title":"EASL Clinical Practice Guidelines: Vascular diseases of the liver","volume":"64","year":"2016","journal-title":"J Hepatol"},{"issue":"3","key":"10.1016\/j.trsl.2020.04.012_bib0022","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jhep.2015.05.022","article-title":"Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension","volume":"63","author":"de Franchis","year":"2015","journal-title":"J Hepatol"},{"issue":"4","key":"10.1016\/j.trsl.2020.04.012_bib0023","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cgh.2018.08.004","article-title":"Harmful and Beneficial Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis","volume":"17","author":"Mazzarelli","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.trsl.2020.04.012_bib0024","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2012.07.018","article-title":"Enoxaparin prevents portal vein thrombosis and liver decompensation in patients with advanced cirrhosis","volume":"143","author":"Villa","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.trsl.2020.04.012_bib0025","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.vph.2018.05.002","article-title":"Randomized controlled trial of rivaroxaban versus warfarin in the management of acute non-neoplastic portal vein thrombosis","volume":"113","author":"Hanafy","year":"2019","journal-title":"Vascul Pharmacol"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0026","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/hepr.12895","article-title":"Efficacy and safety of edoxaban for treatment of portal vein thrombosis following danaparoid sodium in patients with liver cirrhosis","volume":"48","author":"Nagaoki","year":"2018","journal-title":"Hepatol Res"},{"issue":"4","key":"10.1016\/j.trsl.2020.04.012_bib0027","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1182\/bloodadvances.2019001310","article-title":"The efficacy and safety of direct oral anticoagulants in noncirrhotic portal vein thrombosis","volume":"4","author":"Naymagon","year":"2020","journal-title":"Blood Adv"},{"issue":"Suppl 3","key":"10.1016\/j.trsl.2020.04.012_bib0028","doi-asserted-by":"crossref","first-page":"S165","DOI":"10.21037\/cdt.2017.09.16","article-title":"Tumor thrombus: incidence, imaging, prognosis and treatment","volume":"7","author":"Quencer","year":"2017","journal-title":"Cardiovasc Diagn Ther"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0029","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.thromres.2010.01.045","article-title":"Mechanisms of estrogen-induced venous thromboembolism","volume":"126","author":"Tchaikovski","year":"2010","journal-title":"Thromb Res"},{"issue":"5","key":"10.1016\/j.trsl.2020.04.012_bib0030","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1055\/s-0033-1343890","article-title":"JAK2 mutation-related disease and thrombosis","volume":"39","author":"Vannucchi","year":"2013","journal-title":"Semin Thromb Hemost"},{"issue":"6185","key":"10.1016\/j.trsl.2020.04.012_bib0031","doi-asserted-by":"crossref","DOI":"10.1126\/science.1249783","article-title":"Mechanism of activation of protein kinase JAK2 by the growth hormone receptor","volume":"344","author":"Brooks","year":"2014","journal-title":"Science"},{"issue":"21","key":"10.1016\/j.trsl.2020.04.012_bib0032","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.1182\/blood-2008-11-191544","article-title":"The presence of JAK2V617F mutation in the liver endothelial cells of patients with Budd-Chiari syndrome","volume":"113","author":"Sozer","year":"2009","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.trsl.2020.04.012_bib0033","first-page":"169","article-title":"Increased platelet and leukocyte activation as contributing mechanisms for thrombosis in essential thrombocythemia and correlation with the JAK2 mutational status","volume":"91","author":"Arellano-Rodrigo","year":"2006","journal-title":"Haematologica"},{"issue":"23","key":"10.1016\/j.trsl.2020.04.012_bib0034","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1182\/blood-2013-06-501452","article-title":"JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia","volume":"122","author":"Hobbs","year":"2013","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.trsl.2020.04.012_bib0035","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1172\/JCI90312","article-title":"JAK2-V617F promotes venous thrombosis through beta1\/beta2 integrin activation","volume":"128","author":"Edelmann","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2020.04.012_bib0036","doi-asserted-by":"crossref","DOI":"10.1007\/s11239-020-02052-4","article-title":"Portal vein thrombosis patients harboring JAK2V617F have poor long-term outcomes despite anticoagulation","author":"Naymagon","year":"2020","journal-title":"J Thromb Thrombolysis"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0037","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1309\/AJCP7VO4HAIZYATP","article-title":"JAK2 mutations across a spectrum of venous thrombosis cases","volume":"134","author":"Shetty","year":"2010","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.trsl.2020.04.012_bib0038","doi-asserted-by":"crossref","DOI":"10.1097\/MBC.0000000000000901","article-title":"The utility of thrombophilia testing in patients with newly diagnosed portal vein thrombosis","author":"Tremblay","year":"2020","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"10","key":"10.1016\/j.trsl.2020.04.012_bib0039","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1182\/blood-2007-11-125328","article-title":"The impact of JAK2 and MPL mutations on diagnosis and prognosis of splanchnic vein thrombosis: a report on 241 cases","volume":"111","author":"Kiladjian","year":"2008","journal-title":"Blood"},{"issue":"23","key":"10.1016\/j.trsl.2020.04.012_bib0040","first-page":"2298","article-title":"Thrombophilia Testing and Venous Thrombosis","volume":"377","author":"Connors","year":"2017","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.trsl.2020.04.012_bib0041","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1001\/archinte.167.5.497","article-title":"No association between the common MTHFR 677C->T polymorphism and venous thrombosis: results from the MEGA study","volume":"167","author":"Bezemer","year":"2007","journal-title":"Arch Intern Med"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0042","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/hep.23259","article-title":"Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow-up study","volume":"51","author":"Plessier","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.trsl.2020.04.012_bib0043","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-230X-7-34","article-title":"Portal vein thrombosis; risk factors, clinical presentation and treatment","volume":"7","author":"Sogaard","year":"2007","journal-title":"BMC Gastroenterol"},{"issue":"11","key":"10.1016\/j.trsl.2020.04.012_bib0044","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1111\/j.1572-0241.2007.01477.x","article-title":"Prognostic factors in noncirrhotic patients with splanchnic vein thromboses","volume":"102","author":"Amitrano","year":"2007","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"10.1016\/j.trsl.2020.04.012_bib0045","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s11239-019-01949-z","article-title":"The role of anticoagulation in pylephlebitis: a retrospective examination of characteristics and outcomes","volume":"49","author":"Naymagon","year":"2020","journal-title":"J Thromb Thrombolysis"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0046","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.mayocp.2017.10.007","article-title":"Rivaroxaban and Apixaban for Initial Treatment of Acute Venous Thromboembolism of Atypical Location","volume":"93","author":"Janczak","year":"2018","journal-title":"Mayo Clin Proc"},{"issue":"2","key":"10.1016\/j.trsl.2020.04.012_bib0047","doi-asserted-by":"crossref","first-page":"141","DOI":"10.14740\/gr806w","article-title":"Efficacy and Safety of Direct-Acting Oral Anticoagulants Use in Acute Portal Vein Thrombosis Unrelated to Cirrhosis","volume":"10","author":"Nery","year":"2017","journal-title":"Gastroenterology Res"},{"issue":"3","key":"10.1016\/j.trsl.2020.04.012_bib0048","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jceh.2014.03.052","article-title":"Mesenteric venous thrombosis","volume":"4","author":"Hmoud","year":"2014","journal-title":"J Clin Exp Hepatol"},{"issue":"S1","key":"10.1016\/j.trsl.2020.04.012_bib0049","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1002\/lt.24856","article-title":"Liver transplant in patients with portal vein thrombosis: Medical and surgical requirements","volume":"23","author":"Conzen","year":"2017","journal-title":"Liver Transpl"},{"issue":"2 Suppl","key":"10.1016\/j.trsl.2020.04.012_bib0050","doi-asserted-by":"crossref","first-page":"e419S","DOI":"10.1378\/chest.11-2301","article-title":"Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"141","author":"Kearon","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.trsl.2020.04.012_bib0051","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.thromres.2018.12.019","article-title":"Natural history and clinical outcomes in patients with portal vein thrombosis by etiology: A retrospective cohort study","volume":"174","author":"Acuna-Villaorduna","year":"2019","journal-title":"Thromb Res"},{"key":"10.1016\/j.trsl.2020.04.012_bib0052","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8432781","article-title":"Newer Oral Anticoagulants in the Treatment of Acute Portal Vein Thrombosis in Patients with and without Cirrhosis","volume":"2018","author":"Priyanka","year":"2018","journal-title":"Int J Hepatol"},{"issue":"26","key":"10.1016\/j.trsl.2020.04.012_bib0053","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1056\/NEJMoa1007903","article-title":"Oral rivaroxaban for symptomatic venous thromboembolism","volume":"363","author":"Investigators","year":"2010","journal-title":"N Engl J Med"},{"issue":"14","key":"10.1016\/j.trsl.2020.04.012_bib0054","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1056\/NEJMoa1113572","article-title":"Oral rivaroxaban for the treatment of symptomatic pulmonary embolism","volume":"366","author":"Investigators","year":"2012","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.trsl.2020.04.012_bib0055","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMoa1302507","article-title":"Oral apixaban for the treatment of acute venous thromboembolism","volume":"369","author":"Agnelli","year":"2013","journal-title":"N Engl J Med"},{"issue":"24","key":"10.1016\/j.trsl.2020.04.012_bib0056","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1056\/NEJMoa0906598","article-title":"Dabigatran versus warfarin in the treatment of acute venous thromboembolism","volume":"361","author":"Schulman","year":"2009","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0057","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11239-015-1308-1","article-title":"Guidance for the management of venous thrombosis in unusual sites","volume":"41","author":"Ageno","year":"2016","journal-title":"J Thromb Thrombolysis"},{"issue":"25","key":"10.1016\/j.trsl.2020.04.012_bib0058","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1182\/blood-2014-07-551515","article-title":"How I treat splanchnic vein thrombosis","volume":"124","author":"Ageno","year":"2014","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0059","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s11239-015-1310-7","article-title":"Guidance for the practical management of the direct oral anticoagulants (DOACs) in VTE treatment","volume":"41","author":"Burnett","year":"2016","journal-title":"J Thromb Thrombolysis"},{"issue":"6","key":"10.1016\/j.trsl.2020.04.012_bib0060","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1007\/s10620-015-4012-2","article-title":"Direct Oral Anticoagulants in Cirrhosis Patients Pose Similar Risks of Bleeding When Compared to Traditional Anticoagulation","volume":"61","author":"Intagliata","year":"2016","journal-title":"Dig Dis Sci"},{"issue":"6","key":"10.1016\/j.trsl.2020.04.012_bib0061","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/ajh.25475","article-title":"Reversal of direct oral anticoagulants: Guidance from the Anticoagulation Forum","volume":"94","author":"Cuker","year":"2019","journal-title":"Am J Hematol"},{"issue":"Suppl 1","key":"10.1016\/j.trsl.2020.04.012_bib0062","first-page":"S63","article-title":"Predicting the risk of venous thromboembolism recurrence","volume":"87","author":"Heit","year":"2012","journal-title":"Am J Hematol"},{"issue":"3","key":"10.1016\/j.trsl.2020.04.012_bib0063","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1055\/s-0038-1676981","article-title":"Incidence and Recurrence of Portal Vein Thrombosis in Cirrhotic Patients","volume":"119","author":"Violi","year":"2019","journal-title":"Thromb Haemost"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0064","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12876-017-0668-8","article-title":"Portal vein thrombosis in liver cirrhosis: incidence, management, and outcome","volume":"17","author":"Fujiyama","year":"2017","journal-title":"BMC Gastroenterol"},{"issue":"12","key":"10.1016\/j.trsl.2020.04.012_bib0065","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1182\/blood-2013-12-512681","article-title":"Duration of anticoagulant therapy for deep vein thrombosis and pulmonary embolism","volume":"123","author":"Kearon","year":"2014","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.trsl.2020.04.012_bib0066","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.dld.2017.05.020","article-title":"Transjugular local thrombolysis with\/without TIPS in patients with acute non-cirrhotic, non-malignant portal vein thrombosis","volume":"49","author":"Klinger","year":"2017","journal-title":"Dig Liver Dis"},{"issue":"54","key":"10.1016\/j.trsl.2020.04.012_bib0067","first-page":"2098","article-title":"Thrombolytic treatment of portal thrombosis","volume":"50","author":"Malkowski","year":"2003","journal-title":"Hepatogastroenterology"},{"issue":"5","key":"10.1016\/j.trsl.2020.04.012_bib0068","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/01.RVI.0000156265.79960.86","article-title":"Transcatheter thrombolytic therapy for acute mesenteric and portal vein thrombosis","volume":"16","author":"Hollingshead","year":"2005","journal-title":"J Vasc Interv Radiol"},{"issue":"11","key":"10.1016\/j.trsl.2020.04.012_bib0069","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1007\/s00268-011-1198-0","article-title":"Management of acute non-cirrhotic and non-malignant portal vein thrombosis: a systematic review","volume":"35","author":"Hall","year":"2011","journal-title":"World J Surg"},{"issue":"5","key":"10.1016\/j.trsl.2020.04.012_bib0070","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1002\/hep.21354","article-title":"Aiming at minimal invasiveness as a therapeutic strategy for Budd-Chiari syndrome","volume":"44","author":"Plessier","year":"2006","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.trsl.2020.04.012_bib0071","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1002\/hep.26306","article-title":"Good long-term outcome of Budd-Chiari syndrome with a step-wise management","volume":"57","author":"Seijo","year":"2013","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.trsl.2020.04.012_bib0072","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1056\/NEJMra020282","article-title":"The Budd-Chiari syndrome","volume":"350","author":"Menon","year":"2004","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.trsl.2020.04.012_bib0073","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1177\/2050640615582293","article-title":"Budd-Chiari syndrome","volume":"3","author":"Martens","year":"2015","journal-title":"United European Gastroenterol J"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0074","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00270-014-0919-9","article-title":"Diagnosis and management of Budd Chiari syndrome: an update","volume":"38","author":"Copelan","year":"2015","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0075","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jhep.2003.09.028","article-title":"Pharmacological thrombolysis in Budd Chiari syndrome: a single centre experience and review of the literature","volume":"40","author":"Sharma","year":"2004","journal-title":"J Hepatol"},{"issue":"3","key":"10.1016\/j.trsl.2020.04.012_bib0076","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1053\/j.gastro.2008.05.051","article-title":"TIPS for Budd-Chiari syndrome: long-term results and prognostics factors in 124 patients","volume":"135","author":"Garcia-Pagan","year":"2008","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.trsl.2020.04.012_bib0077","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/TP.0b013e3182247b05","article-title":"Long-term follow-up of liver transplantation for Budd-Chiari syndrome with antithrombotic therapy based on the etiology","volume":"92","author":"Chinnakotla","year":"2011","journal-title":"Transplantation"},{"issue":"5","key":"10.1016\/j.trsl.2020.04.012_bib0078","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/hep.510280505","article-title":"Proposal of a new nomenclature for Budd-Chiari syndrome: hepatic vein thrombosis versus thrombosis of the inferior vena cava at its hepatic portion","volume":"28","author":"Okuda","year":"1998","journal-title":"Hepatology"},{"issue":"16","key":"10.1016\/j.trsl.2020.04.012_bib0079","doi-asserted-by":"crossref","first-page":"691","DOI":"10.4254\/wjh.v8.i16.691","article-title":"Redefining Budd-Chiari syndrome: A systematic review","volume":"8","author":"Shin","year":"2016","journal-title":"World J Hepatol"},{"issue":"4","key":"10.1016\/j.trsl.2020.04.012_bib0080","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/hep.510250405","article-title":"Hepatic venous outflow block caused by short-length hepatic vein stenoses","volume":"25","author":"Valla","year":"1997","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.trsl.2020.04.012_bib0081","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/00042737-199705000-00014","article-title":"Poor prognosis and limited therapeutic options in patients with Budd-Chiari syndrome and portal venous system thrombosis","volume":"9","author":"Mahmoud","year":"1997","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.trsl.2020.04.012_bib0082","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0019-4832(12)60054-6","article-title":"Inferior vena cava obstruction: long-term results of endovascular management","volume":"64","author":"Srinivas","year":"2012","journal-title":"Indian Heart J"},{"issue":"3","key":"10.1016\/j.trsl.2020.04.012_bib0083","doi-asserted-by":"crossref","first-page":"167","DOI":"10.7326\/0003-4819-151-3-200908040-00004","article-title":"Etiology, management, and outcome of the Budd-Chiari syndrome","volume":"151","author":"Darwish Murad","year":"2009","journal-title":"Ann Intern Med"},{"issue":"6","key":"10.1016\/j.trsl.2020.04.012_bib0084","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1002\/hep.21435","article-title":"Role of the JAK2 mutation in the diagnosis of chronic myeloproliferative disorders in splanchnic vein thrombosis","volume":"44","author":"Primignani","year":"2006","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.trsl.2020.04.012_bib0085","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1053\/j.gastro.2006.04.008","article-title":"Prevalence of the activating JAK2 tyrosine kinase mutation V617F in the Budd-Chiari syndrome","volume":"130","author":"Patel","year":"2006","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.trsl.2020.04.012_bib0086","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1055\/s-0028-1085099","article-title":"Hepatic vascular involvement related to pregnancy, oral contraceptives, and estrogen replacement therapy","volume":"28","author":"Perarnau","year":"2008","journal-title":"Semin Liver Dis"},{"issue":"8","key":"10.1016\/j.trsl.2020.04.012_bib0087","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/BF01312555","article-title":"Budd-Chiari syndrome associated with oral contraceptive steroids. Review of treatment of 47 cases","volume":"28","author":"Lewis","year":"1983","journal-title":"Dig Dis Sci"},{"issue":"4","key":"10.1016\/j.trsl.2020.04.012_bib0088","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0016-5085(86)90855-3","article-title":"Risk of hepatic vein thrombosis in relation to recent use of oral contraceptives. A case-control study","volume":"90","author":"Valla","year":"1986","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.trsl.2020.04.012_bib0089","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2014.04.026","article-title":"Associations of coagulation factor V Leiden and prothrombin G20210A mutations with Budd-Chiari syndrome and portal vein thrombosis: a systematic review and meta-analysis","volume":"12","author":"Qi","year":"2014","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.trsl.2020.04.012_bib0090","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/0016-5085(87)90920-6","article-title":"Hepatic vein thrombosis in paroxysmal nocturnal hemoglobinuria. A spectrum from asymptomatic occlusion of hepatic venules to fatal Budd-Chiari syndrome","volume":"93","author":"Valla","year":"1987","journal-title":"Gastroenterology."},{"key":"10.1016\/j.trsl.2020.04.012_bib0091","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13023-014-0153-1","article-title":"Behcet's disease in Budd-Chiari syndrome","volume":"9","author":"Desbois","year":"2014","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.trsl.2020.04.012_bib0092","article-title":"Dabigatran as an oral anticoagulant in patients with Budd-Chiari syndrome post-percutaneous endovascular intervention","author":"Sharma","year":"2019","journal-title":"J Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.trsl.2020.04.012_bib0093","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/MEG.0000000000000282","article-title":"An update on the management of Budd-Chiari syndrome: the issues of timing and choice of treatment","volume":"27","author":"Mancuso","year":"2015","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.trsl.2020.04.012_bib0094","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1002\/hep.510240637","article-title":"Can anticoagulation enhance TIPS patency?","volume":"24","author":"Shiffman","year":"1996","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.trsl.2020.04.012_bib0095","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1055\/s-0035-1549376","article-title":"Transjugular intrahepatic portosystemic shunt complications: prevention and management","volume":"32","author":"Suhocki","year":"2015","journal-title":"Semin Intervent Radiol"},{"issue":"6","key":"10.1016\/j.trsl.2020.04.012_bib0096","first-page":"1262","article-title":"Thrombolysis for acute Budd-Chiari syndrome: case report and literature review","volume":"91","author":"Raju","year":"1996","journal-title":"Am J Gastroenterol"},{"issue":"11","key":"10.1016\/j.trsl.2020.04.012_bib0097","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0009-9260(96)80005-5","article-title":"Radiological intervention in Budd-Chiari syndrome: techniques and outcome in 18 patients","volume":"51","author":"Griffith","year":"1996","journal-title":"Clin Radiol"},{"issue":"2","key":"10.1016\/j.trsl.2020.04.012_bib0098","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s00330-002-1475-2","article-title":"Budd-Chiari syndrome due to prothrombotic disorder: mid-term patency and efficacy of endovascular stents","volume":"13","author":"Pelage","year":"2003","journal-title":"Eur Radiol"},{"issue":"6","key":"10.1016\/j.trsl.2020.04.012_bib0099","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1136\/gut.2005.071423","article-title":"Favourable medium term outcome following hepatic vein recanalisation and\/or transjugular intrahepatic portosystemic shunt for Budd Chiari syndrome","volume":"55","author":"Eapen","year":"2006","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.trsl.2020.04.012_bib0100","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1148\/radiol.12120856","article-title":"Percutaneous recanalization for Budd-Chiari syndrome: an 11-year retrospective study on patency and survival in 177 Chinese patients from a single center","volume":"266","author":"Han","year":"2013","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0101","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jhep.2006.08.016","article-title":"Long-term portosystemic shunt patency as a determinant of outcome in Budd-Chiari syndrome","volume":"46","author":"Bachet","year":"2007","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0102","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/hep.23383","article-title":"The Role of Transjugular Intrahepatic Portosystemic Shunt (TIPS) in the Management of Portal Hypertension: update 2009","volume":"51","author":"Boyer","year":"2010","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.trsl.2020.04.012_bib0103","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/hep.20436","article-title":"PTFE-covered stents improve TIPS patency in Budd-Chiari syndrome","volume":"40","author":"Hernandez-Guerra","year":"2004","journal-title":"Hepatology"},{"issue":"12","key":"10.1016\/j.trsl.2020.04.012_bib0104","first-page":"2304","article-title":"Use of transjugular intrahepatic portosystemic shunt as a bridge to transplantation in fulminant hepatic failure due to Budd-Chiari syndrome","volume":"92","author":"Shrestha","year":"1997","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"10.1016\/j.trsl.2020.04.012_bib0105","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/lt.24643","article-title":"Budd-chiari syndrome causing acute liver failure: A multicenter case series","volume":"23","author":"Parekh","year":"2017","journal-title":"Liver Transpl"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0106","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1053\/jhep.2002.30274","article-title":"TIPS is a useful long-term derivative therapy for patients with Budd-Chiari syndrome uncontrolled by medical therapy","volume":"35","author":"Perello","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.trsl.2020.04.012_bib0107","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-230X-10-25","article-title":"Budd-Chiari syndrome: long term success via hepatic decompression using transjugular intrahepatic porto-systemic shunt","volume":"10","author":"Zahn","year":"2010","journal-title":"BMC Gastroenterol"},{"issue":"3","key":"10.1016\/j.trsl.2020.04.012_bib0108","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/00000658-200009000-00006","article-title":"A 27-year experience with surgical treatment of Budd-Chiari syndrome","volume":"232","author":"Orloff","year":"2000","journal-title":"Ann Surg"},{"issue":"3","key":"10.1016\/j.trsl.2020.04.012_bib0109","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.jhep.2005.12.002","article-title":"Liver transplantation for Budd-Chiari syndrome: A European study on 248 patients from 51 centres","volume":"44","author":"Mentha","year":"2006","journal-title":"J Hepatol"},{"issue":"9","key":"10.1016\/j.trsl.2020.04.012_bib0110","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1002\/lt.21220","article-title":"Twenty years of liver transplantation for Budd-Chiari syndrome: a national registry analysis","volume":"13","author":"Segev","year":"2007","journal-title":"Liver Transpl"},{"issue":"5","key":"10.1016\/j.trsl.2020.04.012_bib0111","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/hep.1840210518","article-title":"Which is the best surgery for Budd-Chiari syndrome: venous decompression or liver transplantation? A single-center experience with 50 patients","volume":"21","author":"Ringe","year":"1995","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.trsl.2020.04.012_bib0112","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/lt.21282","article-title":"Eighteen years of liver transplantation experience in patients with advanced Budd-Chiari syndrome","volume":"14","author":"Ulrich","year":"2008","journal-title":"Liver Transpl"},{"issue":"6","key":"10.1016\/j.trsl.2020.04.012_bib0113","first-page":"511","article-title":"Hepatic transplantation with perioperative and long term anticoagulation as treatment for Budd-Chiari syndrome","volume":"166","author":"Campbell","year":"1988","journal-title":"Surg Gynecol Obstet"},{"issue":"1","key":"10.1016\/j.trsl.2020.04.012_bib0114","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jhep.2010.06.019","article-title":"Bleeding in patients with Budd-Chiari syndrome","volume":"54","author":"Rautou","year":"2011","journal-title":"J Hepatol"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193152442030075X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193152442030075X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:40:32Z","timestamp":1761828032000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S193152442030075X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":114,"alternative-id":["S193152442030075X"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2020.04.012","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Venous thrombosis of the liver: current and emerging concepts in management","name":"articletitle","label":"Article Title"},{"value":"Translational Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trsl.2020.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}