{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:34:23Z","timestamp":1790048063330,"version":"4.0.1"},"reference-count":123,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","translationalres.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.trsl.2020.05.005","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T12:30:42Z","timestamp":1589891442000},"page":"95-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Insights from experimental post-thrombotic syndrome and potential for novel therapies"],"prefix":"10.1016","volume":"225","author":[{"given":"Peter","family":"Henke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriganesh","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wakefield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Obi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2020.05.005_bib0001","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1111\/j.1538-7836.2008.03002.x","article-title":"Determinants of health-related quality of life during the 2 years following deep vein thrombosis","volume":"6","author":"Kahn","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.05.005_bib0002","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.blre.2015.09.002","article-title":"The post thrombotic syndrome: ignore it and it will come back to bite you","volume":"30","author":"ten Cate-Hoek","year":"2016","journal-title":"Blood Rev"},{"key":"10.1016\/j.trsl.2020.05.005_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-125-1-199607010-00001","article-title":"The long-term clinical course of acute deep venous thrombosis","volume":"125","author":"Prandoni","year":"1996","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.trsl.2020.05.005_bib0004","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s11239-008-0229-7","article-title":"Multilayer compression bandaging in the acute phase of deep-vein thrombosis has no effect on the development of the post-thrombotic syndrome","volume":"27","author":"Roumen-Klappe","year":"2009","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.trsl.2020.05.005_bib0005","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1055\/s-0037-1616243","article-title":"The epidemiology of venous thromboembolism in the community","volume":"86","author":"Heit","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.05.005_bib0006","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jvs.2010.08.050","article-title":"An update on etiology, prevention, and therapy of postthrombotic syndrome","volume":"53","author":"Henke","year":"2011","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0007","doi-asserted-by":"crossref","first-page":"698","DOI":"10.7326\/0003-4819-149-10-200811180-00004","article-title":"Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis","volume":"149","author":"Kahn","year":"2008","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.trsl.2020.05.005_bib0008","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1001\/archinte.162.10.1144","article-title":"Hirsch A and Shrier I. Effect of postthrombotic syndrome on health-related quality of life after deep venous thrombosis","volume":"162","author":"Kahn","year":"2002","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.trsl.2020.05.005_bib0009","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jvs.2008.03.016","article-title":"The effect of venous thrombus location and extent on the development of post-thrombotic signs and symptoms","volume":"48","author":"Labropoulos","year":"2008","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0010","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/jth.13569","article-title":"The postthrombotic syndrome: current evidence and future challenges","volume":"15","author":"Rabinovich","year":"2017","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.05.005_bib0011","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1055\/s-0032-1302447","article-title":"Multifaceted management of the postthrombotic syndrome","volume":"29","author":"Nayak","year":"2012","journal-title":"Semin Intervent Radiol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0012","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1161\/CIR.0000000000000130","article-title":"American Heart Association Council on Peripheral Vascular Disease CoCC, Council on C and Stroke N. The postthrombotic syndrome: evidence-based prevention, diagnosis, and treatment strategies: a scientific statement from the American Heart Association","volume":"130","author":"Kahn","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.trsl.2020.05.005_bib0013","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/000331979704800111","article-title":"Socioeconomic impact of chronic venous insufficiency and leg ulcers","volume":"48","author":"Ruckley","year":"1997","journal-title":"Angiology"},{"key":"10.1016\/j.trsl.2020.05.005_bib0014","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1182\/blood-2018-01-785956","article-title":"How I treat the postthrombotic syndrome","volume":"131","author":"Rabinovich","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.trsl.2020.05.005_bib0015","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/0741-5214(93)90069-X","article-title":"Deep venous insufficiency: the relationship between lysis and subsequent reflux","volume":"18","author":"Meissner","year":"1993","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0016","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1182\/blood-2018-03-836783","article-title":"Reduced incidence of vein occlusion and postthrombotic syndrome after immediate compression for deep vein thrombosis","volume":"132","author":"Amin","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.trsl.2020.05.005_bib0017","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1056\/NEJMra055289","article-title":"Chronic venous disease","volume":"355","author":"Bergan","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.trsl.2020.05.005_bib0018","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jvs.2010.07.043","article-title":"Postthrombotic vein wall remodeling: Preliminary observations","volume":"53","author":"Deatrick","year":"2011","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0019","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1111\/jth.13793","article-title":"Vein wall remodeling in patients with acute deep vein thrombosis and chronic postthrombotic changes","volume":"15","author":"Chandrashekar","year":"2017","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.05.005_bib0020","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.thromres.2015.02.026","article-title":"A histological and functional description of the tissue causing chronic postthrombotic venous obstruction","volume":"135","author":"Comerota","year":"2015","journal-title":"Thromb Res"},{"key":"10.1016\/j.trsl.2020.05.005_bib0021","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.chest.2015.11.026","article-title":"Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report","volume":"149","author":"Kearon","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.trsl.2020.05.005_bib0022","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.1538-7836.2005.01333.x","article-title":"Relation between quality of anticoagulant treatment and the development of the postthrombotic syndrome","volume":"3","author":"van Dongen","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.05.005_bib0023","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1111\/j.1538-7836.2012.04872.x","article-title":"Risk of post-thrombotic syndrome after subtherapeutic warfarin anticoagulation for a first unprovoked deep vein thrombosis: results from the REVERSE study","volume":"10","author":"Chitsike","year":"2012","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.05.005_bib0024","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.surg.2019.05.030","article-title":"Comparison of the recanalization rate and postthrombotic syndrome in patients with deep venous thrombosis treated with rivaroxaban or warfarin","volume":"166","author":"de Athayde Soares","year":"2019","journal-title":"Surgery"},{"key":"10.1016\/j.trsl.2020.05.005_bib0025","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1160\/TH16-01-0041","article-title":"Post-thrombotic syndrome in patients treated with rivaroxaban or enoxaparin\/vitamin K antagonists for acute deep-vein thrombosis. A post-hoc analysis","volume":"116","author":"Cheung","year":"2016","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.05.005_bib0026","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/S2352-3026(17)30227-2","article-title":"Individualised versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome (IDEAL DVT): a multicentre, randomised, single-blind, allocation-concealed, non-inferiority trial","volume":"5","author":"Ten Cate-Hoek","year":"2018","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0027","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S0140-6736(13)61902-9","article-title":"Compression stockings to prevent post-thrombotic syndrome: a randomised placebo-controlled trial","volume":"383","author":"Kahn","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.trsl.2020.05.005_bib0028","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(11)61753-4","article-title":"Long-term outcome after additional catheter-directed thrombolysis versus standard treatment for acute iliofemoral deep vein thrombosis (the CaVenT study): a randomised controlled trial","volume":"379","author":"Enden","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.trsl.2020.05.005_bib0029","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1016\/S2352-3026(15)00248-3","article-title":"Post-thrombotic syndrome after catheter-directed thrombolysis for deep vein thrombosis (CaVenT): 5-year follow-up results of an open-label, randomised controlled trial","volume":"3","author":"Haig","year":"2016","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0030","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s11239-015-1318-z","article-title":"Guidance for the use of thrombolytic therapy for the treatment of venous thromboembolism","volume":"41","author":"Vedantham","year":"2016","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.trsl.2020.05.005_bib0031","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.jvs.2011.10.032","article-title":"Postthrombotic morbidity correlates with residual thrombus following catheter-directed thrombolysis for iliofemoral deep vein thrombosis","volume":"55","author":"Comerota","year":"2012","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0032","first-page":"2105","article-title":"Acute experimental venous thrombosis impairs venous relaxation but not contraction","volume":"378","author":"Metz","year":"2019","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0033","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa1801214","article-title":"A randomized trial of early endovenous ablation in venous ulceration","author":"Gohel","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.trsl.2020.05.005_bib0034","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/S0140-6736(04)16353-8","article-title":"Comparison of surgery and compression with compression alone in chronic venous ulceration (ESCHAR study): randomised controlled trial","volume":"363","author":"Barwell","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.trsl.2020.05.005_bib0035","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1053\/j.semvascsurg.2015.07.001","article-title":"Treatment of iliac-caval outflow obstruction","volume":"28","author":"Raju","year":"2015","journal-title":"Semin Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0036","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.115.002772","article-title":"Safety and effectiveness of stent placement for iliofemoral venous outflow obstruction: systematic review and meta-analysis","volume":"8","author":"Razavi","year":"2015","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.trsl.2020.05.005_bib0037","doi-asserted-by":"crossref","first-page":"143","DOI":"10.23736\/S0392-9590.18.03975-5","article-title":"Efficacy of micronized purified flavonoid fraction (Daflon(R)) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials","volume":"37","author":"Kakkos","year":"2018","journal-title":"Int Angiol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0038","article-title":"Phlebotonics for venous insufficiency","volume":"4","author":"Martinez-Zapata","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.trsl.2020.05.005_bib0039","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1503\/cmaj.100248","article-title":"Six-month exercise training program to treat post-thrombotic syndrome: a randomized controlled two-centre trial","volume":"183","author":"Kahn","year":"2011","journal-title":"CMAJ"},{"key":"10.1016\/j.trsl.2020.05.005_bib0040","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1136\/jcp.27.7.517","article-title":"The structure and growth of valve-pocket thrombi in femoral veins","volume":"27","author":"Sevitt","year":"1974","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0041","doi-asserted-by":"crossref","unstructured":"van Langevelde K, Sramek A and Rosendaal FR. The effect of aging on venous valves. Arterioscler Thromb Vasc Biol. 30:2075-80.","DOI":"10.1161\/ATVBAHA.110.209049"},{"key":"10.1016\/j.trsl.2020.05.005_bib0042","doi-asserted-by":"crossref","first-page":"5489","DOI":"10.1172\/JCI124791","article-title":"Hemodynamic regulation of perivalvular endothelial gene expression prevents deep venous thrombosis","volume":"129","author":"Welsh","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2020.05.005_bib0043","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1182\/blood-2009-03-209981","article-title":"Valves of the deep venous system: an overlooked risk factor","volume":"114","author":"Brooks","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.trsl.2020.05.005_bib0044","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0741-5214(98)70057-6","article-title":"Determinants of chronic venous disease after acute deep venous thrombosis","volume":"28","author":"Meissner","year":"1998","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0045","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1161\/ATVBAHA.113.302428","article-title":"Deletion of cysteine-cysteine receptor 7 promotes fibrotic injury in experimental post-thrombotic vein wall remodeling","volume":"34","author":"Laser","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0046","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.thromres.2015.02.026","article-title":"A histological and functional description of the tissue causing chronic postthrombotic venous obstruction","volume":"135","author":"Comerota","year":"2015","journal-title":"Thromb Res"},{"key":"10.1016\/j.trsl.2020.05.005_bib0047","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1161\/ATVBAHA.108.162289","article-title":"Mechanisms of venous thrombosis and resolution","volume":"28","author":"Wakefield","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0048","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1182\/blood-2016-05-718114","article-title":"The role of leukocytes in thrombosis","volume":"128","author":"Swystun","year":"2016","journal-title":"Blood"},{"issue":"123 Suppl","key":"10.1016\/j.trsl.2020.05.005_bib0049","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1016\/S0049-3848(09)70148-3","article-title":"Thrombus resolution and vein wall injury: dependence on chemokines and leukocytes","volume":"4","author":"Henke","year":"2009","journal-title":"Thromb Res"},{"key":"10.1016\/j.trsl.2020.05.005_bib0050","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1161\/ATVBAHA.110.213405","article-title":"Leukocytes and the natural history of deep vein thrombosis: current concepts and future directions","volume":"31","author":"Saha","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0051","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"Engelmann","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"123 Suppl","key":"10.1016\/j.trsl.2020.05.005_bib0052","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/S0049-3848(09)70141-0","article-title":"Role of selectins and fibrinolysis in VTE","volume":"4","author":"Wakefield","year":"2009","journal-title":"Thromb Res"},{"key":"10.1016\/j.trsl.2020.05.005_bib0053","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.jvs.2007.11.040","article-title":"Vein wall re-endothelialization after deep vein thrombosis is improved with low-molecular-weight heparin","volume":"47","author":"Moaveni","year":"2008","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0054","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1067\/mva.2002.128636","article-title":"P-selectin inhibition enhances thrombus resolution and decreases vein wall fibrosis in a rat model","volume":"36","author":"Myers","year":"2002","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0055","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1067\/msy.2003.249","article-title":"P-selectin inhibition decreases post-thrombotic vein wall fibrosis in a rat model","volume":"134","author":"Thanaporn","year":"2003","journal-title":"Surgery"},{"key":"10.1016\/j.trsl.2020.05.005_bib0056","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.avsg.2010.09.003","article-title":"and Diaz JA. Interleukin-6: a potential target for post-thrombotic syndrome","volume":"25","author":"Wojcik","year":"2011","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0057","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jvs.2012.02.054","article-title":"The role of urokinase plasminogen activator and plasmin activator inhibitor-1 on vein wall remodeling in experimental deep vein thrombosis","volume":"56","author":"Baldwin","year":"2012","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0058","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1111\/jth.12644","article-title":"Plasminogen activator-1 overexpression decreases experimental postthrombotic vein wall fibrosis by a non-vitronectin-dependent mechanism","volume":"12","author":"Obi","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.05.005_bib0059","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1161\/ATVBAHA.112.251983","article-title":"Inflammation modulates murine venous thrombosis resolution in vivo: assessment by multimodal fluorescence molecular imaging","volume":"32","author":"Ripplinger","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0060","first-page":"1","article-title":"Divergent effects of Tlr9 deletion in experimental late venous thrombosis resolution and vein wall injury","volume":"114","author":"Dewyer","year":"2015","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.05.005_bib0061","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1160\/TH07-03-0190","article-title":"Fibrotic injury after experimental deep vein thrombosis is determined by the mechanism of thrombogenesis","volume":"98","author":"Henke","year":"2007","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.05.005_bib0062","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1055\/s-0038-1645855","article-title":"Pre-clinical model to study recurrent venous thrombosis in the inferior vena cava","volume":"118","author":"Andraska","year":"2018","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.05.005_bib0063","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nri2779","article-title":"Phagocyte partnership during the onset and resolution of inflammation","volume":"10","author":"Soehnlein","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0064","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2010.02.029","article-title":"Nonresolving inflammation","volume":"140","author":"Nathan","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.trsl.2020.05.005_bib0065","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jvsv.2013.10.021","article-title":"Human chronic post-thrombotic intraluminal venous obstruction involves neovascularization","volume":"2","author":"Oostra","year":"2014","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.trsl.2020.05.005_bib0066","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.jvs.2012.11.088","article-title":"The effect of matrix metalloproteinase 2 and matrix metalloproteinase 2\/9 deletion in experimental post-thrombotic vein wall remodeling","volume":"58","author":"Deatrick","year":"2013","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0067","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1160\/TH05-02-0099","article-title":"Neutrophils modulate post-thrombotic vein wall remodeling but not thrombus neovascularization","volume":"95","author":"Henke","year":"2006","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.05.005_bib0068","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1084\/jem.20112322","article-title":"Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo","volume":"209","author":"von Bruhl","year":"2012","journal-title":"J Exp Med"},{"key":"10.1016\/j.trsl.2020.05.005_bib0069","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1160\/TH16-03-0218","article-title":"Endotoxaemia-augmented murine venous thrombosis is dependent on TLR-4 and ICAM-1, and potentiated by neutropenia","volume":"117","author":"Obi","year":"2017","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.05.005_bib0070","doi-asserted-by":"crossref","first-page":"15880","DOI":"10.1073\/pnas.1005743107","article-title":"Extracellular DNA traps promote thrombosis","volume":"107","author":"Fuchs","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2020.05.005_bib0071","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.4049\/jimmunol.177.5.3388","article-title":"Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse model","volume":"177","author":"Henke","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0072","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1161\/01.ATV.0000129537.72553.73","article-title":"Deep vein thrombosis resolution is modulated by monocyte CXCR2-mediated activity in a mouse model","volume":"24","author":"Henke","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0073","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1055\/s-0039-3400959","article-title":"LY6Clo monocyte\/macrophages are essential for thrombus resolution in a murine model of venous thrombosis","volume":"120","author":"Kimball","year":"2020","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.05.005_bib0074","doi-asserted-by":"crossref","first-page":"e110","DOI":"10.1182\/blood-2013-08-520619","article-title":"Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct","volume":"123","author":"Gundra","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.trsl.2020.05.005_bib0075","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1084\/jem.20111009","article-title":"Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis","volume":"209","author":"Leuschner","year":"2012","journal-title":"J Exp Med"},{"key":"10.1016\/j.trsl.2020.05.005_bib0076","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1161\/CIRCRESAHA.114.303204","article-title":"Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium","volume":"114","author":"Hilgendorf","year":"2014","journal-title":"Circ Res"},{"key":"10.1016\/j.trsl.2020.05.005_bib0077","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1084\/jem.20141539","article-title":"A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury","volume":"212","author":"Dal-Secco","year":"2015","journal-title":"J Exp Med"},{"key":"10.1016\/j.trsl.2020.05.005_bib0078","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1084\/jem.20070075","article-title":"Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis","volume":"204","author":"Arnold","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.trsl.2020.05.005_bib0079","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1084\/jem.20170689","article-title":"The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes","volume":"214","author":"Anzai","year":"2017","journal-title":"J Exp Med"},{"key":"10.1016\/j.trsl.2020.05.005_bib0080","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1172\/JCI95612","article-title":"Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage","volume":"128","author":"Chang","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2020.05.005_bib0081","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nm.2184","article-title":"Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases","volume":"16","author":"Massberg","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.trsl.2020.05.005_bib0082","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1182\/blood-2016-04-710632","article-title":"Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice","volume":"128","author":"Stark","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.trsl.2020.05.005_bib0083","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1161\/01.CIR.0000050149.22928.39","article-title":"Failure of thrombus to resolve in urokinase-type plasminogen activator gene-knockout mice: rescue by normal bone marrow-derived cells","volume":"107","author":"Singh","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.trsl.2020.05.005_bib0084","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1160\/TH10-03-0184","article-title":"Urokinase plasminogen activator independent early experimental thrombus resolution: MMP2 as an alternative mechanism","volume":"104","author":"Sood","year":"2010","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.05.005_bib0085","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/jsre.2001.6122","article-title":"Interleukin-8 administration enhances venous thrombosis resolution in a rat model","volume":"99","author":"Henke","year":"2001","journal-title":"J Surg Res"},{"key":"10.1016\/j.trsl.2020.05.005_bib0086","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.jvs.2009.06.047","article-title":"Monocyte urokinase-type plasminogen activator up-regulation reduces thrombus size in a model of venous thrombosis","volume":"50","author":"Humphries","year":"2009","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0087","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0088","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.trsl.2020.05.005_bib0089","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.trsl.2020.05.005_bib0090","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.4049\/jimmunol.1502490","article-title":"Highly dynamic transcriptional signature of distinct macrophage subsets during sterile inflammation, resolution, and tissue repair","volume":"196","author":"Varga","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0091","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1161\/ATVBAHA.118.311022","article-title":"Human monocyte heterogeneity as revealed by high-dimensional mass cytometry","volume":"39","author":"Hamers","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0092","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1182\/blood-2016-07-727180","article-title":"Myeloid p53 regulates macrophage polarization and venous thrombus resolution by inflammatory vascular remodeling in mice","volume":"129","author":"Mukhopadhyay","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.trsl.2020.05.005_bib0093","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1038\/s41598-018-21273-5","article-title":"Lack of T-bet reduces monocytic interleukin-12 formation and accelerates thrombus resolution in deep vein thrombosis","volume":"8","author":"Schonfelder","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.trsl.2020.05.005_bib0094","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.jvs.2006.05.021","article-title":"Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis","volume":"44","author":"Myers","year":"2006","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0095","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.thromres.2013.06.027","article-title":"Matrix metalloproteinase-9 deletion is associated with decreased mid-term vein wall fibrosis in experimental stasis DVT","volume":"132","author":"Deatrick","year":"2013","journal-title":"Thromb Res"},{"key":"10.1016\/j.trsl.2020.05.005_bib0096","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1160\/TH14-12-1031","article-title":"Divergent effects of Tlr9 deletion in experimental late venous thrombosis resolution and vein wall injury","volume":"114","author":"Dewyer","year":"2015","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.05.005_bib0097","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jvsv.2016.03.005","article-title":"Alterations in macrophage phenotypes in experimental venous thrombosis","volume":"4","author":"Gallagher","year":"2016","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.trsl.2020.05.005_bib0098","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1161\/CIRCRESAHA.116.309301","article-title":"Innate effector-memory T-cell activation regulates post-thrombotic vein wall inflammation and thrombus resolution","volume":"119","author":"Luther","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.trsl.2020.05.005_bib0099","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1172\/JCI124804","article-title":"Ectonucleotidase tri(di)phosphohydrolase-1 (ENTPD-1) disrupts inflammasome\/interleukin 1beta-driven venous thrombosis","volume":"129","author":"Yadav","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2020.05.005_bib0100","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jvs.2005.04.014","article-title":"Vein wall remodeling after deep vein thrombosis involves matrix metalloproteinases and late fibrosis in a mouse model","volume":"42","author":"Deatrick","year":"2005","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0101","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jvsv.2014.02.004","article-title":"Low-molecular-weight heparin modulates vein wall fibrotic response in a plasminogen activator inhibitor 1-dependent manner","volume":"2","author":"Obi","year":"2014","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.trsl.2020.05.005_bib0102","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139145","article-title":"Matrix metalloproteinase 9 (MMP-9) regulates vein wall biomechanics in murine thrombus resolution","volume":"10","author":"Nguyen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2020.05.005_bib0103","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/ATVBAHA.110.216317","article-title":"Toll-like receptor 9 signaling is critical for early experimental deep vein thrombosis resolution","volume":"31","author":"Henke","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0104","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1161\/CIRCRESAHA.119.315259","article-title":"Activated endothelial TGFbeta1 signaling promotes venous thrombus non-resolution in mice via endothelin-1: potential role for chronic thromboembolic pulmonary hypertension","volume":"126","author":"Bochenek","year":"2020","journal-title":"Circ Res"},{"key":"10.1016\/j.trsl.2020.05.005_bib0105","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1161\/ATVBAHA.114.304457","article-title":"P-selectin inhibition therapeutically promotes thrombus resolution and prevents vein wall fibrosis better than enoxaparin and an inhibitor to von Willebrand factor","volume":"35","author":"Diaz","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-4804(02)00041-0","article-title":"Decrease in fibrin content of venous thrombi in selectin-deficient mice","volume":"109","author":"Sullivan","year":"2003","journal-title":"J Surg Res"},{"key":"10.1016\/j.trsl.2020.05.005_bib0107","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.amjmed.2011.02.033","article-title":"Long-term low-molecular-weight heparin and the post-thrombotic syndrome: a systematic review","volume":"124","author":"Hull","year":"2011","journal-title":"Am J Med"},{"key":"10.1016\/j.trsl.2020.05.005_bib0108","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1024\/0301-1526\/a000507","article-title":"Effects of rosuvastatin as an adjuvant treatment for deep vein thrombosis","volume":"45","author":"San Norberto","year":"2016","journal-title":"Vasa"},{"key":"10.1016\/j.trsl.2020.05.005_bib0109","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1056\/NEJMoa0900241","article-title":"A randomized trial of rosuvastatin in the prevention of venous thromboembolism","volume":"360","author":"Glynn","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.trsl.2020.05.005_bib0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116621","article-title":"Statins improve the resolution of established murine venous thrombosis: reductions in thrombus burden and vein wall scarring","volume":"10","author":"Kessinger","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2020.05.005_bib0111","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.thromres.2012.12.006","article-title":"Rosuvastatin reduced deep vein thrombosis in ApoE gene deleted mice with hyperlipidemia through non-lipid lowering effects","volume":"131","author":"Patterson","year":"2013","journal-title":"Thromb Res"},{"key":"10.1016\/j.trsl.2020.05.005_bib0112","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1523\/JNEUROSCI.2405-14.2015","article-title":"CCR2 antagonism alters brain macrophage polarization and ameliorates cognitive dysfunction induced by traumatic brain injury","volume":"35","author":"Morganti","year":"2015","journal-title":"J Neurosci"},{"key":"10.1016\/j.trsl.2020.05.005_bib0113","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1161\/CIRCULATIONAHA.112.000116","article-title":"Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice","volume":"127","author":"Majmudar","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.trsl.2020.05.005_bib0114","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/nbt.1989","article-title":"Therapeutic siRNA silencing in inflammatory monocytes in mice","volume":"29","author":"Leuschner","year":"2011","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0115","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1523\/JNEUROSCI.4070-13.2014","article-title":"CCR2+ Ly6C(hi) inflammatory monocyte recruitment exacerbates acute disability following intracerebral hemorrhage","volume":"34","author":"Hammond","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.trsl.2020.05.005_bib0116","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1161\/01.HYP.36.3.360","article-title":"CC chemokine receptor 2 is required for macrophage infiltration and vascular hypertrophy in angiotensin II-induced hypertension","volume":"36","author":"Bush","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.trsl.2020.05.005_bib0117","doi-asserted-by":"crossref","first-page":"16029","DOI":"10.1073\/pnas.1406508111","article-title":"Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart","volume":"111","author":"Lavine","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2020.05.005_bib0118","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.avsg.2009.11.002","article-title":"Vein wall remodeling after deep vein thrombosis: differential effects of low molecular weight heparin and doxycycline","volume":"24","author":"Sood","year":"2010","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0119","doi-asserted-by":"crossref","first-page":"815","DOI":"10.7326\/0003-4819-159-12-201312170-00007","article-title":"Doxycycline for stabilization of abdominal aortic aneurysms: a randomized trial","volume":"159","author":"Meijer","year":"2013","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.trsl.2020.05.005_bib0120","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/jth.12814","article-title":"Inflammation markers and their trajectories after deep vein thrombosis in relation to risk of post-thrombotic syndrome","volume":"13","author":"Rabinovich","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.trsl.2020.05.005_bib0121","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.avsg.2010.09.003","article-title":"Interleukin-6: a potential target for post-thrombotic Syndrome","volume":"25","author":"Wojcik","year":"2011","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.trsl.2020.05.005_bib0122","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/01.ATV.15.2.258","article-title":"Venous thrombosis-associated inflammation and attenuation with neutralizing antibodies to cytokines and adhesion molecules","volume":"15","author":"Wakefield","year":"1995","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.trsl.2020.05.005_bib0123","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.7150\/thno.12494","article-title":"Blood accessibility to fibrin in venous thrombosis is thrombus age-dependent and predicts fibrinolytic efficacy: an in vivo fibrin molecular imaging study","volume":"5","author":"Stein-Merlob","year":"2015","journal-title":"Theranostics"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524420301043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524420301043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:43:01Z","timestamp":1761828181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524420301043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":123,"alternative-id":["S1931524420301043"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2020.05.005","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insights from experimental post-thrombotic syndrome and potential for novel therapies","name":"articletitle","label":"Article Title"},{"value":"Translational Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trsl.2020.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}