{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:16:22Z","timestamp":1789168582616,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","translationalres.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.trsl.2021.02.012","type":"journal-article","created":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T10:53:00Z","timestamp":1615114380000},"page":"88-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis"],"prefix":"10.1016","volume":"232","author":[{"given":"Geraldine","family":"Buitrago","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Pickering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Ruscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Cobos Caceres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Van Waardenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Miles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Field","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Dredge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norelle L.","family":"Daly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Giacomin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Loukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2021.02.012_bib0001","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.trsl.2021.02.012_bib0002","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jaci.2009.08.006","article-title":"Trichuris suis ova therapy for allergic rhinitis: a randomized, double-blind, placebo-controlled clinical trial","volume":"125","author":"Bager","year":"2010","journal-title":"J Allerg Clin Immunol"},{"key":"10.1016\/j.trsl.2021.02.012_bib0003","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/B978-0-12-394596-9.00009-3","article-title":"Animal models of inflammatory bowel disease","volume":"105","author":"Mizoguchi","year":"2012","journal-title":"Prog Mol Biol Transl Sci"},{"key":"10.1016\/j.trsl.2021.02.012_bib0004","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jaci.2014.07.022","article-title":"Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease","volume":"135","author":"Croese","year":"2015","journal-title":"J Allerg Clin Immunol"},{"key":"10.1016\/j.trsl.2021.02.012_bib0005","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1136\/gut.2005.079129","article-title":"A proof of concept study establishing Necator americanus in Crohn's patients and reservoir donors","volume":"55","author":"Croese","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.trsl.2021.02.012_bib0006","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1053\/j.gastro.2005.01.005","article-title":"Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial","volume":"128","author":"Summers","year":"2005","journal-title":"Gastroenterol"},{"key":"10.1016\/j.trsl.2021.02.012_bib0007","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD009400.pub2","article-title":"Helminth therapy (worms) for induction of remission in inflammatory bowel disease","author":"Garg","year":"2014","journal-title":"Cochrane Data Syst Rev"},{"key":"10.1016\/j.trsl.2021.02.012_bib0008","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008508","article-title":"Harnessing helminth-driven immunoregulation in the search for novel therapeutic modalities","volume":"16","author":"Ryan","year":"2020","journal-title":"PLoS Path"},{"key":"10.1016\/j.trsl.2021.02.012_bib0009","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.immuni.2018.10.016","article-title":"Modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules","volume":"49","author":"Maizels","year":"2018","journal-title":"Immunity."},{"key":"10.1016\/j.trsl.2021.02.012_bib0010","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/ibd.20787","article-title":"Therapeutic potential of helminth soluble proteins in TNBS-induced colitis in mice","volume":"15","author":"Ruyssers","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.trsl.2021.02.012_bib0011","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1002\/ibd.21629","article-title":"Hookworm products ameliorate dextran sodium sulfate-induced colitis in BALB\/c mice","volume":"17","author":"Can\u00e7ado","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.trsl.2021.02.012_bib0012","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1128\/IAI.00563-12","article-title":"Hookworm excretory\/secretory products induce interleukin-4 (IL-4) IL-10 CD4 T cell responses and suppress pathology in a mouse model of colitis","volume":"81","author":"Ferreira","year":"2013","journal-title":"Infect Immun"},{"key":"10.1016\/j.trsl.2021.02.012_bib0013","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf8807","article-title":"Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma","volume":"8","author":"Navarro","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.trsl.2021.02.012_bib0014","doi-asserted-by":"crossref","first-page":"e684","DOI":"10.1371\/journal.pntd.0000684","article-title":"Massively parallel sequencing and analysis of the Necator americanus transcriptome","volume":"4","author":"Cantacessi","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.trsl.2021.02.012_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2164-11-307","article-title":"Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation","volume":"11","author":"Wang","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1016\/j.trsl.2021.02.012_bib0016","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/ng.3237","article-title":"The genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families","volume":"47","author":"Schwarz","year":"2015","journal-title":"Nature Genet"},{"key":"10.1016\/j.trsl.2021.02.012_bib0017","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/ng.2875","article-title":"Genome of the human hookworm Necator americanus","volume":"46","author":"Tang","year":"2014","journal-title":"Nature Genet"},{"key":"10.1016\/j.trsl.2021.02.012_bib0018","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4269\/ajtmh.2002.66.238","article-title":"Molecular cloning and purification of Ac-TMP, a developmentally regulated putative tissue inhibitor of metalloprotease released in relative abundance by adult Ancylostoma hookworms","volume":"66","author":"Zhan","year":"2002","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.trsl.2021.02.012_bib0019","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.molbiopara.2008.08.008","article-title":"Molecular cloning and characterization of Ac-TMP-2, a tissue inhibitor of metalloproteinase secreted by adult Ancylostoma caninum","volume":"162","author":"Zhan","year":"2008","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.trsl.2021.02.012_bib0020","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1074\/mcp.M800206-MCP200","article-title":"Proteomics analysis of the excretory\/secretory component of the blood-feeding stage of the hookworm, Ancylostoma caninum","volume":"8","author":"Mulvenna","year":"2009","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.trsl.2021.02.012_bib0021","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/pmic.201700186","article-title":"Revisiting the Ancylostoma caninum secretome provides new information on hookworm-host interactions","volume":"17","author":"Morante","year":"2017","journal-title":"Proteomics"},{"key":"10.1016\/j.trsl.2021.02.012_bib0022","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1110\/ps.8.8.1636","article-title":"The NTR module: domains of netrins, secreted frizzled related proteins, and type I procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases","volume":"8","author":"Banyai","year":"1999","journal-title":"Protein Sci"},{"key":"10.1016\/j.trsl.2021.02.012_bib0023","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jmb.2011.02.033","article-title":"Ancylostoma ceylanicum excretory-secretory protein 2 adopts a netrin-like fold and defines a novel family of nematode proteins","volume":"408","author":"Kucera","year":"2011","journal-title":"J Mol Biol"},{"key":"10.1016\/j.trsl.2021.02.012_bib0024","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/1756-3305-6-156","article-title":"TIMPs of parasitic helminths - a large-scale analysis of high-throughput sequence datasets","volume":"6","author":"Cantacessi","year":"2013","journal-title":"Parasit Vectors"},{"key":"10.1016\/j.trsl.2021.02.012_bib0025","article-title":"Netrin family: role for protein isoforms in cancer","volume":"3947123","author":"Bruikman","year":"2019","journal-title":"J Nucl Acids"},{"key":"10.1016\/j.trsl.2021.02.012_bib0026","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.1038\/cti.2017.42","article-title":"Suppression of inflammation and tissue damage by a hookworm recombinant protein in experimental colitis","volume":"6","author":"Ferreira","year":"2017","journal-title":"Clin Transl Immunol"},{"key":"10.1016\/j.trsl.2021.02.012_bib0027","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0263-7855(96)00009-4","article-title":"MOLMOL: a program for display and analysis of macromolecular structures","volume":"14","author":"Koradi","year":"1996","journal-title":"J Mol Graph"},{"key":"10.1016\/j.trsl.2021.02.012_bib0028","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nmeth.3213","article-title":"The I-TASSER Suite: protein structure and function prediction","volume":"12","author":"Yang","year":"2015","journal-title":"Nature Meth"},{"key":"10.1016\/j.trsl.2021.02.012_bib0029","doi-asserted-by":"crossref","first-page":"10288","DOI":"10.1074\/jbc.M117.779215","article-title":"An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease","volume":"292","author":"Cobos Caceres","year":"2017","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2021.02.012_bib0030","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1152\/ajpgi.90462.2008","article-title":"T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade","volume":"296","author":"Ostanin","year":"2009","journal-title":"Am J Physiol Gastro Liver Physiol"},{"key":"10.1016\/j.trsl.2021.02.012_bib0031","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/978-1-4939-1212-4_14","article-title":"Induction of colitis in mice (T-cell transfer model)","volume":"1193","author":"Weigmann","year":"2014","journal-title":"Meths Mol Biol"},{"key":"10.1016\/j.trsl.2021.02.012_bib0032","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ng.764","article-title":"Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47","volume":"43","author":"Anderson","year":"2011","journal-title":"Nature Genet"},{"key":"10.1016\/j.trsl.2021.02.012_bib0033","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.trsl.2021.02.012_bib0034","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/1471-2105-12-480","article-title":"GC-content normalization for RNA-Seq data","volume":"12","author":"Risso","year":"2011","journal-title":"BMC Bioinform"},{"key":"10.1016\/j.trsl.2021.02.012_bib0035","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/nbt.2931","article-title":"Normalization of RNA-seq data using factor analysis of control genes or samples","volume":"32","author":"Risso","year":"2014","journal-title":"Nature Biotechnol"},{"key":"10.1016\/j.trsl.2021.02.012_bib0036","doi-asserted-by":"crossref","first-page":"e8206","DOI":"10.7717\/peerj.8206","article-title":"consensusDE: an R package for assessing consensus of multiple RNA-seq algorithms with RUV correction","volume":"7","author":"Waardenberg","year":"2019","journal-title":"PeerJ"},{"key":"10.1016\/j.trsl.2021.02.012_bib0037","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1093\/nar\/gks042","article-title":"Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation","volume":"40","author":"McCarthy","year":"2012","journal-title":"Nucl Acids Res"},{"key":"10.1016\/j.trsl.2021.02.012_bib0038","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.trsl.2021.02.012_bib0039","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1039\/C2FO30156C","article-title":"Characterization of polarized THP-1 macrophages and polarizing ability of LPS and food compounds","volume":"4","author":"Chanput","year":"2013","journal-title":"Food Function"},{"key":"10.1016\/j.trsl.2021.02.012_bib0040","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1053\/gast.2003.50141","article-title":"Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease","volume":"124","author":"Abad","year":"2003","journal-title":"Gastroenterol"},{"key":"10.1016\/j.trsl.2021.02.012_bib0041","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.amsu.2016.07.019","article-title":"The TNBS-induced colitis animal model: an overview","volume":"11","author":"Antoniou","year":"2016","journal-title":"Annals Med Surg"},{"key":"10.1016\/j.trsl.2021.02.012_bib0042","article-title":"Anti-IL-12\/23p40 antibodies for induction of remission in Crohn's disease","volume":"11","author":"MacDonald","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.trsl.2021.02.012_bib0043","article-title":"Pharmacological evaluation of the SCID T cell transfer model of colitis: as a model of Crohn's disease","volume":"2012","author":"Lindebo Holm","year":"2012","journal-title":"Int J Inflamm"},{"key":"10.1016\/j.trsl.2021.02.012_bib0044","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.intimp.2006.04.017","article-title":"Reconstitution of Scid mice with CD4+CD25- T cells leads to rapid colitis: an improved model for pharmacologic testing","volume":"6","author":"Kjellev","year":"2006","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.trsl.2021.02.012_bib0045","doi-asserted-by":"crossref","first-page":"7096","DOI":"10.1038\/ncomms8096","article-title":"MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis","volume":"6","author":"Pan","year":"2015","journal-title":"Nature Comm"},{"key":"10.1016\/j.trsl.2021.02.012_bib0046","article-title":"Helminth-induced regulation of T-cell transfer colitis requires intact and regulated T cell Stat6 signaling in mice","author":"Metwali","year":"2020","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.trsl.2021.02.012_bib0047","doi-asserted-by":"crossref","first-page":"e2302","DOI":"10.1038\/cddis.2016.215","article-title":"Granzyme M has a critical role in providing innate immune protection in ulcerative colitis","volume":"7","author":"Souza-Fonseca-Guimaraes","year":"2016","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.trsl.2021.02.012_bib0048","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.4049\/jimmunol.1302238","article-title":"Plasma cells in the mucosa of patients with inflammatory bowel disease produce granzyme B and possess cytotoxic activities","volume":"192","author":"Cupi","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2021.02.012_bib0049","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/imr.12039","article-title":"CD4(+) T-cell subsets in intestinal inflammation","volume":"252","author":"Shale","year":"2013","journal-title":"Immunol Rev"},{"key":"10.1016\/j.trsl.2021.02.012_bib0050","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3389\/fimmu.2018.00850","article-title":"Hookworm secreted extracellular vesicles interact with host cells and prevent inducible colitis in mice","volume":"9","author":"Eichenberger","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.trsl.2021.02.012_bib0051","article-title":"Hookworm-derived metabolites suppress pathology in a mouse model of colitis and inhibit secretion of key inflammatory cytokines in primary human leukocytes","volume":"87(4)","author":"Wangchuk","year":"2019","journal-title":"Infect Immun"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524421000499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524421000499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:44:11Z","timestamp":1761828251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524421000499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":51,"alternative-id":["S1931524421000499"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2021.02.012","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis","name":"articletitle","label":"Article Title"},{"value":"Translational Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trsl.2021.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}