{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:07:27Z","timestamp":1787314047808,"version":"build-2736575974"},"reference-count":226,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"am","delay-in-days":333,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI072648"],"award-info":[{"award-number":["AI072648"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI122176"],"award-info":[{"award-number":["AI122176"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR076092"],"award-info":[{"award-number":["AR076092"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001026","name":"Central New York Community Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","translationalres.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.trsl.2022.03.004","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T20:59:16Z","timestamp":1647032356000},"page":"55-81","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Cell type-specific mechanistic target of rapamycin-dependent distortion of autophagy pathways in lupus nephritis"],"prefix":"10.1016","volume":"245","author":[{"given":"TIFFANY","family":"CAZA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHATHURA","family":"WIJEWARDENA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LAITH","family":"AL-RABADI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5017-1348","authenticated-orcid":false,"given":"Andras","family":"Perl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2022.03.004_bib0001","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/1529-0131(199807)41:7<1173::AID-ART5>3.0.CO;2-A","article-title":"Systemic lupus erythematosus in three ethnic groups: II. Features predictive of disease activity early in its course. LUMINA Study Group. Lupus in minority populations, nature versus nurture","volume":"41","author":"Alarc\u00f3n","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.trsl.2022.03.004_bib0002","article-title":"Systemic lupus erythematosus: lupus nephritis","volume":"2015","author":"Madhok","year":"2015","journal-title":"BMJ Clin Evid"},{"key":"10.1016\/j.trsl.2022.03.004_bib0003","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/638413","article-title":"Biomarkers for lupus nephritis: a critical appraisal","volume":"2010","author":"Mok","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtauto.2020.100042","article-title":"Urinary biomarkers in lupus nephritis","volume":"3","author":"Arag\u00f3n","year":"2020","journal-title":"J Transl Autoimmun"},{"key":"10.1016\/j.trsl.2022.03.004_bib0005","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00296-010-1554-7","article-title":"Abd-El-Aziz DM. Renal involvement in childhood-onset systemic lupus erythematosus in Egypt","volume":"32","author":"Mahmoud","year":"2012","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.trsl.2022.03.004_bib0006","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/art.1780350606","article-title":"Derivation of the SLEDAI. A disease activity index for lupus patients. The committee on prognosis studies in SLE","volume":"35","author":"Bombardier","year":"1992","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.trsl.2022.03.004_bib0007","article-title":"Four systemic lupus erythematosus subgroups, defined by autoantibodies status, differ regarding HLA-DRB1 genotype associations and immunological and clinical manifestations","author":"Diaz-Gallo","year":"2021","journal-title":"ACR Open Rheumatol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0008","article-title":"The economic burden of lupus nephritis: a systematic literature review","author":"Thompson","year":"2021","journal-title":"Rheumatol Ther"},{"key":"10.1016\/j.trsl.2022.03.004_bib0009","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1002\/art.1780400928","article-title":"Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus","volume":"40","author":"Hochberg","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.trsl.2022.03.004_bib0010","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1136\/annrheumdis-2015-eular.1159","article-title":"Understanding delay in diagnosis, access to care and satisfaction with care in lupus: findings from a cross-sectional online survey in the united states","volume":"74","author":"Al Sawah","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.trsl.2022.03.004_bib0011","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1002\/art.34473","article-title":"Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus","volume":"64","author":"Petri","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.trsl.2022.03.004_bib0012","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.kint.2017.11.023","article-title":"Revision of the international society of nephrology\/renal pathology society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices","volume":"93","author":"Bajema","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.trsl.2022.03.004_bib0013","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.ekir.2019.06.011","article-title":"A Systematic review of interpathologist agreement in histologic classification of lupus nephritis","volume":"4","author":"Dasari","year":"2019","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.trsl.2022.03.004_bib0014","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1016\/j.ekir.2020.09.007","article-title":"Low-Level Proteinuria in systemic lupus erythematosus","volume":"5","author":"Chedid","year":"2020","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.trsl.2022.03.004_bib0015","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/rheumatology\/keu343","article-title":"Low complements and high titre of anti-Sm antibody as predictors of histopathologically proven silent lupus nephritis without abnormal urinalysis in patients with systemic lupus erythematosus","volume":"54","author":"Ishizaki","year":"2015","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.trsl.2022.03.004_bib0016","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1681\/ASN.2013010026","article-title":"The pathogenesis of lupus nephritis","volume":"24","author":"Lech","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2020.115327","article-title":"A panoramic review of IL-6: structure, pathophysiological roles and inhibitors","volume":"28","author":"Kaur","year":"2020","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.trsl.2022.03.004_bib0018","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4049\/jimmunol.147.1.117","article-title":"Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis","volume":"147","author":"Linker-Israeli","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0019","article-title":"Autoantibodies in SLE: specificities, isotypes and receptors","volume":"5","author":"Dema","year":"2016","journal-title":"Antibodies (Basel)"},{"key":"10.1016\/j.trsl.2022.03.004_bib0020","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1053\/j.ackd.2019.09.001","article-title":"Utilization of biomarkers in lupus nephritis","volume":"26","author":"Caster","year":"2019","journal-title":"Adv Chronic Kidney Dis"},{"key":"10.1016\/j.trsl.2022.03.004_bib0021","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1080\/15321819.2021.1895215","article-title":"High frequency of concurrent anti-C1q and anti-dsDNA but not anti-C3b antibodies in patients with Lupus Nephritis","volume":"42","author":"Kianmehr","year":"2021","journal-title":"J Immunoassay Immunochem"},{"key":"10.1016\/j.trsl.2022.03.004_bib0022","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/art.20980","article-title":"Relationship between anti-double-stranded DNA antibodies and exacerbation of renal disease in patients with systemic lupus erythematosus","volume":"52","author":"Linnik","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.trsl.2022.03.004_bib0023","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1093\/ndt\/14.6.1418","article-title":"Anti-DNA antibodies in the urine of lupus nephritis patients","volume":"14","author":"Macanovic","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.trsl.2022.03.004_bib0024","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/ki.1982.228","article-title":"Entrapment of anti-DNA antibodies in the kidney of patients with systemic lupus erythematosus","volume":"22","author":"Yamada","year":"1982","journal-title":"Kidney Int"},{"key":"10.1016\/j.trsl.2022.03.004_bib0025","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1080\/08916930410001713016","article-title":"Autoantibodies and autoantigens in the urine of SLE patients","volume":"37","author":"Sciascia","year":"2004","journal-title":"Autoimmunity"},{"key":"10.1016\/j.trsl.2022.03.004_bib0026","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1136\/ard.47.10.820","article-title":"Specificity of anti-Sm antibodies by ELISA for systemic lupus erythematosus: increased sensitivity of detection using purified peptide antigens","volume":"47","author":"Field","year":"1988","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.trsl.2022.03.004_bib0027","first-page":"913","article-title":"Urinary excretion of antinuclear antibodies","volume":"10","author":"Meryhew","year":"1983","journal-title":"J Rheumatol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0028","first-page":"1308","article-title":"Anti-RNA polymerase I antibodies in the urine of patients with systemic lupus erythematosus","volume":"17","author":"Picking","year":"1990","journal-title":"J Rheumatol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0029","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1681\/ASN.2018080852","article-title":"Exostosin 1\/Exostosin 2-Associated membranous nephropathy","volume":"30","author":"Sethi","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0030","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.kint.2020.09.016","article-title":"Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis","volume":"100","author":"Caza","year":"2021","journal-title":"Kidney Int"},{"key":"10.1016\/j.trsl.2022.03.004_bib0031","article-title":"Transforming growth factor beta receptor 3 (TGFBR3)-associated membranous nephropathy","volume":"360","author":"Caza","year":"2021","journal-title":"Kidney"},{"key":"10.1016\/j.trsl.2022.03.004_bib0032","doi-asserted-by":"crossref","DOI":"10.1681\/ASN.2020081181","article-title":"Patients with membranous lupus nephritis, exostosin-positivity and exostosin-negativity represent two different phenotypes","author":"Ravindran","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0033","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1016\/j.ekir.2021.04.025","article-title":"The exostosin immunohistochemical status differentiates lupus membranous nephropathy subsets with different outcomes","volume":"6","author":"Sa\u00efdi","year":"2021","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.trsl.2022.03.004_bib0034","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.semnephrol.2015.08.006","article-title":"The complement system in lupus nephritis","volume":"35","author":"Birmingham","year":"2015","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0035","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1177\/0961203320925165","article-title":"Activation of the alternative complement pathway predicts renal outcome in patients with lupus nephritis","volume":"29","author":"Kim","year":"2020","journal-title":"Lupus"},{"key":"10.1016\/j.trsl.2022.03.004_bib0036","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.3899\/jrheum.171033","article-title":"The lectin pathway of complement activation in patients with systemic lupus erythematosus","volume":"45","author":"Troldborg","year":"2018","journal-title":"J Rheumatol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0037","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.582737","article-title":"Plasma C4d correlates with C4d deposition in kidneys and with treatment response in lupus nephritis patients","volume":"11","author":"Martin","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0038","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.2215\/CJN.02790313","article-title":"Alternative complement pathway activation products in urine and kidneys of patients with ANCA-Associated GN","volume":"8","author":"Gou","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0039","first-page":"265","article-title":"Complement C3 fragments in urine: detection in systemic lupus erythematosus patients by western blotting","volume":"3","author":"Kelly","year":"1993","journal-title":"Appl Theor Electrophor"},{"key":"10.1016\/j.trsl.2022.03.004_bib0040","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/art.1780390716","article-title":"Sensitivity and specificity of plasma and urine complement split products as indicators of lupus disease activity","volume":"39","author":"Manzi","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.trsl.2022.03.004_bib0041","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.clim.2012.07.001","article-title":"Metabolic regulation of organelle homeostasis in lupus T cells","volume":"144","author":"Caza","year":"2012","journal-title":"Clin Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0042","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41584-020-00544-4","article-title":"Toll-like receptor signalling in B cells during systemic lupus erythematosus","volume":"17","author":"Fillatreau","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0043","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7697592","article-title":"Kidney expression of toll like receptors in lupus nephritis: quantification and clinicopathological correlations","volume":"2016","author":"Conti","year":"2016","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.trsl.2022.03.004_bib0044","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3109\/08830185.2013.863305","article-title":"Interplay of infections, autoimmunity, and immunosuppression in systemic lupus erythematosus","volume":"33","author":"Caza","year":"2014","journal-title":"Int Rev Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0045","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1056\/NEJMra1100359","article-title":"Systemic lupus erythematosus","volume":"365","author":"Tsokos","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.trsl.2022.03.004_bib0046","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0896-8411(03)00121-5","article-title":"Quantification of regulatory T cells in patients with systemic lupus erythematosus","volume":"21","author":"Crispin","year":"2003","journal-title":"J Autoimmun"},{"key":"10.1016\/j.trsl.2022.03.004_bib0047","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4049\/jimmunol.141.1.85","article-title":"Immunologic abnormality in NZB\/NZW F1 mice. Thymus-independent occurrence of B cell abnormality and requirement for T cells in the development of autoimmune disease, as evidenced by an analysis of the athymic nude individuals","volume":"141","author":"Mihara","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0048","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/ki.2012.242","article-title":"Kidney-infiltrating CD4+ T-cell clones promote nephritis in lupus-prone mice","volume":"82","author":"Okamoto","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.trsl.2022.03.004_bib0049","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1084\/jem.193.3.329","article-title":"CD4(+) T cells from lupus-prone mice are hyperresponsive to T cell receptor engagement with low and high affinity peptide antigens: a model to explain spontaneous T cell activation in lupus","volume":"193","author":"Vratsanos","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.trsl.2022.03.004_bib0050","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.4049\/jimmunol.177.11.8258","article-title":"Role for nephritogenic T cells in lupus glomerulonephritis: progression to renal failure is accompanied by T cell activation and expansion in regional lymph nodes","volume":"177","author":"Bagavant","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0051","doi-asserted-by":"crossref","first-page":"31880","DOI":"10.1074\/jbc.M113.508655","article-title":"cAMP-responsive element modulator \u03b1 (CREM\u03b1) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease","volume":"288","author":"Hedrich","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2022.03.004_bib0052","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4049\/jimmunol.143.1.103","article-title":"T cell receptor alpha\/beta expressing double-negative (CD4-\/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis","volume":"143","author":"Shivakumar","year":"1989","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0053","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1002\/art.34502","article-title":"N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial","volume":"64","author":"Lai","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.trsl.2022.03.004_bib0054","doi-asserted-by":"crossref","first-page":"8761","DOI":"10.4049\/jimmunol.181.12.8761","article-title":"Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys","volume":"181","author":"Crisp\u00edn","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0055","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.4049\/jimmunol.0803600","article-title":"Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1\/Rab4-regulated lysosomal degradation","volume":"182","author":"Fernandez","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0056","doi-asserted-by":"crossref","first-page":"5338","DOI":"10.4049\/jimmunol.165.9.5338","article-title":"Human double-negative T cells in systemic lupus erythematosus provide help for IgG and are restricted by CD1c","volume":"165","author":"Sieling","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0057","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.4049\/jimmunol.1301005","article-title":"Mechanistic target of rapamycin activation triggers IL-4 production and necrotic death of double-negative T cells in patients with systemic lupus erythematosus","volume":"191","author":"Lai","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0058","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrrheum.2015.172","article-title":"Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases","volume":"12","author":"Perl","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0059","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/art.40380","article-title":"Blockade of treg cell differentiation and function by the interleukin-21-mechanistic target of rapamycin axis via suppression of autophagy in patients with systemic lupus erythematosus","volume":"70","author":"Kato","year":"2018","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"key":"10.1016\/j.trsl.2022.03.004_bib0060","article-title":"Positive and negative selection shape the human na\u00efve B cell repertoire","author":"Chen","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2022.03.004_bib0061","doi-asserted-by":"crossref","first-page":"786","DOI":"10.3389\/fimmu.2018.00786","article-title":"Targeting regulatory T cells to treat patients with systemic lupus erythematosus","volume":"9","author":"Mizui","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0062","doi-asserted-by":"crossref","first-page":"R53","DOI":"10.1186\/ar2964","article-title":"Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus","volume":"12","author":"Shah","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.trsl.2022.03.004_bib0063","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1172\/JCI73411","article-title":"CaMK4-dependent activation of AKT\/mTOR and CREM-\u03b1 underlies autoimmunity-associated Th17 imbalance","volume":"124","author":"Koga","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2022.03.004_bib0064","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4137\/CMAMD.S32269","article-title":"Serum and urinary interleukin-6 in assessment of renal activity in egyptian patients with systemic lupus erythematosus","volume":"9","author":"El-Shereef","year":"2016","journal-title":"Clin Med Insights Arthritis Musculoskelet Disord"},{"key":"10.1016\/j.trsl.2022.03.004_bib0065","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1191\/096120398678919949","article-title":"Renal expression of IL-6 and TNFalpha genes in lupus nephritis","volume":"7","author":"Herrera-Esparza","year":"1998","journal-title":"Lupus"},{"key":"10.1016\/j.trsl.2022.03.004_bib0066","first-page":"89","article-title":"Elevated gene expression of Th1\/Th2 associated transcription factors is correlated with disease activity in patients with systemic lupus erythematosus","volume":"34","author":"Lit","year":"2007","journal-title":"J Rheumatol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0067","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1002\/1529-0131(199908)42:8<1644::AID-ANR12>3.0.CO;2-L","article-title":"Th1\/Th2 balance of peripheral T helper cells in systemic lupus erythematosus","volume":"42","author":"Akahoshi","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.trsl.2022.03.004_bib0068","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1002\/1529-0131(200109)44:9<2097::AID-ART360>3.0.CO;2-6","article-title":"Predominance of Th1 immune response in diffuse proliferative lupus nephritis","volume":"44","author":"Masutani","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.trsl.2022.03.004_bib0069","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1586\/1744666X.2014.944162","article-title":"The role of dead cell clearance in the etiology and pathogenesis of systemic lupus erythematosus: dendritic cells as potential targets","volume":"10","author":"Biermann","year":"2014","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0070","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1073\/pnas.0337679100","article-title":"Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus","volume":"100","author":"Baechler","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2022.03.004_bib0071","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1002\/art.30399","article-title":"Association of endogenous anti-interferon-\u03b1 autoantibodies with decreased interferon-pathway and disease activity in patients with systemic lupus erythematosus","volume":"63","author":"Morimoto","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.trsl.2022.03.004_bib0072","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1177\/0961203320935976","article-title":"Characterization of Type-I IFN subtype autoantibodies and activity in SLE serum and urine","volume":"29","author":"Harris","year":"2020","journal-title":"Lupus"},{"key":"10.1016\/j.trsl.2022.03.004_bib0073","doi-asserted-by":"crossref","first-page":"e67003","DOI":"10.1371\/journal.pone.0067003","article-title":"SLE peripheral blood B cell, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signature","volume":"8","author":"Becker","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.trsl.2022.03.004_bib0074","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/art.38628","article-title":"Modular transcriptional repertoire analyses of adults with systemic lupus erythematosus reveal distinct type I and type II interferon signatures","volume":"66","author":"Chiche","year":"2014","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"key":"10.1016\/j.trsl.2022.03.004_bib0075","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1365-2249.2009.04057.x","article-title":"Interferon signature gene expression is correlated with autoantibody profiles in patients with incomplete lupus syndromes","volume":"159","author":"Li","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0076","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1056\/NEJMoa1912196","article-title":"Trial of anifrolumab in active systemic lupus erythematosus","volume":"382","author":"Morand","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.trsl.2022.03.004_bib0077","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev-immunol-020711-075024","article-title":"Regulation of immune responses by mTOR","volume":"30","author":"Powell","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0078","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ni.2005","article-title":"The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2","volume":"12","author":"Delgoffe","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0079","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1615\/CritRevEukarGeneExpr.v21.i4.20","article-title":"mTOR regulates T-cell differentiation and activation in immunity and autoimmunity","volume":"21","author":"Bi","year":"2011","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"10.1016\/j.trsl.2022.03.004_bib0080","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.immuni.2009.10.010","article-title":"The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin","volume":"32","author":"Rao","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.trsl.2022.03.004_bib0081","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.immuni.2009.04.014","article-title":"The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment","volume":"30","author":"Delgoffe","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.trsl.2022.03.004_bib0082","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.635531","article-title":"Double-edged sword: interleukin-2 promotes T regulatory cell differentiation but also expands interleukin-13- and interferon-\u03b3-producing CD8(+) T cells via STAT6-GATA-3 axis in systemic lupus erythematosus","volume":"12","author":"Kato","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0083","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1002\/art.22085","article-title":"Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosus","volume":"54","author":"Fernandez","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.trsl.2022.03.004_bib0084","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1136\/annrheumdis-2013-203794","article-title":"HRES-1\/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE","volume":"73","author":"Caza","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.trsl.2022.03.004_bib0085","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.clim.2015.03.024","article-title":"Oxidative stress and Treg depletion in lupus patients with anti-phospholipid syndrome","volume":"158","author":"Lai","year":"2015","journal-title":"Clin Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0086","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/1529-0131(200201)46:1<175::AID-ART10015>3.0.CO;2-H","article-title":"Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus","volume":"46","author":"Gergely","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.trsl.2022.03.004_bib0087","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.trsl.2018.07.014","article-title":"Mitochondria in innate immune signaling","volume":"202","author":"Banoth","year":"2018","journal-title":"Transl Res"},{"key":"10.1016\/j.trsl.2022.03.004_bib0088","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1681\/ASN.2008121259","article-title":"Autoimmunity in membranous nephropathy targets aldose reductase and SOD2","volume":"21","author":"Prunotto","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0089","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.2215\/CJN.02170312","article-title":"Coexistence of different circulating anti-podocyte antibodies in membranous nephropathy","volume":"7","author":"Murtas","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0090","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02334","article-title":"Exploring the role of autophagy-related gene 5 (ATG5) yields important insights into autophagy in autoimmune\/autoinflammatory diseases","volume":"9","author":"Ye","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0091","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.molimm.2018.05.009","article-title":"Autophagy and MHC-restricted antigen presentation","volume":"99","author":"Vale\u010dka","year":"2018","journal-title":"Mol Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0092","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.3389\/fimmu.2018.02914","article-title":"Modulating T cell responses via autophagy: the intrinsic influence controlling the function of both antigen-presenting cells and T cells","volume":"9","author":"Merkley","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0093","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/15548627.2017.1362525","article-title":"Autophagy dictates metabolism and differentiation of inflammatory immune cells","volume":"14","author":"Riffelmacher","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.trsl.2022.03.004_bib0094","doi-asserted-by":"crossref","first-page":"14050","DOI":"10.1073\/pnas.0704014104","article-title":"The Atg5 Atg12 conjugate associates with innate antiviral immune responses","volume":"104","author":"Jounai","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2022.03.004_bib0095","doi-asserted-by":"crossref","first-page":"4722","DOI":"10.1096\/fj.12-206060","article-title":"T lymphocytes from patients with systemic lupus erythematosus are resistant to induction of autophagy","volume":"26","author":"Alessandri","year":"2012","journal-title":"Faseb J"},{"key":"10.1016\/j.trsl.2022.03.004_bib0096","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.4161\/auto.20275","article-title":"Macroautophagy is deregulated in murine and human lupus T lymphocytes","volume":"8","author":"Gros","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.trsl.2022.03.004_bib0097","first-page":"705","article-title":"Blockade of macrophage autophagy ameliorates activated lymphocytes-derived DNA induced murine lupus possibly via inhibition of proinflammatory cytokine production","volume":"32","author":"Li","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0098","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41418-018-0252-y","article-title":"Autophagy-dependent cell death","volume":"26","author":"Denton","year":"2019","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.trsl.2022.03.004_bib0099","doi-asserted-by":"crossref","first-page":"9813","DOI":"10.1073\/pnas.0909927107","article-title":"Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis","volume":"107","author":"Hakkim","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2022.03.004_bib0100","doi-asserted-by":"crossref","first-page":"24005","DOI":"10.1038\/s41598-021-03520-4","article-title":"Spontaneous formation of neutrophil extracellular traps is associated with autophagy","volume":"11","author":"Guo","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.trsl.2022.03.004_bib0101","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3001201","article-title":"Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus","volume":"3","author":"Garcia-Romo","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.trsl.2022.03.004_bib0102","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0103","doi-asserted-by":"crossref","first-page":"17396","DOI":"10.1073\/pnas.1113421108","article-title":"Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells","volume":"108","author":"Martinez","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2022.03.004_bib0104","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature17950","article-title":"Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells","volume":"533","author":"Martinez","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.trsl.2022.03.004_bib0105","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.3389\/fimmu.2018.01023","article-title":"Cell-intrinsic roles for autophagy in modulating CD4 T cell functions","volume":"9","author":"Jacquin","year":"2018","journal-title":"Front Immunol"},{"issue":"9","key":"10.1016\/j.trsl.2022.03.004_bib0106","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O'Neill","year":"2016","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"10.1016\/j.trsl.2022.03.004_bib0107","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.smim.2016.10.009","article-title":"Metabolic pathways in T cell activation and lineage differentiation","volume":"28","author":"Almeida","year":"2016","journal-title":"Semin Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0108","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.20110278","article-title":"HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells","volume":"208","author":"Shi","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.trsl.2022.03.004_bib0109","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/ni.3365","article-title":"Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis","volume":"17","author":"Wei","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0110","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/ni.3025","article-title":"Autophagy is essential for effector CD8(+) T cell survival and memory formation","volume":"15","author":"Xu","year":"2014","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0111","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1002\/art.21943","article-title":"Abnormal differentiation of memory T cells in systemic lupus erythematosus","volume":"54","author":"Fritsch","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.trsl.2022.03.004_bib0112","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1038\/s41467-021-22312-y","article-title":"Type I interferons affect the metabolic fitness of CD8(+) T cells from patients with systemic lupus erythematosus","volume":"12","author":"Buang","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.trsl.2022.03.004_bib0113","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.immuni.2007.07.022","article-title":"T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis","volume":"27","author":"Harris","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.trsl.2022.03.004_bib0114","doi-asserted-by":"crossref","first-page":"e12444","DOI":"10.7554\/eLife.12444","article-title":"The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation","volume":"5","author":"Kabat","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.trsl.2022.03.004_bib0115","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.vetimm.2008.10.293","article-title":"Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages","volume":"128","author":"Harris","year":"2009","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0116","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.4049\/jimmunol.0803458","article-title":"Autophagy and its role in MHC-mediated antigen presentation","volume":"182","author":"Crotzer","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0117","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1136\/ard.2010.140111","article-title":"Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population","volume":"70","author":"Zhou","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.trsl.2022.03.004_bib0118","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature11910","article-title":"Autophagosomes form at ER-mitochondria contact sites","volume":"495","author":"Hamasaki","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.trsl.2022.03.004_bib0119","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41580-018-0003-4","article-title":"Mechanism and medical implications of mammalian autophagy","volume":"19","author":"Dikic","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0120","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41580-020-0241-0","article-title":"Mechanisms governing autophagosome biogenesis","volume":"21","author":"Nakatogawa","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0121","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/ng.468","article-title":"A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus","volume":"41","author":"Gateva","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.trsl.2022.03.004_bib0122","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/ng.472","article-title":"Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus","volume":"41","author":"Han","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.trsl.2022.03.004_bib0123","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1177\/0961203318776108","article-title":"Evaluation of ATG5 polymorphisms in Italian patients with systemic lupus erythematosus: contribution to disease susceptibility and clinical phenotypes","volume":"27","author":"Ciccacci","year":"2018","journal-title":"Lupus"},{"key":"10.1016\/j.trsl.2022.03.004_bib0124","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41580-018-0033-y","article-title":"Autophagy as a promoter of longevity: insights from model organisms","volume":"19","author":"Hansen","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0125","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1002\/art.38749","article-title":"Brief Report: identification of MTMR3 as a novel susceptibility gene for lupus nephritis in northern Han Chinese by shared-gene analysis with IgA nephropathy","volume":"66","author":"Zhou","year":"2014","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"key":"10.1016\/j.trsl.2022.03.004_bib0126","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1177\/0961203315622823","article-title":"Association between toll-like receptor polymorphisms and systemic lupus erythematosus: a meta-analysis update","volume":"25","author":"Lee","year":"2016","journal-title":"Lupus"},{"key":"10.1016\/j.trsl.2022.03.004_bib0127","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1126\/science.1124978","article-title":"Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication","volume":"312","author":"Pisitkun","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.trsl.2022.03.004_bib0128","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.4049\/jimmunol.174.7.4043","article-title":"Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN","volume":"174","author":"Bekeredjian-Ding","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0129","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/art.38220","article-title":"End-stage kidney disease in African Americans with lupus nephritis associates with APOL1","volume":"66","author":"Freedman","year":"2014","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"key":"10.1016\/j.trsl.2022.03.004_bib0130","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1681\/ASN.2012121180","article-title":"Apolipoprotein L1 risk variants associate with systemic lupus erythematosus-associated collapsing glomerulopathy","volume":"24","author":"Larsen","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0131","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1136\/annrheumdis-2013-204343","article-title":"Autophagy is activated in systemic lupus erythematosus and required for plasmablast development","volume":"74","author":"Clarke","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.trsl.2022.03.004_bib0132","article-title":"ApoL1, a BH3-only lipid-binding protein, induces autophagic cell death","volume":"16","author":"Zhaorigetu","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.trsl.2022.03.004_bib0133","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.it.2004.05.001","article-title":"Mitochondrial hyperpolarization: a checkpoint of T-cell life, death and autoimmunity","volume":"25","author":"Perl","year":"2004","journal-title":"Trends Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0134","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41467-017-00348-3","article-title":"The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity","volume":"8","author":"Yi","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.trsl.2022.03.004_bib0135","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.4049\/jimmunol.1002795","article-title":"Type I interferon in the pathogenesis of lupus","volume":"192","author":"Crow","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0136","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1080\/15548627.2019.1580512","article-title":"Podocytes and autophagy: a potential therapeutic target in lupus nephritis","volume":"15","author":"Zhou","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.trsl.2022.03.004_bib0137","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/RHU.0b013e318289c033","article-title":"Tuberous sclerosis and fulminant lupus in a young woman","volume":"19","author":"Singh","year":"2013","journal-title":"J Clin Rheumatol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0138","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.reuma.2015.08.003","article-title":"Coincidence of tuberous sclerosis and systemic lupus erythematosus-a case report","volume":"12","author":"Carrasco Cubero","year":"2016","journal-title":"Reumatol Clin"},{"key":"10.1016\/j.trsl.2022.03.004_bib0139","doi-asserted-by":"crossref","first-page":"e28263","DOI":"10.4161\/trns.28263","article-title":"mTOR signaling and transcriptional regulation in T lymphocytes","volume":"5","author":"Zeng","year":"2014","journal-title":"Transcription"},{"key":"10.1016\/j.trsl.2022.03.004_bib0140","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s10157-008-0083-0","article-title":"A case of lymphangioleiomyomatosis with membranous nephropathy and likely systemic lupus","volume":"13","author":"Sam","year":"2009","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0141","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13023-018-0933-0","article-title":"Comorbid connective tissue diseases and autoantibodies in lymphangioleiomyomatosis: a retrospective cohort study","volume":"13","author":"Futami","year":"2018","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.trsl.2022.03.004_bib0142","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s13023-021-01905-2","article-title":"The etiology of diffuse cystic lung diseases: an analysis of 1010 consecutive cases in a LAM clinic","volume":"16","author":"Cui","year":"2021","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.trsl.2022.03.004_bib0143","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1177\/0961203316636466","article-title":"Coexistence of systemic lupus erythematosus, tuberous sclerosis and aggressive natural killer-cell leukaemia: coincidence or correlated?","volume":"25","author":"Olde Bekkink","year":"2016","journal-title":"Lupus"},{"key":"10.1016\/j.trsl.2022.03.004_bib0144","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.4049\/jimmunol.171.10.5188","article-title":"T cell activation-induced mitochondrial hyperpolarization is mediated by Ca2+- and redox-dependent production of nitric oxide","volume":"171","author":"Nagy","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0145","doi-asserted-by":"crossref","first-page":"26457","DOI":"10.1074\/jbc.272.42.26457","article-title":"Regulation of eIF-4E BP1 phosphorylation by mTOR","volume":"272","author":"Hara","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2022.03.004_bib0146","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A gene network regulating lysosomal biogenesis and function","volume":"325","author":"Sardiello","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.trsl.2022.03.004_bib0147","doi-asserted-by":"crossref","first-page":"15790","DOI":"10.1073\/pnas.1521919112","article-title":"mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy","volume":"112","author":"Zhao","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2022.03.004_bib0148","doi-asserted-by":"crossref","first-page":"579","DOI":"10.4049\/jimmunol.1800602","article-title":"The mTORC1\/4E-BP\/eIF4E axis promotes antibody class switching in B lymphocytes","volume":"202","author":"Chiu","year":"2019","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0149","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.4049\/jimmunol.1600492","article-title":"Conditional disruption of raptor reveals an essential role for mTORC1 in B cell development, survival, and metabolism","volume":"197","author":"Iwata","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0150","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cmet.2016.03.008","article-title":"AMPK is essential to balance glycolysis and mitochondrial metabolism to control T-ALL cell stress and survival","volume":"23","author":"Kishton","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.trsl.2022.03.004_bib0151","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1089\/ars.2013.5702","article-title":"Increased mitochondrial electron transport chain activity at complex I is regulated by N-acetylcysteine in lymphocytes of patients with systemic lupus erythematosus","volume":"21","author":"Doherty","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.trsl.2022.03.004_bib0152","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1365-2249.2009.03924.x","article-title":"Activation of AMPK inhibits inflammation in MRL\/lpr mouse mesangial cells","volume":"156","author":"Peairs","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0153","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.4049\/jimmunol.1403088","article-title":"Metformin suppresses systemic autoimmunity in roquin(san\/san) mice through inhibiting B cell differentiation into plasma cells via regulation of AMPK\/mTOR\/STAT3","volume":"198","author":"Lee","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0154","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2020-000429","article-title":"Effects of metformin on disease flares in patients with systemic lupus erythematosus: post hoc analyses from two randomised trials","volume":"7","author":"Sun","year":"2020","journal-title":"Lupus Sci Med"},{"key":"10.1016\/j.trsl.2022.03.004_bib0155","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1016\/j.jmb.2017.08.012","article-title":"LC3-associated phagocytosis and inflammation","volume":"429","author":"Heckmann","year":"2017","journal-title":"J Mol Biol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0156","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/ni833","article-title":"B cells regulate autoimmunity by provision of IL-10","volume":"3","author":"Fillatreau","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0157","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.4049\/jimmunol.1400977","article-title":"IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells","volume":"193","author":"Mizui","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0158","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/art.1780291005","article-title":"Rook AH. Deficient gamma-interferon production in patients with systemic lupus erythematosus","volume":"29","author":"Tsokos","year":"1986","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.trsl.2022.03.004_bib0159","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3899\/jrheum.091071","article-title":"On anti-tumor necrosis factor-induced systemic lupus erythematosus","volume":"37","author":"Jacob","year":"2010","journal-title":"J Rheumatol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0160","doi-asserted-by":"crossref","first-page":"19396","DOI":"10.1074\/jbc.M106585200","article-title":"Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site","volume":"277","author":"Rabilloud","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2022.03.004_bib0161","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3899\/jrheum.081312","article-title":"Induction of systemic lupus erythematosus with tumor necrosis factor blockers","volume":"37","author":"Soforo","year":"2010","journal-title":"J Rheumatol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0162","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1080\/15548627.2015.1052206","article-title":"B cell autophagy mediates TLR7-dependent autoimmunity and inflammation","volume":"11","author":"Weindel","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.trsl.2022.03.004_bib0163","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.4049\/jimmunol.1601307","article-title":"Autophagy in dendritic cells and B cells is critical for the inflammatory state of TLR7-mediated autoimmunity","volume":"198","author":"Weindel","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0164","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1172\/JCI86504","article-title":"mTOR has distinct functions in generating versus sustaining humoral immunity","volume":"126","author":"Jones","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2022.03.004_bib0165","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1172\/JCI75417","article-title":"KIM-1-mediated phagocytosis reduces acute injury to the kidney","volume":"125","author":"Yang","year":"2015","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2022.03.004_bib0166","doi-asserted-by":"crossref","first-page":"e84392","DOI":"10.1371\/journal.pone.0084392","article-title":"HRES-1\/Rab4 promotes the formation of LC3(+) autophagosomes and the accumulation of mitochondria during autophagy","volume":"9","author":"Talaber","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.trsl.2022.03.004_bib0167","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.celrep.2018.09.001","article-title":"IFN\u03b1 impairs autophagic degradation of mtDNA promoting autoreactivity of SLE monocytes in a STING-dependent fashion","volume":"25","author":"Gkirtzimanaki","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.trsl.2022.03.004_bib0168","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41586-018-0448-9","article-title":"Parkin and PINK1 mitigate STING-induced inflammation","volume":"561","author":"Sliter","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.trsl.2022.03.004_bib0169","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.3389\/fimmu.2018.01473","article-title":"B cell-related circulating MicroRNAs with the potential value of biomarkers in the differential diagnosis, and distinguishment between the disease activity and lupus nephritis for systemic lupus erythematosus","volume":"9","author":"Zhang","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0170","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/art.37890","article-title":"Circulating microRNA expression profiles associated with systemic lupus erythematosus","volume":"65","author":"Carlsen","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.trsl.2022.03.004_bib0171","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/3746335","article-title":"miR-20a overexpression in adipose-derived mesenchymal stem cells promotes therapeutic efficacy in murine lupus nephritis by regulating autophagy","volume":"2021","author":"Wei","year":"2021","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.trsl.2022.03.004_bib0172","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1136\/annrheumdis-2018-213028","article-title":"Increased autophagy is cytoprotective against podocyte injury induced by antibody and interferon-\u03b1 in lupus nephritis","volume":"77","author":"Qi","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.trsl.2022.03.004_bib0173","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1093\/ndt\/gfq058","article-title":"Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis","volume":"25","author":"Machida","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.trsl.2022.03.004_bib0174","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.4049\/jimmunol.1801610","article-title":"Tris DBA ameliorates accelerated and severe lupus nephritis in mice by activating regulatory T cells and autophagy and inhibiting the NLRP3 inflammasome","volume":"204","author":"Wu","year":"2020","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0175","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/941893","article-title":"Rapamycin ameliorates proteinuria and restores nephrin and podocin expression in experimental membranous nephropathy","volume":"2013","author":"Stratakis","year":"2013","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0176","doi-asserted-by":"crossref","first-page":"912","DOI":"10.4161\/auto.6.7.13290","article-title":"Glucocorticoids downregulate Fyn and inhibit IP(3)-mediated calcium signaling to promote autophagy in T lymphocytes","volume":"6","author":"Harr","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.trsl.2022.03.004_bib0177","doi-asserted-by":"crossref","DOI":"10.1093\/rheumatology\/keac037","article-title":"Renal mTORC1 activation is associated with disease activity and prognosis in lupus nephritis","author":"Mao","year":"2022","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.trsl.2022.03.004_bib0178","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/S0140-6736(18)30485-9","article-title":"Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1\/2 trial","volume":"391","author":"Lai","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.trsl.2022.03.004_bib0179","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2100295118","article-title":"SLC15A4 mediates M1-prone metabolic shifts in macrophages and guards immune cells from metabolic stress","volume":"118","author":"Kobayashi","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2022.03.004_bib0180","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41572-019-0141-9","article-title":"Lupus nephritis","volume":"6","author":"Anders","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.trsl.2022.03.004_bib0181","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/ki.1984.75","article-title":"Diffuse proliferative lupus nephritis: identification of specific pathologic features affecting renal outcome","volume":"25","author":"Austin","year":"1984","journal-title":"Kidney Int"},{"key":"10.1016\/j.trsl.2022.03.004_bib0182","doi-asserted-by":"crossref","first-page":"549","DOI":"10.7326\/0003-4819-125-7-199610010-00003","article-title":"Methylprednisolone and cyclophosphamide, alone or in combination, in patients with lupus nephritis. A randomized, controlled trial","volume":"125","author":"Gourley","year":"1996","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.trsl.2022.03.004_bib0183","doi-asserted-by":"crossref","first-page":"e21983","DOI":"10.1096\/fj.202101052R","article-title":"Tacrolimus ameliorates podocyte injury by restoring FK506 binding protein 12 (FKBP12) at actin cytoskeleton","volume":"35","author":"Yasuda","year":"2021","journal-title":"Faseb J"},{"key":"10.1016\/j.trsl.2022.03.004_bib0184","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.autrev.2015.09.006","article-title":"Tacrolimus use in lupus nephritis: a systematic review and meta-analysis","volume":"15","author":"Hannah","year":"2016","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.trsl.2022.03.004_bib0185","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1056\/NEJM199009203231215","article-title":"Role of a prostaglandin E1 analogue in the prevention of acute graft rejection by cyclosporine","volume":"323","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.trsl.2022.03.004_bib0186","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0272-6386(96)90106-7","article-title":"Divergent effects of calcium channel and angiotensin converting enzyme blockade on glomerulotubular function in cyclosporine-treated renal allograft recipients","volume":"27","author":"Sennesael","year":"1996","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.trsl.2022.03.004_bib0187","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1016\/S0140-6736(21)00578-X","article-title":"Efficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial","volume":"397","author":"Rovin","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.trsl.2022.03.004_bib0188","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/art.24538","article-title":"Protective effect of hydroxychloroquine on renal damage in patients with lupus nephritis: LXV, data from a multiethnic US cohort","volume":"61","author":"Pons-Estel","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.trsl.2022.03.004_bib0189","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1191\/0961203306lu2313oa","article-title":"Hydroxychloroquine use predicts complete renal remission within 12 months among patients treated with mycophenolate mofetil therapy for membranous lupus nephritis","volume":"15","author":"Kasitanon","year":"2006","journal-title":"Lupus"},{"key":"10.1016\/j.trsl.2022.03.004_bib0190","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1182\/blood-2012-03-416776","article-title":"Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1\/2) inhibition","volume":"120","author":"Cea","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.trsl.2022.03.004_bib0191","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1080\/15548627.2015.1017179","article-title":"Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide","volume":"11","author":"Macri","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.trsl.2022.03.004_bib0192","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1136\/ard.2010.139832","article-title":"HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus","volume":"70","author":"Page","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.trsl.2022.03.004_bib0193","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11926-016-0622-8","article-title":"Activation of the mechanistic target of rapamycin in SLE: explosion of evidence in the last five years","volume":"18","author":"Oaks","year":"2016","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.trsl.2022.03.004_bib0194","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/art.1780370219","article-title":"Rapamycin prolongs survival and arrests pathophysiologic changes in murine systemic lupus erythematosus","volume":"37","author":"Warner","year":"1994","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.trsl.2022.03.004_bib0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2021.108781","article-title":"Improvement of renal and non-renal SLE outcome measures on sirolimus therapy - A 21-year follow-up study of 73 patients","volume":"229","author":"Piranavan","year":"2021","journal-title":"Clin Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0196","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1093\/ndt\/gfn216","article-title":"Rapamycin attenuates the severity of established nephritis in lupus-prone NZB\/W F1 mice","volume":"23","author":"Lui","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.trsl.2022.03.004_bib0197","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1440-1797.2012.01646.x","article-title":"Proliferation signal inhibitors in the treatment of lupus nephritis: preliminary experience","volume":"17","author":"Yap","year":"2012","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/j.trsl.2022.03.004_bib0198","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1093\/abbs\/gmy088","article-title":"mTOR regulates NLRP3 inflammasome activation via reactive oxygen species in murine lupus","volume":"50","author":"Li","year":"2018","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1016\/j.trsl.2022.03.004_bib0199","doi-asserted-by":"crossref","first-page":"8338","DOI":"10.4049\/jimmunol.177.12.8338","article-title":"Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients","volume":"177","author":"Battaglia","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0200","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.3899\/jrheum.180507","article-title":"Longterm data on sirolimus treatment in patients with lupus nephritis","volume":"45","author":"Yap","year":"2018","journal-title":"J Rheumatol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0201","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1056\/NEJMoa1312890","article-title":"Inhibition of the mTORC pathway in the antiphospholipid syndrome","volume":"371","author":"Canaud","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.trsl.2022.03.004_bib0202","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/740619","article-title":"The IL-2 defect in systemic lupus erythematosus disease has an expansive effect on host immunity","volume":"2010","author":"Lieberman","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0203","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1136\/annrheumdis-2019-215396","article-title":"Efficacy and safety of low-dose IL-2 in the treatment of systemic lupus erythematosus: a randomised, double-blind, placebo-controlled trial","volume":"79","author":"He","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.trsl.2022.03.004_bib0204","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3109\/08916934.2014.915954","article-title":"KN-93, an inhibitor of calcium\/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3\u207a regulatory T cells in MRL\/lpr mice","volume":"47","author":"Koga","year":"2014","journal-title":"Autoimmunity"},{"key":"10.1016\/j.trsl.2022.03.004_bib0205","article-title":"Current insights and future prospects for targeting IL-17 to treat patients with systemic lupus erythematosus","volume":"11","author":"Koga","year":"2020","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.trsl.2022.03.004_bib0206","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1365-2567.2006.02433.x","article-title":"Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus","volume":"119","author":"Liang","year":"2006","journal-title":"Immunology"},{"key":"10.1016\/j.trsl.2022.03.004_bib0207","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/annrheumdis-2016-209668","article-title":"Efficacy and safety of an interleukin 6 monoclonal antibody for the treatment of systemic lupus erythematosus: a phase II dose-ranging randomised controlled trial","volume":"76","author":"Wallace","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.trsl.2022.03.004_bib0208","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00005792-198905000-00005","article-title":"Primary acute renal failure (\"acute tubular necrosis\") in the transplanted kidney: morphology and pathogenesis","volume":"68","author":"Olsen","year":"1989","journal-title":"Medicine"},{"key":"10.1016\/j.trsl.2022.03.004_bib0209","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.4049\/jimmunol.0903595","article-title":"Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL\/6-lpr\/lpr mice","volume":"184","author":"Kyttaris","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0210","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/S0140-6736(18)32167-6","article-title":"Efficacy and safety of ustekinumab, an IL-12 and IL-23 inhibitor, in patients with active systemic lupus erythematosus: results of a multicentre, double-blind, phase 2, randomised, controlled study","volume":"392","author":"van Vollenhoven","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.trsl.2022.03.004_bib0211","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/art.38955","article-title":"Function of the Th17\/interleukin-17A immune response in murine lupus nephritis","volume":"67","author":"Schmidt","year":"2015","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"key":"10.1016\/j.trsl.2022.03.004_bib0212","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2018-000286","article-title":"Type I interferon receptor blockade with anifrolumab corrects innate and adaptive immune perturbations of SLE","volume":"5","author":"Casey","year":"2018","journal-title":"Lupus Sci Med"},{"key":"10.1016\/j.trsl.2022.03.004_bib0213","article-title":"Baricitinib attenuates autoimmune phenotype and podocyte injury in a murine model of systemic lupus erythematosus","volume":"12","author":"Lee","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0214","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/ki.2008.396","article-title":"Increased survival and reduced renal injury in MRL\/lpr mice treated with a novel sphingosine-1-phosphate receptor agonist","volume":"74","author":"Wenderfer","year":"2008","journal-title":"Kidney Int"},{"key":"10.1016\/j.trsl.2022.03.004_bib0215","first-page":"707","article-title":"Effects of FTY720 in MRL-lpr\/lpr mice: therapeutic potential in systemic lupus erythematosus","volume":"29","author":"Okazaki","year":"2002","journal-title":"J Rheumatol"},{"key":"10.1016\/j.trsl.2022.03.004_bib0216","article-title":"Fingolimod for relapsing-remitting multiple sclerosis","volume":"4","author":"La Mantia","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.trsl.2022.03.004_bib0217","doi-asserted-by":"crossref","first-page":"39898","DOI":"10.1074\/jbc.M112.416552","article-title":"Regulation of autophagy and its associated cell death by \"sphingolipid rheostat\": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway","volume":"287","author":"Taniguchi","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2022.03.004_bib0218","article-title":"B-cell depletion with obinutuzumab for the treatment of proliferative lupus nephritis: a randomised, double-blind, placebo-controlled trial","author":"Furie","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.trsl.2022.03.004_bib0219","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/art.38260","article-title":"Efficacy and safety of abatacept in lupus nephritis: a twelve-month, randomized, double-blind study","volume":"66","author":"Furie","year":"2014","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"key":"10.1016\/j.trsl.2022.03.004_bib0220","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/art.40932","article-title":"Rituximab as maintenance treatment for systemic lupus erythematosus: a multicenter observational study of 147 patients","volume":"71","author":"Cassia","year":"2019","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"key":"10.1016\/j.trsl.2022.03.004_bib0221","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1056\/NEJMoa2023325","article-title":"Targeting CD38 with daratumumab in refractory systemic lupus erythematosus","volume":"383","author":"Ostendorf","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.trsl.2022.03.004_bib0222","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/s41598-020-80244-x","article-title":"Adenosine A2A receptor signaling promotes FoxO associated autophagy in chondrocytes","volume":"11","author":"Friedman","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.trsl.2022.03.004_bib0223","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.1096\/fj.201902459R","article-title":"Adenosine A2A receptor (A2AR) stimulation enhances mitochondrial metabolism and mitigates reactive oxygen species-mediated mitochondrial injury","volume":"34","author":"Castro","year":"2020","journal-title":"Faseb J"},{"key":"10.1016\/j.trsl.2022.03.004_bib0224","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41467-022-28086-1","article-title":"Adenosine receptor 2a agonists target mouse CD11c(+)T-bet(+) B cells in infection and autoimmunity","volume":"13","author":"Levack","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.trsl.2022.03.004_bib0225","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1002\/art.40223","article-title":"Review: metabolic control of immune system activation in rheumatic diseases","volume":"69","author":"Perl","year":"2017","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"key":"10.1016\/j.trsl.2022.03.004_bib0226","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.it.2018.04.006","article-title":"Metabolism as a target for modulation in autoimmune diseases","volume":"39","author":"Huang","year":"2018","journal-title":"Trends Immunol"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524422000470?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524422000470?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:45:59Z","timestamp":1761828359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524422000470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":226,"alternative-id":["S1931524422000470"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2022.03.004","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell type-specific mechanistic target of rapamycin-dependent distortion of autophagy pathways in lupus nephritis","name":"articletitle","label":"Article Title"},{"value":"Translational Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trsl.2022.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}