{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:59:18Z","timestamp":1785869958211,"version":"3.56.0"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"am","delay-in-days":317,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL111130"],"award-info":[{"award-number":["R01 HL111130"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 CA009501"],"award-info":[{"award-number":["T32 CA009501"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007345","name":"University of Arizona Cancer Center","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100007345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","translationalres.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.trsl.2023.01.005","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T11:53:03Z","timestamp":1675252383000},"page":"43-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Topical captopril: a promising treatment for secondary lymphedema"],"prefix":"10.1016","volume":"257","author":[{"given":"Stav","family":"Brown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela D.G.","family":"Nores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananta","family":"Sarker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeung Ju","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey E.","family":"Hespe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Gardenier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Kuonqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adana","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyeon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghu P.","family":"Kataru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Aras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak J.","family":"Mehrara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2023.01.005_bib0001","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1196\/annals.1413.014","article-title":"Estimating the population burden of lymphedema","volume":"1131","author":"Rockson","year":"2008","journal-title":"Ann N Y Acad Sci"},{"issue":"22","key":"10.1016\/j.trsl.2023.01.005_bib0002","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1002\/cncr.25458","article-title":"Lymphedema beyond breast cancer: a systematic review and meta-analysis of cancer-related secondary lymphedema","volume":"116","author":"Cormier","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.trsl.2023.01.005_bib0003","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev-med-060116-022900","article-title":"Lymphedema: Pathogenesis and Novel Therapies","volume":"69","author":"Dayan","year":"2018","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.trsl.2023.01.005_bib0004","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.trsl.2019.04.001","article-title":"Fibrosis and secondary lymphedema: chicken or egg?","volume":"209","author":"Kataru","year":"2019","journal-title":"Transl Res"},{"issue":"7","key":"10.1016\/j.trsl.2023.01.005_bib0005","doi-asserted-by":"crossref","first-page":"e41126","DOI":"10.1371\/journal.pone.0041126","article-title":"Pathological steps of cancer-related lymphedema: histological changes in the collecting lymphatic vessels after lymphadenectomy","volume":"7","author":"Mihara","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.trsl.2023.01.005_bib0006","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.2353\/ajpath.2010.100594","article-title":"Blockade of transforming growth factor-beta1 accelerates lymphatic regeneration during wound repair","volume":"177","author":"Avraham","year":"2010","journal-title":"Am J Pathol"},{"issue":"18","key":"10.1016\/j.trsl.2023.01.005_bib0007","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM200005043421807","article-title":"Role of transforming growth factor beta in human disease","volume":"342","author":"Blobe","year":"2000","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.trsl.2023.01.005_bib0008","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat Rev Nephrol"},{"issue":"7","key":"10.1016\/j.trsl.2023.01.005_bib0009","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1111\/cas.14457","article-title":"Potential role of transforming growth factor-beta 1\/Smad signaling in secondary lymphedema after cancer surgery","volume":"111","author":"Sano","year":"2020","journal-title":"Cancer Sci"},{"issue":"6","key":"10.1016\/j.trsl.2023.01.005_bib0010","doi-asserted-by":"crossref","first-page":"e758","DOI":"10.1002\/ctm2.758","article-title":"TGF-\u03b21 mediates pathologic changes of secondary lymphedema by promoting fibrosis and inflammation","volume":"12","author":"Baik","year":"2022","journal-title":"Clin Transl Med"},{"issue":"11","key":"10.1016\/j.trsl.2023.01.005_bib0011","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/labinvest.3700669","article-title":"Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations","volume":"87","author":"Prud'homme","year":"2007","journal-title":"Lab Invest"},{"issue":"5","key":"10.1016\/j.trsl.2023.01.005_bib0012","doi-asserted-by":"crossref","first-page":"H958","DOI":"10.1152\/ajpheart.00723.2018","article-title":"The renin-angiotensin system: going beyond the classical paradigms","volume":"316","author":"Santos","year":"2019","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"10.1016\/j.trsl.2023.01.005_bib0013","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jaad.2005.09.027","article-title":"Cutaneous tissue angiotensin-converting enzyme may participate in pathologic scar formation in human skin","volume":"54","author":"Morihara","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.trsl.2023.01.005_bib0014","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13069-015-0023-z","article-title":"Modulation of angiotensin II signaling in the prevention of fibrosis","volume":"8","author":"Murphy","year":"2015","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"1","key":"10.1016\/j.trsl.2023.01.005_bib0015","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/hr.2013.119","article-title":"Telmisartan delays myocardial fibrosis in rats with hypertensive left ventricular hypertrophy by TGF-\u03b21\/Smad signal pathway","volume":"37","author":"Zhang","year":"2014","journal-title":"Hypertens Res"},{"issue":"1","key":"10.1016\/j.trsl.2023.01.005_bib0016","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1053\/gast.2001.25480","article-title":"Angiotensin-converting enzyme inhibition attenuates the progression of rat hepatic fibrosis","volume":"121","author":"Jonsson","year":"2001","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.trsl.2023.01.005_bib0017","doi-asserted-by":"crossref","first-page":"6530","DOI":"10.4049\/jimmunol.169.11.6530","article-title":"Inhibition of TGFbeta1 by anti-TGFbeta1 antibody or lisinopril reduces thyroid fibrosis in granulomatous experimental autoimmune thyroiditis","volume":"169","author":"Chen","year":"2002","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.trsl.2023.01.005_bib0018","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000368549","article-title":"Angiotensin-Converting Enzyme Inhibitor (ACEI)-mediated amelioration in renal fibrosis involves suppression of mast cell degranulation","volume":"41","author":"Sun","year":"2016","journal-title":"Kidney Blood Press Res"},{"issue":"1","key":"10.1016\/j.trsl.2023.01.005_bib0019","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1038\/s41598-018-21600-w","article-title":"Angiotensin-converting enzyme inhibitor reduces scar formation by inhibiting both canonical and noncanonical TGF-\u03b21 pathways","volume":"8","author":"Fang","year":"2018","journal-title":"Sci Rep"},{"issue":"30","key":"10.1016\/j.trsl.2023.01.005_bib0020","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.2174\/092986706779026138","article-title":"Impact of inhibitors of the Renin-Angiotensin-aldosterone system on liver fibrosis and portal hypertension","volume":"13","author":"T\u00f6x","year":"2006","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.trsl.2023.01.005_bib0021","first-page":"S83","article-title":"The effect of ACE inhibitors on the expression of matrix genes and the role of p53 and p21 (WAF1) in experimental renal fibrosis","volume":"54","author":"Morrissey","year":"1996","journal-title":"Kidney Int Suppl"},{"issue":"5","key":"10.1016\/j.trsl.2023.01.005_bib0022","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/00054725-200409000-00007","article-title":"Prevention of fibrosis in experimental colitis by captopril: the role of tgf-beta1","volume":"10","author":"Wengrower","year":"2004","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"10.1016\/j.trsl.2023.01.005_bib0023","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1067\/mlc.2002.122279","article-title":"The renin-angiotensin system in experimental radiation nephropathy","volume":"139","author":"Cohen","year":"2002","journal-title":"J Lab Clin Med"},{"issue":"8","key":"10.1016\/j.trsl.2023.01.005_bib0024","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1042\/CS20150778","article-title":"Epoxyeicosatrienoic acid analogue mitigates kidney injury in a rat model of radiation nephropathy","volume":"130","author":"Hye Khan","year":"2016","journal-title":"Clin Sci (Lond)"},{"issue":"3","key":"10.1016\/j.trsl.2023.01.005_bib0025","doi-asserted-by":"crossref","first-page":"112e","DOI":"10.1097\/PRS.0b013e31819a34db","article-title":"Treatment of a Postburn Keloid scar with topical captopril: report of the first case","volume":"123","author":"Ardekani","year":"2009","journal-title":"Plastic and Reconstructive Surgery"},{"issue":"1","key":"10.1016\/j.trsl.2023.01.005_bib0026","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1038\/s41467-018-04418-y","article-title":"CD4(+) T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema","volume":"9","author":"Garcia Nores","year":"2018","journal-title":"Nat Commun"},{"issue":"11","key":"10.1016\/j.trsl.2023.01.005_bib0027","doi-asserted-by":"crossref","first-page":"e49940","DOI":"10.1371\/journal.pone.0049940","article-title":"CD4(+) cells regulate fibrosis and lymphangiogenesis in response to lymphatic fluid stasis","volume":"7","author":"Zampell","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.trsl.2023.01.005_bib0028","doi-asserted-by":"crossref","first-page":"77e","DOI":"10.1097\/PRS.0000000000005091","article-title":"Baseline lymphatic dysfunction amplifies the negative effects of lymphatic injury","volume":"143","author":"Hespe","year":"2019","journal-title":"Plast Reconstr Surg"},{"issue":"5","key":"10.1016\/j.trsl.2023.01.005_bib0029","doi-asserted-by":"crossref","first-page":"H2113","DOI":"10.1152\/ajpheart.00879.2008","article-title":"TGF-beta1 is a negative regulator of lymphatic regeneration during wound repair","volume":"295","author":"Clavin","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"10.1016\/j.trsl.2023.01.005_bib0030","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.mvr.2006.05.009","article-title":"Secondary lymphedema in the mouse tail: Lymphatic hyperplasia, VEGF-C upregulation, and the protective role of MMP-9","volume":"72","author":"Rutkowski","year":"2006","journal-title":"Microvasc Res"},{"issue":"3","key":"10.1016\/j.trsl.2023.01.005_bib0031","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1096\/fj.12-222695","article-title":"Th2 differentiation is necessary for soft tissue fibrosis and lymphatic dysfunction resulting from lymphedema","volume":"27","author":"Avraham","year":"2013","journal-title":"Faseb j"},{"issue":"389","key":"10.1016\/j.trsl.2023.01.005_bib0032","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.1126\/scitranslmed.aal3920","article-title":"Leukotriene B(4) antagonism ameliorates experimental lymphedema","volume":"9","author":"Tian","year":"2017","journal-title":"Sci Transl Med"},{"issue":"12","key":"10.1016\/j.trsl.2023.01.005_bib0033","doi-asserted-by":"crossref","first-page":"e8380","DOI":"10.1371\/journal.pone.0008380","article-title":"Anti-inflammatory pharmacotherapy with ketoprofen ameliorates experimental lymphatic vascular insufficiency in mice","volume":"4","author":"Nakamura","year":"2009","journal-title":"PLoS One"},{"issue":"16","key":"10.1016\/j.trsl.2023.01.005_bib0034","doi-asserted-by":"crossref","first-page":"e89081","DOI":"10.1172\/jci.insight.89081","article-title":"Regulatory T cell transfer ameliorates lymphedema and promotes lymphatic vessel function","volume":"1","author":"Gousopoulos","year":"2016","journal-title":"JCI Insight"},{"issue":"7","key":"10.1016\/j.trsl.2023.01.005_bib0035","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1371\/journal.pmed.0030254","article-title":"Inflammatory manifestations of experimental lymphatic insufficiency","volume":"3","author":"Tabibiazar","year":"2006","journal-title":"PLoS Med"},{"issue":"8","key":"10.1016\/j.trsl.2023.01.005_bib0036","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/j.ajpath.2016.04.006","article-title":"Prominent lymphatic vessel hyperplasia with progressive dysfunction and distinct immune cell infiltration in lymphedema","volume":"186","author":"Gousopoulos","year":"2016","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.trsl.2023.01.005_bib0037","first-page":"105","article-title":"Morphological and immunochemical differences between keloid and hypertrophic scar","volume":"145","author":"Ehrlich","year":"1994","journal-title":"Am J Pathol"},{"issue":"21","key":"10.1016\/j.trsl.2023.01.005_bib0038","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1016\/j.biomaterials.2013.03.034","article-title":"Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis","volume":"34","author":"Proulx","year":"2013","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.trsl.2023.01.005_bib0039","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.immuni.2011.10.017","article-title":"Lymph node T cell homeostasis relies on steady state homing of dendritic cells","volume":"35","author":"Wendland","year":"2011","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.trsl.2023.01.005_bib0040","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1111\/jdv.13565","article-title":"Hyperkeratosis in human lower limb lymphedema: the effect of stagnant tissue fluid\/lymph","volume":"30","author":"Domaszewska-Szostek","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"6","key":"10.1016\/j.trsl.2023.01.005_bib0041","first-page":"322","article-title":"The pathophysiology of lymphedema - 2012","volume":"44","author":"Olszewski","year":"2012","journal-title":"Handchir Mikrochir Plast Chir"},{"issue":"3","key":"10.1016\/j.trsl.2023.01.005_bib0042","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.jid.2015.12.001","article-title":"Excess lymphangiogenesis cooperatively induced by macrophages and CD4(+) T cells drives the pathogenesis of lymphedema","volume":"136","author":"Ogata","year":"2016","journal-title":"J Invest Dermatol"},{"issue":"1","key":"10.1016\/j.trsl.2023.01.005_bib0043","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1038\/s41598-020-62799-x","article-title":"Axial stretch regulates rat tail collecting lymphatic vessel contractions","volume":"10","author":"Razavi","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.trsl.2023.01.005_bib0044","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.1038\/s41598-022-09028-9","article-title":"The effects of gravity and compression on interstitial fluid transport in the lower limb","volume":"12","author":"Baish","year":"2022","journal-title":"Sci Rep"},{"issue":"46","key":"10.1016\/j.trsl.2023.01.005_bib0045","doi-asserted-by":"crossref","first-page":"18784","DOI":"10.1073\/pnas.1116152108","article-title":"Impaired lymphatic contraction associated with immunosuppression","volume":"108","author":"Liao","year":"2011","journal-title":"Proc Natl Acad Sci U S A,"},{"issue":"1","key":"10.1016\/j.trsl.2023.01.005_bib0046","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s10549-013-2537-7","article-title":"Dynamics of lymphatic regeneration and flow patterns after lymph node dissection","volume":"139","author":"Blum","year":"2013","journal-title":"Breast Cancer Res Treat"},{"issue":"8","key":"10.1016\/j.trsl.2023.01.005_bib0047","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106034","article-title":"Spatio-temporal changes of lymphatic contractility and drainage patterns following lymphadenectomy in mice","volume":"9","author":"Kwon","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.trsl.2023.01.005_bib0048","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3390\/ijms18010171","article-title":"Inflammatory manifestations of lymphedema","volume":"18","author":"Ly","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.trsl.2023.01.005_bib0049","doi-asserted-by":"crossref","first-page":"H1328","DOI":"10.1152\/ajpheart.00538.2010","article-title":"Local angiotensin II aggravates cardiac remodeling in hypertension","volume":"299","author":"Xu","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.trsl.2023.01.005_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105924","article-title":"Renin angiotensin aldosterone system in pulmonary fibrosis: Pathogenesis to therapeutic possibilities","volume":"174","author":"Gupta","year":"2021","journal-title":"Pharmacol Res"},{"issue":"4","key":"10.1016\/j.trsl.2023.01.005_bib0051","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/labinvest.2010.190","article-title":"Myocardial fibrosis in response to Angiotensin II is preceded by the recruitment of mesenchymal progenitor cells","volume":"91","author":"Sopel","year":"2011","journal-title":"Lab Invest"},{"issue":"3","key":"10.1016\/j.trsl.2023.01.005_bib0052","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1152\/physrev.00036.2005","article-title":"Physiology of local renin-angiotensin systems","volume":"86","author":"Paul","year":"2006","journal-title":"Physiol Rev"},{"issue":"1","key":"10.1016\/j.trsl.2023.01.005_bib0053","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1161\/01.CIR.89.1.493","article-title":"Tissue angiotensin system in cardiovascular medicine. A paradigm shift?","volume":"89","author":"Dzau","year":"1994","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.trsl.2023.01.005_bib0054","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0008-6363(99)00202-3","article-title":"Is there a local renin-angiotensin system in the heart?","volume":"44","author":"Danser","year":"1999","journal-title":"Cardiovasc Res"},{"issue":"4","key":"10.1016\/j.trsl.2023.01.005_bib0055","doi-asserted-by":"crossref","first-page":"R194","DOI":"10.1186\/ar4028","article-title":"Angiotensin II induces skin fibrosis: a novel mouse model of dermal fibrosis","volume":"14","author":"Stawski","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"10.1016\/j.trsl.2023.01.005_bib0056","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/art.11364","article-title":"Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors","volume":"50","author":"Kawaguchi","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.trsl.2023.01.005_bib0057","doi-asserted-by":"crossref","first-page":"112e","DOI":"10.1097\/PRS.0b013e31819a34db","article-title":"Treatment of a postburn keloid scar with topical captopril: report of the first case","volume":"123","author":"Ardekani","year":"2009","journal-title":"Plast Reconstr Surg"},{"issue":"1","key":"10.1016\/j.trsl.2023.01.005_bib0058","doi-asserted-by":"crossref","first-page":"F122","DOI":"10.1152\/ajprenal.2000.278.1.F122","article-title":"Age-related progressive renal fibrosis in rats and its prevention with ACE inhibitors and taurine","volume":"278","author":"Cruz","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"issue":"3","key":"10.1016\/j.trsl.2023.01.005_bib0059","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/hep.23104","article-title":"Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice","volume":"50","author":"Osterreicher","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.trsl.2023.01.005_bib0060","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3389\/fcvm.2020.00115","article-title":"Angiotensin Converting Enzyme Inhibitors (ACEIs) decrease the progression of cardiac fibrosis in rheumatic heart disease through the inhibition of IL-33\/sST2","volume":"7","author":"Ambari","year":"2020","journal-title":"Front Cardiovasc Med"},{"issue":"2","key":"10.1016\/j.trsl.2023.01.005_bib0061","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.surg.2008.03.043","article-title":"Transanal delivery of angiotensin converting enzyme inhibitor prevents colonic fibrosis in a mouse colitis model: development of a unique mode of treatment","volume":"144","author":"Koga","year":"2008","journal-title":"Surgery"},{"issue":"3","key":"10.1016\/j.trsl.2023.01.005_bib0062","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1161\/hy09t1.094234","article-title":"Angiotensin II and renal fibrosis","volume":"38","author":"Mezzano","year":"2001","journal-title":"Hypertension"},{"issue":"8","key":"10.1016\/j.trsl.2023.01.005_bib0063","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1161\/CIRCRESAHA.109.216036","article-title":"Nicotinamide adenine dinucleotide phosphate reduced oxidase 5 (Nox5) regulation by angiotensin II and endothelin-1 is mediated via calcium\/calmodulin-dependent, rac-1-independent pathways in human endothelial cells","volume":"106","author":"Montezano","year":"2010","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.trsl.2023.01.005_bib0064","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0008-6363(98)00121-7","article-title":"Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta 1 and endothelin-1 from fibroblasts","volume":"40","author":"Gray","year":"1998","journal-title":"Cardiovasc Res"},{"issue":"7","key":"10.1016\/j.trsl.2023.01.005_bib0065","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1006\/jmcc.1997.0435","article-title":"Angiotensin II stimulated expression of transforming growth factor-beta1 in cardiac fibroblasts and myofibroblasts","volume":"29","author":"Campbell","year":"1997","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"10.1016\/j.trsl.2023.01.005_bib0066","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1476-5381.1996.tb15437.x","article-title":"Effects of an AT1 receptor antagonist, an ACE inhibitor and a calcium channel antagonist on cardiac gene expressions in hypertensive rats","volume":"118","author":"Kim","year":"1996","journal-title":"Br J Pharmacol"},{"issue":"4","key":"10.1016\/j.trsl.2023.01.005_bib0067","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/S0735-1097(01)01518-2","article-title":"Effects of combination of angiotensin-converting enzyme inhibitor and angiotensin receptor antagonist on inflammatory cellular infiltration and myocardial interstitial fibrosis after acute myocardial infarction","volume":"38","author":"Yu","year":"2001","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"10.1016\/j.trsl.2023.01.005_bib0068","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1006\/jmcc.1998.0721","article-title":"Angiotensin II, transforming growth factor-beta1 and repair in the infarcted heart","volume":"30","author":"Sun","year":"1998","journal-title":"J Mol Cell Cardiol"},{"issue":"6","key":"10.1016\/j.trsl.2023.01.005_bib0069","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI0214190","article-title":"TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II","volume":"109","author":"Schultz Jel","year":"2002","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.trsl.2023.01.005_bib0070","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1096\/fj.08-114611","article-title":"JunD and HIF-1alpha mediate transcriptional activation of angiotensinogen by TGF-beta1 in human lung fibroblasts","volume":"23","author":"Abdul-Hafez","year":"2009","journal-title":"Faseb j"},{"issue":"5","key":"10.1016\/j.trsl.2023.01.005_bib0071","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/1523-1747.ep12606979","article-title":"Increased types I and III collagen and transforming growth factor-beta 1 mRNA and protein in hypertrophic burn scar","volume":"104","author":"Zhang","year":"1995","journal-title":"J Invest Dermatol"},{"issue":"3","key":"10.1016\/j.trsl.2023.01.005_bib0072","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.bbrc.2009.05.081","article-title":"Angiotensin II induces type I collagen gene expression in human dermal fibroblasts through an AP-1\/TGF-beta1-dependent pathway","volume":"385","author":"Tang","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.trsl.2023.01.005_bib0073","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1080\/08037050310001057","article-title":"Angiotensin AT1\/AT2 receptors: regulation, signalling and function","volume":"12","author":"Kaschina","year":"2003","journal-title":"Blood Press"},{"issue":"3","key":"10.1016\/j.trsl.2023.01.005_bib0074","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0031-6997(24)01458-3","article-title":"International union of pharmacology. XXIII. The angiotensin II receptors","volume":"52","author":"de Gasparo","year":"2000","journal-title":"Pharmacol Rev"},{"issue":"8","key":"10.1016\/j.trsl.2023.01.005_bib0075","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1161\/01.RES.0000218782.52610.dc","article-title":"Essential role of Smad3 in angiotensin II-induced vascular fibrosis","volume":"98","author":"Wang","year":"2006","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.trsl.2023.01.005_bib0076","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jdermsci.2003.12.006","article-title":"TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing","volume":"35","author":"Schiller","year":"2004","journal-title":"J Dermatol Sci"},{"issue":"1","key":"10.1016\/j.trsl.2023.01.005_bib0077","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0735-1097(00)01044-5","article-title":"Should an angiotensin-converting enzyme inhibitor be standard therapy for patients with atherosclerotic disease?","volume":"37","author":"O'Keefe","year":"2001","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"10.1016\/j.trsl.2023.01.005_bib0078","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1097\/00007890-199810270-00009","article-title":"Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation","volume":"66","author":"Awad","year":"1998","journal-title":"Transplantation"},{"issue":"15","key":"10.1016\/j.trsl.2023.01.005_bib0079","doi-asserted-by":"crossref","first-page":"15167","DOI":"10.1074\/jbc.M309798200","article-title":"Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone","volume":"279","author":"Xavier","year":"2004","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.trsl.2023.01.005_bib0080","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1113\/jphysiol.2012.250662","article-title":"Genetic removal of basal nitric oxide enhances contractile activity in isolated murine collecting lymphatic vessels","volume":"591","author":"Scallan","year":"2013","journal-title":"J Physiol"},{"issue":"6","key":"10.1016\/j.trsl.2023.01.005_bib0081","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1080\/10739680490476033","article-title":"Regional variations of contractile activity in isolated rat lymphatics","volume":"11","author":"Gashev","year":"2004","journal-title":"Microcirculation"},{"issue":"6","key":"10.1016\/j.trsl.2023.01.005_bib0082","first-page":"H2059","article-title":"Characterization of intact mesenteric lymphatic pump and its responsiveness to acute edemagenic stress","volume":"257","author":"Benoit","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1016\/j.trsl.2023.01.005_bib0083","doi-asserted-by":"crossref","first-page":"14345","DOI":"10.1038\/ncomms14345","article-title":"Topical tacrolimus for the treatment of secondary lymphedema","volume":"8","author":"Gardenier","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.trsl.2023.01.005_bib0084","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.560170","article-title":"Angiotensin II stimulates the proliferation and migration of lymphatic endothelial cells through angiotensin type 1 receptors","volume":"11","author":"Lin","year":"2020","journal-title":"Front Physiol"},{"issue":"21","key":"10.1016\/j.trsl.2023.01.005_bib0085","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1097\/00029330-200811010-00012","article-title":"Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers on lymphangiogenesis of gastric cancer in a nude mouse model","volume":"121","author":"Wang","year":"2008","journal-title":"Chin Med J (Engl)"},{"issue":"2","key":"10.1016\/j.trsl.2023.01.005_bib0086","doi-asserted-by":"crossref","first-page":"C392","DOI":"10.1152\/ajpcell.00306.2011","article-title":"Lymphatic function is regulated by a coordinated expression of lymphangiogenic and anti-lymphangiogenic cytokines","volume":"302","author":"Zampell","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"issue":"9","key":"10.1016\/j.trsl.2023.01.005_bib0087","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1016\/j.jid.2017.04.033","article-title":"An important role of VEGF-C in promoting lymphedema development","volume":"137","author":"Gousopoulos","year":"2017","journal-title":"J Invest Dermatol"},{"issue":"6","key":"10.1016\/j.trsl.2023.01.005_bib0088","doi-asserted-by":"crossref","first-page":"e12403","DOI":"10.14814\/phy2.12403","article-title":"Higher vascular endothelial growth factor-C concentration in plasma is associated with increased forearm capillary filtration capacity in breast cancer-related lymphedema","volume":"3","author":"Jensen","year":"2015","journal-title":"Physiol Rep"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524423000178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524423000178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:47:20Z","timestamp":1761828440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524423000178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":88,"alternative-id":["S1931524423000178"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2023.01.005","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Topical captopril: a promising treatment for secondary lymphedema","name":"articletitle","label":"Article Title"},{"value":"Translational Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trsl.2023.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}