{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:01:23Z","timestamp":1789671683133,"version":"4.0.1"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T00:00:00Z","timestamp":1694217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","translationalres.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.trsl.2023.09.006","type":"journal-article","created":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T01:21:03Z","timestamp":1694913663000},"page":"33-65","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Dysfunctional Cori and Krebs cycle and inhibition of lactate transporters constitute a mechanism of primary nonfunction of fatty liver allografts"],"prefix":"10.1016","volume":"264","author":[{"given":"Ulf","family":"Kulik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Moesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Spanel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1558-9519","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Borlak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2023.09.006_bib0001","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5604\/16652681.1184212","article-title":"Early allograft dysfunction after liver transplantation: an intermediate outcome measure for targeted improvements","volume":"15","author":"Lee","year":"2016","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.trsl.2023.09.006_bib0002","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/liv.13404","article-title":"Primary non-function is frequently associated with fatty liver allografts and high mortality after re-transplantation","volume":"37","author":"Kulik","year":"2017","journal-title":"Liver Int"},{"key":"10.1016\/j.trsl.2023.09.006_bib0003","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.plipres.2014.02.002","article-title":"Recent insights into the molecular pathophysiology of lipid droplet formation in hepatocytes","volume":"54","author":"Sahini","year":"2014","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.trsl.2023.09.006_bib0004","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.jhep.2016.07.033","article-title":"NAFLD and liver transplantation: current burden and expected challenges","volume":"65","author":"Pais","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.trsl.2023.09.006_bib0005","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1055\/s-2006-947292","article-title":"Extended-donor criteria liver allografts","volume":"26","author":"Alkofer","year":"2006","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.trsl.2023.09.006_bib0006","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s11605-015-2832-1","article-title":"Donor hepatic steatosis and outcome after liver transplantation: a systematic review","volume":"19","author":"Chu","year":"2015","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.trsl.2023.09.006_bib0007","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.jhep.2013.06.017","article-title":"Hepatic ischemia and reperfusion injury: effects on the liver sinusoidal milieu","volume":"59","author":"Peralta","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.trsl.2023.09.006_bib0008","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1007\/s00595-013-0736-9","article-title":"Ischemia\u2013reperfusion injury in patients with fatty liver and the clinical impact of steatotic liver on hepatic surgery","volume":"44","author":"Tashiro","year":"2014","journal-title":"Surg Today"},{"key":"10.1016\/j.trsl.2023.09.006_bib0009","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/00000658-200010000-00004","article-title":"Long-term survival after liver transplantation in 4,000 consecutive patients at a single center","volume":"232","author":"Jain","year":"2000","journal-title":"Ann Surg"},{"key":"10.1016\/j.trsl.2023.09.006_bib0010","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/bjs.9059","article-title":"Hepatic regeneration and functional recovery following partial liver resection in an experimental model of hepatic steatosis treated with omega-3 fatty acids","volume":"100","author":"Marsman","year":"2013","journal-title":"Br J Surg"},{"key":"10.1016\/j.trsl.2023.09.006_bib0011","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1002\/bjs.5672","article-title":"Mild steatosis impairs functional recovery after liver resection in an experimental model","volume":"94","author":"Vetel\u00e4inen","year":"2007","journal-title":"Br J Surg"},{"key":"10.1016\/j.trsl.2023.09.006_bib0012","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/hep.510310108","article-title":"Failure of regeneration of the steatotic rat liver: disruption at two different levels in the regeneration pathway","volume":"31","author":"Selzner","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.trsl.2023.09.006_bib0013","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1210\/en.2014-1010","article-title":"GH administration rescues fatty liver regeneration impairment by restoring GH\/EGFR pathway deficiency","volume":"155","author":"Collin de l'Hortet","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.trsl.2023.09.006_bib0014","article-title":"Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease","volume":"10","author":"Machado","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2023.09.006_bib0015","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.jhep.2011.04.010","article-title":"NASH animal models: are we there yet?","volume":"55","author":"Kohli","year":"2011","journal-title":"J Hepatol"},{"key":"10.1016\/j.trsl.2023.09.006_bib0016","doi-asserted-by":"crossref","first-page":"21833","DOI":"10.3390\/ijms141121833","article-title":"Rodent models of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"14","author":"Imajo","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.trsl.2023.09.006_bib0017","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1194\/jlr.M800042-JLR200","article-title":"Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet","volume":"49","author":"Rinella","year":"2008","journal-title":"J Lipid Res"},{"key":"10.1016\/j.trsl.2023.09.006_bib0018","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00007890-197907000-00011","article-title":"Orthotopic liver transplantation in the rat. Technique using cuff for portal vein anastomosis and biliary drainage","volume":"28","author":"Kamada","year":"1979","journal-title":"Transplantation"},{"key":"10.1016\/j.trsl.2023.09.006_bib0019","first-page":"571","article-title":"Techniques for orthotopic liver transplantation in the rat and some studies of the immunologic responses to fully allogeneic liver grafts","volume":"11","author":"Zimmermann","year":"1979","journal-title":"Transplant Proc"},{"key":"10.1016\/j.trsl.2023.09.006_bib0020","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.transproceed.2004.12.257","article-title":"A review of various techniques of orthotopic liver transplantation in the rat","volume":"37","author":"Kashfi","year":"2005","journal-title":"Transplant Proc"},{"key":"10.1016\/j.trsl.2023.09.006_bib0021","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jhep.2008.03.026","article-title":"MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes","volume":"49","author":"Larter","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.trsl.2023.09.006_bib0022","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1161\/01.RES.19.1.63","article-title":"Increased susceptibility of the heart to ventricular fibrillation during metabolic acidosis","volume":"19","author":"Gerst","year":"1966","journal-title":"Circ Res"},{"key":"10.1016\/j.trsl.2023.09.006_bib0023","first-page":"242","article-title":"Relationship between acidosis and ventricular fibrillation","volume":"15","author":"Gerst","year":"1964","journal-title":"Surg Forum"},{"key":"10.1016\/j.trsl.2023.09.006_bib0024","first-page":"1050","article-title":"A quantitative evaluation of the effects of acidosis and alkalosis upon the ventricular fibrillation threshold","volume":"59","author":"Gerst","year":"1966","journal-title":"Surgery"},{"key":"10.1016\/j.trsl.2023.09.006_bib0025","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.dld.2011.07.009","article-title":"Omega-3 fatty acids reduce hepatic steatosis and consequently attenuate ischemia-reperfusion injury following partial hepatectomy in rats","volume":"43","author":"Marsman","year":"2011","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.trsl.2023.09.006_bib0026","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bbalip.2009.04.002","article-title":"PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores","volume":"1791","author":"Bickel","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.trsl.2023.09.006_bib0027","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1113\/JP277140","article-title":"Perilipin-2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra-hepatocyte actions","volume":"597","author":"Orlicky","year":"2019","journal-title":"J Physiol"},{"key":"10.1016\/j.trsl.2023.09.006_bib0028","doi-asserted-by":"crossref","first-page":"10318","DOI":"10.1074\/jbc.M113.526749","article-title":"Kruppel-like transcription factor 6 regulates inflammatory macrophage polarization","volume":"289","author":"Date","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2023.09.006_bib0029","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.bbrc.2015.10.052","article-title":"An SOD1 deficiency enhances lipid droplet accumulation in the fasted mouse liver by aborting lipophagy","volume":"467","author":"Kurahashi","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.trsl.2023.09.006_bib0030","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00418-011-0847-6","article-title":"Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice","volume":"136","author":"Shiozaki","year":"2011","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.trsl.2023.09.006_bib0031","first-page":"105","article-title":"Hypoxia-inducible factors as essential regulators of inflammation","volume":"345","author":"Imtiyaz","year":"2010","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.trsl.2023.09.006_bib0032","doi-asserted-by":"crossref","first-page":"790","DOI":"10.4161\/cc.6.7.4084","article-title":"HIF-1-regulated glucose metabolism: a key to apoptosis resistance?","volume":"6","author":"Fulda","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.trsl.2023.09.006_bib0033","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3390\/cells8030214","article-title":"Hypoxia-inducible factors and the regulation of lipid metabolism","volume":"8","author":"Mylonis","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.trsl.2023.09.006_bib0034","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.trre.2015.05.001","article-title":"Systematic review with meta-analysis: HIF-1\u03b1 attenuates liver ischemia-reperfusion injury","volume":"29","author":"Guo","year":"2015","journal-title":"Transplant Rev (Orlando)"},{"key":"10.1016\/j.trsl.2023.09.006_bib0035","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00109-016-1408-1","article-title":"Hypoxia-inducible factors as molecular targets for liver diseases","volume":"94","author":"Ju","year":"2016","journal-title":"J Mol Med"},{"key":"10.1016\/j.trsl.2023.09.006_bib0036","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1423-0127-18-79","article-title":"Ischemic postconditioning attenuates liver warm ischemia-reperfusion injury through Akt-eNOS-NO-HIF pathway","volume":"18","author":"Guo","year":"2011","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.trsl.2023.09.006_bib0037","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1016\/j.transproceed.2008.05.037","article-title":"Liver HIF-1 alpha induction precedes apoptosis following normothermic ischemia-reperfusion in rats","volume":"40","author":"Cursio","year":"2008","journal-title":"Transplant Proc"},{"key":"10.1016\/j.trsl.2023.09.006_bib0038","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1021\/ar300234c","article-title":"Protein tyrosine nitration: biochemical mechanisms and structural basis of functional effects","volume":"46","author":"Radi","year":"2013","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.trsl.2023.09.006_bib0039","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1097\/TP.0000000000001699","article-title":"Peritransplant energy changes and their correlation to outcome after human liver transplantation","volume":"101","author":"Bruinsma","year":"2017","journal-title":"Transplantation"},{"key":"10.1016\/j.trsl.2023.09.006_bib0040","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jhep.2015.10.008","article-title":"Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency","volume":"64","author":"Farah","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.trsl.2023.09.006_bib0041","doi-asserted-by":"crossref","first-page":"24223","DOI":"10.1074\/jbc.M109.016816","article-title":"Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases","volume":"284","author":"Yalcin","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2023.09.006_bib0042","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cell.2014.04.046","article-title":"A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation","volume":"158","author":"Sutendra","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.trsl.2023.09.006_bib0043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4062\/biomolther.2015.078","article-title":"Alpha-ketoglutarate: physiological functions and applications","volume":"24","author":"Wu","year":"2016","journal-title":"Biomol Ther (Seoul)"},{"key":"10.1016\/j.trsl.2023.09.006_bib0044","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s00134-015-4127-0","article-title":"Severe hyperlactatemia, lactate clearance and mortality in unselected critically ill patients","volume":"42","author":"Haas","year":"2016","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.trsl.2023.09.006_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/iub.573","article-title":"The monocarboxylate transporter family: structure and functional characterization","volume":"64","author":"Halestrap","year":"2012","journal-title":"IUBMB Life"},{"key":"10.1016\/j.trsl.2023.09.006_bib0046","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/jcmm.12481","article-title":"Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer","volume":"19","author":"Valen\u00e7a","year":"2015","journal-title":"J Cell Mol Med"},{"issue":"Pt 1","key":"10.1016\/j.trsl.2023.09.006_bib0047","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1042\/bj3500219","article-title":"The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells","volume":"350","author":"Dimmer","year":"2000","journal-title":"Biochem J"},{"issue":"Pt 2","key":"10.1016\/j.trsl.2023.09.006_bib0048","first-page":"285","article-title":"Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle","volume":"529","author":"Manning-Fox","year":"2000","journal-title":"J Physiol"},{"key":"10.1016\/j.trsl.2023.09.006_bib0049","doi-asserted-by":"crossref","first-page":"38278","DOI":"10.1038\/srep38278","article-title":"Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention","volume":"6","author":"Walenbergh","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.trsl.2023.09.006_bib0050","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/hep.22753","article-title":"Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential","volume":"49","author":"Moles","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.trsl.2023.09.006_bib0051","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1038\/s41598-017-03796-5","article-title":"Cathepsin D regulates lipid metabolism in murine steatohepatitis","volume":"7","author":"Houben","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.trsl.2023.09.006_bib0052","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10495-006-3486-y","article-title":"Cathepsin-regulated apoptosis","volume":"11","author":"Chwieralski","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.trsl.2023.09.006_bib0053","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.critrevonc.2008.02.008","article-title":"Cathepsin D-many functions of one aspartic protease","volume":"68","author":"Benes","year":"2008","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.trsl.2023.09.006_bib0054","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1124\/pr.119.018762","article-title":"Monocarboxylate transporters (SLC16): function, regulation, and role in health and disease","volume":"72","author":"Felmlee","year":"2020","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.trsl.2023.09.006_bib0055","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/(SICI)1520-7560(199911\/12)15:6<412::AID-DMRR72>3.0.CO;2-8","article-title":"Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes","volume":"15","author":"Laffel","year":"1999","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.trsl.2023.09.006_bib0056","first-page":"243","article-title":"Monocarboxylate transporters: past, present, and future","volume":"24","author":"Merezhinskaya","year":"2009","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.trsl.2023.09.006_bib0057","first-page":"677","article-title":"Contribution of liver and skeletal muscle to alanine and lactate metabolism in humans","volume":"259","author":"Consoli","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1016\/j.trsl.2023.09.006_bib0058","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000176571","article-title":"A model of L(+)-lactate metabolism in normal man","volume":"26","author":"Connor","year":"1982","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.trsl.2023.09.006_bib0059","first-page":"504","article-title":"Metabolic and thermogenic effects of lactate infusion in humans","volume":"265","author":"Ferrannini","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1016\/j.trsl.2023.09.006_bib0060","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1475-097X.1982.tb00006.x","article-title":"Pathophysiology of metabolic acidosis: effect of low pH on the hepatic uptake of lactate, pyruvate and alanine","volume":"2","author":"Sestoft","year":"1982","journal-title":"Clin Physiol"},{"key":"10.1016\/j.trsl.2023.09.006_bib0061","first-page":"E747","article-title":"Hepatic and extrahepatic lactate metabolism in sheep: effects of lactate loading and pH","volume":"247","author":"Naylor","year":"1984","journal-title":"Am J Physiol"},{"key":"10.1016\/j.trsl.2023.09.006_bib0062","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0026-0495(93)90084-2","article-title":"Bicarbonate in the treatment of metabolic acidosis: effects on hepatic intracellular pH, gluconeogenesis, and lactate disposal in rats","volume":"42","author":"Beech","year":"1993","journal-title":"Metabolism"},{"key":"10.1016\/j.trsl.2023.09.006_bib0063","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199177","article-title":"Upregulation of Krebs cycle and anaerobic glycolysis activity early after onset of liver ischemia","volume":"13","author":"Chan","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2023.09.006_bib0064","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/cs0410159","article-title":"The effect of changes in lactate uptake on the intracellular pH of the perfused rat liver","volume":"41","author":"Cohen","year":"1971","journal-title":"Clin Sci"},{"key":"10.1016\/j.trsl.2023.09.006_bib0065","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1126\/science.156.3771.82","article-title":"Rabbit lactate dehydrogenase isozymes: effect of pH on activity","volume":"156","author":"Fritz","year":"1967","journal-title":"Science"},{"key":"10.1016\/j.trsl.2023.09.006_bib0066","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1126\/science.154.3748.527","article-title":"Pyruvate inhibition of lactate dehydrogenase activity in human tissue extracts","volume":"154","author":"Latner","year":"1966","journal-title":"Science"},{"key":"10.1016\/j.trsl.2023.09.006_bib0067","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1749-8090-8-34","article-title":"Intracellular lactate signaling cascade in atrial remodeling of mitral valvular patients with atrial fibrillation","volume":"8","author":"Xu","year":"2013","journal-title":"J Cardiothorac Surg"},{"key":"10.1016\/j.trsl.2023.09.006_bib0068","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.726931","article-title":"A novel function of mitochondrial phosphoenolpyruvate carboxykinase as a regulator of inflammatory response in Kupffer cells","volume":"9","author":"Dong","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.trsl.2023.09.006_bib0069","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.jhep.2021.06.031","article-title":"The multifaceted role of cathepsins in liver disease","volume":"75","author":"Ruiz-Bl\u00e1zquez","year":"2021","journal-title":"J Hepatol"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524423001469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524423001469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:48:41Z","timestamp":1761828521000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524423001469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":69,"alternative-id":["S1931524423001469"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2023.09.006","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysfunctional Cori and Krebs cycle and inhibition of lactate transporters constitute a mechanism of primary nonfunction of fatty liver allografts","name":"articletitle","label":"Article Title"},{"value":"Translational Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trsl.2023.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}