{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:56:04Z","timestamp":1792522564526,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","translationalres.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.trsl.2023.09.007","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T02:30:00Z","timestamp":1695781800000},"page":"66-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Inhibition of gasdermin D palmitoylation by disulfiram is crucial for the treatment of myocardial infarction"],"prefix":"10.1016","volume":"264","author":[{"given":"ZEHAO","family":"ZHUANG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIANING","family":"GU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BO","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LING","family":"YANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2023.09.007_bib0001","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1056\/NEJMra1606915","article-title":"Acute myocardial infarction","volume":"376","author":"Anderson","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.trsl.2023.09.007_bib0002","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0140-6736(16)30677-8","article-title":"Acute myocardial infarction","volume":"389","author":"Reed","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.trsl.2023.09.007_bib0003","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.physiol.010908.163111","article-title":"Cell death in the pathogenesis of heart disease: mechanisms and significance","volume":"72","author":"Whelan","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.trsl.2023.09.007_bib0004","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.yjmcc.2018.01.018","article-title":"Programmed necrosis in heart disease: molecular mechanisms and clinical implications","volume":"116","author":"Zhu","year":"2018","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.trsl.2023.09.007_bib0005","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41569-020-0403-y","article-title":"Myocardial ischaemia-reperfusion injury and cardioprotection in perspective","volume":"17","author":"Heusch","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.trsl.2023.09.007_bib0006","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1161\/CIRCRESAHA.120.318629","article-title":"GSDMD-mediated cardiomyocyte pyroptosis promotes myocardial I\/R injury","volume":"129","author":"Shi","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.trsl.2023.09.007_bib0007","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1126\/science.abb9818","article-title":"Succination inactivates gasdermin D and blocks pyroptosis","volume":"369","author":"Humphries","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.trsl.2023.09.007_bib0008","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ejphar.2017.11.005","article-title":"SIRT5 and post-translational protein modifications: a potential therapeutic target for myocardial ischemia-reperfusion injury with regard to mitochondrial dynamics and oxidative metabolism","volume":"818","author":"Zou","year":"2018","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.trsl.2023.09.007_bib0009","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1210\/en.2016-1577","article-title":"Posttranslational modifications of lipid-activated nuclear receptors: focus on metabolism","volume":"158","author":"Becares","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.trsl.2023.09.007_bib0010","doi-asserted-by":"crossref","first-page":"6","DOI":"10.15252\/embj.201592595","article-title":"Spatiotemporal regulation of posttranslational modifications in the DNA damage response","volume":"35","author":"Dantuma","year":"2016","journal-title":"EMBO J"},{"key":"10.1016\/j.trsl.2023.09.007_bib0011","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.molmed.2016.07.002","article-title":"Microbiomic and posttranslational modifications as preludes to autoimmune diseases","volume":"22","author":"Opdenakker","year":"2016","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.trsl.2023.09.007_bib0012","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5716409","article-title":"Protein posttranslational modifications: roles in aging and age-related disease","volume":"2017","author":"Santos","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.trsl.2023.09.007_bib0013","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/s41418-020-00722-7","article-title":"The regulation of necroptosis by post-translational modifications","volume":"28","author":"Meng","year":"2021","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.trsl.2023.09.007_bib0014","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41551-019-0375-6","article-title":"Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours","volume":"3","author":"Yao","year":"2019","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.trsl.2023.09.007_bib0015","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.molcel.2016.04.003","article-title":"Inhibition of DHHC20-mediated EGFR palmitoylation creates a dependence on EGFR signaling","volume":"62","author":"Runkle","year":"2016","journal-title":"Mol Cell"},{"key":"10.1016\/j.trsl.2023.09.007_bib0016","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nchembio.1392","article-title":"Single-cell imaging of wnt palmitoylation by the acyltransferase porcupine","volume":"10","author":"Gao","year":"2014","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.trsl.2023.09.007_bib0017","doi-asserted-by":"crossref","first-page":"5872","DOI":"10.1038\/s41467-021-26180-4","article-title":"DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.trsl.2023.09.007_bib0018","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/s41590-020-0669-6","article-title":"FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation","volume":"21","author":"Hu","year":"2020","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trsl.2023.09.007_bib0019","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/protein\/gzn039","article-title":"CSS-Palm 2.0: an updated software for palmitoylation sites prediction","volume":"21","author":"Ren","year":"2008","journal-title":"Protein Eng Des Sel."},{"key":"10.1016\/j.trsl.2023.09.007_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0179529","article-title":"MDD-palm: identification of protein S-palmitoylation sites with substrate motifs based on maximal dependence decomposition","volume":"12","author":"Weng","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2023.09.007_bib0021","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-1-4939-9532-5_16","article-title":"SwissPalm 2: protein S-palmitoylation database","volume":"2009","author":"Blanc","year":"2019","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.trsl.2023.09.007_bib0022","doi-asserted-by":"crossref","DOI":"10.1172\/JCI151268","article-title":"Gasdermin D inhibition confers antineutrophil-mediated cardioprotection in acute myocardial infarction","volume":"132","author":"Jiang","year":"2022","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2023.09.007_bib0023","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jacbts.2021.08.006","article-title":"Targeting the inflammasome in cardiovascular disease","volume":"7","author":"Olsen","year":"2022","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.trsl.2023.09.007_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.893914","article-title":"GSDMD contributes to myocardial reperfusion injury by regulating pyroptosis","volume":"13","author":"Ye","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.trsl.2023.09.007_bib0025","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1038\/s41418-022-00942-z","article-title":"Palmitoylation restricts SQSTM1\/p62-mediated autophagic degradation of NOD2 to modulate inflammation","volume":"29","author":"Zhou","year":"2022","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.trsl.2023.09.007_bib0026","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41419-020-2476-2","article-title":"Chemotherapy-induced pyroptosis is mediated by BAK\/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate","volume":"11","author":"Hu","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.trsl.2023.09.007_bib0027","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2799-2","article-title":"A STAT3 palmitoylation cycle promotes T(H)17 differentiation and colitis","volume":"586","author":"Zhang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.trsl.2023.09.007_bib0028","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.trsl.2023.09.007_bib0029","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3109\/09637486.2013.768213","article-title":"Palm oil and palmitic acid: a review on cardiovascular effects and carcinogenicity","volume":"64","author":"Fattore","year":"2013","journal-title":"Int J Food Sci Nutr"},{"key":"10.1016\/j.trsl.2023.09.007_bib0030","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1007\/s00018-019-03092-7","article-title":"Palmitic acid is an intracellular signaling molecule involved in disease development","volume":"76","author":"Fatima","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.trsl.2023.09.007_bib0031","article-title":"Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction","volume":"10","author":"Park","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2023.09.007_bib0032","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ijcard.2018.10.064","article-title":"Consumption of individual saturated fatty acids and the risk of myocardial infarction in a UK and a Danish cohort","volume":"279","author":"Praagman","year":"2019","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.trsl.2023.09.007_bib0033","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.drudis.2011.12.010","article-title":"Nonprofit drugs as the salvation of the world's healthcare systems: the case of Antabuse (disulfiram)","volume":"17","author":"Cvek","year":"2012","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.trsl.2023.09.007_bib0034","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.autrev.2018.07.001","article-title":"Dimethyl fumarate treatment in multiple sclerosis: recent advances in clinical and immunological studies","volume":"17","author":"Montes Diaz","year":"2018","journal-title":"Autoimmun Rev"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524423001585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524423001585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:49:09Z","timestamp":1761828549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524423001585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":34,"alternative-id":["S1931524423001585"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2023.09.007","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of gasdermin D palmitoylation by disulfiram is crucial for the treatment of myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"Translational Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trsl.2023.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}