{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:58:43Z","timestamp":1792205923912,"version":"4.4.0"},"reference-count":184,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019018","name":"CAMS Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","award":["2019-I2M-5-044"],"award-info":[{"award-number":["2019-I2M-5-044"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072629"],"award-info":[{"award-number":["82072629"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","translationalres.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.trsl.2024.04.003","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T02:32:01Z","timestamp":1713234721000},"page":"81-93","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Targeting the devil: Strategies against cancer-associated fibroblasts in colorectal cancer"],"prefix":"10.1016","volume":"270","author":[{"given":"Yuting","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maode","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2024.04.003_bib0001","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000486721","article-title":"Tumor heterogeneity in colorectal cancer: what do we know so far?","volume":"85","author":"Sagaert","year":"2018","journal-title":"Pathobiology"},{"key":"10.1016\/j.trsl.2024.04.003_bib0002","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/nm.3967","article-title":"The consensus molecular subtypes of colorectal cancer","volume":"21","author":"Guinney","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.trsl.2024.04.003_bib0003","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12943-021-01367-x","article-title":"Cancer-associated fibroblast-derived gene signatures determine prognosis in colon cancer patients","volume":"20","author":"Herrera","year":"2021","journal-title":"Mol Cancer"},{"key":"10.1016\/j.trsl.2024.04.003_bib0004","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/ng.3224","article-title":"Stromal contribution to the colorectal cancer transcriptome","volume":"47","author":"Isella","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.trsl.2024.04.003_bib0005","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0006","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190103","article-title":"Transforming growth factor-\u03b2 in tissue fibrosis","volume":"217","author":"Frangogiannis","year":"2020","journal-title":"J Exp Med"},{"key":"10.1016\/j.trsl.2024.04.003_bib0007","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.semcancer.2013.12.008","article-title":"Batlle E. TGF-beta in CAF-mediated tumor growth and metastasis","volume":"25","author":"Calon","year":"2014","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0008","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1158\/1078-0432.CCR-20-4226","article-title":"Molecular features of cancer-associated fibroblast subtypes and their implication on cancer pathogenesis, prognosis, and immunotherapy resistance","volume":"27","author":"Galbo","year":"2021","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.trsl.2024.04.003_bib0009","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1186\/s12935-021-02252-9","article-title":"Integrated single-cell and bulk RNA sequencing analysis identifies a cancer associated fibroblast-related signature for predicting prognosis and therapeutic responses in colorectal cancer","volume":"21","author":"Zheng","year":"2021","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.trsl.2024.04.003_bib0010","article-title":"Cancer-associated fibroblasts suppress cancer development: the other side of the coin","volume":"9","author":"Wang","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0011","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/cas.14346","article-title":"Cancer-associated fibroblasts that restrain cancer progression: hypotheses and perspectives","volume":"111","author":"Miyai","year":"2020","journal-title":"Cancer Sci"},{"key":"10.1016\/j.trsl.2024.04.003_bib0012","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jcmgh.2023.07.001","article-title":"The origin, differentiation, and functions of cancer-associated fibroblasts in gastrointestinal cancer","volume":"16","author":"Huang","year":"2023","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0013","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ccr.2011.01.020","article-title":"Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth","volume":"19","author":"Quante","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.trsl.2024.04.003_bib0014","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrc1877","article-title":"Fibroblasts in cancer","volume":"6","author":"Kalluri","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.trsl.2024.04.003_bib0015","doi-asserted-by":"crossref","first-page":"10123","DOI":"10.1158\/0008-5472.CAN-07-3127","article-title":"Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts","volume":"67","author":"Zeisberg","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.trsl.2024.04.003_bib0016","doi-asserted-by":"crossref","first-page":"E5618","DOI":"10.1073\/pnas.1608384113","article-title":"Pericyte-fibroblast transition promotes tumor growth and metastasis","volume":"113","author":"Hosaka","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.trsl.2024.04.003_bib0017","doi-asserted-by":"crossref","first-page":"7551","DOI":"10.1073\/pnas.1600363113","article-title":"Tumor-associated fibroblasts predominantly come from local and not circulating precursors","volume":"113","author":"Arina","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.trsl.2024.04.003_bib0018","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/ijc.25440","article-title":"Mesenchymal stem cells enhance growth and metastasis of colon cancer","volume":"127","author":"Shinagawa","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1016\/j.trsl.2024.04.003_bib0019","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/stem.63","article-title":"Human gastrointestinal neoplasia-associated myofibroblasts can develop from bone marrow-derived cells following allogeneic stem cell transplantation","volume":"27","author":"Worthley","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.trsl.2024.04.003_bib0020","doi-asserted-by":"crossref","first-page":"5150","DOI":"10.1038\/s41467-018-07582-3","article-title":"Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing","volume":"9","author":"Bartoschek","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.trsl.2024.04.003_bib0021","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1053\/j.gastro.2021.11.037","article-title":"The origin and contribution of cancer-associated fibroblasts in colorectal carcinogenesis","volume":"162","author":"Kobayashi","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.trsl.2024.04.003_bib0022","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41575-021-00573-8","article-title":"Origin of CAFs in colorectal cancer","volume":"19","author":"Kotsiliti","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0023","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.3748\/wjg.v22.i48.10512","article-title":"Liver fibrosis and hepatic stellate cells: etiology, pathological hallmarks and therapeutic targets","volume":"22","author":"Zhang","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0024","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/cphy.c120035","article-title":"Hepatic stellate cells and liver fibrosis","volume":"3","author":"Puche","year":"2013","journal-title":"Compr Physiol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0025","first-page":"131","article-title":"Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts","author":"Bhattacharjee","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2024.04.003_bib0026","doi-asserted-by":"crossref","first-page":"7624","DOI":"10.7150\/thno.72853","article-title":"The landscape of cancer-associated fibroblasts in colorectal cancer liver metastases","volume":"12","author":"Giguelay","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.trsl.2024.04.003_bib0027","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3390\/cells12081139","article-title":"TGF\u03b2 and the tumor microenvironment in colorectal cancer","volume":"12","author":"Waldner","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.trsl.2024.04.003_bib0028","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/onc.2012.536","article-title":"Interaction with colon cancer cells hyperactivates TGF-\u03b2 signaling in cancer-associated fibroblasts","volume":"33","author":"Hawinkels","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.trsl.2024.04.003_bib0029","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.devcel.2020.10.014","article-title":"Stromal SOX2 upregulation promotes tumorigenesis through the generation of a SFRP1\/2-expressing cancer-associated fibroblast population","volume":"56","author":"Kasashima","year":"2021","journal-title":"Dev Cell"},{"key":"10.1016\/j.trsl.2024.04.003_bib0030","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.1158\/1078-0432.CCR-18-3957","article-title":"Noncanonical TGF\u03b2 pathway relieves the blockade of IL1\u03b2\/TGF\u03b2-mediated crosstalk between tumor and stroma: TGFBR1 and TAK1 inhibition in colorectal cancer","volume":"25","author":"Guill\u00e9n D\u00edaz-Maroto","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.trsl.2024.04.003_bib0031","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1002\/ijc.31586","article-title":"Serum-derived carcinoembryonic antigen (CEA) activates fibroblasts to induce a local re-modeling of the extracellular matrix that favors the engraftment of CEA-expressing tumor cells","volume":"143","author":"Abdul-Wahid","year":"2018","journal-title":"Int J Cancer"},{"key":"10.1016\/j.trsl.2024.04.003_bib0032","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41389-018-0085-z","article-title":"Endothelial cell activation on 3D-matrices derived from PDGF-BB-stimulated fibroblasts is mediated by Snail1","volume":"7","author":"Herrera","year":"2018","journal-title":"Oncogenesis"},{"key":"10.1016\/j.trsl.2024.04.003_bib0033","doi-asserted-by":"crossref","first-page":"6245","DOI":"10.1038\/s41467-020-20054-x","article-title":"Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer","volume":"11","author":"Levi-Galibov","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.trsl.2024.04.003_bib0034","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41467-018-07987-0","article-title":"Dickkopf-3 links HSF1 and YAP\/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts","volume":"10","author":"Ferrari","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.trsl.2024.04.003_bib0035","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.3390\/cancers12123537","article-title":"Interleukin-34 enhances the tumor promoting function of colorectal cancer-associated fibroblasts","volume":"12","author":"Franz\u00e8","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.trsl.2024.04.003_bib0036","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.celrep.2015.02.006","article-title":"Metabolic reprogramming of cancer-associated fibroblasts by IDH3\u03b1 downregulation","volume":"10","author":"Zhang","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.trsl.2024.04.003_bib0037","doi-asserted-by":"crossref","first-page":"eaau6977","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.trsl.2024.04.003_bib0038","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0039","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800148","article-title":"Exosomes derived from human primary and metastatic colorectal cancer cells contribute to functional heterogeneity of activated fibroblasts by reprogramming their proteome","volume":"19","author":"Rai","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/j.trsl.2024.04.003_bib0040","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41419-022-04825-6","article-title":"Exosomal miR-146a-5p and miR-155-5p promote CXCL12\/CXCR7-induced metastasis of colorectal cancer by crosstalk with cancer-associated fibroblasts","volume":"13","author":"Wang","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.trsl.2024.04.003_bib0041","article-title":"The BAP31\/miR-181a-5p\/RECK axis promotes angiogenesis in colorectal cancer via fibroblast activation","volume":"13","author":"Zhang","year":"2023","journal-title":"Front Oncol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0042","doi-asserted-by":"crossref","first-page":"e12226","DOI":"10.1002\/jev2.12226","article-title":"Epithelial to mesenchymal transition influences fibroblast phenotype in colorectal cancer by altering miR-200 levels in extracellular vesicles","volume":"11","author":"Bhome","year":"2022","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.trsl.2024.04.003_bib0043","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1101\/gad.1640608","article-title":"The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2","volume":"22","author":"Park","year":"2008","journal-title":"Genes Dev"},{"key":"10.1016\/j.trsl.2024.04.003_bib0044","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1084\/jem.20110235","article-title":"p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2","volume":"208","author":"Kim","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.trsl.2024.04.003_bib0045","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1038\/s41388-022-02218-9","article-title":"Extravesicular TIMP-1 is a non-invasive independent prognostic marker and potential therapeutic target in colorectal liver metastases","volume":"41","author":"Rao","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.trsl.2024.04.003_bib0046","doi-asserted-by":"crossref","first-page":"e77366","DOI":"10.1371\/journal.pone.0077366","article-title":"TIMP-1 promotes accumulation of cancer associated fibroblasts and cancer progression","volume":"8","author":"Gong","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2024.04.003_bib0047","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.1021\/acsbiomaterials.1c00611","article-title":"LINC01915 facilitates the conversion of normal fibroblasts into cancer-associated fibroblasts induced by colorectal cancer-derived extracellular vesicles through the miR-92a-3p\/KLF4\/CH25H Axis","volume":"7","author":"Zhou","year":"2021","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.trsl.2024.04.003_bib0048","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41419-022-04506-4","article-title":"Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.trsl.2024.04.003_bib0049","doi-asserted-by":"crossref","DOI":"10.1172\/JCI157399","article-title":"Targeting FAP\u03b1-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models","volume":"132","author":"Qi","year":"2022","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2024.04.003_bib0050","article-title":"FGF19-induced inflammatory CAF promoted neutrophil extracellular trap formation in the liver metastasis of colorectal cancer","volume":"10","author":"Li","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.trsl.2024.04.003_bib0051","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/ijc.32193","article-title":"In search of definitions: cancer-associated fibroblasts and their markers","volume":"146","author":"Nurmik","year":"2020","journal-title":"Int J Cancer"},{"key":"10.1016\/j.trsl.2024.04.003_bib0052","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41573-018-0004-1","article-title":"Turning foes to friends: targeting cancer-associated fibroblasts","volume":"18","author":"Chen","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.trsl.2024.04.003_bib0053","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1016\/j.cell.2021.08.003","article-title":"Spatially organized multicellular immune hubs in human colorectal cancer","volume":"184","author":"Pelka","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.trsl.2024.04.003_bib0054","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/ng.3818","article-title":"Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors","volume":"49","author":"Li","year":"2017","journal-title":"Nat Genet"},{"key":"10.1016\/j.trsl.2024.04.003_bib0055","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1084\/jem.20162024","article-title":"Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer","volume":"214","author":"\u00d6hlund","year":"2017","journal-title":"J Exp Med"},{"key":"10.1016\/j.trsl.2024.04.003_bib0056","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.3390\/cancers12051307","article-title":"Single-cell transcriptomic analysis of tumor-derived fibroblasts and normal tissue-resident fibroblasts reveals fibroblast heterogeneity in breast cancer","volume":"12","author":"Sebastian","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.trsl.2024.04.003_bib0057","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13059-022-02677-z","article-title":"Refining colorectal cancer classification and clinical stratification through a single-cell atlas","volume":"23","author":"Khaliq","year":"2022","journal-title":"Genome Biol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0058","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12967-022-03510-8","article-title":"Spatial transcriptomics atlas reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment components in colorectal cancer","volume":"20","author":"Peng","year":"2022","journal-title":"J Transl Med"},{"key":"10.1016\/j.trsl.2024.04.003_bib0059","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1158\/2159-8290.CD-19-1384","article-title":"Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer","volume":"10","author":"Kieffer","year":"2020","journal-title":"Cancer Discov"},{"key":"10.1016\/j.trsl.2024.04.003_bib0060","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.ccell.2021.03.012","article-title":"Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations","volume":"39","author":"Affo","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.trsl.2024.04.003_bib0061","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.jhep.2020.05.039","article-title":"Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma","volume":"73","author":"Zhang","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0062","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003591","article-title":"Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S","volume":"10","author":"Harryvan","year":"2022","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.trsl.2024.04.003_bib0063","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1158\/2159-8290.CD-19-0094","article-title":"Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts","volume":"9","author":"Elyada","year":"2019","journal-title":"Cancer Discov"},{"key":"10.1016\/j.trsl.2024.04.003_bib0064","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210815","article-title":"Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts","volume":"219","author":"Kerdidani","year":"2022","journal-title":"J Exp Med"},{"key":"10.1016\/j.trsl.2024.04.003_bib0065","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41421-021-00312-y","article-title":"A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy","volume":"7","author":"Che","year":"2021","journal-title":"Cell Discov"},{"key":"10.1016\/j.trsl.2024.04.003_bib0066","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1053\/j.gastro.2020.11.011","article-title":"The balance of stromal BMP signaling mediated by GREM1 and ISLR drives colorectal carcinogenesis","volume":"160","author":"Kobayashi","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.trsl.2024.04.003_bib0067","doi-asserted-by":"crossref","first-page":"12321","DOI":"10.1038\/ncomms12321","article-title":"Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth","volume":"7","author":"Gerling","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.trsl.2024.04.003_bib0068","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019104063","article-title":"Stromal cell diversity associated with immune evasion in human triple-negative breast cancer","volume":"39","author":"Wu","year":"2020","journal-title":"Embo j"},{"key":"10.1016\/j.trsl.2024.04.003_bib0069","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/s41571-021-00546-5","article-title":"Clinical and therapeutic relevance of cancer-associated fibroblasts","volume":"18","author":"Chen","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0070","doi-asserted-by":"crossref","first-page":"5569","DOI":"10.1158\/0008-5472.CAN-20-0263","article-title":"A Wnt-induced phenotypic switch in cancer-associated fibroblasts inhibits EMT in colorectal cancer","volume":"80","author":"Mosa","year":"2020","journal-title":"Cancer Res"},{"key":"10.1016\/j.trsl.2024.04.003_bib0071","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.3389\/fonc.2020.01747","article-title":"Increased RAB31 expression in cancer-associated fibroblasts promotes colon cancer progression through HGF-MET signaling","volume":"10","author":"Yang","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0072","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s41416-020-0973-9","article-title":"Cancer-associated fibroblasts mediate cancer progression and remodel the tumouroid stroma","volume":"123","author":"Pape","year":"2020","journal-title":"Br J Cancer"},{"key":"10.1016\/j.trsl.2024.04.003_bib0073","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.3390\/cells11162490","article-title":"Modulation of fibroblast phenotype by colorectal cancer cell-secreted factors is mostly independent of oncogenic KRAS","volume":"11","author":"Dias Carvalho","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.trsl.2024.04.003_bib0074","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1084\/jem.20150576","article-title":"IKK\u03b2 acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis","volume":"212","author":"Pallangyo","year":"2015","journal-title":"J Exp Med"},{"key":"10.1016\/j.trsl.2024.04.003_bib0075","doi-asserted-by":"crossref","first-page":"11585","DOI":"10.3390\/ijms241411585","article-title":"High CD142 level marks tumor-promoting fibroblasts with targeting potential in colorectal cancer","volume":"24","author":"So\u00f3s","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.trsl.2024.04.003_bib0076","doi-asserted-by":"crossref","first-page":"377","DOI":"10.18632\/oncotarget.28399","article-title":"Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism","volume":"14","author":"Vill\u00e9ger","year":"2023","journal-title":"Oncotarget"},{"key":"10.1016\/j.trsl.2024.04.003_bib0077","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1038\/s41467-021-24687-4","article-title":"Stromal induction of BRD4 phosphorylation results in chromatin remodeling and BET inhibitor resistance in colorectal cancer","volume":"12","author":"Wang","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.trsl.2024.04.003_bib0078","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1158\/0008-5472.CAN-17-0524","article-title":"Radiotherapy-activated cancer-associated fibroblasts promote tumor progression through paracrine IGF1R activation","volume":"78","author":"Tommelein","year":"2018","journal-title":"Cancer Res"},{"key":"10.1016\/j.trsl.2024.04.003_bib0079","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/path.6033","article-title":"Cancer-associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2-IGF1R and Hippo-YAP1 signaling pathways","volume":"259","author":"Zhang","year":"2023","journal-title":"J Pathol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0080","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1158\/0008-5472.CAN-12-1875","article-title":"STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer","volume":"73","author":"Pe\u00f1a","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.trsl.2024.04.003_bib0081","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3892\/or.2022.8323","article-title":"Cancer cell\u2011induced tissue inhibitor of metalloproteinase\u20111 secretion by cancer\u2011associated fibroblasts promotes cancer cell migration","volume":"47","author":"Nakai","year":"2022","journal-title":"Oncol Rep"},{"key":"10.1016\/j.trsl.2024.04.003_bib0082","first-page":"821","article-title":"[Human colorectal cancer cells induce fibroblasts to secrete stromal cell-derived factor 1 (SDF-1) to stimulate cancer cell migration]","volume":"37","author":"Li","year":"2021","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"10.1016\/j.trsl.2024.04.003_bib0083","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1158\/1541-7786.MCR-21-0924","article-title":"TGF-\u03b2-induced FLRT3 attenuation is essential for cancer-associated fibroblast-mediated epithelial-mesenchymal transition in colorectal cancer","volume":"20","author":"Yang","year":"2022","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.trsl.2024.04.003_bib0084","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/s41419-022-05240-7","article-title":"CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway","volume":"13","author":"Yang","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.trsl.2024.04.003_bib0085","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bbrc.2022.12.026","article-title":"Cancer-associated fibroblast-derived exosome miR-181b-3p promotes the occurrence and development of colorectal cancer by regulating SNX2 expression","volume":"641","author":"Jiang","year":"2023","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.trsl.2024.04.003_bib0086","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/carcin\/bgad014","article-title":"Cancer-associated fibroblasts-derived exosome-mediated transfer of miR-345-5p promotes the progression of colorectal cancer by targeting CDKN1A","volume":"44","author":"Shi","year":"2023","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.trsl.2024.04.003_bib0087","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/CAD.0000000000001445","article-title":"Cancer-associated fibroblasts-derived exosomes from chemoresistant patients regulate cisplatin resistance and angiogenesis by delivering VEGFA in colorectal cancer","volume":"34","author":"Shi","year":"2023","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.trsl.2024.04.003_bib0088","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.7150\/thno.25541","article-title":"Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19","volume":"8","author":"Ren","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.trsl.2024.04.003_bib0089","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.dld.2023.06.010","article-title":"CAF-derived exosomal lncRNA FAL1 promotes chemoresistance to oxaliplatin by regulating autophagy in colorectal cancer","volume":"56","author":"Zhu","year":"2024","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.trsl.2024.04.003_bib0090","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.omtn.2020.11.003","article-title":"Exosomal miR-590-3p derived from cancer-associated fibroblasts confers radioresistance in colorectal cancer","volume":"24","author":"Chen","year":"2021","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.trsl.2024.04.003_bib0091","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ymben.2021.11.006","article-title":"Elucidating tumor-stromal metabolic crosstalk in colorectal cancer through integration of constraint-based models and LC-MS metabolomics","volume":"69","author":"Wang","year":"2022","journal-title":"Metab Eng"},{"key":"10.1016\/j.trsl.2024.04.003_bib0092","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3390\/nu11010164","article-title":"Colorectal cancer and nutrition","volume":"11","author":"Thanikachalam","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.trsl.2024.04.003_bib0093","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s13045-022-01358-5","article-title":"Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications","volume":"15","author":"Zhong","year":"2022","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0094","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.7150\/thno.22717","article-title":"Cancer-associated fibroblasts enhance tumor (18)F-FDG uptake and contribute to the intratumor heterogeneity of PET-CT","volume":"8","author":"Shangguan","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.trsl.2024.04.003_bib0095","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41419-020-2434-z","article-title":"Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells","volume":"11","author":"Gong","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.trsl.2024.04.003_bib0096","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/1878-0261.12917","article-title":"Enhancing cancer-associated fibroblast fatty acid catabolism within a metabolically challenging tumor microenvironment drives colon cancer peritoneal metastasis","volume":"15","author":"Peng","year":"2021","journal-title":"Mol Oncol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0097","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.7150\/ijbs.68484","article-title":"Metabolomics reveals that CAF-derived lipids promote colorectal cancer peritoneal metastasis by enhancing membrane fluidity","volume":"18","author":"Peng","year":"2022","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.trsl.2024.04.003_bib0098","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.canlet.2021.07.006","article-title":"Stromal fibroblasts shape the myeloid phenotype in normal colon and colorectal cancer and induce CD163 and CCL2 expression in macrophages","volume":"520","author":"Stadler","year":"2021","journal-title":"Cancer Lett"},{"key":"10.1016\/j.trsl.2024.04.003_bib0099","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.semcancer.2022.02.007","article-title":"Chemokines in colon cancer progression","volume":"86","author":"Jia","year":"2022","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0100","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.celrep.2015.06.024","article-title":"CCL2 promotes colorectal carcinogenesis by enhancing polymorphonuclear myeloid-derived suppressor cell population and function","volume":"12","author":"Chun","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.trsl.2024.04.003_bib0101","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.immuni.2014.06.010","article-title":"Tumor-associated macrophages: from mechanisms to therapy","volume":"41","author":"Noy","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.trsl.2024.04.003_bib0102","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13045-019-0760-3","article-title":"Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications","volume":"12","author":"Lin","year":"2019","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0103","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s10020-021-00402-3","article-title":"Cancer-associated fibroblasts impact the clinical outcome and treatment response in colorectal cancer via immune system modulation: a comprehensive genome-wide analysis","volume":"27","author":"Chen","year":"2021","journal-title":"Mol Med"},{"key":"10.1016\/j.trsl.2024.04.003_bib0104","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41419-019-1435-2","article-title":"Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer","volume":"10","author":"Zhang","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.trsl.2024.04.003_bib0105","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1158\/2326-6066.CIR-21-0124","article-title":"Remodeling chondroitin-6-sulfate-mediated immune exclusion enhances anti-PD-1 response in colorectal cancer with microsatellite stability","volume":"10","author":"Wu","year":"2022","journal-title":"Cancer Immunol Res"},{"key":"10.1016\/j.trsl.2024.04.003_bib0106","doi-asserted-by":"crossref","first-page":"12127","DOI":"10.7150\/thno.52450","article-title":"3D printed in vitro tumor tissue model of colorectal cancer","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.trsl.2024.04.003_bib0107","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2018.1440167","article-title":"Unveiling a CD70-positive subset of cancer-associated fibroblasts marked by pro-migratory activity and thriving regulatory T cell accumulation","volume":"7","author":"Jacobs","year":"2018","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.trsl.2024.04.003_bib0108","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112475","article-title":"Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment","volume":"42","author":"Egan","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.trsl.2024.04.003_bib0109","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1136\/gutjnl-2020-322924","article-title":"Targeting cancer-associated fibroblast-secreted WNT2 restores dendritic cell-mediated antitumour immunity","volume":"71","author":"Huang","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.trsl.2024.04.003_bib0110","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1186\/s12885-021-08669-9","article-title":"Exosomal circEIF3K from cancer-associated fibroblast promotes colorectal cancer (CRC) progression via miR-214\/PD-L1 axis","volume":"21","author":"Yang","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.trsl.2024.04.003_bib0111","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1002\/ijc.32278","article-title":"Cancer-associated fibroblasts promote PD-L1 expression in mice cancer cells via secreting CXCL5","volume":"145","author":"Li","year":"2019","journal-title":"Int J Cancer"},{"key":"10.1016\/j.trsl.2024.04.003_bib0112","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10456-019-09688-8","article-title":"Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer","volume":"23","author":"Unterleuthner","year":"2020","journal-title":"Angiogenesis"},{"key":"10.1016\/j.trsl.2024.04.003_bib0113","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1136\/gutjnl-2019-319200","article-title":"STAT3 activation through IL-6\/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis","volume":"69","author":"Heichler","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.trsl.2024.04.003_bib0114","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13046-022-02300-w","article-title":"Tumor bud-derived CCL5 recruits fibroblasts and promotes colorectal cancer progression via CCR5-SLC25A24 signaling","volume":"41","author":"Gao","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.trsl.2024.04.003_bib0115","first-page":"2593","article-title":"Fibroblast activation protein-\u03b1 in tumor cells promotes colorectal cancer angiogenesis via the Akt and ERK signaling pathways","volume":"17","author":"Cao","year":"2018","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.trsl.2024.04.003_bib0116","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3892\/ijo.2021.5293","article-title":"Chitinase 3-like 1 secreted from cancer-associated fibroblasts promotes tumor angiogenesis via interleukin-8 secretion in colorectal cancer","volume":"60","author":"Watanabe","year":"2022","journal-title":"Int J Oncol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0117","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.ccell.2020.05.005","article-title":"Reduction of liver metastasis stiffness improves response to Bevacizumab in metastatic colorectal cancer","volume":"37","author":"Shen","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.trsl.2024.04.003_bib0118","doi-asserted-by":"crossref","first-page":"12574","DOI":"10.1038\/s41598-017-13006-x","article-title":"Cancer-associated fibroblasts support vascular growth through mechanical force","volume":"7","author":"Sewell-Loftin","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.trsl.2024.04.003_bib0119","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1053920","article-title":"Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer","volume":"14","author":"Strating","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0120","doi-asserted-by":"crossref","first-page":"e88018","DOI":"10.1371\/journal.pone.0088018","article-title":"Human subperitoneal fibroblast and cancer cell interaction creates microenvironment that enhances tumor progression and metastasis","volume":"9","author":"Kojima","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2024.04.003_bib0121","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/ncb2756","article-title":"Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts","volume":"15","author":"Calvo","year":"2013","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0122","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113757","article-title":"YAP, a novel target regulates F-actin rearrangement-associated CAFs transformation and promotes colorectal cancer cell progression","volume":"155","author":"Naktubtim","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.trsl.2024.04.003_bib0123","doi-asserted-by":"crossref","DOI":"10.1016\/j.mbplus.2022.100101","article-title":"Uncovering mediators of collagen degradation in the tumor microenvironment","volume":"13","author":"Thorseth","year":"2022","journal-title":"Matrix Biol Plus"},{"key":"10.1016\/j.trsl.2024.04.003_bib0124","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jcmgh.2023.04.004","article-title":"Cancer-associated fibroblasts are key determinants of cancer cell invasion in the earliest stage of colorectal cancer","volume":"16","author":"Dang","year":"2023","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0125","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1200\/JCO.1994.12.6.1193","article-title":"Antibody targeting in metastatic colon cancer: a phase I study of monoclonal antibody F19 against a cell-surface protein of reactive tumor stromal fibroblasts","volume":"12","author":"Welt","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0126","first-page":"44","article-title":"Stromal antigen targeting by a humanised monoclonal antibody: an early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer","volume":"26","author":"Hofheinz","year":"2003","journal-title":"Onkologie"},{"key":"10.1016\/j.trsl.2024.04.003_bib0127","first-page":"1639","article-title":"A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer","volume":"9","author":"Scott","year":"2003","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.trsl.2024.04.003_bib0128","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.4161\/cbt.6.11.4874","article-title":"Phase II trial of single agent Val-boroPro (Talabostat) inhibiting Fibroblast Activation Protein in patients with metastatic colorectal cancer","volume":"6","author":"Narra","year":"2007","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.trsl.2024.04.003_bib0129","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.969855","article-title":"Consensus molecular subtype 4 (CMS4)-targeted therapy in primary colon cancer: a proof-of-concept study","volume":"12","author":"Peters","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0130","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.2147\/IJN.S176928","article-title":"Gold nanoparticles enhance cisplatin delivery and potentiate chemotherapy by decompressing colorectal cancer vessels","volume":"13","author":"Zhao","year":"2018","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.trsl.2024.04.003_bib0131","first-page":"3907","article-title":"Pirfenidone suppresses TGF\u2011\u03b21\u2011induced human intestinal fibroblasts activities by regulating proliferation and apoptosis via the inhibition of the Smad and PI3K\/AKT signaling pathway","volume":"18","author":"Sun","year":"2018","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.trsl.2024.04.003_bib0132","doi-asserted-by":"crossref","first-page":"6331","DOI":"10.1158\/1078-0432.CCR-18-0329","article-title":"Endoglin expression on cancer-associated fibroblasts regulates invasion and stimulates colorectal cancer metastasis","volume":"24","author":"Paauwe","year":"2018","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.trsl.2024.04.003_bib0133","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.actbio.2023.04.001","article-title":"Multifunctional nanodrug performs sonodynamic therapy and inhibits TGF-\u03b2 to boost immune response against colorectal cancer and liver metastasis","volume":"164","author":"Huang","year":"2023","journal-title":"Acta Biomater"},{"key":"10.1016\/j.trsl.2024.04.003_bib0134","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1080\/15384047.2019.1685156","article-title":"CXCR4\/TGF-\u03b21 mediated self-differentiation of human mesenchymal stem cells to carcinoma-associated fibroblasts and promoted colorectal carcinoma development","volume":"21","author":"Tan","year":"2020","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.trsl.2024.04.003_bib0135","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/15384047.2019.1685157","article-title":"CXCR4\/TGF-\u03b21 mediated hepatic stellate cells differentiation into carcinoma-associated fibroblasts and promoted liver metastasis of colon cancer","volume":"21","author":"Tan","year":"2020","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.trsl.2024.04.003_bib0136","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1007\/s00018-016-2441-5","article-title":"Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO\/ROCK and Ca(2+) signalling","volume":"74","author":"Stadler","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.trsl.2024.04.003_bib0137","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41586-019-1173-8","article-title":"Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts","volume":"569","author":"Eckert","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.trsl.2024.04.003_bib0138","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.3390\/nu13051665","article-title":"Advances in NAD-lowering agents for cancer treatment","volume":"13","author":"Ghanem","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.trsl.2024.04.003_bib0139","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41392-020-00354-w","article-title":"NAD(+) metabolism, stemness, the immune response, and cancer","volume":"6","author":"Navas","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.trsl.2024.04.003_bib0140","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s13258-022-01318-w","article-title":"FK866 inhibits colorectal cancer metastasis by reducing NAD(+) levels in cancer-associated fibroblasts","volume":"44","author":"Xie","year":"2022","journal-title":"Genes Genomics"},{"key":"10.1016\/j.trsl.2024.04.003_bib0141","article-title":"Targeted reprogramming of vitamin B(3) metabolism as a nanotherapeutic strategy towards chemoresistant cancers","author":"Guo","year":"2023","journal-title":"Adv Mater"},{"key":"10.1016\/j.trsl.2024.04.003_bib0142","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1158\/0008-5472.CAN-21-2778","article-title":"Ketogenesis attenuates KLF5-dependent production of CXCL12 to overcome the immunosuppressive tumor microenvironment in colorectal cancer","volume":"82","author":"Wei","year":"2022","journal-title":"Cancer Res"},{"key":"10.1016\/j.trsl.2024.04.003_bib0143","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.jcmgh.2021.12.015","article-title":"A high-fat diet activates the BAs-FXR axis and triggers cancer-associated fibroblast properties in the colon","volume":"13","author":"Kim","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0144","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3892\/or.2022.8315","article-title":"Blue light irradiation inhibits the growth of colon cancer and activation of cancer\u2011associated fibroblasts","volume":"47","author":"Yoshimoto","year":"2022","journal-title":"Oncol Rep"},{"key":"10.1016\/j.trsl.2024.04.003_bib0145","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1136\/gutjnl-2015-310977","article-title":"Vitamin D receptor expression and associated gene signature in tumour stromal fibroblasts predict clinical outcome in colorectal cancer","volume":"66","author":"Ferrer-Mayorga","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.trsl.2024.04.003_bib0146","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1158\/0008-5472.CAN-18-2952","article-title":"Cancer-associated fibroblasts produce netrin-1 to control cancer cell plasticity","volume":"79","author":"Sung","year":"2019","journal-title":"Cancer Res"},{"key":"10.1016\/j.trsl.2024.04.003_bib0147","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1039\/D2TB02253B","article-title":"Cancer-associated fibroblast-targeted nanodrugs reshape colorectal tumor microenvironments to suppress tumor proliferation, metastasis and improve drug penetration","volume":"11","author":"Shen","year":"2023","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.trsl.2024.04.003_bib0148","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s10495-023-01819-3","article-title":"Bufalin reverses cancer-associated fibroblast-mediated colorectal cancer metastasis by inhibiting the STAT3 signaling pathway","volume":"28","author":"Wang","year":"2023","journal-title":"Apoptosis"},{"key":"10.1016\/j.trsl.2024.04.003_bib0149","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1038\/onc.2015.326","article-title":"Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling","volume":"35","author":"Sanchez-Lopez","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.trsl.2024.04.003_bib0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153797","article-title":"Gamma-mangostin isolated from garcinia mangostana suppresses colon carcinogenesis and stemness by downregulating the GSK3\u03b2\/\u03b2-catenin\/CDK6 cancer stem pathway","volume":"95","author":"Wu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.trsl.2024.04.003_bib0151","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1158\/1078-0432.CCR-20-3715","article-title":"Inhibition of hedgehog signaling alters fibroblast composition in pancreatic cancer","volume":"27","author":"Steele","year":"2021","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.trsl.2024.04.003_bib0152","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1158\/2159-8290.CD-18-0710","article-title":"IL1-induced JAK\/STAT signaling is antagonized by TGF\u03b2 to shape CAF heterogeneity in pancreatic ductal adenocarcinoma","volume":"9","author":"Biffi","year":"2019","journal-title":"Cancer Discov"},{"key":"10.1016\/j.trsl.2024.04.003_bib0153","doi-asserted-by":"crossref","first-page":"e1438","DOI":"10.1002\/ctm2.1438","article-title":"Hypoxic microenvironment determines the phenotypic plasticity and spatial distribution of cancer-associated fibroblasts","volume":"13","author":"Choi","year":"2023","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.trsl.2024.04.003_bib0154","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrclinonc.2016.217","article-title":"Tumour-associated macrophages as treatment targets in oncology","volume":"14","author":"Mantovani","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0155","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","article-title":"Diversity, mechanisms, and significance of macrophage plasticity","volume":"15","author":"Locati","year":"2020","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0156","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.trsl.2024.04.003_bib0157","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1038\/s41388-022-02288-9","article-title":"Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics","volume":"41","author":"Iida","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.trsl.2024.04.003_bib0158","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.1158\/0008-5472.CAN-19-0454","article-title":"Meflin-positive cancer-associated fibroblasts inhibit pancreatic carcinogenesis","volume":"79","author":"Mizutani","year":"2019","journal-title":"Cancer Res"},{"key":"10.1016\/j.trsl.2024.04.003_bib0159","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1182\/blood.V90.3.967","article-title":"Treatment with a new synthetic retinoid, Am80, of acute promyelocytic leukemia relapsed from complete remission induced by all-trans retinoic acid","volume":"90","author":"Tobita","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.trsl.2024.04.003_bib0160","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12885-022-09272-2","article-title":"Safety and efficacy of MIKE-1 in patients with advanced pancreatic cancer: a study protocol for an open-label phase I\/II investigator-initiated clinical trial based on a drug repositioning approach that reprograms the tumour stroma","volume":"22","author":"Mizutani","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.trsl.2024.04.003_bib0161","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cell.2014.08.007","article-title":"Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy","volume":"159","author":"Sherman","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.trsl.2024.04.003_bib0162","doi-asserted-by":"crossref","first-page":"12630","DOI":"10.1038\/ncomms12630","article-title":"ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion","volume":"7","author":"Chronopoulos","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.trsl.2024.04.003_bib0163","doi-asserted-by":"crossref","first-page":"4841","DOI":"10.1038\/s41467-020-18636-w","article-title":"Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer","volume":"11","author":"Kocher","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.trsl.2024.04.003_bib0164","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1053\/j.gastro.2022.07.076","article-title":"Combined MEK and STAT3 inhibition uncovers stromal plasticity by enriching for cancer-associated fibroblasts with mesenchymal stem cell-like features to overcome immunotherapy resistance in pancreatic cancer","volume":"163","author":"Datta","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.trsl.2024.04.003_bib0165","doi-asserted-by":"crossref","first-page":"TPS713","DOI":"10.1200\/JCO.2024.42.3_suppl.TPS713","article-title":"A phase 1 trial of combined MEK, STAT3 and PD-1 inhibition in metastatic pancreatic ductal adenocarcinoma (PDAC)","volume":"42","author":"Hosein","year":"2024","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0166","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14143396","article-title":"Type IV collagen in human colorectal liver metastases-cellular origin and a circulating biomarker","volume":"14","author":"Lindgren","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.trsl.2024.04.003_bib0167","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.956270","article-title":"Contribution of MMP14-expressing cancer-associated fibroblasts in the tumor immune microenvironment to progression of colorectal cancer","volume":"12","author":"Makutani","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0168","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1002\/ijc.29851","article-title":"Gene expression profile in the activation of subperitoneal fibroblasts reflects prognosis of patients with colon cancer","volume":"138","author":"Yokota","year":"2016","journal-title":"Int J Cancer"},{"key":"10.1016\/j.trsl.2024.04.003_bib0169","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/3781091","article-title":"Cancer-associated fibroblast risk model for prediction of colorectal carcinoma prognosis and therapeutic responses","volume":"2023","author":"Wang","year":"2023","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.trsl.2024.04.003_bib0170","doi-asserted-by":"crossref","first-page":"15107","DOI":"10.1038\/ncomms15107","article-title":"Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer","volume":"8","author":"Isella","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.trsl.2024.04.003_bib0171","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1158\/1078-0432.CCR-14-3096","article-title":"LOXL2 is highly expressed in cancer-associated fibroblasts and associates to poor colon cancer survival","volume":"21","author":"Torres","year":"2015","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.trsl.2024.04.003_bib0172","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.ccr.2014.04.005","article-title":"Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival","volume":"25","author":"\u00d6zdemir","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.trsl.2024.04.003_bib0173","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1158\/0008-5472.CAN-12-3022","article-title":"Fibroblast-specific protein 1\/S100A4-positive cells prevent carcinoma through collagen production and encapsulation of carcinogens","volume":"73","author":"Zhang","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.trsl.2024.04.003_bib0174","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ccr.2014.04.021","article-title":"Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma","volume":"25","author":"Rhim","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.trsl.2024.04.003_bib0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001871","article-title":"Asporin is a fibroblast-derived TGF-\u03b21 inhibitor and a tumor suppressor associated with good prognosis in breast cancer","volume":"12","author":"Maris","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.trsl.2024.04.003_bib0176","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.cell.2023.03.016","article-title":"Fibroblasts in cancer: Unity in heterogeneity","volume":"186","author":"Chhabra","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.trsl.2024.04.003_bib0177","doi-asserted-by":"crossref","DOI":"10.3791\/51475-v","article-title":"Molecular profiling of the invasive tumor microenvironment in a 3-dimensional model of colorectal cancer cells and ex vivo fibroblasts","author":"Bullock","year":"2014","journal-title":"J Vis Exp"},{"key":"10.1016\/j.trsl.2024.04.003_bib0178","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ajpath.2011.03.015","article-title":"Modeling colon adenocarcinomas in vitro a 3D co-culture system induces cancer-relevant pathways upon tumor cell and stromal fibroblast interaction","volume":"179","author":"Dolznig","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0179","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.actbio.2020.12.037","article-title":"Hydrogel-based colorectal cancer organoid co-culture models","volume":"132","author":"Luo","year":"2021","journal-title":"Acta Biomater"},{"key":"10.1016\/j.trsl.2024.04.003_bib0180","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1148930","article-title":"Three-dimensional heterotypic colorectal cancer spheroid models for evaluation of drug response","volume":"13","author":"Yau","year":"2023","journal-title":"Front Oncol"},{"key":"10.1016\/j.trsl.2024.04.003_bib0181","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218119","article-title":"Expression of EMT-related genes in hybrid E\/M colorectal cancer cells determines fibroblast activation and collagen remodeling","volume":"21","author":"Druzhkova","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.trsl.2024.04.003_bib0182","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.7150\/thno.63359","article-title":"Three-dimensional colon cancer organoids model the response to CEA-CD3 T-cell engagers","volume":"12","author":"Teijeira","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.trsl.2024.04.003_bib0183","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7053872","article-title":"Establishment of a novel model for anticancer drug resistance in three-dimensional primary culture of tumor microenvironment","volume":"2016","author":"Usui","year":"2016","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.trsl.2024.04.003_bib0184","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3390\/nano13010107","article-title":"Resveratrol loaded liposomes disrupt cancer associated fibroblast communications within the tumor microenvironment to inhibit colorectal cancer aggressiveness","volume":"13","author":"Dana","year":"2022","journal-title":"Nanomaterials (Basel)"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193152442400080X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193152442400080X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T15:17:22Z","timestamp":1717946242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S193152442400080X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":184,"alternative-id":["S193152442400080X"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2024.04.003","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting the devil: Strategies against cancer-associated fibroblasts in colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Translational Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trsl.2024.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}