{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:18:00Z","timestamp":1788020280209,"version":"build-2784847793"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370728"],"award-info":[{"award-number":["82370728"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200841"],"award-info":[{"award-number":["82200841"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100794"],"award-info":[{"award-number":["82100794"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300851"],"award-info":[{"award-number":["82300851"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570881"],"award-info":[{"award-number":["82570881"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300786"],"award-info":[{"award-number":["82300786"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","translationalres.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.trsl.2026.06.022","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:46:39Z","timestamp":1782924399000},"page":"15-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Activating transcription factor 3 aggravates renal fibrosis by regulating EGR2-mediated autophagy"],"prefix":"10.1016","volume":"296","author":[{"given":"Ruiwei","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anni","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingcun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjie","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3565-8024","authenticated-orcid":false,"given":"Chun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4s","key":"10.1016\/j.trsl.2026.06.022_bib0001","first-page":"S117","article-title":"2024 Clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"105","year":"2024","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.trsl.2026.06.022_bib0002","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s41392-022-01036-5","article-title":"Signaling pathways of chronic kidney diseases, implications for therapeutics","volume":"7","author":"Yuan","year":"2022","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"10.1016\/j.trsl.2026.06.022_bib0003","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41392-023-01379-7","article-title":"Kidney fibrosis: from mechanisms to therapeutic medicines","volume":"8","author":"Huang","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"10","key":"10.1016\/j.trsl.2026.06.022_bib0004","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s41419-023-06154-8","article-title":"Autophagy: regulator of cell death","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis"},{"issue":"1\u20132","key":"10.1016\/j.trsl.2026.06.022_bib0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cell.2018.09.048","article-title":"Biological functions of autophagy genes: a disease perspective","volume":"176","author":"Levine","year":"2019","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.trsl.2026.06.022_bib0006","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nrendo.2014.35","article-title":"Autophagy\u2013a key player in cellular and body metabolism","volume":"10","author":"Kim","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.trsl.2026.06.022_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102260","article-title":"Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy","volume":"50","author":"Liu","year":"2022","journal-title":"Redox Biol"},{"issue":"5","key":"10.1016\/j.trsl.2026.06.022_bib0008","doi-asserted-by":"crossref","DOI":"10.1172\/JCI140695","article-title":"Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis","volume":"131","author":"Miguel","year":"2021","journal-title":"J Clin Investig"},{"issue":"9","key":"10.1016\/j.trsl.2026.06.022_bib0009","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41581-020-0309-2","article-title":"Autophagy in kidney homeostasis and disease","volume":"16","author":"Tang","year":"2020","journal-title":"Nat Rev Nephrol"},{"issue":"3","key":"10.1016\/j.trsl.2026.06.022_bib0010","doi-asserted-by":"crossref","first-page":"C935","DOI":"10.1152\/ajpcell.00458.2023","article-title":"HIF-1 contributes to autophagy activation via BNIP3 to facilitate renal fibrosis in hypoxia in vitro and UUO in vivo","volume":"326","author":"Liu","year":"2024","journal-title":"Am J Physiol Cell Physiol"},{"issue":"Pt B","key":"10.1016\/j.trsl.2026.06.022_bib0011","article-title":"Trimethylamine N-oxide promotes PERK-mediated endothelial-mesenchymal transition and apoptosis thereby aggravates atherosclerosis","volume":"142","author":"Bingyu","year":"2024","journal-title":"Int Immunopharmacol"},{"issue":"11","key":"10.1016\/j.trsl.2026.06.022_bib0012","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1161\/CIRCRESAHA.124.324323","article-title":"Spatiotemporal ATF3 expression determines VSMC fate in abdominal aortic aneurysm","volume":"134","author":"Wen","year":"2024","journal-title":"Circ Res"},{"issue":"9","key":"10.1016\/j.trsl.2026.06.022_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2021.07.015","article-title":"Exercise-induced angiogenesis is dependent on metabolically primed ATF3\/4(+) endothelial cells","volume":"33","author":"Fan","year":"2021","journal-title":"Cell Metab"},{"key":"10.1016\/j.trsl.2026.06.022_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121331","article-title":"Formononetin ameliorates ferroptosis-associated fibrosis in renal tubular epithelial cells and in mice with chronic kidney disease by suppressing the Smad3\/ATF3\/SLC7A11 signaling","volume":"315","author":"Zhu","year":"2023","journal-title":"Life Sci"},{"key":"10.1016\/j.trsl.2026.06.022_bib0015","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.trsl.2024.04.005","article-title":"Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis","volume":"271","author":"Song","year":"2024","journal-title":"Transl Res"},{"issue":"10","key":"10.1016\/j.trsl.2026.06.022_bib0016","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70040","article-title":"ATF3-mediated transactivation of CXCL14 in HSCs during liver fibrosis","volume":"14","author":"Li","year":"2024","journal-title":"Clin Transl Med"},{"issue":"12","key":"10.1016\/j.trsl.2026.06.022_bib0017","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/s12276-022-00904-y","article-title":"Loss of KDM5B ameliorates pathological cardiac fibrosis and dysfunction by epigenetically enhancing ATF3 expression","volume":"54","author":"Wang","year":"2022","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.trsl.2026.06.022_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104314","article-title":"A potential role of the renin-angiotensin-aldosterone system in epithelial-to-mesenchymal transition-induced renal abnormalities: mechanisms and therapeutic implications","volume":"146","author":"Balakumar","year":"2019","journal-title":"Pharmacol Res"},{"issue":"1","key":"10.1016\/j.trsl.2026.06.022_bib0019","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1080\/15548627.2022.2072054","article-title":"Tubular cells produce FGF2 via autophagy after acute kidney injury leading to fibroblast activation and renal fibrosis","volume":"19","author":"Livingston","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.trsl.2026.06.022_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.918732","article-title":"Persistent activation of autophagy after cisplatin nephrotoxicity promotes renal fibrosis and chronic kidney disease","volume":"13","author":"Fu","year":"2022","journal-title":"Front Pharmacol"},{"issue":"3","key":"10.1016\/j.trsl.2026.06.022_bib0021","doi-asserted-by":"crossref","first-page":"F288","DOI":"10.1152\/ajprenal.00097.2022","article-title":"Pharmacological inhibitors of autophagy have opposite effects in acute and chronic cisplatin-induced kidney injury","volume":"323","author":"Sears","year":"2022","journal-title":"Am J Physiol Ren Physiol"},{"issue":"12","key":"10.1016\/j.trsl.2026.06.022_bib0022","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1681\/ASN.2013101068","article-title":"Autophagy regulates TGF-\u03b2 expression and suppresses kidney fibrosis induced by unilateral ureteral obstruction","volume":"25","author":"Ding","year":"2014","journal-title":"J Am Soc Nephrol: JASN"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524426001428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524426001428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T15:32:18Z","timestamp":1788017538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524426001428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":22,"alternative-id":["S1931524426001428"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2026.06.022","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activating transcription factor 3 aggravates renal fibrosis by regulating EGR2-mediated autophagy","name":"articletitle","label":"Article Title"},{"value":"Translational Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trsl.2026.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}