{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:49:38Z","timestamp":1792799378259,"version":"4.5.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transactions of the Royal Society of Tropical Medicine and Hygiene"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.trstmh.2006.02.010","type":"journal-article","created":{"date-parts":[[2006,5,27]],"date-time":"2006-05-27T11:15:13Z","timestamp":1148728513000},"page":"S17-S20","source":"Crossref","is-referenced-by-count":162,"special_numbering":"S1","title":["Development of miltefosine as an oral treatment for leishmaniasis"],"prefix":"10.1093","volume":"100","author":[{"given":"H.","family":"Sindermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.trstmh.2006.02.010_bib1","article-title":"Miltefosine \u2013 discovery of the antileishmanial activity of phospholipid derivatives","volume":"100.","author":"Croft","year":"2006","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.trstmh.2006.02.010_bib2","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/0190-9622(93)70275-X","article-title":"Topical administration of hexadecylphosphocholine in patients with cutaneous lymphomas: results of a phase I\/II study","volume":"29","author":"Dummer","year":"1993","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.trstmh.2006.02.010_bib3","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0959-8049(97)89020-X","article-title":"D-21266, a new heterocyclic alkylphospholipid with antitumour activity","volume":"33","author":"Hilgard","year":"1997","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.trstmh.2006.02.010_bib4","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1200\/JCO.2001.19.21.4150","article-title":"Randomized, double-blind, placebo-controlled, multicenter trial of 6% miltefosine solution, a topical chemotherapy in cutaneous metastases from breast cancer","volume":"19","author":"Leonard","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.trstmh.2006.02.010_bib5","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S0959-8049(05)80142-X","article-title":"Phase II study of daily oral miltefosine (hexadecylphosphocholine) in advanced colorectal cancer","volume":"29A","author":"Planting","year":"1993","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.trstmh.2006.02.010_bib6","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/0959-8049(94)90135-X","article-title":"Increases in leucocyte and platelet counts induced by the alkyl phospholipid hexadecylphosphocholine","volume":"30A","author":"Pronk","year":"1994","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.trstmh.2006.02.010_bib7","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1097\/00001813-200011000-00006","article-title":"Phase II study of miltefosine 6% solution as topical treatment of skin metastases in breast cancer patients","volume":"11","author":"Smorenburg","year":"2000","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.trstmh.2006.02.010_bib8","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1086\/383321","article-title":"Miltefosine for new world cutaneous leishmaniasis","volume":"38","author":"Soto","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.trstmh.2006.02.010_bib9","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/S0140-6736(98)04367-0","article-title":"Trial of oral miltefosine for visceral leishmaniasis","volume":"352","author":"Sundar","year":"1998","journal-title":"Lancet"},{"issue":"Suppl. 1","key":"10.1016\/j.trstmh.2006.02.010_bib10","article-title":"Oral miltefosine for the treatment of Indian visceral leishmaniasis","volume":"100","author":"Sundar","year":"2006","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.trstmh.2006.02.010_bib11","first-page":"113","article-title":"Hexadecylphosphocholine may produce reversible functional defects of the retinal pigment epithelium","volume":"2","author":"Theischen","year":"1993","journal-title":"Ger. J. Ophthalmol."},{"key":"10.1016\/j.trstmh.2006.02.010_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000420840","article-title":"Hexadecylphosphocholine in the topical treatment of skin metastases in breast cancer patients","volume":"34","author":"Unger","year":"1992","journal-title":"Prog. Exp. Tumor Res."},{"key":"10.1016\/j.trstmh.2006.02.010_bib13","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/BF01211805","article-title":"A dose-finding study of miltefosine (hexadecylphosphocholine) in patients with metastatic solid tumours","volume":"118","author":"Verweij","year":"1992","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.trstmh.2006.02.010_bib14","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0959-8049(93)90177-H","article-title":"Phase II study of miltefosine (hexadecylphosphocholine) in advanced soft tissue sarcomas of the adult: an EORTC Soft Tissue and Bone Sarcoma Group Study","volume":"29A","author":"Verweij","year":"1993","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.trstmh.2006.02.010_bib15","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0959-8049(05)80369-7","article-title":"Phase II study of oral miltefosine in patients with squamous cell head and neck cancer","volume":"29A","author":"Verweij","year":"1993","journal-title":"Eur. J. Cancer"}],"container-title":["Transactions of the Royal Society of Tropical Medicine and Hygiene"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/trstmh\/article-pdf\/100\/Supplement_1\/S17\/5329197\/100-Supplement_1-S17.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T01:27:22Z","timestamp":1555637242000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/trstmh\/article-lookup\/doi\/10.1016\/j.trstmh.2006.02.010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":15,"alternative-id":["S003592030600109X"],"URL":"https:\/\/doi.org\/10.1016\/j.trstmh.2006.02.010","relation":{},"ISSN":["0035-9203"],"issn-type":[{"value":"0035-9203","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}