{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:40:05Z","timestamp":1777426805411,"version":"3.51.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transactions of the Royal Society of Tropical Medicine and Hygiene"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.trstmh.2011.07.001","type":"journal-article","created":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T19:16:48Z","timestamp":1315336608000},"page":"568-573","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of the safety and tolerability of a short higher-dose primaquine regimen for presumptive anti-relapse therapy in healthy subjects"],"prefix":"10.1093","volume":"105","author":[{"given":"Andrew","family":"Ebringer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Heathcote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Waller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Dennis","family":"Shanks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Edstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"10.1016\/j.trstmh.2011.07.001_bib0005","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4269\/ajtmh.2001.64.97","article-title":"The neglected burden of Plasmodium vivax malaria","volume":"64","author":"Mendis","year":"2001","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0010","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4269\/ajtmh.2007.77.79","article-title":"Vivax malaria: neglected and not benign","volume":"77","author":"Price","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0015","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1471-4922(03)00005-9","article-title":"Can primaquine therapy for vivax malaria be improved?","volume":"19","author":"Baird","year":"2003","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0020","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1086\/379714","article-title":"Primaquine for prevention of malaria in travelers","volume":"37","author":"Baird","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0025","doi-asserted-by":"crossref","first-page":"402","DOI":"10.4269\/ajtmh.2006.75.402","article-title":"Primaquine: report from CDC Expert Meeting on Malaria Chemoprophylaxis I","volume":"75","author":"Hill","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0030","doi-asserted-by":"crossref","first-page":"322","DOI":"10.4269\/ajtmh.1995.52.322","article-title":"Long-term efficacy of primaquine in the treatment of vivax malaria in nonimmune travelers","volume":"52","author":"Jelinek","year":"1995","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0035","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1172\/JCI101963","article-title":"The clinical trial of 18 analogues of pamaquin (plasmochin) in vivax malaria, Chesson strain","volume":"27","author":"Alving","year":"1948","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0040","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0035-9203(94)90305-0","article-title":"High dose of primaquine in primaquine resistant vivax malaria","volume":"88","author":"Bunnag","year":"1994","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0045","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1080\/00034989760338","article-title":"Primaquine-tolerant vivax malaria in Thailand","volume":"91","author":"Looareesuwan","year":"1997","journal-title":"Ann Trop Med Parasitol"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0050","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4269\/ajtmh.1997.56.231","article-title":"Plasmodium vivax infections in U.S. army troops: failure of primaquine to prevent relapse in studies from Somalia","volume":"56","author":"Smoak","year":"1997","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0055","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4269\/ajtmh.2000.62.393","article-title":"Short report: a consideration of primaquine dose adjustment for radical cure of Plasmodium vivax malaria","volume":"62","author":"Schwartz","year":"2000","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0060","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4269\/ajtmh.2001.65.471","article-title":"Association of subtherapeutic dosages of a standard drug regimen with failures in preventing relapses of vivax malaria","volume":"65","author":"Duarte","year":"2001","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0065","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0035-9203(03)90082-4","article-title":"Efficacy of a 14-day primaquine regimen in preventing relapses in patients with Plasmodium vivax malaria in Mumbai, India","volume":"97","author":"Rajgor","year":"2003","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0070","doi-asserted-by":"crossref","first-page":"599","DOI":"10.4269\/ajtmh.2005.73.599","article-title":"Clinical characteristics of imported malaria in Japan: analysis at a referral hospital","volume":"73","author":"Miura","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0075","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1086\/424508","article-title":"Randomized trial of 3-dose regimens of tafenoquine (WR238605) versus low-dose primaquine for preventing Plasmodium vivax malaria relapse","volume":"39","author":"Walsh","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0080","first-page":"49","article-title":"Seven patients with relapses of Plasmodium vivax or P. ovale despite primaquine treatment","volume":"38","author":"Rombo","year":"1987","journal-title":"Trop Med Parasitol"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0085","series-title":"Guidelines for the treatment of malaria","author":"WHO","year":"2010"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0090","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1001\/jama.1952.72930340022010b","article-title":"Toxicity of primaquine in Caucasians","volume":"149","author":"Clayman","year":"1952","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0095","first-page":"391","article-title":"Clinical problems associated with the use of primaquine as a tissue schizontocidal and gametocytocidal drug","volume":"59","author":"Clyde","year":"1981","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0100","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/S0140-6736(95)92898-7","article-title":"Randomised placebo-controlled trial of primaquine for prophylaxis of falciparum and vivax malaria","volume":"346","author":"Fryauff","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0105","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1086\/324085","article-title":"Randomized, parallel placebo-controlled trial of primaquine for malaria prophylaxis in Papua, Indonesia","volume":"33","author":"Baird","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0110","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0035-9203(03)00041-5","article-title":"Compliance with 14-day primaquine therapy for radical cure of vivax malaria\u2014a randomized placebo-controlled trial comparing unsupervised with supervised treatment","volume":"98","author":"Leslie","year":"2004","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0115","doi-asserted-by":"crossref","first-page":"562","DOI":"10.4269\/ajtmh.1977.26.562","article-title":"Radical cure of Chesson strain vivax malaria in man by 7, not 14, days of treatment with primaquine","volume":"26","author":"Clyde","year":"1977","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0120","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.4269\/ajtmh.1977.26.1116","article-title":"Radical cure of infections with Plasmodium cynomolgi: a function of total 8-aminoquinoline dose","volume":"26","author":"Schmidt","year":"1977","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0125","doi-asserted-by":"crossref","first-page":"949","DOI":"10.4269\/ajtmh.1953.2.949","article-title":"Studies in human malaria. XXXI. Comparison of primaquine, isopentaquine, SN-3883, and pamaquine as curative agents against Chesson strain vivax malaria","volume":"2","author":"Cooper","year":"1953","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0130","first-page":"285","article-title":"Primaquine, SN 13272, a new curative agent in vivax malaria; a preliminary report","volume":"9","author":"Edgcomb","year":"1950","journal-title":"J Natl Malar Soc"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0135","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1365-2125.1985.tb02709.x","article-title":"Pharmacokinetics of primaquine in man. I. Studies of the absolute bioavailability and effects of dose size","volume":"19","author":"Mihaly","year":"1985","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0140","doi-asserted-by":"crossref","first-page":"951","DOI":"10.4269\/ajtmh.2006.74.951","article-title":"Lack of sex effect on the pharmacokinetics of primaquine","volume":"74","author":"Elmes","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0145","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1365-2125.1984.tb02369.x","article-title":"Pharmacokinetics of primaquine in man: identification of the carboxylic acid derivative as a major plasma metabolite","volume":"17","author":"Mihaly","year":"1984","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0150","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/j.1365-2125.2006.02601.x","article-title":"Does gender, food or grapefruit juice alter the pharmacokinetics of primaquine in healthy subjects?","volume":"61","author":"Cuong","year":"2006","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0155","doi-asserted-by":"crossref","first-page":"747","DOI":"10.4269\/ajtmh.2009.09-0214","article-title":"Sex affects the steady-state pharmacokinetics of primaquine but not doxycycline in healthy subjects","volume":"81","author":"Binh","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0160","doi-asserted-by":"crossref","first-page":"736","DOI":"10.4269\/ajtmh.2008.78.736","article-title":"High-dose primaquine regimens against relapse of Plasmodium vivax malaria","volume":"78","author":"Krudsood","year":"2008","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0165","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4269\/ajtmh.2010.09-0428","article-title":"A comparison of two short-course primaquine regimens for the treatment and radical cure of Plasmodium vivax malaria in Thailand","volume":"82","author":"Pukrittayakamee","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0170","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.trstmh.2007.01.003","article-title":"Vivax malaria: preliminary observations following a shorter course of treatment with artesunate plus primaquine","volume":"101","author":"Dao","year":"2007","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0175","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1086\/512242","article-title":"Relapses of Plasmodium vivax infection result from clonal hypnozoites activated at predetermined intervals","volume":"195","author":"Chen","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0180","doi-asserted-by":"crossref","first-page":"394","DOI":"10.2165\/00002018-199614060-00005","article-title":"Drug-induced methaemoglobinaemia. Treatment issues","volume":"14","author":"Coleman","year":"1996","journal-title":"Drug Saf"},{"key":"10.1016\/j.trstmh.2011.07.001_bib0185","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF03259842","article-title":"Drug- and chemical-induced methaemoglobinaemia. Clinical features and management","volume":"1","author":"Hall","year":"1986","journal-title":"Med Toxicol"}],"container-title":["Transactions of the Royal Society of Tropical Medicine and Hygiene"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/trstmh\/article-pdf\/105\/10\/568\/5374936\/105-10-568.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,15]],"date-time":"2019-06-15T01:24:42Z","timestamp":1560561882000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/trstmh\/article-lookup\/doi\/10.1016\/j.trstmh.2011.07.001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0035920311001313"],"URL":"https:\/\/doi.org\/10.1016\/j.trstmh.2011.07.001","relation":{},"ISSN":["0035-9203"],"issn-type":[{"value":"0035-9203","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}