{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:28:38Z","timestamp":1790166518884,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI-065359"],"award-info":[{"award-number":["AI-065359"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ticks and Tick-borne Diseases"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.ttbdis.2015.04.009","type":"journal-article","created":{"date-parts":[[2015,5,2]],"date-time":"2015-05-02T12:04:39Z","timestamp":1430568279000},"page":"549-558","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Broad diversity of host responses of the white-footed mouse Peromyscus leucopus to Borrelia infection and antigens"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5293-0619","authenticated-orcid":false,"given":"Vanessa","family":"Cook","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0719-5248","authenticated-orcid":false,"given":"Alan G.","family":"Barbour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ttbdis.2015.04.009_bib0005","doi-asserted-by":"crossref","first-page":"132","DOI":"10.7589\/2012-02-041","article-title":"Association between movement and Sin Nombre virus (Bunyaviridae: Hantavirus) infection in North American deermice (Peromyscus maniculatus) in Colorado","volume":"49","author":"Amman","year":"2013","journal-title":"J. Wildl. Dis."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0010","series-title":"Biology of Peromyscus (Rodentia)","article-title":"Habitats and distribution","author":"Baker","year":"1968"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0015","first-page":"521","article-title":"Isolation and cultivation of Lyme disease spirochetes","volume":"57","author":"Barbour","year":"1984","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0020","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1128\/IAI.69.2.1009-1015.2001","article-title":"In vitro and in vivo neutralization of the relapsing fever agent Borrelia hermsii with serotype-specific immunoglobulin M antibodies","volume":"69","author":"Barbour","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0025","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.4269\/ajtmh.2009.09-0208","article-title":"Niche partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the same tick vector and mammalian reservoir species","volume":"81","author":"Barbour","year":"2009","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0030","doi-asserted-by":"crossref","first-page":"e00153","DOI":"10.1128\/mBio.00153-10","article-title":"Evolution and distribution of the ospC gene, a transferable serotype determinant of Borrelia burgdorferi","volume":"1","author":"Barbour","year":"2010","journal-title":"MBio"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0035","series-title":"Borrelia: Molecular Biology, Host Interaction, and Pathogenesis","first-page":"359","article-title":"Animal models of borreliosis","author":"Barthold","year":"2010"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0040","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00434-12","article-title":"Experimental infections of the reservoir species Peromyscus leucopus with diverse strains of Borrelia burgdorferi, a Lyme disease agent","volume":"3","author":"Baum","year":"2012","journal-title":"MBio"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0045","doi-asserted-by":"crossref","first-page":"7818","DOI":"10.1016\/j.vaccine.2011.07.100","article-title":"Development of a baited oral vaccine for use in reservoir-targeted strategies against Lyme disease","volume":"29","author":"Bhattacharya","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0050","doi-asserted-by":"crossref","first-page":"10578","DOI":"10.1073\/pnas.180197197","article-title":"Experimental infection model for Sin Nombre hantavirus in the deer mouse (Peromyscus maniculatus)","volume":"97","author":"Botten","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0055","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1098\/rspb.2007.1208","article-title":"Conspicuous impacts of inconspicuous hosts on the Lyme disease epidemic","volume":"275","author":"Brisson","year":"2008","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0060","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.immuni.2013.10.010","article-title":"The spleen in local and systemic regulation of immunity","volume":"39","author":"Bronte","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0065","series-title":"Tickborne Diseases of the United States: A Reference Manual for Health Care Professionals","author":"Centers for Disease Control","year":"2014"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0070","first-page":"96","article-title":"Efficacy of a nonadjuvanted, outer surface protein A, recombinant vaccine in dogs after challenge by ticks naturally infected with Borrelia burgdorferi","volume":"1","author":"Conlon","year":"2000","journal-title":"Vet. Ther."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0075","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/laban.504","article-title":"Caring for Peromyscus spp. in research environments","volume":"43","author":"Crossland","year":"2014","journal-title":"Lab. Anim."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0080","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1111\/j.1365-2958.2006.05177.x","article-title":"Antigenic variation by Borrelia hermsii occurs through recombination between extragenic repetitive elements on linear plasmids","volume":"60","author":"Dai","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0085","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/gene.1011","article-title":"Deer mice: \u201cThe Drosophila of North American mammalogy\u201d","volume":"29","author":"Dewey","year":"2001","journal-title":"Genesis"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0090","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4269\/ajtmh.2000.63.36","article-title":"Enzootic transmission of deer tick virus in New England and Wisconsin sites","volume":"63","author":"Ebel","year":"2000","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/09291010903016002","article-title":"An unusual timing of blood coagulation in deer mice (Peromyscus leucopus)","volume":"41","author":"Folk","year":"2010","journal-title":"Biol. Rhythm. Res."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0100","series-title":"Mammals of North America","author":"Hall","year":"1979"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0105","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1056\/NEJM197207272870401","article-title":"The bleeding time as a screening test for evaluation of platelet function","volume":"287","author":"Harker","year":"1972","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0110","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1128\/JCM.20.6.1099-1101.1984","article-title":"Infection of Syrian hamsters with Lyme disease spirochetes","volume":"20","author":"Johnson","year":"1984","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0115","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1093\/ilar.39.4.322","article-title":"Deer mice as laboratory animals","volume":"39","author":"Joyner","year":"1998","journal-title":"ILAR"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0120","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s00335-014-9500-8","article-title":"A genetic map of Peromyscus with chromosomal assignment of linkage groups (a Peromyscus genetic map)","volume":"25","author":"Kenney-Hunt","year":"2014","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0125","series-title":"Advances in the Study of Peromyscus (Rodentia)","author":"Kirkland","year":"1989"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0130","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.2307\/2410448","article-title":"Evolution of basal metabolic rate and organ masses in laboratory mice","author":"Konarzewski","year":"1995","journal-title":"Evolution"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0135","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.3201\/eid2007.131587","article-title":"Borrelia miyamotoi sensu lato seroreactivity and seroprevalence in the northeastern United States","volume":"20","author":"Krause","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0140","doi-asserted-by":"crossref","first-page":"355","DOI":"10.4269\/ajtmh.1985.34.355","article-title":"Mice as reservoirs of the Lyme disease spirochete","volume":"34","author":"Levine","year":"1985","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0145","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1128\/IAI.01582-14","article-title":"Fibronectin-binding protein of Borrelia hermsii expressed in the blood of mice with relapsing fever","volume":"82","author":"Lewis","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0150","doi-asserted-by":"crossref","first-page":"R316","DOI":"10.1152\/ajpregu.00386.2006","article-title":"Immunological memory is compromised by food restriction in deer mice Peromyscus maniculatus","volume":"292","author":"Martin","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0155","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1890\/07-0060.1","article-title":"Immune defense and reproductive pace of life in Peromyscus mice","volume":"88","author":"Martin","year":"2007","journal-title":"Ecology"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0160","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1098\/rstb.2007.2142","article-title":"Seasonal changes in vertebrate immune activity: mediation by physiological trade-offs","volume":"363","author":"Martin","year":"2008","journal-title":"Philos. Trans. R. Soc. Lond. B: Biol. Sci."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0165","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1128\/CVI.05226-11","article-title":"Reservoir targeted vaccine for Lyme borreliosis induces a yearlong, neutralizing antibody response to OspA in white-footed mice","volume":"18","author":"Meirelles Richer","year":"2011","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0170","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1084\/jem.48.1.65","article-title":"Relapse phenomena of Spironema recurrentis","volume":"48","author":"Meleney","year":"1928","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0175","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/S0264-410X(02)00680-1","article-title":"Immunization with the Chlamydia trachomatis major outer membrane protein, using the outer surface protein A of Borrelia burgdorferi as an adjuvant, can induce protection against a chlamydial genital challenge","volume":"21","author":"Pal","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0180","series-title":"Peromyscus Genetic Stock Center","author":"Peromyscus Genetic Stock Center","year":"2015"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0185","series-title":"Borrelia: Molecular Biology, Host Interaction, and Pathogensis","first-page":"251","article-title":"Ecology of borreliae and their arthropod vectors","author":"Piesman","year":"2010"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0190","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1128\/IAI.00542-13","article-title":"Borrelia hermsii acquisition order in superinfected ticks determines transmission efficiency","volume":"81","author":"Policastro","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0195","doi-asserted-by":"crossref","first-page":"e1000444","DOI":"10.1371\/journal.ppat.1000444","article-title":"Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta","volume":"5","author":"Salazar","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0200","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1128\/JCM.34.10.2483-2492.1996","article-title":"GlpQ: an antigen for serological discrimination between relapsing fever and Lyme borreliosis","volume":"34","author":"Schwan","year":"1996","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0205","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1089\/153036601750137624","article-title":"A relapsing fever group spirochete transmitted by Ixodes scapularis ticks","volume":"1","author":"Scoles","year":"2001","journal-title":"Vector Borne Zoonotic Dis."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0210","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.2460\/ajvr.1985.46.06.1396","article-title":"Borrelia theileri: isolation from ticks (Boophilus microplus) and tick-borne transmission between splenectomized calves","volume":"46","author":"Smith","year":"1985","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0215","series-title":"Biology of Ticks","article-title":"Mouthparts and digestive system: anatomy and molecular biology of feeding and digestion","author":"Sonenshine","year":"2014"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0220","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1080\/10635150490468701","article-title":"Phylogeny and divergence-date estimates of rapid radiations in muroid rodents based on multiple nuclear genes","volume":"53","author":"Steppan","year":"2004","journal-title":"Syst. Biol."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0225","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/iep.12091","article-title":"Peromyscus leucopus mice: a potential animal model for haematological studies","volume":"95","author":"Sun","year":"2014","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0230","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1073\/pnas.93.12.6209","article-title":"Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle","volume":"93","author":"Telford","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0235","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/jmedent\/30.1.223","article-title":"Reservoir competence of white-footed mice for Babesia microti","volume":"30","author":"Telford","year":"1993","journal-title":"J. Med. Entomol."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0240","series-title":"Morphometric (organ weight) survey of 11 inbred strains of mice","author":"The Jackson Laboratory","year":"2015"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0245","series-title":"On Growth and Form","author":"Thompson","year":"1961"},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0250","doi-asserted-by":"crossref","first-page":"18159","DOI":"10.1073\/pnas.0405763102","article-title":"An ecological approach to preventing human infection: vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle","volume":"101","author":"Tsao","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0255","first-page":"336","article-title":"Hematologic and serum biochemical values of 4 species of Peromyscus mice and their hybrids","volume":"53","author":"Wiedmeyer","year":"2014","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"10.1016\/j.ttbdis.2015.04.009_bib0260","series-title":"Peromyscus Genome Project of the Human Genome Sequencing Center","author":"Worley","year":"2015"}],"container-title":["Ticks and Tick-borne Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877959X15000771?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877959X15000771?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T19:41:40Z","timestamp":1748374900000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877959X15000771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1877959X15000771"],"URL":"https:\/\/doi.org\/10.1016\/j.ttbdis.2015.04.009","relation":{},"ISSN":["1877-959X"],"issn-type":[{"value":"1877-959X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Broad diversity of host responses of the white-footed mouse Peromyscus leucopus to Borrelia infection and antigens","name":"articletitle","label":"Article Title"},{"value":"Ticks and Tick-borne Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ttbdis.2015.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}