{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:57:23Z","timestamp":1778864243973,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Czech Science Foundation (GA CR)","award":["13-27630P"],"award-info":[{"award-number":["13-27630P"]}]},{"name":"Czech Science Foundation (GA CR)","award":["13-11043S"],"award-info":[{"award-number":["13-11043S"]}]},{"name":"Czech Science Foundation (GA CR)","award":["13-12816P"],"award-info":[{"award-number":["13-12816P"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ticks and Tick-borne Diseases"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.ttbdis.2016.01.006","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T13:51:42Z","timestamp":1453125102000},"page":"565-572","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Tick iron and heme metabolism \u2013 New target for an anti-tick intervention"],"prefix":"10.1016","volume":"7","author":[{"given":"Ondrej","family":"Hajdusek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radek","family":"Sima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Perner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Loosova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adela","family":"Harcubova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2412-5724","authenticated-orcid":false,"given":"Petr","family":"Kopacek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ttbdis.2016.01.006_bib0005","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1242\/jeb.051664","article-title":"Iron depletion in the intestines of Malvolio mutant flies does not occur in the absence of a multicopper oxidase","volume":"214","author":"Bettedi","year":"2011","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0010","series-title":"Ticks: Biology, Disease and Control","author":"Bowman","year":"2008"},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0015","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1126\/science.1109730","article-title":"Global topology analysis of the Escherichia coli inner membrane proteome","volume":"308","author":"Daley","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0020","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00436-005-1351-5","article-title":"RNA interference screening in ticks for identification of protective antigens","volume":"96","author":"de la Fuente","year":"2005","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0025","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1017\/S1466252307001193","article-title":"A ten-year review of commercial vaccine performance for control of tick infestations on cattle","volume":"8","author":"de la Fuente","year":"2007","journal-title":"Anim. Health Res. Rev."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0030","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1586\/14760584.2.4.583","article-title":"Advances in the identification and characterization of protective antigens for recombinant vaccines against tick infestations","volume":"2","author":"de la Fuente","year":"2003","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0035","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jinsphys.2009.01.002","article-title":"Heme-binding storage proteins in the Chelicerata","volume":"55","author":"Donohue","year":"2009","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.tcb.2006.12.003","article-title":"Iron uptake and metabolism in the new millennium","volume":"17","author":"Dunn","year":"2007","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0045","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1242\/jeb.081240","article-title":"Multiple ferritins are vital to successful blood feeding and reproduction of the hard tick Haemaphysalis longicornis","volume":"216","author":"Galay","year":"2013","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0050","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1186\/s13071-014-0482-x","article-title":"Evaluation and comparison of the potential of two ferritins as anti-tick vaccines against Haemaphysalis longicornis","volume":"7","author":"Galay","year":"2014","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0055","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0022-1910(02)00050-1","article-title":"Hemolymph proteins in ticks","volume":"48","author":"Gudderra","year":"2002","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0060","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1016\/j.vaccine.2010.02.008","article-title":"Characterization of ferritin 2 for the control of tick infestations","volume":"28","author":"Hajdusek","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0065","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fcimb.2013.00026","article-title":"Interaction of the tick immune system with transmitted pathogens","volume":"3","author":"Hajdusek","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0070","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1073\/pnas.0807961106","article-title":"Knockdown of proteins involved in iron metabolism limits tick reproduction and development","volume":"106","author":"Hajdusek","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0075","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.bbamcr.2012.04.009","article-title":"One ring to rule them all: trafficking of heme and heme synthesis intermediates in the metazoans","volume":"1823","author":"Hamza","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0080","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0092-8674(04)00343-5","article-title":"Balancing acts: molecular control of mammalian iron metabolism","volume":"117","author":"Hentze","year":"2004","journal-title":"Cell"},{"issue":"Suppl.","key":"10.1016\/j.ttbdis.2016.01.006_bib0085","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1017\/S0031182004005967","article-title":"The global importance of ticks","volume":"129","author":"Jongejan","year":"2004","journal-title":"Parasitology"},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0090","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0965-1748(02)00181-9","article-title":"Molecular cloning, expression and isolation of ferritins from two tick species \u2013 Ornithodoros moubata and Ixodes ricinus","volume":"33","author":"Kopacek","year":"2003","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0095","doi-asserted-by":"crossref","first-page":"e1003088","DOI":"10.1371\/journal.ppat.1003088","article-title":"Make it, take it, or leave it: heme metabolism of parasites","volume":"9","author":"Koreny","year":"2013","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0100","doi-asserted-by":"crossref","first-page":"D583","DOI":"10.1093\/nar\/gkn857","article-title":"VectorBase: a data resource for invertebrate vector genomics","volume":"37","author":"Lawson","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0105","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1099\/vir.0.011437-0","article-title":"Tick-borne encephalitis virus \u2013 a review of an emerging zoonosis","volume":"90","author":"Mansfield","year":"2009","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0110","doi-asserted-by":"crossref","first-page":"36584","DOI":"10.1074\/jbc.M007344200","article-title":"HeLp, a heme lipoprotein from the hemolymph of the cattle tick, Boophilus microplus","volume":"275","author":"Maya-Monteiro","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0115","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fcimb.2013.00030","article-title":"Tick vaccines and the control of tick-borne pathogens","volume":"3","author":"Merino","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0120","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/524406a","article-title":"The growing global battle against blood-sucking ticks","volume":"524","author":"Moyer","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0125","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1471-2199-10-112","article-title":"Selection of reference genes for quantitative RT-PCR studies in Rhipicephalus (Boophilus) microplus and Rhipicephalus appendiculatus ticks and determination of the expression profile of Bm86","volume":"10","author":"Nijhof","year":"2009","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0130","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.imbio.2006.02.004","article-title":"Iron-withholding strategy in innate immunity","volume":"211","author":"Ong","year":"2006","journal-title":"Immunobiology"},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0135","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0140","first-page":"16","article-title":"Lyme borreliosis in Europe","author":"Rizzoli","year":"2011","journal-title":"Euro Surveill."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0145","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.ijpara.2006.12.020","article-title":"IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus","volume":"37","author":"Sojka","year":"2007","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0150","series-title":"Biology of Ticks","author":"Sonenshine","year":"2014"},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0155","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.dci.2014.05.016","article-title":"IrFC \u2013 An Ixodes ricinus injury-responsive molecule related to Limulus Factor C","volume":"46","author":"Urbanova","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0160","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.dci.2014.09.004","article-title":"Thioester-containing proteins of the tick Ixodes ricinus: gene expression, response to microbial challenge and their role in phagocytosis of the yeast Candida albicans","volume":"48","author":"Urbanova","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0165","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.3748\/wjg.14.4101","article-title":"Mechanisms of heme iron absorption: current questions and controversies","volume":"14","author":"West","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0170","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.cmet.2013.01.005","article-title":"HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis","volume":"17","author":"White","year":"2013","journal-title":"Cell. Metab."},{"issue":"Suppl.","key":"10.1016\/j.ttbdis.2016.01.006_bib0175","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1017\/S0031182000001487","article-title":"Commercialisation of a recombinant vaccine against Boophilus microplus","volume":"110","author":"Willadsen","year":"1995","journal-title":"Parasitology"},{"key":"10.1016\/j.ttbdis.2016.01.006_bib0180","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ibmb.2008.12.004","article-title":"Differential regulation of transferrin 1 and 2 in Aedes aegypti","volume":"39","author":"Zhou","year":"2009","journal-title":"Insect Biochem. Mol. Biol."}],"container-title":["Ticks and Tick-borne Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877959X16300061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877959X16300061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T16:05:18Z","timestamp":1567526718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877959X16300061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S1877959X16300061"],"URL":"https:\/\/doi.org\/10.1016\/j.ttbdis.2016.01.006","relation":{},"ISSN":["1877-959X"],"issn-type":[{"value":"1877-959X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tick iron and heme metabolism \u2013 New target for an anti-tick intervention","name":"articletitle","label":"Article Title"},{"value":"Ticks and Tick-borne Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ttbdis.2016.01.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}