{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T03:13:04Z","timestamp":1767064384815,"version":"3.41.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T00:00:00Z","timestamp":1491523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007917","name":"USDA-ARS","doi-asserted-by":"publisher","award":["5348-32000-028-00D"],"award-info":[{"award-number":["5348-32000-028-00D"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]},{"name":"GHTM","award":["UID\/Multi\/04413\/2013"],"award-info":[{"award-number":["UID\/Multi\/04413\/2013"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["TDC\/CVT\/098290\/2008"],"award-info":[{"award-number":["TDC\/CVT\/098290\/2008"]}]},{"name":"European Union FEDER"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ticks and Tick-borne Diseases"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.ttbdis.2017.04.002","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T16:00:53Z","timestamp":1491840053000},"page":"593-597","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Inhibition of the in vitro growth of Babesia bigemina, Babesia caballi and Theileria equi parasites by trifluralin analogues"],"prefix":"10.1016","volume":"8","author":[{"given":"Marta","family":"G. Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald P.","family":"Knowles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Domingos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Esteves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos E.","family":"Suarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ttbdis.2017.04.002_bib0005","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1292\/jvms.59.479","article-title":"Improved in vitro cultivation of Babesia caballi","volume":"59","author":"Avarzed","year":"1997","journal-title":"J. Vet. Med. Sci.\/ Jpn. Soc. Vet. Sci."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0010","first-page":"233","article-title":"Recent advances in the chemotherapy of babesiosis by Asian scientists: toxoplasmosis and babesiosis in Asia","volume":"4","author":"Bork","year":"2005","journal-title":"Asian Parasitol."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0015","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1126\/science.2392684","article-title":"Inhibition of leishmanias but not host macrophages by the antitubulin herbicide trifluralin","volume":"249","author":"Chan","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0020","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1128\/AAC.37.9.1909","article-title":"Structure-function analysis of antimicrotubule dinitroanilines against promastigotes of the parasitic protozoan Leishmania mexicana","volume":"37","author":"Chan","year":"1993","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0025","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s00709-014-0633-0","article-title":"Microtubule drugs: action, selectivity, and resistance across the kingdoms of life","volume":"251","author":"Dostal","year":"2014","journal-title":"Protoplasma"},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0030","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.bmc.2009.10.059","article-title":"Synthesis and biological evaluation of trifluralin analogues as antileishmanial agents","volume":"18","author":"Esteves","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0035","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.molbiopara.2005.08.020","article-title":"Cellular and molecular actions of dinitroaniline and phosphorothioamidate herbicides on Plasmodium falciparum: tubulin as a specific antimalarial target","volume":"145","author":"Fennell","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetpar.2015.12.024","article-title":"In vitro growth inhibitory efficacy of some target specific novel drug molecules against Theileria equi","volume":"217","author":"Gopalakrishnan","year":"2016","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0045","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/ps.2284","article-title":"Mutation of alpha-tubulin genes in trifluralin-resistant water foxtail (Alopecurus aequalis)","volume":"68","author":"Hashim","year":"2012","journal-title":"Pest Manage. Sci."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0050","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1534\/genetics.108.092494","article-title":"Secondary mutations correct fitness defects in Toxoplasma gondii with dinitroaniline resistance mutations","volume":"180","author":"Ma","year":"2008","journal-title":"Genetics"},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0055","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/ps.1108","article-title":"Environmental fate of herbicides trifluralin, metazachlor, metamitron and sulcotrione compared with that of glyphosate, a substitute broad spectrum herbicide for different glyphosate-resistant crops","volume":"61","author":"Mamy","year":"2005","journal-title":"Pest Manage. Sci."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0060","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.1021\/jm060472+","article-title":"Binding and interaction of dinitroanilines with apicomplexan and kinetoplastid alpha-tubulin","volume":"49","author":"Mitra","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0065","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1091\/mbc.e03-07-0530","article-title":"Dinitroanilines bind alpha-tubulin to disrupt microtubules","volume":"15","author":"Morrissette","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0070","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.bcp.2008.01.002","article-title":"Accumulation of the antimalarial microtubule inhibitors trifluralin and vinblastine by Plasmodium falciparum","volume":"75","author":"Naughton","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0075","first-page":"10","article-title":"Optimization of a fluorescence-based assay for large-scale drug screening against Babesia and Theileria parasites","author":"Rizk","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0080","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ijpddr.2013.01.003","article-title":"Evaluation of the growth-inhibitory effect of trifluralin analogues on in vitro cultured Babesia bovis parasites","volume":"3","author":"Silva","year":"2013","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0085","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0167-4781(03)00159-3","article-title":"Molecular characterization and expression of a divergent alpha-tubulin in planarian Schmidtea polychroa","volume":"1629","author":"Simoncelli","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0090","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.vetpar.2011.05.032","article-title":"Emerging perspectives in the research of bovine babesiosis and anaplasmosis","volume":"180","author":"Suarez","year":"2011","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0095","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S1471-4922(00)01834-1","article-title":"Dinitroaniline herbicides against protozoan parasites: the case of Trypanosoma cruzi","volume":"17","author":"Traub-Cseko","year":"2001","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0100","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0304-4017(94)03107-8","article-title":"International collaborative research: significance of tick-borne hemoparasitic diseases to world animal health","volume":"57","author":"Uilenberg","year":"1995","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0105","doi-asserted-by":"crossref","first-page":"416","DOI":"10.2460\/ajvr.1985.46.02.416","article-title":"In vitro cultivation of Babesia bigemina","volume":"46","author":"Vega","year":"1985","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0110","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.vetpar.2006.01.048","article-title":"Chemotherapy against babesiosis","volume":"138","author":"Vial","year":"2006","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0115","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2174\/1389557023405648","article-title":"Tubulin as an antiprotozoal drug target","volume":"2","author":"Werbovetz","year":"2002","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0120","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1111\/jvim.12168","article-title":"Review of equine piroplasmosis","volume":"27","author":"Wise","year":"2013","journal-title":"J. Vet. Inter. Med.\/Am. Coll. Vet. Intern. Med."},{"key":"10.1016\/j.ttbdis.2017.04.002_bib0125","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF00931544","article-title":"Continuous in vitro cultivation of erythrocytic stages of Babesia equi","volume":"81","author":"Zweygarth","year":"1995","journal-title":"Parasitol. Res."}],"container-title":["Ticks and Tick-borne Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877959X16302783?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877959X16302783?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T21:43:41Z","timestamp":1750196621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877959X16302783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S1877959X16302783"],"URL":"https:\/\/doi.org\/10.1016\/j.ttbdis.2017.04.002","relation":{},"ISSN":["1877-959X"],"issn-type":[{"type":"print","value":"1877-959X"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of the in vitro growth of Babesia bigemina, Babesia caballi and Theileria equi parasites by trifluralin analogues","name":"articletitle","label":"Article Title"},{"value":"Ticks and Tick-borne Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ttbdis.2017.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}]}}