{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T06:22:49Z","timestamp":1775542969208,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Key Basic Research Program (973 program) of China","award":["2015CB150300"],"award-info":[{"award-number":["2015CB150300"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ticks and Tick-borne Diseases"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.ttbdis.2018.01.021","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T18:40:25Z","timestamp":1518115225000},"page":"645-653","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Babesia microti thioredoxin 3 is an effective antioxidant and involved in the response to antiprotozoal drugs"],"prefix":"10.1016","volume":"9","author":[{"given":"Jingwei","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houshuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanzhen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzhi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinlin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ttbdis.2018.01.021_bib0005","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/jac\/dkt486","article-title":"Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential","volume":"69","author":"Antoine","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0010","first-page":"171","article-title":"Structural model of the Plasmodium falciparum thioredoxin reductase: a novel target for antimalarial drugs","volume":"46","author":"Banerjee","year":"2009","journal-title":"J. Vector. Borne. Dis."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0015","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijpara.2003.09.011","article-title":"Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions","volume":"34","author":"Becker","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0020","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.foodchem.2010.09.065","article-title":"The cellular antioxidant activity in red blood cells (CAA-RBC): a new approach to bioavailability and synergy of phytochemicals and botanical extracts","volume":"125","author":"Blasa","year":"2011","journal-title":"Food. Chem."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0025","doi-asserted-by":"crossref","first-page":"351289","DOI":"10.1155\/2015\/351289","article-title":"Oxidative stress control by apicomplexan parasites","volume":"2015","author":"Bosch","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0030","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.bbrc.2012.07.156","article-title":"Crystal structure of Plasmodium falciparum thioredoxin reductase, a validated drug target","volume":"425","author":"Boumis","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0035","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.3201\/eid2211.151028","article-title":"Transmission of Babesia microti parasites by solid organ transplantation","volume":"22","author":"Brennan","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0040","doi-asserted-by":"crossref","first-page":"9102","DOI":"10.1093\/nar\/gks700","article-title":"Sequencing of the smallest Apicomplexan genome from the human pathogen Babesia microti","volume":"40","author":"Cornillot","year":"2012","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0045","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/nature08104","article-title":"A newly discovered protein export machine in malaria parasites","volume":"459","author":"De Koningward","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0050","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.vetpar.2011.10.001","article-title":"Evaluation of antioxidant status and oxidative stress in sheep naturally infected with Babesia ovis","volume":"185","author":"Esmaeilnejad","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0055","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/1475-2875-12-315","article-title":"Lipid peroxidation and antioxidant enzymes activity in Plasmodium vivax malaria patients evolving with cholestatic jaundice","volume":"12","author":"Fabbri","year":"2013","journal-title":"Malar. J."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0060","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1365-3083.2004.01433.x","article-title":"Red blood cells inhibit proliferation and stimulate apoptosis in human lung fibroblasts in vitro","volume":"59","author":"Fredriksson","year":"2004","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0065","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.3389\/fmicb.2017.01959","article-title":"Identification of 2-Cys peroxiredoxin (BmTPx-2) as antioxidant active molecule from Babesia microti","volume":"8","author":"Hai","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0070","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.exppara.2015.04.018","article-title":"Development of monoclonal antibodies against Plasmodium falciparum thioredoxin peroxidase 1 and its possible application for malaria diagnosis","volume":"154","author":"Hakimi","year":"2015","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0075","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/brain\/awv350","article-title":"Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration","volume":"139","author":"Holzerova","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0080","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.3389\/fmicb.2017.02006","article-title":"Babesia microti aldo-keto reductase-like protein involved in antioxidant and anti-parasite response","volume":"8","author":"Huang","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0085","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ijmm.2012.07.007","article-title":"Thioredoxin and glutathione systems in Plasmodium falciparum","volume":"302","author":"Jortzik","year":"2012","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0090","doi-asserted-by":"crossref","first-page":"40180","DOI":"10.1074\/jbc.M007633200","article-title":"The thioredoxin system of the malaria parasite Plasmodium falciparum glutathione reduction revisited","volume":"275","author":"Kanzok","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0095","doi-asserted-by":"crossref","first-page":"e1001242","DOI":"10.1371\/journal.ppat.1001242","article-title":"Compartmentation of redox metabolism in malaria parasites","volume":"6","author":"Kehr","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0100","doi-asserted-by":"crossref","first-page":"25970","DOI":"10.1074\/jbc.M203539200","article-title":"Thioredoxin reductase is essential for the survival of Plasmodium falciparum erythrocytic stages","volume":"277","author":"Krnajski","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0105","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.abb.2016.09.011","article-title":"Thioredoxin and redox signaling: roles of the thioredoxin system in control of cell fate","volume":"617","author":"Matsuzawa","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0110","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1111\/febs.12964","article-title":"Molecular characterization of the thioredoxin system from Methanosarcina acetivorans","volume":"281","author":"McCarver","year":"2014","journal-title":"FEBS. J."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0115","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1021\/ar000063m","article-title":"Oxidative folding of proteins","volume":"33","author":"Narayan","year":"2000","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0120","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.bbrc.2014.11.096","article-title":"Crystal structure and solution characterization of the thioredoxin-2 from Plasmodium falciparum, a constituent of an essential parasitic protein export complex","volume":"456","author":"Peng","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0125","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/srep00179","article-title":"Structural insights into thioredoxin-2: a component of malaria parasite protein secretion machinery","volume":"1","author":"Sharma","year":"2011","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0130","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1128\/JCM.05848-11","article-title":"A new real-time PCR assay for improved detection of the parasite Babesia microti","volume":"50","author":"Teal","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0135","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1056\/NEJMra1202018","article-title":"Human babesiosis","volume":"366","author":"Vannier","year":"2012","journal-title":"New. Engl. J. Med."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0140","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.idc.2008.03.010","article-title":"Human babesiosis","volume":"22","author":"Vannier","year":"2008","journal-title":"Infect. Dis. N. Am."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0145","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1186\/s13071-016-1790-0","article-title":"Specific histamine binding activity of a new lipocalin from Hyalomma asiaticum (Ixodidae) and therapeutic effects on allergic asthma in mice","volume":"9","author":"Wang","year":"2016","journal-title":"Parasite. Vector."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0150","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.vetpar.2017.03.017","article-title":"The immunomodulatory protein RH36 is relating to blood-feeding success and oviposition in hard ticks","volume":"240","author":"Wang","year":"2017","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0155","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.exppara.2016.08.005","article-title":"Identification and functional study of a novel 2-cys peroxiredoxin (BmTPx-1) of Babesia microti","volume":"170","author":"Zhang","year":"2016","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0160","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1007\/s00436-016-5084-4","article-title":"Identification of a thioredoxin reductase from Babesia microti during mammalian infection","volume":"115","author":"Zhao","year":"2016","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ttbdis.2018.01.021_bib0165","first-page":"509","article-title":"Human babesiosis, an emerging tick-borne disease in the People\u2019s Republic of China","volume":"7","author":"Zhou","year":"2014","journal-title":"Parasite. Vector."}],"container-title":["Ticks and Tick-borne Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877959X17304776?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877959X17304776?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T11:34:32Z","timestamp":1594812872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877959X17304776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S1877959X17304776"],"URL":"https:\/\/doi.org\/10.1016\/j.ttbdis.2018.01.021","relation":{},"ISSN":["1877-959X"],"issn-type":[{"value":"1877-959X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Babesia microti thioredoxin 3 is an effective antioxidant and involved in the response to antiprotozoal drugs","name":"articletitle","label":"Article Title"},{"value":"Ticks and Tick-borne Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ttbdis.2018.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}