{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:27:43Z","timestamp":1787059663065,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ticks and Tick-borne Diseases"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.ttbdis.2018.06.006","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T04:06:55Z","timestamp":1529035615000},"page":"1343-1349","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["The oligopeptide ABC transporter OppA4 negatively regulates the virulence factor OspC production of the Lyme disease pathogen"],"prefix":"10.1016","volume":"9","author":[{"given":"Bibi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youyun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongliang","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. Frank","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ttbdis.2018.06.006_bib0005","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1099\/00221287-144-4-1033","article-title":"Oligopeptide permease in Borrelia burgdorferi: putative peptide-binding components encoded by both chromosomal and plasmid loci","volume":"144","author":"Bono","year":"1998","journal-title":"Microbiology"},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0010","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.mimet.2011.05.004","article-title":"Multiplex PCR as a tool for validating plasmid content of Borrelia burgdorferi","volume":"86","author":"Bunikis","year":"2011","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0015","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/cmi.12609","article-title":"Interaction of the Lyme disease spirochete with its tick vector","volume":"18","author":"Caimano","year":"2016","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0020","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1046\/j.1365-2958.2000.01698.x","article-title":"A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi","volume":"35","author":"Casjens","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0025","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4269\/ajtmh.1995.53.397","article-title":"Growth and migration of Borrelia burgdorferi in Ixodes ticks during blood feeding","volume":"53","author":"de Silva","year":"1995","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0030","article-title":"The Borrelia burgdorferi RelA\/SpoT homolog and stringent response regulate survival in the tick vector and global gene expression during starvation","volume":"11","author":"Drecktrah","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093141","article-title":"Global repression of host-associated genes of the Lyme disease spirochete through post-transcriptional modulation of the alternative sigma factor RpoS","volume":"9","author":"Dulebohn","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136707","article-title":"Absence of sodA increases the levels of oxidation of key metabolic determinants of Borrelia burgdorferi","volume":"10","author":"Esteve-Gassent","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0045","series-title":"X-ray Crystal Structure of a Periplasmic Oligopeptide-Binding protein\/Oligopeptide ABC Transporter (OppAIV) from Borrelia Burgdorferi","author":"Fairman","year":"2012"},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0050","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/37551","article-title":"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi","volume":"390","author":"Fraser","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0055","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/21505594.2016.1221025","article-title":"Bacterial peptide transporters: messengers of nutrition to virulence","volume":"8","author":"Garai","year":"2017","journal-title":"Virulence"},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0060","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1128\/JB.00253-12","article-title":"Rrp2, a prokaryotic enhancer-like binding protein, is essential for viability of Borrelia burgdorferi","volume":"194","author":"Groshong","year":"2012","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0065","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02047-17","article-title":"Peptide uptake is essential for Borrelia burgdorferi viability and involves structural and regulatory complexity of its oligopeptide transporter","volume":"8","author":"Groshong","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0070","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1128\/IAI.01238-13","article-title":"The cyclic di-GMP receptor PlzA controls virulence gene expression through RpoS in Borrelia burgdorferi","volume":"82","author":"He","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0075","doi-asserted-by":"crossref","first-page":"12724","DOI":"10.1073\/pnas.231442498","article-title":"Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway","volume":"98","author":"H\u00fcbner","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0080","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1128\/JB.01109-06","article-title":"Borrelia burgdorferi alters its gene expression and antigenic profile in response to CO2 levels","volume":"189","author":"Hyde","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0085","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/j.1365-2958.2009.06951.x","article-title":"The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete","volume":"74","author":"Hyde","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0090","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/mmi.12882","article-title":"Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptation","volume":"95","author":"Iyer","year":"2015","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0095","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1128\/IAI.00043-06","article-title":"Infectivity of the highly transformable BBE02- lp56- mutant of borrelia burgdorferi, the Lyme disease spirochete, via ticks","volume":"74","author":"Jacobs","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0100","doi-asserted-by":"crossref","first-page":"7147","DOI":"10.1128\/IAI.72.12.7147-7154.2004","article-title":"BBE02 disruption mutants of Borrelia burgdorferi B31 have a highly transformable, infectious phenotype","volume":"72","author":"Kawabata","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0105","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/cmi.12138","article-title":"Microbial quest for food in vivo: \u2018Nutritional virulence\u2019 as an emerging paradigm","volume":"15","author":"Kwaik","year":"2013","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0110","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1146\/annurev.en.36.010191.003103","article-title":"Lyme borreliosis: relation of its causative agent to its vectors and hosts in North America and Europe","volume":"36","author":"Lane","year":"1991","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0115","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0167-4889(00)00121-X","article-title":"Functional testing of putative oligopeptide permease (Opp) proteins of Borrelia burgdorferi: a complementation model in opp(\u2212) Escherichia coli","volume":"1499","author":"Lin","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0120","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1365-2958.2007.05716.x","article-title":"Temperature-induced regulation of RpoS by a small RNA in Borrelia burgdorferi","volume":"64","author":"Lybecker","year":"2007","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0125","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1128\/JB.01760-06","article-title":"Regulators of expression of the oligopeptide permease A proteins of Borrelia burgdorferi","volume":"189","author":"Medrano","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0130","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/mmi.12171","article-title":"Borrelia host adaptation regulator (BadR) regulates rpoS to modulate host adaptation and virulence factors in Borrelia burgdorferi","volume":"88","author":"Miller","year":"2013","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0135","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1007\/s00018-003-3054-3","article-title":"Bacterial oligopeptide-binding proteins","volume":"60","author":"Monnet","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0140","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1099\/mic.0.2008\/019992-0","article-title":"Transcriptional interplay among the regulators Rrp2, RpoN, and RpoS in Borrelia burgdorferi","volume":"154","author":"Ouyang","year":"2008","journal-title":"Microbiology"},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0145","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1111\/j.1365-2958.2009.06945.x","article-title":"BosR (BB0647) governs virulence expression in Borrelia burgdorferi","volume":"74","author":"Ouyang","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001272","article-title":"BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism","volume":"7","author":"Ouyang","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0155","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/mmi.13206","article-title":"BadR (BB0693) controls growth phase-dependent induction of rpoS and bosR in Borrelia burgdorferi via recognizing TAAAATAT motifs","volume":"98","author":"Ouyang","year":"2015","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0160","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/mmi.13545","article-title":"The putative walker A and walker B motifs of Rrp2 are required for the growth of Borrelia burgdorferi","volume":"103","author":"Ouyang","year":"2016","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0165","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrmicro2714","article-title":"Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes","volume":"10","author":"Radolf","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0170","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1128\/IAI.05234-11","article-title":"Oligopeptide permease A5 modulates vertebrate host-specific adaptation of Borrelia burgdorferi","volume":"79","author":"Raju","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144472","article-title":"Acetyl-phosphate is not a global regulatory bridge between virulence and central metabolism in Borrelia burgdorferi","volume":"10","author":"Richards","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0180","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/j.1365-2958.2009.06621.x","article-title":"Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functions","volume":"71","author":"Rogers","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0185","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev.micro.112408.134040","article-title":"Gene regulation in Borrelia burgdorferi","volume":"65","author":"Samuels","year":"2011","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0190","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1128\/JCM.38.1.382-388.2000","article-title":"Temporal changes in outer surface proteins A and C of the Lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice","volume":"38","author":"Schwan","year":"2000","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0195","series-title":"Curr Top Microbiol Immunol","doi-asserted-by":"crossref","DOI":"10.1007\/82_2017_49","article-title":"Regulation of Gene and protein expression in the Lyme disease spirochete","author":"Stevenson","year":"2017"},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0200","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1089\/vbz.2005.5.237","article-title":"Plasmid requirements for infection of ticks by borrelia burgdorferi","volume":"5","author":"Strother","year":"2005","journal-title":"Vector Borne Zoonotic Dis."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0205","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1128\/IAI.00050-13","article-title":"Study of the response regulator Rrp1 reveals its regulatory role in chitobiose utilization and virulence of Borrelia burgdorferi","volume":"81","author":"Sze","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0210","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1365-2958.2009.06961.x","article-title":"Homes for the orphans: utilization of multiple substrate-binding proteins by ABC transporters","volume":"75","author":"Thomas","year":"2010","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0215","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fcimb.2013.00079","article-title":"Metal-dependent gene regulation in the causative agent of Lyme disease","volume":"3","author":"Troxell","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0220","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1128\/IAI.00507-13","article-title":"Manganese and zinc regulate virulence determinants in Borrelia burgdorferi","volume":"81","author":"Troxell","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084625","article-title":"Pyruvate protects pathogenic spirochetes from H2O2 killing","volume":"9","author":"Troxell","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0230","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/mmi.13437","article-title":"Global Tn-seq analysis of carbohydrate utilization and vertebrate infectivity of Borrelia burgdorferi","volume":"101","author":"Troy","year":"2016","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038171","article-title":"Effect of levels of acetate on the mevalonate pathway of Borrelia burgdorferi","volume":"7","author":"Van Laar","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0240","doi-asserted-by":"crossref","first-page":"6198","DOI":"10.1128\/JB.184.22.6198-6206.2002","article-title":"Effects of environmental changes on expression of the oligopeptide permease (opp) genes of Borrelia burgdorferi","volume":"184","author":"Wang","year":"2002","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0245","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1128\/JB.186.1.51-60.2004","article-title":"Analysis of differences in the functional properties of the substrate binding proteins of the Borrelia burgdorferi oligopeptide permease (opp) operon","volume":"186","author":"Wang","year":"2004","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0250","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1128\/JB.00276-17","article-title":"BosR is a novel Fur family member responsive to copper and regulating copper homeostasis in Borrelia burgdorferi","volume":"199","author":"Wang","year":"2017","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2017.00131","article-title":"Investigation of ospC expression variation among Borrelia burgdorferi strains","volume":"7","author":"Xiang","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0260","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/88293342-3534-4b8b-8800-c63a8c86bf6d","article-title":"Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi","volume":"6","author":"Xu","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0265","doi-asserted-by":"crossref","first-page":"11001","DOI":"10.1073\/pnas.1834315100","article-title":"The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferi","volume":"100","author":"Yang","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0270","doi-asserted-by":"crossref","first-page":"4822","DOI":"10.1128\/JB.187.14.4822-4829.2005","article-title":"Analysis of the ospC regulatory element controlled by the RpoN-RpoS regulatory pathway in Borrelia burgdorferi","volume":"187","author":"Yang","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000326","article-title":"A chromosomally encoded virulence factor protects the Lyme disease pathogen against host-adaptive immunity","volume":"5","author":"Yang","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0280","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1128\/IAI.00030-14","article-title":"DhhP, a c-di-AMP phosphodiesterase of Borrelia burgdorferi, is essential for cell growth and virulence","volume":"82","author":"Ye","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0285","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11427-015-4996-z","article-title":"Genome reduction of Borrelia burgdorferi: two TCS signaling pathways for two distinct host habitats","volume":"59","author":"Ye","year":"2016","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.ttbdis.2018.06.006_bib0290","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1128\/JB.01010-15","article-title":"Insight into the dual functions of bacterial enhancer-binding protein Rrp2 of Borrelia burgdorferi","volume":"198","author":"Yin","year":"2016","journal-title":"J. Bacteriol."}],"container-title":["Ticks and Tick-borne Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877959X18301596?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877959X18301596?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T17:32:17Z","timestamp":1604424737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877959X18301596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S1877959X18301596"],"URL":"https:\/\/doi.org\/10.1016\/j.ttbdis.2018.06.006","relation":{},"ISSN":["1877-959X"],"issn-type":[{"value":"1877-959X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The oligopeptide ABC transporter OppA4 negatively regulates the virulence factor OspC production of the Lyme disease pathogen","name":"articletitle","label":"Article Title"},{"value":"Ticks and Tick-borne Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ttbdis.2018.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}