{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T17:05:19Z","timestamp":1789232719217,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIAID\/NIH"},{"name":"Steven and Alexandra Cohen Foundation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ticks and Tick-borne Diseases"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.ttbdis.2018.12.001","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T12:20:50Z","timestamp":1543839650000},"page":"386-397","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Host-specific expression of Ixodes scapularis salivary genes"],"prefix":"10.1016","volume":"10","author":[{"given":"Sukanya","family":"Narasimhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen J.","family":"Booth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"DePonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Ji","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianping","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhasis","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Kantor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Fikrig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ttbdis.2018.12.001_bib0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/BF01200448","article-title":"Immunology of interactions between ticks and laboratory animals","volume":"7","author":"Allen","year":"1989","journal-title":"Exp. Appl. Acarol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0010","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.3389\/fimmu.2017.01784","article-title":"Ticks, ixodes scapularis, feed repeatedly on white-footed mice despite strong inflammatory response: an expanding paradigm for understanding tick-host interactions","volume":"8","author":"Anderson","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0015","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1126\/science.8503006","article-title":"The biological and social phenomenon of Lyme disease","volume":"260","author":"Barbour","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0020","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1189\/jlb.71.6.1033","article-title":"In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration","volume":"71","author":"Borchers","year":"2002","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0025","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1017\/S0031182000056365","article-title":"Ixodes ricinus L.: mast cells, basophils and eosinophils in the sequence of cellular events in the skin of infested or re-infested rabbits","volume":"85","author":"Brossard","year":"1982","journal-title":"Parasitology"},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0030","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.4269\/ajtmh.1982.31.1285","article-title":"Antibody- and cell-mediated immune resistance by guinea pigs to adult Amblyomma americanum ticks","volume":"31","author":"Brown","year":"1982","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0035","first-page":"1744","article-title":"Immune rejection of ectoparasites (ticks) by T cell and IgG1 antibody recruitment of basophils and eosinophils","volume":"42","author":"Brown","year":"1983","journal-title":"Fed. Proc."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0040","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.4049\/jimmunol.134.2.1160","article-title":"Rejection of ticks from guinea pigs by anti-hapten-antibody-mediated degranulation of basophils at cutaneous basophil hypersensitivity sites: role of mediators other than histamine","volume":"134","author":"Brown","year":"1985","journal-title":"J. Immunol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0045","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3201\/eid1101.040303","article-title":"Hypersensitivity to ticks and Lyme disease risk","volume":"11","author":"Burke","year":"2005","journal-title":"Emerging Infect. Dis."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0050","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.exppara.2009.12.013","article-title":"Rhipicephalus (Boophilus) microplus: clotting time in tick-infested skin varies according to local inflammation and gene expression patterns in tick salivary glands","volume":"124","author":"Carvalho","year":"2010","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0055","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/1471-2164-9-233","article-title":"Insight into the sialome of the castor bean tick, Ixodes ricinus","volume":"9","author":"Chmelar","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0060","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1086\/323351","article-title":"Salp25D, an Ixodes scapularis antioxidant, is 1 of 14 immunodominant antigens in engorged tick salivary glands","volume":"184","author":"Das","year":"2001","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0065","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3389\/fcimb.2017.00114","article-title":"Tick-pathogen interactions and vector competence: identification of molecular drivers for tick-borne diseases","volume":"7","author":"de la Fuente","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0070","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nbt1385","article-title":"Direct multiplexed measurement of gene expression with color-coded probe pairs","volume":"26","author":"Geiss","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0075","doi-asserted-by":"crossref","first-page":"10507","DOI":"10.1038\/ncomms10507","article-title":"Genomic insights into the Ixodes scapularis tick vector of Lyme disease","volume":"7","author":"Gulia-Nuss","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0080","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1128\/IAI.01507-08","article-title":"Inhibition of neutrophil function by two tick salivary proteins","volume":"77","author":"Guo","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0085","series-title":"Histotechnology: A Self-Instructional Text American Society for Clinical Pathology","first-page":"400","author":"Hladik","year":"1997"},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0090","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev-immunol-031210-101257","article-title":"Nonredundant roles of basophils in immunity","volume":"29","author":"Karasuyama","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0095","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/j.1398-9995.2011.02613.x","article-title":"Newly appreciated roles for basophils in allergy and protective immunity","volume":"66","author":"Karasuyama","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0100","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nprot.2015.053","article-title":"The Phyre2 web portal for protein modeling, prediction and analysis","volume":"10","author":"Kelley","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004323","article-title":"Ixodes scapularis tick saliva proteins sequentially secreted every 24 h during blood feeding","volume":"10","author":"Kim","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0110","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1089\/vbz.2008.0091","article-title":"Dermatologic changes induced by repeated Ixodes scapularis bites and implications for prevention of tick-borne infection","volume":"9","author":"Krause","year":"2009","journal-title":"Vector Borne Zoonotic Dis."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0115","first-page":"1","article-title":"Summary of notifiable diseases--United States, 2006","volume":"55","author":"McNabb","year":"2008","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0120","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1128\/IAI.00685-06","article-title":"Recruitment of macrophages and polymorphonuclear leukocytes in L:yme carditis","volume":"75","author":"Montgomery","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035934","article-title":"Barcoded DNA-tag reporters for multiplex cis-regulatory analysis","volume":"7","author":"Nam","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0130","doi-asserted-by":"crossref","first-page":"e451","DOI":"10.1371\/journal.pone.0000451","article-title":"Immunity against Ixodes scapularis salivary proteins expressed within 24 hours of attachment thwarts tick feeding and impairs Borrelia transmission","volume":"2","author":"Narasimhan","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0135","doi-asserted-by":"crossref","first-page":"780","DOI":"10.4269\/ajtmh.1998.58.780","article-title":"Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity","volume":"58","author":"Nazario","year":"1998","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0140","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s13071-016-1529-y","article-title":"Human pathogens associated with the blacklegged tick Ixodes scapularis: a systematic review","volume":"9","author":"Nelder","year":"2016","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0145","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S1097-2765(00)80359-7","article-title":"Tick histamine-binding proteins: isolation, cloning, and three-dimensional structure","volume":"3","author":"Paesen","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006410","article-title":"Sialome diversity of ticks revealed by RNAseq of single tick salivary glands","volume":"12","author":"Perner","year":"2018","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0155","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1002\/1521-4141(200009)30:9<2660::AID-IMMU2660>3.0.CO;2-I","article-title":"MMCP-8, the first lineage-specific differentiation marker for mouse basophils. Elevated numbers of potent IL-4-producing and MMCP-8-positive cells in spleens of malaria-infected mice","volume":"30","author":"Poorafshar","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0160","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1126\/science.1221064","article-title":"New paradigms in type 2 immunity","volume":"337","author":"Pulendran","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0165","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrmicro2714","article-title":"Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes","volume":"10","author":"Radolf","year":"2012","journal-title":"Nat. Rev. Micro"},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0170","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1152\/physiolgenomics.00009.2012","article-title":"Multiplexed digital quantification of binge-like alcohol-mediated alterations in maternal uterine angiogenic mRNA transcriptome","volume":"44","author":"Ramadoss","year":"2012","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0175","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF01200449","article-title":"Role of saliva in tick\/host interactions","volume":"7","author":"Ribeiro","year":"1989","journal-title":"Exp. Appl. Acarol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0180","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.0962-1075.2001.00311.x","article-title":"A high affinity serotonin- and histamine-binding lipocalin from tick saliva","volume":"11","author":"Sangamnatdej","year":"2002","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0185","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.chom.2011.06.010","article-title":"A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent","volume":"10","author":"Schuijt","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0190","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/art.1780200102","article-title":"Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities","volume":"20","author":"Steere","year":"1977","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0195","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/ni.2036","article-title":"Genetic analysis of basophil function in vivo","volume":"12","author":"Sullivan","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0200","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.3389\/fimmu.2018.01540","article-title":"Histamine released from skin-infiltrating basophils but not mast cells is crucial for acquired tick resistance in mice","volume":"9","author":"Tabakawa","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0205","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3389\/fcimb.2017.00506","article-title":"Cattle tick rhipicephalus microplus-host interface: a review of resistant and susceptible host responses","volume":"7","author":"Tabor","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0210","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1186\/s13071-015-0918-y","article-title":"Saliva from nymph and adult females of Haemaphysalis longicornis: a proteomic study","volume":"8","author":"Tirloni","year":"2015","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0215","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3389\/fcimb.2017.00517","article-title":"Tick-host range adaptation: changes in protein profiles in unfed adult ixodes scapularis and amblyomma americanum saliva stimulated to feed on different hosts","volume":"7","author":"Tirloni","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0220","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2307\/3272160","article-title":"Accquired immunity to ticks","volume":"25","author":"Trager","year":"1939","journal-title":"J. Parasitol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0225","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1189\/jlb.0609400","article-title":"Basophils preferentially express mouse Mast Cell Protease 11 among the mast cell tryptase family in contrast to mast cells","volume":"86","author":"Ugajin","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0230","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1172\/JCI42680","article-title":"Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks","volume":"120","author":"Wada","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.en.41.010196.000245","article-title":"Host immunity to ticks","volume":"41","author":"Wikel","year":"1996","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0240","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0304-4017(01)00556-8","article-title":"Progress toward molecular characterization of ectoparasite modulation of host immunity","volume":"101","author":"Wikel","year":"2001","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0245","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1128\/IAI.65.1.335-338.1997","article-title":"Infestation with pathogen-free nymphs of the tick ixodes scapularis induces host resistance to transmission of Borrelia burgdorferi by ticks","volume":"65","author":"Wikel","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ttbdis.2018.12.001_bib0250","first-page":"71","article-title":"Two-dimensional difference gel electrophoresis","volume":"328","author":"Wu","year":"2006","journal-title":"Methods Mol. Biol."}],"container-title":["Ticks and Tick-borne Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877959X18302851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877959X18302851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T08:30:33Z","timestamp":1775291433000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877959X18302851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S1877959X18302851"],"URL":"https:\/\/doi.org\/10.1016\/j.ttbdis.2018.12.001","relation":{},"ISSN":["1877-959X"],"issn-type":[{"value":"1877-959X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Host-specific expression of Ixodes scapularis salivary genes","name":"articletitle","label":"Article Title"},{"value":"Ticks and Tick-borne Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ttbdis.2018.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}