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Parasitol."},{"key":"10.1016\/j.ttbdis.2024.102379_bib0107","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.dci.2009.12.004","article-title":"Structure and function of invertebrate kazal-type serine proteinase inhibitors","volume":"34","author":"Rimphanitchayakit","year":"2010","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.ttbdis.2024.102379_bib0108","first-page":"341","article-title":"The role of the fat body, midgut and ovary in vitellogenin production and vitellogenesis in the female tick, Dermacentor variabilis. Intl","volume":"22","author":"Rosell","year":"1992","journal-title":"J. Parasitol."},{"key":"10.1016\/j.ttbdis.2024.102379_bib0109","first-page":"289","article-title":"The heme synthesis and degradation pathways: Role in oxidant sensitivity. Free Radic","volume":"28","author":"Ryter","year":"2000","journal-title":"Biol. Med."},{"key":"10.1016\/j.ttbdis.2024.102379_bib0110","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-017-2005-z","article-title":"Proteases of haematophagous arthropod vectors are involved in blood-feeding, yolk formation and immunity - A Review","volume":"10","author":"Santiago","year":"2017","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.ttbdis.2024.102379_bib0111","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.exppara.2007.08.003","article-title":"BMSI-7, a novel subtilisin inhibitor from Boophilus microplus, with activity toward PR1 proteases from the fungus Metarhizium anisopliae","volume":"118","author":"Sasaki","year":"2008","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ttbdis.2024.102379_bib0112","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ttbdis.2012.03.004","article-title":"The role of Cystatins in tick physiology and blood feeding","volume":"3","author":"Schwarz","year":"2012","journal-title":"Ticks. Tick. 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Endocrinol."},{"issue":"3","key":"10.1016\/j.ttbdis.2024.102379_bib132","doi-asserted-by":"crossref","first-page":"103781","DOI":"10.1016\/j.isci.2022.103781","article-title":"Cas9-mediated gene editing in the black-legged tick, Ixodes scapularis, by embryo injection and ReMOT Control","volume":"25","author":"Sharma","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.ttbdis.2024.102379_bib0115","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2014.00116","article-title":"Immunity-related genes in Ixodes scapularis: perspectives from genome information","volume":"4","author":"Smith","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ttbdis.2024.102379_bib0116","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1756-3305-1-7","article-title":"Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases","volume":"1","author":"Sojka","year":"2008","journal-title":"Parasit.Vectors"},{"key":"10.1016\/j.ttbdis.2024.102379_bib0117","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.pt.2013.04.002","article-title":"New insights into the machinery of blood digestion by ticks","volume":"29","author":"Sojka","year":"2013","journal-title":"Trends. 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Identification of a protective antigen from Boophilus microplus","volume":"143","author":"Willadsen","year":"1989","journal-title":"J. Immunol."},{"key":"10.1016\/j.ttbdis.2024.102379_bib0125","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Cambridge (Mass.))"},{"key":"10.1016\/j.ttbdis.2024.102379_bib0126","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.meegid.2015.12.005","article-title":"De novo assembly and analysis of midgut transcriptome of Haemaphysalis flava and identification of genes involved in blood digestion, feeding and defending from pathogens","volume":"38","author":"Xu","year":"2016","journal-title":"Genet. Evol."},{"key":"10.1016\/j.ttbdis.2024.102379_bib0127","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1292\/jvms.09-0561","article-title":"Hlcyst-1 and Hlcyst-2 are potential inhibitors of HlCPL-A in the midgut of the ixodid tick Haemaphysalis longicornis","volume":"72","author":"Yamaji","year":"2010","journal-title":"J. Vet. Med. Sci."},{"issue":"1","key":"10.1016\/j.ttbdis.2024.102379_bib133","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00436-009-1626-3","article-title":"A salivary cystatin, HlSC-1, from the ixodid tick Haemaphysalis longicornis play roles in the blood-feeding processes","volume":"106","author":"Yamaji","year":"2009","journal-title":"Parasitol. 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Res."},{"key":"10.1016\/j.ttbdis.2024.102379_bib0130","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00436-006-0243-7","article-title":"Identification of a glycine-rich protein from the tick Rhipicephalus haemaphysaloides and evaluation of its vaccine potential against tick feeding","volume":"100","author":"Zhou","year":"2006","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ttbdis.2024.102379_bib0131","first-page":"70","article-title":"Pyrethroid resistance in Iranian field populations of Rhipicephalus (Boophilus) annulatus. Pestic","volume":"136","author":"Ziapour","year":"2017","journal-title":"Biochem. 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