{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:28:15Z","timestamp":1791268095319,"version":"4.1.0"},"reference-count":92,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tuberculosis"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1016\/j.tube.2003.08.010","type":"journal-article","created":{"date-parts":[[2003,12,6]],"date-time":"2003-12-06T06:47:31Z","timestamp":1070693251000},"page":"93-101","source":"Crossref","is-referenced-by-count":222,"title":["Immunology of tuberculosis and implications in vaccine development"],"prefix":"10.1016","volume":"84","author":[{"given":"JoAnne L","family":"Flynn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tube.2003.08.010_BIB1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1056\/NEJM198903023200901","article-title":"A prospective study of the risk of tuberculosis among intravenous drug users with human immunodeficiency virus infection","volume":"320","author":"Selwyn","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tube.2003.08.010_BIB2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1084\/jem.75.3.247","article-title":"Studies on the mechanism of immunity in tuberculosis. The fate of tubercle bacilli ingested by mononuclear phagocytes derived from normal and immunized animals","volume":"75","author":"Lurie","year":"1942","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2003.08.010_BIB3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1084\/jem.96.2.137","article-title":"The multiplication of tubercle bacilli within normal phagocytes in tissue cultures","volume":"96","author":"Suter","year":"1952","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2003.08.010_BIB4","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1084\/jem.129.5.973","article-title":"The influence of immunologically committed lynphoid cells on macrophage activation in vivo","volume":"129","author":"Mackaness","year":"1969","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2003.08.010_BIB5","first-page":"333","article-title":"Activation of macrophages to inhibit proliferation of Mycobacterium tuberculosis","volume":"59","author":"Rook","year":"1986","journal-title":"Immunology"},{"key":"10.1016\/j.tube.2003.08.010_BIB6","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.4049\/jimmunol.138.12.4408","article-title":"Mycobacterial growth inhibition by interferon-g activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis","volume":"138","author":"Flesch","year":"1987","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB7","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1128\/IAI.58.8.2675-2677.1990","article-title":"Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor","volume":"58","author":"Flesch","year":"1990","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB8","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.4049\/jimmunol.141.7.2407","article-title":"Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages","volume":"141","author":"Ding","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB9","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1128\/IAI.63.2.736-740.1995","article-title":"Effect of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis","volume":"63","author":"Chan","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB10","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.1073\/pnas.94.10.5243","article-title":"Identification of nitric oxide synthase as a protective locus against tuberculosis","volume":"94","author":"MacMicking","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.tube.2003.08.010_BIB11","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.4049\/jimmunol.160.4.1796","article-title":"Effects of aminoguanidine on latent murine tuberculosis","volume":"160","author":"Flynn","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB12","doi-asserted-by":"crossref","first-page":"7711","DOI":"10.1128\/IAI.69.12.7711-7717.2001","article-title":"The NOS2 locus confers protection in mice against aerogenic challenge of both clinical and laboratory strains of Mycobacterium tuberculosis","volume":"69","author":"Scanga","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB13","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0167-5699(98)01321-8","article-title":"Novel human immunodeficiencies reveal the essential role of type-1 cytokines in immunity to intracellular bacteria","volume":"19","author":"Ottenhof","year":"1998","journal-title":"Immunol Today"},{"key":"10.1016\/j.tube.2003.08.010_BIB14","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1084\/jem.183.5.2293","article-title":"Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis","volume":"184","author":"Nicholson","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2003.08.010_BIB15","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.4049\/jimmunol.160.9.4490","article-title":"Induction of in vitro human macrophage anti-Mycobacterium tuberculosis activity","volume":"160","author":"Bonecini-Almeida","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB16","doi-asserted-by":"crossref","first-page":"5314","DOI":"10.1128\/IAI.66.11.5314-5321.1998","article-title":"1,25-Dihydroxyvitamin D3 induces nitric oxide synthase and suppresses growth of Mycobacterium tuberculosis in a human macrophage-like cell line","volume":"66","author":"Rockett","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB17","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1183\/09031936.98.11040809","article-title":"Increased exhaled nitric oxide in active pulmonary tuberculosis due to inducible NO synthase upregulation in alveolar macrophages","volume":"11","author":"Wang","year":"1998","journal-title":"Eur Respir J"},{"key":"10.1016\/j.tube.2003.08.010_BIB18","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/35021074","article-title":"Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase","volume":"406","author":"McKinney","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.tube.2003.08.010_BIB19","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1084\/jem.134.3.713","article-title":"Response of cultured macrophages to Mycobacterium tuberculosis, with observations on fusion of lysosomes with phagosomes","volume":"134","author":"Armstrong","year":"1971","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2003.08.010_BIB20","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1128\/IAI.5.5.803-807.1972","article-title":"Ultrastructural study of the behavior of macrophages toward parasitic mycobacteria","volume":"5","author":"Hart","year":"1972","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB21","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.8303277","article-title":"Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase","volume":"263","author":"Sturgill-Koszycki","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.tube.2003.08.010_BIB22","doi-asserted-by":"crossref","first-page":"635","DOI":"10.4049\/jimmunol.159.2.635","article-title":"Activation of human dendritic cells following infection with Mycobacterium tuberculosis","volume":"159","author":"Henderson","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB23","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1128\/IAI.65.5.1936-1938.1997","article-title":"Interleukin-12 secretion by Mycobacterium tuberculosis-infected macrophages","volume":"65","author":"Ladel","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB24","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1165\/ajrcmb.20.6.3546","article-title":"Ovalbumin (OVA) and Myocbacterium tuberculosis bacilli cooperatively polarize anti-OVA T-helper cells foward a Th1-dominant phenotype and ameliorate murine tracheal eosinophilia","volume":"20","author":"Sano","year":"1999","journal-title":"Am J Resp Cell Mol Biol"},{"key":"10.1016\/j.tube.2003.08.010_BIB25","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.4049\/jimmunol.155.5.2515","article-title":"IL-12 increases resistance of BALB\/c mice to Mycobacterium tuberculosis infection","volume":"155","author":"Flynn","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1084\/jem.186.1.39","article-title":"Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis","volume":"186","author":"Cooper","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2003.08.010_BIB27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/22326","article-title":"Therapy of tuberculosis in mice by DNA vaccination","volume":"400","author":"Lowrie","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.tube.2003.08.010_BIB28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4049\/jimmunol.148.1.189","article-title":"T Lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection","volume":"148","author":"Orme","year":"1992","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB29","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1128\/IAI.61.1.197-203.1993","article-title":"Patterns of cytokine production by Mycobacterium-reactive human T-cell clones","volume":"61","author":"Barnes","year":"1993","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB30","doi-asserted-by":"crossref","first-page":"518","DOI":"10.4049\/jimmunol.151.1.518","article-title":"Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection","volume":"151","author":"Orme","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB31","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1073\/pnas.95.1.270","article-title":"Human cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis","volume":"95","author":"Lalvani","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.tube.2003.08.010_BIB32","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.1128\/IAI.66.10.4981-4988.1998","article-title":"An ex vivo study of T lymphocytes recovered from the lungs of I\/St mice infected with and susceptible to Mycobacterium tuberculosis","volume":"66","author":"Lyadova","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB33","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1128\/IAI.67.8.3980-3988.1999","article-title":"Early emergence of CD8+ T cells primed for production of Type 1 cytokines in the lungs of Mycobacterium tuberculosis-infected mice","volume":"67","author":"Serbina","year":"1999","journal-title":"Infect Immunology"},{"key":"10.1016\/j.tube.2003.08.010_BIB34","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1084\/jem.178.6.2243","article-title":"Disseminated tuberculosis in IFN-\u03b3 gene-disrupted mice","volume":"178","author":"Cooper","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2003.08.010_BIB35","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1084\/jem.178.6.2249","article-title":"An essential role for interferon-\u03b3 in resistance to Mycobacterium tuberculosis infection","volume":"178","author":"Flynn","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2003.08.010_BIB36","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1126\/science.8456300","article-title":"Multiple defects of immune cell function in mice with disrupted interferon-gamma genes","volume":"259","author":"Dalton","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.tube.2003.08.010_BIB37","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1128\/IAI.63.8.3231-3234.1995","article-title":"T cell cytokine responses in human infection with Mycobacterium tuberculosis","volume":"63","author":"Zhang","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB38","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1128\/IAI.64.4.1351-1356.1996","article-title":"Absence of a prominent TH2 cytokine response in human tuberculosis","volume":"64","author":"Lin","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB39","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.4049\/jimmunol.163.7.3898","article-title":"Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1","volume":"163","author":"Ting","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB40","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/1074-7613(95)90001-2","article-title":"Tumor necrosis factor-\u03b1 is required in the protective immune response against M tuberculosis in mice","volume":"2","author":"Flynn","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.tube.2003.08.010_BIB41","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.4049\/jimmunol.162.6.3504","article-title":"Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin","volume":"162","author":"Bean","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB42","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.4049\/jimmunol.145.12.4306","article-title":"Tumor necrosis factor-\u03b1 synergizes with IFN-\u03b3 in mediating killing of Leishmania major through the induction of nitric oxide","volume":"145","author":"Liew","year":"1990","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB43","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1084\/jem.175.4.1111","article-title":"Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages","volume":"175","author":"Chan","year":"1992","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2003.08.010_BIB44","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1128\/IAI.69.3.1847-1855.2001","article-title":"Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis","volume":"69","author":"Mohan","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB45","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/0092-8674(89)90676-4","article-title":"The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection","volume":"56","author":"Kindler","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.tube.2003.08.010_BIB46","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1002\/eji.1830271215","article-title":"High sensitivity of transgenic mice expressing soluble TNFR1 fusion protein to mycobacterial infections","volume":"27","author":"Garcia","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB47","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1128\/IAI.67.7.3571-3579.1999","article-title":"Fatal granuloma necrosis without exacerbated mycobacterial growth in tumor necrosis factor receptor p55 gene-deficient mice intravenously infected with Mycobacterium avium","volume":"67","author":"Ehlers","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB48","first-page":"229","article-title":"The role of gamma-interferon, vitamin D3 metabolites and tumour necrosis factor in the pathogenesis of tuberculosis","volume":"62","author":"Rook","year":"1987","journal-title":"Immunology"},{"key":"10.1016\/j.tube.2003.08.010_BIB49","first-page":"276","article-title":"Mycobacteria, cytokines and antibiotics","volume":"38","author":"Rook","year":"1990","journal-title":"Pathol Biol (Paris)"},{"key":"10.1016\/j.tube.2003.08.010_BIB50","doi-asserted-by":"crossref","unstructured":"Moreira AL, Tsenova-Berkova L, Wang J, Laochumroonvorapong P, Freeman S, VH, Freedman GK. Effect of cytokine modulation by thalidomide on the granomatous response in murine tuberculosis. Tubercle Lung Dis 1997;78:47-55.","DOI":"10.1016\/S0962-8479(97)90015-0"},{"key":"10.1016\/j.tube.2003.08.010_BIB51","doi-asserted-by":"crossref","first-page":"6954","DOI":"10.1128\/IAI.68.12.6954-6961.2000","article-title":"Immunopathologic effects of tumor necrosis factor alpha in murine mycobacterial infection are dose-dependent","volume":"68","author":"Bekker","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB52","doi-asserted-by":"crossref","first-page":"13806","DOI":"10.1073\/pnas.95.23.13806","article-title":"Inhibition of interferon \u03b3 induced interleukin 12 production","volume":"95","author":"Hodge-Dufour","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.tube.2003.08.010_BIB53","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/S0140-6736(99)05246-0","article-title":"Infliximab (chimeric anti-tumour necrosis factor a monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate","volume":"354","author":"Maini","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.tube.2003.08.010_BIB54","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1128\/IAI.67.7.3242-3247.1999","article-title":"Increase in gamma interferon-secreting CD8+, as well as CD4+, T cells in lungs following aerosol infection with Mycobacterium tuberculosis","volume":"67","author":"Feng","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB55","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4049\/jimmunol.165.1.353","article-title":"CD8+ cytotoxic T lymphocytes from lungs of M. tuberculosis infected mice express perforin in vivo and lyse infected macrophages","volume":"165","author":"Serbina","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB56","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/00313029009063555","article-title":"Lymphocyte subsets in granulomas of human tuberculosis","volume":"22","author":"Randhawa","year":"1990","journal-title":"Pathology"},{"key":"10.1016\/j.tube.2003.08.010_BIB57","doi-asserted-by":"crossref","first-page":"12013","DOI":"10.1073\/pnas.89.24.12013","article-title":"Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection","volume":"89","author":"Flynn","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.tube.2003.08.010_BIB58","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1128\/IAI.55.9.2037-2041.1987","article-title":"Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt2+ T cells","volume":"55","author":"Muller","year":"1987","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB59","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1128\/IAI.66.2.830-834.1998","article-title":"Protection against Mycobacterium tuberculosis infection by CD8 T cells requires production of gamma interferon","volume":"66","author":"Tascon","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB60","doi-asserted-by":"crossref","first-page":"5407","DOI":"10.4049\/jimmunol.162.9.5407","article-title":"Mice deficient in CD4 T cells have only transiently diminished levels of IFN-\u03b3, yet succumb to tuberculosis","volume":"162","author":"Caruso","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB61","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0008-8749(84)90082-0","article-title":"Adoptive protection of the Mycobacteria tuberculosis-infected lung","volume":"84","author":"Orme","year":"1984","journal-title":"Cell Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB62","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1084\/jem.158.1.74","article-title":"Protection against Mycobacterium tuberculosis infection by adoptive immunotherapy","volume":"158","author":"Orme","year":"1983","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2003.08.010_BIB63","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1128\/IAI.65.1.298-304.1997","article-title":"Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis","volume":"65","author":"Keane","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB64","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.4049\/jimmunol.161.5.2636","article-title":"Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-R2, resulting in inactivation of TNF-\u03b1","volume":"161","author":"Balcewicz-Sablinska","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB65","doi-asserted-by":"crossref","first-page":"11786","DOI":"10.1073\/pnas.93.21.11786","article-title":"Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection","volume":"93","author":"Mazzaccaro","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.tube.2003.08.010_BIB66","doi-asserted-by":"crossref","first-page":"4882","DOI":"10.4049\/jimmunol.161.9.4882","article-title":"Attenuation of HLA-DR expression by mononuclear phagocytes infected with Mycobacterium tuberculosis is related to intracellular sequestration of immature Class II heterodimers","volume":"161","author":"Hmama","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB67","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.4049\/jimmunol.163.5.2688","article-title":"Attenuation of MHC Class II expression in macrophages infected with Mycobacterium bovis BCG involves Class II transactivator and depends on the Nramp1 gene","volume":"163","author":"Wojciechowski","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB68","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/cimm.2000.1633","article-title":"Mycobacterium tuberculosis inhibits MHC Class II antigen processing in murine bone marrow macrophages","volume":"201","author":"Noss","year":"2000","journal-title":"Cell Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB69","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.4049\/jimmunol.161.7.3582","article-title":"Down-regulation of CD1 on antigen presenting cells by infection with Mycobacterium tuberculosis","volume":"161","author":"Stenger","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB70","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1128\/IAI.69.2.800-809.2001","article-title":"Interaction of Mycobacterium tuberculosis with murine dendritic cells","volume":"69","author":"Bodnar","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB71","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1128\/IAI.64.3.913-918.1996","article-title":"Interleukin-10 downregulates Mycobacterium tuberculosis-induced Th1 responses and CTLA4 expression","volume":"64","author":"Gong","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB72","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1073\/pnas.94.8.3926","article-title":"In vitro restoration of T cell responses in tuberculosis and augmentation of monocyte effector function against Mycobacterium tuberculosis by natural inhibitors of transforming growth factor beta","volume":"94","author":"Hirsch","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.tube.2003.08.010_BIB73","doi-asserted-by":"crossref","first-page":"6461","DOI":"10.1128\/IAI.67.12.6461-6472.1999","article-title":"Regulation of human CD4+ \u03b1\u03b2 TCR+ and \u03b3\u03b4 TCR+ T cell responses to Mycobacterium tuberculosis by interleukin-10 and transforming growth factor \u03b2","volume":"67","author":"Rojas","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2003.08.010_BIB74","doi-asserted-by":"crossref","first-page":"15190","DOI":"10.1073\/pnas.96.26.15190","article-title":"Mycobacterial infection of macrophages results in membrane-permeable phagosomes","volume":"96","author":"Teitelbaum","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.tube.2003.08.010_BIB75","doi-asserted-by":"crossref","first-page":"372","DOI":"10.4049\/jimmunol.162.1.372","article-title":"Activation of human CD8+ \u03b1\u03b2 TCR+ cells by Mycobacterium tuberculosis via an alternate Class I MHC antigen processing pathway","volume":"162","author":"Canaday","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB76","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/eji.1830180110","article-title":"Mycobacteria-reactive Lyt-2+ T cell lines","volume":"18","author":"De Libero","year":"1988","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB77","first-page":"341","article-title":"Protection against tuberculosis by passive transfer with T-cell clones recognizing mycobacterial heat shock protein 65","volume":"83","author":"Silva","year":"1994","journal-title":"Immunology"},{"key":"10.1016\/j.tube.2003.08.010_BIB78","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1126\/science.276.5319.1684","article-title":"Differential effects of cytolytic T cell subsets on intracellular infection","volume":"276","author":"Stenger","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.tube.2003.08.010_BIB79","doi-asserted-by":"crossref","first-page":"290","DOI":"10.4049\/jimmunol.159.1.290","article-title":"Human alveolar T lymphocyte responses to Mycobacterium tuberculosis infection","volume":"159","author":"Tan","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB80","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1093\/intimm\/9.11.1669","article-title":"Specificity of CD8+ T cells from subunit vaccinated or infected H-2b mice recognizing the 38kDa antigen of Mycobacterium tuberculosis","volume":"9","author":"Zhu","year":"1997","journal-title":"Int Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB81","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.4049\/jimmunol.161.5.2400","article-title":"CTL response to Mycobacterium tuberculosis","volume":"161","author":"Mohagheghpour","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB82","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1084\/jem.187.10.1633","article-title":"Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen presenting cells","volume":"187","author":"Lewinsohn","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2003.08.010_BIB83","doi-asserted-by":"crossref","first-page":"925","DOI":"10.4049\/jimmunol.165.2.925","article-title":"Mycobacterium tuberculosis-reactive CD8+ T lymphocytes","volume":"165","author":"Lewinsohn","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB84","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1084\/jem.189.12.1973","article-title":"Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis","volume":"189","author":"Behar","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2003.08.010_BIB85","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1073\/pnas.97.8.4204","article-title":"Relative contributions of distinct MHC Class I-dependent cell populations in protection to tuberculosis infection in mice","volume":"97","author":"Sousa","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.tube.2003.08.010_BIB86","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1002\/1521-4141(200012)30:12<3689::AID-IMMU3689>3.0.CO;2-4","article-title":"Control of latent Mycobacterium tuberculosis infection is dependent on CD8 T cells","volume":"30","author":"van Pinxteren","year":"2000","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB87","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1002\/1521-4141(200106)31:6<1944::AID-IMMU1944>3.0.CO;2-R","article-title":"MHC Class Ia-restricted T cells partially account for \u03b22-microglobulin-dependent resistance to Mycobacterium tuberculosis","volume":"31","author":"Rolph","year":"2001","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB88","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1084\/jem.193.3.271","article-title":"The relative importance of T cell subsets in immunity and immunopathology of airborne Mycobacterium tuberculosis infection in mice","volume":"193","author":"Mogues","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2003.08.010_BIB89","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.immunol.17.1.297","article-title":"The CD1 system","volume":"17","author":"Porcelli","year":"1999","journal-title":"Ann Rev Immunol"},{"key":"10.1016\/j.tube.2003.08.010_BIB90","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1084\/jem.193.10.1213","article-title":"Induction of M3-restricted cytotoxic T lymphocyte responses by N-formylated peptides derived from Mycobacterium tuberculosis","volume":"193","author":"Chun","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2003.08.010_BIB91","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1084\/jem.192.3.347","article-title":"Depletion of CD4+ T cells causes reactivation of murine persistent tuberculosis despite continued expression of IFN-\u03b3 and NOS2","volume":"192","author":"Scanga","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2003.08.010_BIB92","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1126\/science.282.5386.121","article-title":"An antimicrobial activity of cytotoxic T cells mediated by granulysin","volume":"282","author":"Stenger","year":"1998","journal-title":"Science"}],"container-title":["Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979203000921?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979203000921?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T11:59:11Z","timestamp":1682596751000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472979203000921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":92,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S1472979203000921"],"URL":"https:\/\/doi.org\/10.1016\/j.tube.2003.08.010","relation":{},"ISSN":["1472-9792"],"issn-type":[{"value":"1472-9792","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}