{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:53:20Z","timestamp":1790650400661,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tuberculosis"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.tube.2005.04.003","type":"journal-article","created":{"date-parts":[[2005,10,26]],"date-time":"2005-10-26T11:24:07Z","timestamp":1130325847000},"page":"20-27","source":"Crossref","is-referenced-by-count":25,"title":["Superior virulence of Mycobacterium bovis over Mycobacterium tuberculosis (Mtb) for Mtb-resistant and Mtb-susceptible mice is manifest as an ability to cause extrapulmonary disease"],"prefix":"10.1016","volume":"86","author":[{"given":"Eva","family":"Medina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"LaCourse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"North","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tube.2005.04.003_bib1","doi-asserted-by":"crossref","first-page":"7877","DOI":"10.1073\/pnas.1130426100","article-title":"The complete genome sequence of Mycobacterium bovis","volume":"100","author":"Garnier","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Suppl. 1","key":"10.1016\/j.tube.2005.04.003_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0962-8479(95)90591-X","article-title":"The epidemiology of Mycobacterium bovis infections in animals and man: a review","volume":"76","author":"O\u2019Reilly","year":"1995","journal-title":"Tuberc. Lung Dis."},{"key":"10.1016\/j.tube.2005.04.003_bib3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1136\/vr.148.10.299","article-title":"Pathology of natural Mycobacterium bovis infection in European badgers (Meles meles) and its relationship with bacterial excretion","volume":"148","author":"Gavier-Widen","year":"2001","journal-title":"Vet Rec"},{"key":"10.1016\/j.tube.2005.04.003_bib4","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0021-9975(05)80094-5","article-title":"Tuberculosis in the brushtail possum (Trichosurus vulpecula) after intratracheal inoculation with a low dose of Mycobacterium bovis","volume":"111","author":"Pfeffer","year":"1994","journal-title":"J Comp Pathol"},{"key":"10.1016\/j.tube.2005.04.003_bib5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1054\/tube.2000.0263","article-title":"Mycobacterium bovis infection in human beings","volume":"81","author":"Grange","year":"2001","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.tube.2005.04.003_bib6","series-title":"Tuberculosis in animals and man. A study in comparative pathology","author":"Francis","year":"1958"},{"key":"10.1016\/j.tube.2005.04.003_bib7","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1128\/IAI.63.9.3428-3437.1995","article-title":"Virulence ranking of some Mycobacterium tuberculosis and Mycobacterium bovis strains according to their ability to multiply in the lungs, induce lung pathology, and cause mortality in mice","volume":"63","author":"Dunn","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2005.04.003_bib8","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0966-842X(98)01364-X","article-title":"How important is Nramp1 in tuberculosis?","volume":"6","author":"North","year":"1998","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.tube.2005.04.003_bib9","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.1128\/IAI.67.10.5483-5485.1999","article-title":"Growth rate of mycobcteria in mice as an unreliable indicator of virulence","volume":"67","author":"North","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2005.04.003_bib10","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1046\/j.1365-2567.1998.00419.x","article-title":"Resistance ranking of some common inbred mouse strains to Mycobacterium tuberculosis and relationship to major histocompatibility haplotype and Nramp1 genotype","volume":"93","author":"Medina","year":"1998","journal-title":"Immunology"},{"key":"10.1016\/j.tube.2005.04.003_bib11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/jcp.46.6.559","article-title":"A safer staining method for acid fast bacilli","volume":"46","author":"Ellis","year":"1993","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.tube.2005.04.003_bib12","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1084\/jem.183.3.1045","article-title":"Evidence inconsistent with a role for the bcg (Nramp1) gene in resistance of mice to infection with Mycobacterium tuberculosis","volume":"183","author":"Medina","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2005.04.003_bib13","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/sj.gene.6363712","article-title":"Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice","volume":"1","author":"Mitos","year":"2000","journal-title":"Genes Immun"},{"key":"10.1016\/j.tube.2005.04.003_bib14","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1472-9792(03)00017-9","article-title":"Susceptibility to Mycobacterium tuberculosis: lessons from inbred strains of mice","volume":"83","author":"Chackerian","year":"2003","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.tube.2005.04.003_bib15","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1146\/annurev.immunol.22.012703.104635","article-title":"Immunity to tuberculosis","volume":"22","author":"North","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.tube.2005.04.003_bib16","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1046\/j.1365-2567.1996.d01-700.x","article-title":"The Nramp1 antimicrobial resistance gene segregates independently of resistance to virulent Mycobacterium tuberculosis","volume":"88","author":"Medina","year":"1996","journal-title":"Immunology"},{"key":"10.1016\/j.tube.2005.04.003_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1086\/322044","article-title":"Host-pathogen interactions: the attributes of virulence","volume":"184","author":"Casadevall","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.tube.2005.04.003_bib18","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1099\/00222615-45-2-103","article-title":"Persistent infection with virulent but not avirulent Mycobacterium tuberculosis in the lungs of mice causes progressive pathology","volume":"45","author":"Dunn","year":"1996","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.tube.2005.04.003_bib19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1086\/345862","article-title":"Deletion of RD1 from Mycobacterium tuberculosis mimics bacille Calmette-Guerin attenuation","volume":"187","author":"Lewis","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.tube.2005.04.003_bib20","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1084\/jem.182.3.655","article-title":"The Ity\/Lsh\/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene","volume":"182","author":"Vidal","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2005.04.003_bib21","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0092-8674(93)90135-D","article-title":"Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg","volume":"73","author":"Vidal","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.tube.2005.04.003_bib22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1054\/tube.2000.0256","article-title":"Cattle-to-cattle transmission of Mycobacterium bovis","volume":"81","author":"Goodchild","year":"2001","journal-title":"Tuberculosis (Edinb)"}],"container-title":["Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979205000338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979205000338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T14:00:19Z","timestamp":1586527219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472979205000338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S1472979205000338"],"URL":"https:\/\/doi.org\/10.1016\/j.tube.2005.04.003","relation":{},"ISSN":["1472-9792"],"issn-type":[{"value":"1472-9792","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}