{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T20:46:45Z","timestamp":1764276405470},"reference-count":53,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tuberculosis"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.tube.2006.02.001","type":"journal-article","created":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T12:44:41Z","timestamp":1155127481000},"page":"397-403","source":"Crossref","is-referenced-by-count":34,"title":["Beneficial non-targeted effects of BCG\u2014Ethical implications for the coming introduction of new TB vaccines"],"prefix":"10.1016","volume":"86","author":[{"given":"A.E.","family":"Roth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.G.","family":"Stensballe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Garly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Aaby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tube.2006.02.001_bib1","series-title":"Resultats des experiences de vaccination par le BCG poursuivies dans le Norrbotten (Suede)","author":"Naeslund","year":"1932"},{"key":"10.1016\/j.tube.2006.02.001_bib2","unstructured":"Aaby P, Jensen H. Routine vaccinations and child survival: effect of gender. bmj.com\/cgi\/eletters\/321\/7274\/1435#27803. BMJ December 13, 2002."},{"key":"10.1016\/j.tube.2006.02.001_bib3","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1136\/bmj.321.7274.1435","article-title":"Routine immunizations and child survival in Guinea-Bissau, West-Africa","volume":"321","author":"Kristensen","year":"2000","journal-title":"Br Med J"},{"issue":"1","key":"10.1016\/j.tube.2006.02.001_bib4","first-page":"65","article-title":"Guidelines on diagnosis and treatment of superficial bladder cancer","volume":"56","author":"Oosterlinck","year":"2004","journal-title":"Minerva Urol Nefrol"},{"issue":"3-4","key":"10.1016\/j.tube.2006.02.001_bib5","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0264-410X(01)00339-5","article-title":"BCG vaccination among West African infants is associated with less anergy to tuberculin and diphtheria-tetanus antigens","volume":"20","author":"Garly","year":"2001","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.tube.2006.02.001_bib6","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.4049\/jimmunol.163.4.2249","article-title":"Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette\u2013Guerin vaccination","volume":"163","author":"Marchant","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2006.02.001_bib7","doi-asserted-by":"crossref","first-page":"919","DOI":"10.4049\/jimmunol.168.2.919","article-title":"Influence of Mycobacterium bovis Bacillus Calmette\u2013Gu\u00e9rin on antibody and cytokine responses to human neonatal vaccination","volume":"168","author":"Ota","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2006.02.001_bib8","unstructured":"Roth A, Sodemann M, Jensen H, Poulsen A, Gustafson P, Weise C, et al. Tuberculin reaction, BCG scar and lower female mortality: a prospective community study in Guinea-Bissau. Epidemiology, accepted."},{"issue":"10","key":"10.1016\/j.tube.2006.02.001_bib9","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.vaccine.2004.09.006","article-title":"BCG vaccination, acute lower respiratory tract infections, and respiratory syncytial virus in children in Guinea-Bissau: a beneficial effect for girls","volume":"23","author":"Stensballe","year":"2005","journal-title":"Vaccine"},{"issue":"9","key":"10.1016\/j.tube.2006.02.001_bib10","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1398-9995.2005.00834.x","article-title":"Inverse association between Mycobacterium tuberculosis infection and atopic rhinitis in children","volume":"60","author":"Obihara","year":"2005","journal-title":"Allergy"},{"issue":"3","key":"10.1016\/j.tube.2006.02.001_bib11","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1067\/mai.2003.171","article-title":"The effect of neonatal BCG vaccination on atopy and asthma at age 7 to 14 years: an historical cohort study in a community with a very low prevalence of tuberculosis infection and a high prevalence of atopic disease","volume":"111","author":"Marks","year":"2003","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.tube.2006.02.001_bib12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1399-3038.2005.00254.x","article-title":"Does childhood immunization against infectious diseases protect from the development of atopic disease?","volume":"16","author":"Martignon","year":"2005","journal-title":"Pediatr Allergy Immunol"},{"issue":"8","key":"10.1016\/j.tube.2006.02.001_bib13","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1398-9995.2004.00517.x","article-title":"Lower prevalence of reported asthma in adolescents with symptoms of rhinitis that received neonatal BCG","volume":"59","author":"da Cunha","year":"2004","journal-title":"Allergy"},{"issue":"3","key":"10.1016\/j.tube.2006.02.001_bib14","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S1081-1206(10)61574-8","article-title":"The effect of BCG vaccine at birth on the development of atopy or allergic disease in young children","volume":"92","author":"Townley","year":"2004","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"10","key":"10.1016\/j.tube.2006.02.001_bib15","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/j.1398-9995.2004.00557.x","article-title":"Atopic disorders among Estonian schoolchildren in relation to tuberculin reactivity and the age at BCG vaccination","volume":"59","author":"Annus","year":"2004","journal-title":"Allergy"},{"issue":"5296","key":"10.1016\/j.tube.2006.02.001_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1126\/science.275.5296.77","article-title":"The inverse association between tuberculin responses and atopic disorder see comments","volume":"275","author":"Shirakawa","year":"1997","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.tube.2006.02.001_bib17","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1046\/j.1365-2222.2003.01796.x","article-title":"Age at bacille Calmette\u2013Guerin vaccination and risk of allergy and asthma","volume":"33","author":"Bager","year":"2003","journal-title":"Clin Exp Allergy"},{"issue":"5","key":"10.1016\/j.tube.2006.02.001_bib18","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/j.1365-2222.2005.02230.x","article-title":"Childhood atopy and allergic disease and skin test responses to environmental mycobacteria in rural Crete: a cross-sectional survey","volume":"35","author":"Bibakis","year":"2005","journal-title":"Clin Exp Allergy"},{"issue":"8","key":"10.1016\/j.tube.2006.02.001_bib19","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1001\/jama.289.8.1012","article-title":"BCG vaccination and risk of atopy","volume":"289","author":"Krause","year":"2003","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.tube.2006.02.001_bib20","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1046\/j.1365-2222.2003.01599.x","article-title":"Absence of association between delayed type hypersensitivity to tuberculin and atopy in children in The Gambia","volume":"33","author":"Ota","year":"2003","journal-title":"Clin Exp Allergy"},{"issue":"2","key":"10.1016\/j.tube.2006.02.001_bib21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1365-2222.2004.01861.x","article-title":"Effect of repeated intradermal injections of heat-inactivated Mycobacterium bovis bacillus Calmette\u2013Guerin in adult asthma","volume":"34","author":"Shirtcliffe","year":"2004","journal-title":"Clin Exp Allergy"},{"issue":"1 and 2","key":"10.1016\/j.tube.2006.02.001_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0264-410X(02)00441-3","article-title":"Routine vaccinations and child survival in a war situation with high mortality: effect of gender","volume":"21","author":"Aaby","year":"2002","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.tube.2006.02.001_bib23","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/ije\/dyh005","article-title":"The introduction of Ditptheria\u2013Tetanus\u2013Pertussis vaccine and child mortality in rural Guinea-Bissau: an observational study","volume":"33","author":"Aaby","year":"2004","journal-title":"Int J Epidemiol"},{"issue":"4","key":"10.1016\/j.tube.2006.02.001_bib24","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1590\/S0034-89101992000400004","article-title":"Risk factors for death caused by pneumonia in children younger than 1 year old in a metropolitan region of southeastern Brazil. A case\u2013control study","volume":"26","author":"Niobey","year":"1992","journal-title":"Rev Saude Publica"},{"issue":"6","key":"10.1016\/j.tube.2006.02.001_bib25","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/01.inf.0000129693.81082.a0","article-title":"Low birth weight infants and Calmette\u2013Guerin bacillus vaccination at birth: community study from Guinea-Bissau","volume":"23","author":"Roth","year":"2004","journal-title":"Pediatr Infect Dis J"},{"issue":"2","key":"10.1016\/j.tube.2006.02.001_bib26","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/ije\/20.2.474","article-title":"Childhood mortality among users and non-users of primary health care in a rural west African community","volume":"20","author":"Velema","year":"1991","journal-title":"Int J Epidemiol"},{"issue":"2","key":"10.1016\/j.tube.2006.02.001_bib27","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/ije\/dyh004","article-title":"Divergent female\u2013male mortality ratios associated with different routine vaccinations among female\u2013male twin pairs","volume":"33","author":"Aaby","year":"2004","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.tube.2006.02.001_bib28","doi-asserted-by":"crossref","unstructured":"Veirum JE, Sodemann M, Biai S, Jakobsen M, Garly ML, Hedegaard K, et al. Routine vaccinations associated with divergent effects on female and male mortality at the paediatric ward in Bissau, Guinea-Bissau. Vaccine 2005; 23 (9):1197\u2013204.","DOI":"10.1016\/j.vaccine.2004.02.053"},{"key":"10.1016\/j.tube.2006.02.001_bib29","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1016\/j.vaccine.2004.10.022","article-title":"Vaccination technique, PPD reaction and BCG scarring in a cohort of children born in Guinea-Bissau 2000\u20132002","volume":"23","author":"Roth","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.tube.2006.02.001_bib30","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1016\/S0264-410X(03)00181-6","article-title":"BCG scar and positive tuberculin reaction associated with reduced child mortality in West-Africa. A non-specific beneficial effect of BCG?","volume":"21","author":"Garly","year":"2003","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.tube.2006.02.001_bib31","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/ije\/dyh392","article-title":"BCG vaccination scar associated with better childhood survival in Guinea-Bissau","volume":"34","author":"Roth","year":"2005","journal-title":"Int J Epidemiol"},{"issue":"1 Pt 1","key":"10.1016\/j.tube.2006.02.001_bib32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1542\/peds.96.1.29","article-title":"The efficacy of bacillus Calmette\u2013Guerin vaccination of newborns and infants in the prevention of tuberculosis: meta-analyses of the published literature","volume":"96","author":"Colditz","year":"1995","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.tube.2006.02.001_bib33","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/ije\/22.6.1154","article-title":"Protective effect of BCG against tuberculous meningitis and miliary tuberculosis: a meta-analysis","volume":"22","author":"Rodrigues","year":"1993","journal-title":"Int J Epidemiol"},{"issue":"5","key":"10.1016\/j.tube.2006.02.001_bib34","first-page":"424","article-title":"Childhood tuberculosis in Malawi: nationwide case-finding and treatment outcomes","volume":"6","author":"Harries","year":"2002","journal-title":"Int J Tuberc Lung Dis"},{"issue":"10","key":"10.1016\/j.tube.2006.02.001_bib35","first-page":"23","article-title":"Tuberclin reactivity in a pediatric population with high BCG vaccination coverage","volume":"3","author":"Lockman","year":"1999","journal-title":"Int J Tuberc Lung Dis"},{"issue":"11","key":"10.1016\/j.tube.2006.02.001_bib36","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1097\/00006454-200111000-00011","article-title":"Use of purified protein derivative to assess the risk of infection in children in close contact with adults with tuberculosis in a population with high Calmette\u2013Guerin bacillus coverage","volume":"20","author":"Almeida","year":"2001","journal-title":"Pediatr Infect Dis J"},{"issue":"1","key":"10.1016\/j.tube.2006.02.001_bib37","first-page":"38","article-title":"A prospective evaluation of children under the age of 5 years living in the same household as adults with recently diagnosed pulmonary tuberculosis","volume":"1","author":"Beyers","year":"1997","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.tube.2006.02.001_bib38","article-title":"Commentary: an unexpected finding that needs confirmation or rejection","volume":"321","author":"Fine","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.tube.2006.02.001_bib39","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/ije\/25.3.665","article-title":"Child mortality following standard, medium and high titre measles vaccination in West Africa","volume":"25","author":"Knudsen","year":"1996","journal-title":"Int J Epidemiol"},{"issue":"8","key":"10.1016\/j.tube.2006.02.001_bib40","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1097\/00002030-199905280-00020","article-title":"HIV-negative infants born to HIV-1 but not HIV-2-positive mothers fail to develop a Bacillus Calmette\u2013Guerin scar","volume":"13","author":"Ota","year":"1999","journal-title":"AIDS"},{"key":"10.1016\/j.tube.2006.02.001_bib41","first-page":"833","article-title":"BCG vaccination and pediatric HIV infection\u2014Rwanda, 1988\u20131990","volume":"40","year":"1991","journal-title":"MMWR"},{"key":"10.1016\/j.tube.2006.02.001_bib42","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00002030-199102000-00010","article-title":"Bacillus Calmette\u2013Guerin immunisation in infants born to HIV-1 seropositive mothers","volume":"5","author":"Lallemant-Le Coeur","year":"1991","journal-title":"AIDS"},{"issue":"2","key":"10.1016\/j.tube.2006.02.001_bib43","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0022-3476(96)70249-4","article-title":"Delayed-type hypersensitivity skin testing in human immunodeficiency virus-infected pediatric patients","volume":"129","author":"Raszka","year":"1996","journal-title":"J Pediatr"},{"issue":"8","key":"10.1016\/j.tube.2006.02.001_bib44","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrmicro1211","article-title":"The success and failure of BCG\u2014implications for a novel tuberculosis vaccine","volume":"3","author":"Andersen","year":"2005","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"10.1016\/j.tube.2006.02.001_bib45","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1086\/499953","article-title":"Bacille Calmette\u2013Guerin vaccine-induced disease in HIV-infected and HIV-uninfected children","volume":"42","author":"Hesseling","year":"2006","journal-title":"Clin Infect Dis"},{"issue":"Suppl. 3","key":"10.1016\/j.tube.2006.02.001_bib46","doi-asserted-by":"crossref","first-page":"S206","DOI":"10.1086\/313863","article-title":"Evaluation of vaccines to prevent childhood pneumonia: lessons relevant to planning tuberculosis vaccine trials","volume":"30","author":"Mulholland","year":"2000","journal-title":"Clin Infect Dis"},{"issue":"11","key":"10.1016\/j.tube.2006.02.001_bib47","doi-asserted-by":"crossref","first-page":"6188","DOI":"10.1128\/IAI.70.11.6188-6195.2002","article-title":"Clinical and immune impact of Mycobacterium bovis BCG vaccination scarring","volume":"70","author":"Jason","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2006.02.001_bib48","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1046\/j.1365-2222.2000.00803.x","article-title":"Early BCG vaccination and reduction in atopy in Guinea-Bissau","volume":"30","author":"Aaby","year":"2000","journal-title":"Clin Exp Allergy"},{"issue":"6","key":"10.1016\/j.tube.2006.02.001_bib49","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1086\/317627","article-title":"Lower hookworm incidence, prevalence, and intensity of infection in children with a Bacillus Calmette\u2013Guerin vaccination scar","volume":"182","author":"Barreto","year":"2000","journal-title":"J Infect Dis"},{"issue":"9183","key":"10.1016\/j.tube.2006.02.001_bib50","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0140-6736(99)03290-0","article-title":"Inverse association between BCG immunisation and intestinal nematode infestation among HIV-1-positive individuals in Uganda","volume":"354","author":"Elliott","year":"1999","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.tube.2006.02.001_bib51","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0035-9203(02)90229-4","article-title":"Patterns of helminth infection and relationship to BCG vaccination in Karonga District, northern Malawi","volume":"96","author":"Randall","year":"2002","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"8505","key":"10.1016\/j.tube.2006.02.001_bib52","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0140-6736(86)90367-3","article-title":"Protective efficacy of BCG against leprosy in Northern Malawi","volume":"2","author":"Fine","year":"1986","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.tube.2006.02.001_bib53","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1128\/IAI.72.1.62-65.2004","article-title":"Mycobacterium bovis BCG vaccination as prophylaxis against Mycobacterium ulcerans osteomyelitis in Buruli ulcer disease","volume":"72","author":"Portaels","year":"2004","journal-title":"Infect Immun"}],"container-title":["Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979206000461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979206000461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T13:09:25Z","timestamp":1683551365000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472979206000461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S1472979206000461"],"URL":"https:\/\/doi.org\/10.1016\/j.tube.2006.02.001","relation":{},"ISSN":["1472-9792"],"issn-type":[{"value":"1472-9792","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}