{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T06:31:32Z","timestamp":1794378692241,"version":"4.9.0"},"reference-count":111,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tuberculosis"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.tube.2010.07.002","type":"journal-article","created":{"date-parts":[[2010,8,15]],"date-time":"2010-08-15T08:49:21Z","timestamp":1281862161000},"page":"279-292","source":"Crossref","is-referenced-by-count":205,"title":["Cerebrospinal fluid concentrations of antituberculosis agents in adults and children"],"prefix":"10.1016","volume":"90","author":[{"given":"P.R.","family":"Donald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tube.2010.07.002_bib1","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1056\/NEJMoa040573","article-title":"Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults","volume":"351","author":"Thwaites","year":"2004","journal-title":"N Eng J Med"},{"key":"10.1016\/j.tube.2010.07.002_bib2","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1093\/jac\/5.6.630","article-title":"Pharmacokinetic aspects of the treatment of infections of the central nervous system","volume":"5","author":"Norrby","year":"1979","journal-title":"J Antimicrob Chemothr"},{"key":"10.1016\/j.tube.2010.07.002_bib3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2165\/00003088-199835030-00005","article-title":"Pharmacokinetic optimization of the treatment of\u00a0bacterial central nervous system infections","volume":"35","author":"Nau","year":"1998","journal-title":"Clin Pharmacokin"},{"key":"10.1016\/j.tube.2010.07.002_bib4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s002849900095","article-title":"In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against virulent H37 Rv strain in human macrophages","volume":"33","author":"Rastogi","year":"1996","journal-title":"Curr Microbiol"},{"key":"10.1016\/j.tube.2010.07.002_bib5","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1016\/S1472-9792(08)70038-6","article-title":"The early bactericidal activity of anti-tuberculosis drugs: a literature review","volume":"88","author":"Donald","year":"2008","journal-title":"Tuberculosis"},{"key":"10.1016\/j.tube.2010.07.002_bib6","first-page":"796","article-title":"Role of individual drugs in the chemotherapy of tuberculosis","volume":"4","author":"Mitchison","year":"2000","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib7","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM195711282572202","article-title":"Clinical implications of isoniazid blood levels in pulmonary tuberculosis","volume":"257","author":"Mitchell","year":"1957","journal-title":"N Eng J Med"},{"key":"10.1016\/j.tube.2010.07.002_bib8","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1086\/424999","article-title":"The influence of human N-acetyltransfearase genotype on the early bactericidal activity of isoniazid","volume":"39","author":"Donald","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib9","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00228-007-0305-5","article-title":"The influence of dose and N-acetyltransferase genotype and phenotype on the pharmacokinetics and pharmacodynamics of isoniazid","volume":"63","author":"Donald","year":"2007","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.tube.2010.07.002_bib10","first-page":"535","article-title":"A concurrent comparison of isoniazid plus PAS with three regimens of isoniazid alone in the domiciliary treatment of pulmonary tuberculosis in South India","volume":"23","author":"Tuberculosis Chemotherapy Centre, Madras","year":"1960","journal-title":"Bull Wld Hlth Org"},{"key":"10.1016\/j.tube.2010.07.002_bib11","first-page":"31","article-title":"Therapeutic drug monitoring: principles and applications in mycobacterial infections","volume":"22","author":"Peloquin","year":"1992","journal-title":"Drug Ther"},{"key":"10.1016\/j.tube.2010.07.002_bib12","first-page":"429","article-title":"The absorption, distribution, excretion, and short-term toxicity of isonicotinic acid hydrazide (nydrazid) in man","volume":"65","author":"Elmendorf","year":"1952","journal-title":"Am Rev Tuberc"},{"key":"10.1016\/j.tube.2010.07.002_bib13","first-page":"1384","article-title":"Distribution and excretion of radioactive isoniazid in tuberculosis patients","volume":"151","author":"Barclay","year":"1953","journal-title":"JAMA"},{"key":"10.1016\/j.tube.2010.07.002_bib14","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/S0140-6736(53)90420-6","article-title":"CSF-isoniazid levels in tuberculosis meningitis","volume":"2","author":"Fletcher","year":"1953","journal-title":"Lancet"},{"key":"10.1016\/j.tube.2010.07.002_bib15","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1378\/chest.26.2.146","article-title":"The treatment of tuberculosis meningitis in infants with streptomycin and isonicotinic acid hydrazide (isoniazid)","volume":"26","author":"Pellegrino","year":"1954","journal-title":"Dis Chest"},{"key":"10.1016\/j.tube.2010.07.002_bib16","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1542\/peds.21.6.910","article-title":"Concentrations of active isoniazid in serum and cerebrospinal fluid of patients with tuberculosis treated with isoniazid","volume":"21","author":"Lanier","year":"1958","journal-title":"Pediatrics"},{"key":"10.1016\/j.tube.2010.07.002_bib17","first-page":"374","article-title":"Pyrazinamide and other drugs in tuberculosis meningitis","volume":"2","author":"Forgan Smith","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/j.tube.2010.07.002_bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3346\/jkms.1990.5.1.39","article-title":"Kinetics of isoniazid transfer into cerebrospinal fluid in patients with tuberculous meningitis","volume":"5","author":"Shin","year":"1990","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.tube.2010.07.002_bib19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/clpt.1991.2","article-title":"Effect of steroids on cerebrospinal fluid penetration of antituberculosis drugs in tuberculosis meningitis","volume":"49","author":"Kaojarern","year":"1991","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.tube.2010.07.002_bib20","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1542\/peds.89.2.247","article-title":"Cerebrospinal fluid isoniazid concentrations in children with tuberculous meningitis: the influence of dosage and acetylation status","volume":"89","author":"Donald","year":"1992","journal-title":"Pediatrics"},{"key":"10.1016\/j.tube.2010.07.002_bib21","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1164\/ajrccm\/148.3.650","article-title":"Cerebrospinal fluid drug concentrations and the treatment of tuberculosis meningitis","volume":"148","author":"Ellard","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib22","first-page":"657","article-title":"Le concentrazioni dell\u2019isoniazide nel sangue e nel liquor in rapporto a varie dosi orali","volume":"45","author":"Ricci","year":"1954","journal-title":"Minerva Med"},{"key":"10.1016\/j.tube.2010.07.002_bib23","series-title":"The acetylator genes and drug responses","first-page":"32","article-title":"The genetics of acetylation","author":"Weber","year":"1987"},{"key":"10.1016\/j.tube.2010.07.002_bib24","first-page":"237","article-title":"Controlled clinical trial of four short-course (6-month) regimens of chemotherapy for treatment of pulmonary tuberculosis. Third report","volume":"2","author":"East African\/British Medical Research Council","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/j.tube.2010.07.002_bib25","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1164\/ajrccm\/143.4_Pt_1.700","article-title":"Controlled trial of 2, 4 & 6 months of pyrazinamide in a 6-month, 3-times weekly regimens for smear-positive pulmonary tuberculosis, including an assessment of a combined preparation of isoniazid, rifampin and pyrazinamide","volume":"143","author":"Hong Kong Chest Service\/British Medical Research Council","year":"1991","journal-title":"Am Rev Resp Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib26","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1159\/000220750","article-title":"Kinetic studies on rifampicin","volume":"16","author":"Acocella","year":"1971","journal-title":"Chemotherapy"},{"key":"10.1016\/j.tube.2010.07.002_bib27","first-page":"534","article-title":"Rifampicin: a new rifamycin","volume":"17","author":"Furesz","year":"1967","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.tube.2010.07.002_bib28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1378\/chest.115.1.12","article-title":"Pharmacokinetics of rifampin under fasting conditions, with food and with antacids","volume":"115","author":"Peloquin","year":"1999","journal-title":"Chest"},{"key":"10.1016\/j.tube.2010.07.002_bib29","first-page":"2799","article-title":"Ricerche sull\u2019assorbimento orale e sulla eliminaxione urinaria della rifampicina","volume":"73","author":"Vello","year":"1968","journal-title":"Gaz Intern Med Chirurg"},{"key":"10.1016\/j.tube.2010.07.002_bib30","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/BF00558209","article-title":"Binding of rifampicin by human plasma proteins","volume":"7","author":"Boman","year":"1974","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.tube.2010.07.002_bib31","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2165\/00003088-200140050-00002","article-title":"Comparative pharmacokinetics and pharmacodynamics of rifamycin antibacterials","volume":"40","author":"Burman","year":"2001","journal-title":"Clin Pharmacokin"},{"key":"10.1016\/j.tube.2010.07.002_bib32","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1476-0711-5-3","article-title":"Roles of rifampicin in drug\u2013drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor","volume":"5","author":"Chen","year":"2006","journal-title":"Ann Clin Microb Antimicrob"},{"key":"10.1016\/j.tube.2010.07.002_bib33","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2165\/00044011-200323070-00005","article-title":"Serum rifampicin levels in patients with tuberculosis","volume":"23","author":"Prakash","year":"2003","journal-title":"Clin Drug Invest"},{"key":"10.1016\/j.tube.2010.07.002_bib34","first-page":"879","article-title":"U.S. Public Health Service trial of three rifampin-isoniazid regimens in treatment of pulmonary tuberculosis","volume":"119","author":"Long","year":"1979","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib35","first-page":"939","article-title":"The early bactericidal activity of drugs in patients with pulmonary tuberculosis","volume":"121","author":"Jindani","year":"1980","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0962-8479(92)90077-W","article-title":"The early bactericidal activity of rifabutin measured by sputum viable counts in Honk Kong patients with pulmonary tuberculosis","volume":"73","author":"Chan","year":"1992","journal-title":"Tubercle Lung Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib37","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/jac\/32.6.867","article-title":"The early bactericidal activity of rifabutin in patients with pulmonary tuberculosis measured by sputum viable counts: a new method of drug assessment","volume":"32","author":"Sirgel","year":"1993","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.tube.2010.07.002_bib38","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1164\/rccm.200411-1557OC","article-title":"The early bactericidal activities of rifampin and rifapentine in pulmonary tuberculosis","volume":"172","author":"Sirgel","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.tube.2010.07.002_bib39","series-title":"Mycobacteria II, chemotherapy","first-page":"15","article-title":"Basic concepts in the chemotherapy of tuberculosis","author":"Mitchison","year":"1998"},{"key":"10.1016\/j.tube.2010.07.002_bib40","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1128\/AAC.01474-06","article-title":"Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears","volume":"51","author":"Diacon","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.tube.2010.07.002_bib41","first-page":"2399","article-title":"Sulla ripartizione fra sangue e liquor della rifampicina AMP","volume":"60","author":"Curci","year":"1969","journal-title":"Minerva Med"},{"key":"10.1016\/j.tube.2010.07.002_bib42","first-page":"1349","article-title":"La rifampicina nella terapia della meningite tubercolare","volume":"85","author":"Ninni","year":"1971","journal-title":"Riforma Med"},{"key":"10.1016\/j.tube.2010.07.002_bib43","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1164\/arrd.1972.106.3.432","article-title":"Cerebrospinal fluid concentrations of rifampin in meningeal tuberculosis","volume":"106","author":"D\u2019Oliviera","year":"1972","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib44","first-page":"171","article-title":"Etude des taux s\u00e9riques et rachidiens de rifampicine (AMP)","volume":"51\u201352","author":"Larbaoui","year":"1972","journal-title":"Arch Inst Pasteur Alger"},{"key":"10.1016\/j.tube.2010.07.002_bib45","first-page":"837","article-title":"Passage de la rifampicine dans leliquide cephalo-rachidien au cours des meningites tuberculeuses","volume":"227","author":"Woerle","year":"1972","journal-title":"Lyon Med"},{"key":"10.1016\/j.tube.2010.07.002_bib46","first-page":"477","article-title":"Taux de rifampicine dans le s\u00e9rum et le liquide c\u00e9phalo-racidiene chez l\u2019enfant","volume":"31","author":"De Rautlin de la Roy","year":"1974","journal-title":"Arch France P\u00e9d"},{"key":"10.1016\/j.tube.2010.07.002_bib47","first-page":"579","article-title":"Rifampin concentrations in cerebrospinal fluid of patients with tuberculosis meningitis","volume":"109","author":"Sippel","year":"1974","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib48","first-page":"200","article-title":"Rifampicin in neonatal ventriculitis","volume":"18","author":"Stanley","year":"1982","journal-title":"Aust Paediatr"},{"key":"10.1016\/j.tube.2010.07.002_bib49","first-page":"309","article-title":"Cerebrospinal fluid serum concentrations of rifampin in meningeal tuberculosis after intravenous administration","volume":"2","author":"Mikhail","year":"1986","journal-title":"Chemioterapia"},{"key":"10.1016\/j.tube.2010.07.002_bib50","first-page":"235","article-title":"Cerebrospinal fluid and serum levels of pyrazinamide and rifampicin in patients with tuberculosis meningitis","volume":"42","author":"Woo","year":"1987","journal-title":"Curr Ther Res"},{"key":"10.1016\/j.tube.2010.07.002_bib51","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/BF02336694","article-title":"Pharmacokinetics, cerebrospinal fluid concentration, and safety of intravenous rifampin in pediatric patients undergoing shunt placements","volume":"38","author":"Nahata","year":"1990","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.tube.2010.07.002_bib52","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/jac\/29.6.719","article-title":"Penetration of rifampicin into the cerebrospinal fluid of adults with uninflamed meninges","volume":"29","author":"Nau","year":"1992","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.tube.2010.07.002_bib53","first-page":"269","article-title":"Serum and cerebrospinal fluid concentrations of rifampicin at two dose levels in children with tuberculosis meningitis","volume":"29","author":"Mahajan","year":"1997","journal-title":"J Commun Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib54","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1469-0691.2004.00953.x","article-title":"Penetration of fusidic acid and rifampicin into cerebrospinal fluid in low-grade inflammatory meningitis caused by Staphylococcus epidermidis","volume":"10","author":"Hedberg","year":"2004","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.tube.2010.07.002_bib55","first-page":"755","article-title":"Absorption and elimination of the antibiotic rifampicin in newborns and children","volume":"vol. 2","author":"Acocella","year":"1970"},{"key":"10.1016\/j.tube.2010.07.002_bib56","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1186\/1741-7015-7-19","article-title":"Rifampin pharmacokinetics in children, with and without human immunodeficiency virus infection, hospitalized for the management of severe forms of tuberculosis","volume":"22","author":"Schaaf","year":"2009","journal-title":"BMC Med"},{"key":"10.1016\/j.tube.2010.07.002_bib57","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1086\/430616","article-title":"Effect of antituberculosis drug resistance on response to treatment and outcome in adults with tuberculosis meningitis","volume":"192","author":"Thwaites","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib58","first-page":"1072","article-title":"Determination of drug susceptibility of mycobacteria to pyrazinamide in 7H10 agar","volume":"96","author":"Stottmeier","year":"1967","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib59","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1128\/AAC.32.7.1002","article-title":"Determination of pyrazinamide MICs for Mycobacterium tuberculosis at different pHs by the radiometric method","volume":"32","author":"Salfinger","year":"1988","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.tube.2010.07.002_bib60","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1086\/381096","article-title":"The clinical pharmacokinetics of pyrazinamide in HIV-infected patients with tuberculosis","volume":"38","author":"Perlman","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib61","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1086\/599040","article-title":"Isoniazid, rifampin, ethambutol, and pyrazinamide phramacokinetics and treatment outcomes among a predominantly HIV-infected cohort of adults with tuberculosis from Botswana","volume":"48","author":"Chideya","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib62","first-page":"40","article-title":"La concentrazione nel liquido cerebro-spinale della pirazinamide somministrata a dosi terapeutiche","volume":"39","author":"Corsini","year":"1957","journal-title":"Clin Pediatr (Bologna)"},{"key":"10.1016\/j.tube.2010.07.002_bib63","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/bmj.294.6567.284","article-title":"Penetration of pyrazinamide into the cerebrospinal fluid in tuberculosis meningitis","volume":"294","author":"Ellard","year":"1987","journal-title":"Br Med J"},{"key":"10.1016\/j.tube.2010.07.002_bib64","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/00006454-198807000-00003","article-title":"Cerebrospinal fluid pyrazinamide concentrations in children with tuberculosis meningitis","volume":"7","author":"Donald","year":"1988","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.tube.2010.07.002_bib65","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/jnnp.53.1.81","article-title":"The blood\/cerebrospinal fluid portioning of pyrazinamide: a study during the course of treatment of tuberculosis meningitis","volume":"53","author":"Phuapradit","year":"1990","journal-title":"J Neurol Neurosurg Psychiatr"},{"key":"10.1016\/j.tube.2010.07.002_bib66","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1086\/318698","article-title":"Novel treatment of meningitis caused by multidrug-resistant Mycobacterium tuberculosis with intrathecal levofloxacin and amikacin: case report","volume":"32","author":"Berning","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib67","series-title":"Treatment of tuberculosis: guidelines for national programmes","author":"World Health Organization Stop TB Department","year":"2003"},{"key":"10.1016\/j.tube.2010.07.002_bib68","first-page":"582","article-title":"Streptomycin in tuberculosis trials committee. Streptomycin treatment of tuberculosis meningitis","volume":"254","author":"Medical Research Council","year":"1948","journal-title":"Lancet"},{"key":"10.1016\/j.tube.2010.07.002_bib69","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1345\/aph.19008","article-title":"Multidrug-resistant tuberculosis meningitis: clinical problems and concentrations of second-line antituberculosis medications","volume":"33","author":"DeVincenzo","year":"1999","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.tube.2010.07.002_bib70","series-title":"Antibiotics annual 1958\u201359","first-page":"677","article-title":"Kanamycin: its cerebrospinal fluid diffusion, renal clearance, and comparison with streptomycin","author":"Boger","year":"1959"},{"key":"10.1016\/j.tube.2010.07.002_bib71","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1111\/j.1749-6632.1966.tb43021.x","article-title":"Some observations on dosage and toxicity of kanamycin in premature and full-term infants","volume":"132","author":"Eichenwald","year":"1966","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.tube.2010.07.002_bib72","first-page":"76","article-title":"CSF levels of amikacin following systemic application in patients with slightly and severely impaired cerebrospinal barrier","volume":"10","author":"Br\u00fcckner","year":"1982","journal-title":"Immun Infect"},{"key":"10.1016\/j.tube.2010.07.002_bib73","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1227\/00006123-198201000-00009","article-title":"Intraventricular cerebrospinal fluid antibiotic concentrations in patients with intraventricular infections","volume":"10","author":"James","year":"1982","journal-title":"Neurosurgery"},{"key":"10.1016\/j.tube.2010.07.002_bib74","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/030006057900700107","article-title":"Amikacin concentration in the cerebrospinal fluid of children with acute bacterial meningitis","volume":"7","author":"Trujillo","year":"1979","journal-title":"J Int Med Res"},{"key":"10.1016\/j.tube.2010.07.002_bib75","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1128\/AAC.39.1.253","article-title":"Cerebrospinal fluid penetration of amikacin in children with community acquired bacterial meningitis","volume":"39","author":"Gaillard","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.tube.2010.07.002_bib76","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1128\/JCM.01473-08","article-title":"Evolution of central nervous system multidrug-resistant Mycobacterium tuberculosis and late relapse of cryptic prosthetic hip joint tuberculosis: complications during treatment of disseminated isoniazid-resistant tuberculosis in an immunocompromised host","volume":"47","author":"Upton","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.tube.2010.07.002_bib77","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1021\/jm01239a017","article-title":"Antituberculosis agents. II. N, N\u2019-diisopropylethylenediamine and analogs","volume":"5","author":"Shepherd","year":"1962","journal-title":"J Med Chem"},{"key":"10.1016\/j.tube.2010.07.002_bib78","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1001\/archopht.1962.00960020566009","article-title":"Ocular manifestations of ethambutol","volume":"67","author":"Carr","year":"1962","journal-title":"Arch Opthal"},{"key":"10.1016\/j.tube.2010.07.002_bib79","first-page":"783","article-title":"Ethambutol in tuberculosis meningitis","volume":"99","author":"Place","year":"1969","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib80","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0041-3879(71)90017-1","article-title":"Concentrations of ethambutol in the cerebrospinal fluid after oral administration","volume":"52","author":"Pilheu","year":"1971","journal-title":"Tubercle"},{"key":"10.1016\/j.tube.2010.07.002_bib81","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1378\/chest.61.7.629","article-title":"Ethambutol in tuberculosis meningitis","volume":"61","author":"Bobrowitz","year":"1972","journal-title":"Chest"},{"key":"10.1016\/j.tube.2010.07.002_bib82","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF00562440","article-title":"Concentration of ethambutol in cerebrospinal fluid in man as a function of the non-protein-bound drug fraction","volume":"6","author":"Gundert-Remy","year":"1973","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.tube.2010.07.002_bib83","first-page":"352","article-title":"Therapeutic effect of a new antibacterial substance ofloxacin (DL-8280) on pulmonary tuberculosis","volume":"131","author":"Tsukamura","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib84","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2165\/00003495-199300453-00065","article-title":"Ofloxacin-based chemotherapy in multiply drug-resistant pulmonary tuberculosis","volume":"45","author":"Willcox","year":"1993","journal-title":"Drugs"},{"key":"10.1016\/j.tube.2010.07.002_bib85","first-page":"27","article-title":"Shortening short course chemotherapy: a randomized clinical trial for treatment of smear positive pulmonary tuberculosis with regimens using ofloxacin in the intensive phase","volume":"49","author":"Tuberculosis Research Centre","year":"2002","journal-title":"Ind J Tuberc"},{"key":"10.1016\/j.tube.2010.07.002_bib86","first-page":"S256","article-title":"Penetration of ciprofloxacin into the cerebrospinal fluid","volume":"10","author":"Kitzes-Cohen","year":"1988","journal-title":"Rev Infect Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib87","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1128\/AAC.31.6.899","article-title":"Penetration of ciprofloxacin into cerebrospinal fluid of patients with bacterial meningitis","volume":"31","author":"Wolff","year":"1987","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.tube.2010.07.002_bib88","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/jac\/25.6.965","article-title":"Penetration of ciprofloxacin into the cerebrospinal fluid of patients with uninflammed meninges","volume":"25","author":"Nau","year":"1990","journal-title":"J Antimicrob Chemother"},{"issue":"suppl 4","key":"10.1016\/j.tube.2010.07.002_bib89","doi-asserted-by":"crossref","first-page":"S254","DOI":"10.1007\/BF01661286","article-title":"Diffusion of ofloxacin into the cerebrospinal fluid in patients with bacterial meningitis","volume":"14","author":"Stahl","year":"1986","journal-title":"Infection"},{"key":"10.1016\/j.tube.2010.07.002_bib90","doi-asserted-by":"crossref","first-page":"S250","DOI":"10.1007\/BF01661285","article-title":"Study of the cerebrospinal fluid penetrability of ofloxacin","volume":"14","author":"St\u00fcbner","year":"1986","journal-title":"Infection"},{"key":"10.1016\/j.tube.2010.07.002_bib91","first-page":"264","article-title":"Ofloxacin penetration into cerebrospinal fluid","volume":"22","author":"Drancourt","year":"1988","journal-title":"J Antimocrob Chemother"},{"key":"10.1016\/j.tube.2010.07.002_bib92","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1128\/AAC.33.10.1686","article-title":"Concentrations of ofloxacin in serum and cerebrospinal fluid of patients without meningitis receiving the drug intravenously and orally","volume":"33","author":"Bitar","year":"1989","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.tube.2010.07.002_bib93","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1128\/AAC.33.6.933","article-title":"Diffusion of ofloxacin into the cerebrospinal fluid in patients with purulent meningitis or ventriculitis","volume":"33","author":"Pioget","year":"1989","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.tube.2010.07.002_bib94","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1128\/AAC.38.8.1849","article-title":"Kinetics of ofloxacin and its metabolites in cerebrospinal fluid after a single intravenous infusion of 400 milligrams of ofloxacin","volume":"38","author":"Nau","year":"1994","journal-title":"Antimocrob Agents Chemother"},{"key":"10.1016\/j.tube.2010.07.002_bib95","first-page":"937","article-title":"Determination of levofloxacin in plasma and cerebrospinal fluid with HPLC and its pharmacokinetics in patients undergoing neurosurgical operations","volume":"33","author":"Luo","year":"1998","journal-title":"Yao Xue Xue Bao"},{"key":"10.1016\/j.tube.2010.07.002_bib96","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1128\/AAC.47.10.3104-3108.2003","article-title":"Levofloxacin disposition in cerebrospinal fluid in patients with external ventriculostomy","volume":"47","author":"Pea","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.tube.2010.07.002_bib97","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1128\/AAC.01637-07","article-title":"Plasma and cerebrospinal fluid pharmacokinetics of moxifloxacin in a patient with tuberculosis meningitis","volume":"52","author":"Alffenaar","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.tube.2010.07.002_bib98","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/jac\/dkn110","article-title":"Pharmacokinetics of moxifloxacin in no-inflammed cerebrospinal fluid of humans: implication for bactericidal effect","volume":"61","author":"Kannelakopoulou","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.tube.2010.07.002_bib99","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1086\/605576","article-title":"Pharmacokinetics of moxifloxacin in cerebrospinal fluid and plasma in patients with tuberculous meningitis","volume":"49","author":"Alffenaar","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib100","first-page":"774","article-title":"Multidrug-resistant tuberculosis meningitis in a health care worker","volume":"2","author":"Silber","year":"1998","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib101","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/01.inf.0000199314.88063.4c","article-title":"Multidrug-resistant tuberculosis meningitis in children in Durban, South Africa","volume":"25","author":"Padayatchi","year":"2006","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.tube.2010.07.002_bib102","first-page":"1","article-title":"Experiments on the antituberculosis activity of alpha-ethyl-thioisonicotinamide","volume":"79","author":"Rist","year":"1959","journal-title":"Am Rev Tuberc Pulmon Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib103","first-page":"685","article-title":"Comparison of ethionamide with isoniazid in original treatment cases of pulmonary tuberculosis","volume":"93","author":"Schwartz","year":"1966","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.tube.2010.07.002_bib104","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0140-6736(62)91602-1","article-title":"Ethionamide: its passage into the cerebrospinal fluid in man","volume":"1","author":"Hughes","year":"1962","journal-title":"Lancet"},{"key":"10.1016\/j.tube.2010.07.002_bib105","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0022-3476(89)80862-5","article-title":"Cerebrospinal fluid ethionamide concentrations in children with tuberculosis meningitis","volume":"115","author":"Donald","year":"1989","journal-title":"J Pediatr"},{"key":"10.1016\/j.tube.2010.07.002_bib106","first-page":"165","article-title":"Antituberculosis drugs in meningitis","volume":"2","author":"Anonymous","year":"1963","journal-title":"Br Med J"},{"key":"10.1016\/j.tube.2010.07.002_bib107","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0022-3476(75)80328-3","article-title":"Treatment of tuberculous meningitis","volume":"87","author":"Kernbaum","year":"1975","journal-title":"J Pediatr"},{"key":"10.1016\/j.tube.2010.07.002_bib108","first-page":"469","article-title":"Association isoniazide-\u00c9thionamide dans le traitement de la m\u00e9ningite tuberculeuse","volume":"26","author":"Fouquet","year":"1962","journal-title":"Rev Tuberc Pneumol"},{"key":"10.1016\/j.tube.2010.07.002_bib109","first-page":"136","article-title":"Absorption, distribution and excretion of cycloserine in man","author":"Nair","year":"1956","journal-title":"Antibio Ann 1955\u20131956"},{"key":"10.1016\/j.tube.2010.07.002_bib110","series-title":"The treatment of tuberculosis in childhood","first-page":"155","article-title":"The treatment of acute tuberculosis in childhood","author":"Dubois","year":"1956"},{"issue":"642","key":"10.1016\/j.tube.2010.07.002_bib111","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0022-3565(25)29547-7","article-title":"The active transport of para-aminosalicylic acid from the cerebrospinal fluid","volume":"185","author":"Spector","year":"1973","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979210000818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979210000818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T14:48:45Z","timestamp":1740408525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472979210000818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":111,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S1472979210000818"],"URL":"https:\/\/doi.org\/10.1016\/j.tube.2010.07.002","relation":{},"ISSN":["1472-9792"],"issn-type":[{"value":"1472-9792","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}