{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:16:24Z","timestamp":1786997784520,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007197","name":"USPHS","doi-asserted-by":"crossref","award":["R01-15495"],"award-info":[{"award-number":["R01-15495"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007235","name":"Colorado State University","doi-asserted-by":"crossref","award":["HHSN 266200400091c"],"award-info":[{"award-number":["HHSN 266200400091c"]}],"id":[{"id":"10.13039\/100007235","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tuberculosis"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.tube.2010.11.006","type":"journal-article","created":{"date-parts":[[2010,12,17]],"date-time":"2010-12-17T04:29:29Z","timestamp":1292560169000},"page":"47-56","source":"Crossref","is-referenced-by-count":23,"title":["Cloning of guinea pig IL-4: Reduced IL-4 mRNA after vaccination or Mycobacterium tuberculosis infection"],"prefix":"10.1016","volume":"91","author":[{"given":"Amminikutty","family":"Jeevan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teizo","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan H.","family":"Ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya R.","family":"Dirisala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"McMurray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tube.2010.11.006_bib1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0923-2494(05)80010-0","article-title":"Effects of interleukin 4 on human B-cell growth and differentiation","volume":"144","author":"Banchereau","year":"1993","journal-title":"Res Immunol"},{"key":"10.1016\/j.tube.2010.11.006_bib2","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.4049\/jimmunol.136.7.2348","article-title":"Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins","volume":"136","author":"Mosmann","year":"1986","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2010.11.006_bib3","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1067\/mai.2001.114989","article-title":"The other side of the coin: the protective role of the TH2 cytokines","volume":"107","author":"Finkelman","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.tube.2010.11.006_bib4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1084\/jem.169.1.59","article-title":"Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets","volume":"169","author":"Heinzel","year":"1989","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.tube.2010.11.006_bib5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1126\/science.1925582","article-title":"Defining protective responses to pathogens: cytokine profiles in leprosy lesions","volume":"254","author":"Yamamura","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.tube.2010.11.006_bib6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1365-3083.1991.tb01543.x","article-title":"Impaired balance of interleukin-4 and interferon-gamma production in infections with Schistosoma mansoni and intestinal nematodes","volume":"34","author":"Zwingenberger","year":"1991","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.tube.2010.11.006_bib7","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.micinf.2005.10.033","article-title":"Lessons from experimental Mycobacterium tuberculosis infections","volume":"8","author":"Flynn","year":"2006","journal-title":"Microbes Infect"},{"key":"10.1016\/j.tube.2010.11.006_bib8","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10875-007-9084-0","article-title":"Host immune response to Mycobacterium tuberculosis","volume":"27","author":"Bhatt","year":"2007","journal-title":"J\u00a0Clin Immunol"},{"key":"10.1016\/j.tube.2010.11.006_bib9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1600-065X.2008.00702.x","article-title":"The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis","volume":"226","author":"Cooper","year":"2008","journal-title":"Immunol Rev"},{"key":"10.1016\/j.tube.2010.11.006_bib10","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/0092-8674(89)90676-4","article-title":"The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection","volume":"56","author":"Kindler","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.tube.2010.11.006_bib11","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1073\/pnas.0400983101","article-title":"Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria","volume":"101","author":"Verreck","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.tube.2010.11.006_bib12","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1172\/JCI2901","article-title":"Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection","volume":"101","author":"Dorman","year":"1998","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.tube.2010.11.006_bib13","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJMoa011110","article-title":"Tuberculosis associated with infliximab, a tumor necrosis factor \u03b1-neutralizing agent","volume":"345","author":"Keane","year":"2001","journal-title":"New Engl J Med"},{"key":"10.1016\/j.tube.2010.11.006_bib14","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1093\/infdis\/168.4.1056","article-title":"Cytokine gene activation and modified responsiveness to interleukin-2 in the blood of tuberculosis patients","volume":"168","author":"Schauf","year":"1993","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.tube.2010.11.006_bib15","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/eji.200324253","article-title":"Pulmonary tuberculosis in BALB\/c mice with non-functional IL-4 genes: changes in the inflammatory effects of TNF-alpha and in the regulation of fibrosis","volume":"34","author":"Hernandez-Pando","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.tube.2010.11.006_bib16","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.it.2004.06.005","article-title":"IL-4 in tuberculosis: implications for vaccine design","volume":"25","author":"Rook","year":"2004","journal-title":"Trends Immunol"},{"key":"10.1016\/j.tube.2010.11.006_bib17","first-page":"340","article-title":"Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response","volume":"56","author":"Djoba Siawaya","year":"2008","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.tube.2010.11.006_bib18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1086\/315200","article-title":"Type 2 cytokine gene activation and its relationship to extent of disease in patients with tuberculosis","volume":"181","author":"Seah","year":"2000","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.tube.2010.11.006_bib19","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/1521-4141(200206)32:6<1605::AID-IMMU1605>3.0.CO;2-6","article-title":"Active tuberculosis in Africa is associated with reduced Th1 and increased Th2 activity in vivo","volume":"32","author":"Lienhardt","year":"2002","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.tube.2010.11.006_bib20","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1164\/rccm.200502-278OC","article-title":"In vivo and in vitro studies of a novel cytokine, interleukin 4delta2, in pulmonary tuberculosis","volume":"172","author":"Dheda","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.tube.2010.11.006_bib21","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1086\/315325","article-title":"Increased production of interleukin 4 by CD4+ and CD8+ T cells from patients with tuberculosis is related to the presence of pulmonary cavities","volume":"181","author":"van Crevel","year":"2000","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.tube.2010.11.006_bib22","doi-asserted-by":"crossref","first-page":"5597","DOI":"10.1128\/IAI.67.11.5597-5603.1999","article-title":"Dichotomy of cytokine profiles in patients and high-risk healthy subjects exposed to tuberculosis","volume":"67","author":"Bhattacharyya","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2010.11.006_bib23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tube.2006.11.001","article-title":"The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4delta2, is not","volume":"87","author":"Dheda","year":"2007","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.tube.2010.11.006_bib24","first-page":"26","article-title":"Correlation between the kinetics of Th1, Th2 cells and pathology in a murine model of experimental pulmonary tuberculosis","volume":"89","author":"Hernandez-Pando","year":"1996","journal-title":"Immunology"},{"key":"10.1016\/j.tube.2010.11.006_bib25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.tube.2007.11.005","article-title":"Beneficial effect of anti-interleukin-4 antibody when administered in a murine model of tuberculosis infection","volume":"88","author":"Roy","year":"2008","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.tube.2010.11.006_bib26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1472-9792(02)00079-3","article-title":"Hematogenous reseeding of the lung in low-dose, aerosol-infected guinea pigs: unique features of the host-pathogen interface in secondary tubercles","volume":"83","author":"McMurray","year":"2003","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.tube.2010.11.006_bib27","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.1128\/IAI.71.8.4271-4277.2003","article-title":"Coordinate cytokine gene expression in vivo following induction of tuberculous pleurisy in guinea pigs","volume":"71","author":"Allen","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2010.11.006_bib28","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.molimm.2006.03.023","article-title":"Cloning and characterization of guinea pig CXCR1","volume":"44","author":"Takahashi","year":"2007","journal-title":"Mol Immunol"},{"key":"10.1016\/j.tube.2010.11.006_bib29","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.clim.2006.11.009","article-title":"CD4(+)CD25(+)FoxP3(+) regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease","volume":"123","author":"Chen","year":"2007","journal-title":"Clin Immunol"},{"key":"10.1016\/j.tube.2010.11.006_bib30","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-2249.2007.03425.x","article-title":"Lung macrophages from bacille Calmette-Guerin-vaccinated guinea pigs suppress T cell proliferation but restrict intracellular growth of M. tuberculosis after recombinant guinea pig interferon-\u03b3 activation","volume":"149","author":"Jeevan","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.tube.2010.11.006_bib31","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.tube.2008.05.001","article-title":"Altered inflammatory responses following transforming growth factor-beta neutralization in experimental guinea pig tuberculous pleurisy","volume":"88","author":"Allen","year":"2008","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.tube.2010.11.006_bib32","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1128\/IAI.71.1.354-364.2003","article-title":"Differential expression of gamma interferon mRNA induced by attenuated and virulent Mycobacterium tuberculosis in guinea pig cells after Mycobacterium bovis BCG vaccination","volume":"71","author":"Jeevan","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2010.11.006_bib33","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1128\/IAI.70.3.1245-1253.2002","article-title":"Effect of Mycobacterium bovis BCG vaccination on interleukin-1 beta and RANTES mRNA expression in guinea pig cells exposed to attenuated and virulent mycobacteria","volume":"70","author":"Jeevan","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2010.11.006_bib34","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1128\/IAI.74.1.213-224.2006","article-title":"Production and characterization of guinea pig recombinant gamma interferon and its effect on macrophage activation","volume":"74","author":"Jeevan","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2010.11.006_bib35","doi-asserted-by":"crossref","first-page":"5025","DOI":"10.4049\/jimmunol.150.11.5025","article-title":"cDNA cloning of guinea pig monocyte chemoattractant protein-1 and expression of the recombinant protein","volume":"150","author":"Yoshimura","year":"1993","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2010.11.006_bib36","first-page":"307","article-title":"CLUSTAL V: multiple alignment of DNA and protein sequences","volume":"25","author":"Higgins","year":"1994","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.tube.2010.11.006_bib37","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1128\/JB.94.4.832-835.1967","article-title":"Host-parasite relationships in experimental airborne tuberculosis. II. Reproducible infection by means of an inoculum preserved at \u221270\u00b0C","volume":"94","author":"Grover","year":"1967","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.tube.2010.11.006_bib38","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1471-4914(00)01901-8","article-title":"Disease model: pulmonary tuberculosis","volume":"7","author":"McMurray","year":"2001","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.tube.2010.11.006_bib39","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1165\/ajrcmb.20.6.3546","article-title":"Ovalbumin (OVA) and Mycobacterium tuberculosis bacilli cooperatively polarize anti-OVA T-helper (Th) cells toward a Th1-dominant phenotype and ameliorate murine tracheal eosinophilia","volume":"20","author":"Sano","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.tube.2010.11.006_bib40","doi-asserted-by":"crossref","first-page":"e296","DOI":"10.1111\/j.1365-2567.2008.02962.x","article-title":"Expression of interferon-gamma and tumour necrosis factor-alpha messenger RNA does not correlate with protection in guinea pigs challenged with virulent Mycobacterium tuberculosis by the respiratory route","volume":"128","author":"Jeevan","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.tube.2010.11.006_bib41","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jmb.2006.11.039","article-title":"The solution structure of antigen MPT64 from Mycobacterium tuberculosis defines a new family of beta-grasp proteins","volume":"366","author":"Wang","year":"2007","journal-title":"J\u00a0Mol Biol"},{"key":"10.1016\/j.tube.2010.11.006_bib42","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1128\/IAI.63.12.4613-4618.1995","article-title":"Mapping of the delayed-type hypersensitivity-inducing epitope of secreted protein MPT64 from Mycobacterium tuberculosis","volume":"63","author":"Oettinger","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2010.11.006_bib43","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.tube.2003.09.003","article-title":"Interleukin (IL)-8 (CXCL8) induces cytokine expression and superoxide formation by guinea pig neutrophils infected with Mycobacterium tuberculosis","volume":"84","author":"Lyons","year":"2004","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.tube.2010.11.006_bib44","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4049\/jimmunol.139.1.135","article-title":"B\u00a0cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens","volume":"139","author":"Crawford","year":"1987","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2010.11.006_bib45","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1165\/rcmb.2007-0326OC","article-title":"Cytokine profiles in primary and secondary pulmonary granulomas of guinea pigs with tuberculosis","volume":"38","author":"Ly","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.tube.2010.11.006_bib46","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/j.1462-5822.2006.00854.x","article-title":"Microdissection of the cytokine milieu of pulmonary granulomas from tuberculous guinea pigs","volume":"9","author":"Ly","year":"2007","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.tube.2010.11.006_bib47","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2174\/156652407780598557","article-title":"Th2 cytokines in susceptibility to tuberculosis","volume":"7","author":"Rook","year":"2007","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.tube.2010.11.006_bib48","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1046\/j.1440-1711.2001.01042.x","article-title":"Induction of CD8+ T-lymphocyte responses to a secreted antigen of Mycobacterium tuberculosis by an attenuated vaccinia virus","volume":"79","author":"Feng","year":"2001","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.tube.2010.11.006_bib49","doi-asserted-by":"crossref","first-page":"e1522","DOI":"10.1371\/journal.pone.0001522","article-title":"Ex vivo cytokine mRNA levels correlate with changing clinical status of ethiopian TB patients and their contacts over time","volume":"3","author":"Wassie","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tube.2010.11.006_bib50","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1093\/intimm\/12.12.1733","article-title":"Induction of IL-4-dependent, anaphylactic-type and IL-4-independent, non-anaphylactic-type IgG1 antibodies is modulated by adjuvants","volume":"12","author":"Faquim-Mauro","year":"2000","journal-title":"Int Immunol"},{"key":"10.1016\/j.tube.2010.11.006_bib51","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tube.2005.01.001","article-title":"Evaluating the role of tumor necrosis factor-alpha in experimental pulmonary tuberculosis in the guinea pig","volume":"85","author":"Lasco","year":"2005","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.tube.2010.11.006_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.micinf.2009.04.015","article-title":"Neutralization of TNFalpha alters inflammation in guinea pig tuberculous pleuritis","author":"Ly","year":"2009","journal-title":"Microbes Infect"}],"container-title":["Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979210001356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979210001356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T10:49:37Z","timestamp":1685875777000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472979210001356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S1472979210001356"],"URL":"https:\/\/doi.org\/10.1016\/j.tube.2010.11.006","relation":{},"ISSN":["1472-9792"],"issn-type":[{"value":"1472-9792","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}