{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:13:47Z","timestamp":1789910027998,"version":"4.0.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tuberculosis"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.tube.2010.12.006","type":"journal-article","created":{"date-parts":[[2011,1,23]],"date-time":"2011-01-23T09:34:40Z","timestamp":1295775280000},"page":"146-154","source":"Crossref","is-referenced-by-count":114,"title":["Dormant ovoid cells of Mycobacterium tuberculosis are formed in response to gradual external acidification"],"prefix":"10.1016","volume":"91","author":[{"given":"Margarita O.","family":"Shleeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia K.","family":"Kudykina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina N.","family":"Vostroknutova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia E.","family":"Suzina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey L.","family":"Mulyukin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arseny S.","family":"Kaprelyants","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tube.2010.12.006_bib1","doi-asserted-by":"crossref","first-page":"5726","DOI":"10.1056\/NEJM193810132191504","article-title":"The significance of latent forms of tuberculosis","volume":"219","author":"Amberson","year":"1938","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.tube.2010.12.006_bib2","doi-asserted-by":"crossref","first-page":"4195201","DOI":"10.1128\/IAI.69.7.4195-4201.2001","article-title":"Tuberculosis: latency and reactivation","volume":"69","author":"Flynn","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2010.12.006_bib3","doi-asserted-by":"crossref","first-page":"21338","DOI":"10.1016\/S0140-6736(00)03493-0","article-title":"Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection","volume":"356","author":"Hern\u00e1ndez-Pando","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.tube.2010.12.006_bib4","doi-asserted-by":"crossref","first-page":"23340","DOI":"10.1111\/j.1574-695X.2000.tb01528.x","article-title":"Culturability of Mycobacterium tuberculosis cells isolated from murine macrophages: a bacterial growth factor promotes recovery","volume":"29","author":"Biketov","year":"2000","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.tube.2010.12.006_bib5","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1084\/jem.104.5.763","article-title":"The fate of Mycobacterium tuberculosis in mouse tissues as determined by the microbial enumeration technique. II. The conversion of tuberculous infection to the latent state by administration of pyrazinamide and a companion drug","volume":"104","author":"McCune","year":"1956","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.tube.2010.12.006_bib6","doi-asserted-by":"crossref","first-page":"55562","DOI":"10.1016\/0962-8479(95)90534-0","article-title":"The bacterial DNA content of mouse organs in the Cornell model of dormant tuberculosis","volume":"76","author":"de Wit","year":"1995","journal-title":"Tuber Lung Dis"},{"key":"10.1016\/j.tube.2010.12.006_bib7","first-page":"4","article-title":"Mycobacterium tuberculosis from chronic murine infections that grows in liquid but not on solid medium","volume":"17","author":"Dhillon","year":"2004","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.tube.2010.12.006_bib8","first-page":"14754","article-title":"Filterable forms of Mycobacterium tuberculosis","volume":"162","author":"Khomenko","year":"1984","journal-title":"Z\u00a0Erkrank Atm-Org"},{"key":"10.1016\/j.tube.2010.12.006_bib9","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0966-842X(01)02238-7","article-title":"Mycobacterial persistence: adaptation to a changing environment","volume":"9","author":"Honer zu Bentrup","year":"2001","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.tube.2010.12.006_bib10","series-title":"Mycobacterial molecular biology","first-page":"265","article-title":"Mycobacterial dormancy and its relation to persistence","author":"Young","year":"2005"},{"key":"10.1016\/j.tube.2010.12.006_bib11","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1128\/IAI.37.3.1042-1049.1982","article-title":"Glyoxalate metabolism and adaptation of Mycobacterium tuberculosis to survival under anaerobic conditions","volume":"37","author":"Wayne","year":"1982","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2010.12.006_bib12","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1183\/09031936.01.17305370","article-title":"M. tuberculosis: immunology and vaccination","volume":"17","author":"Rook","year":"2001","journal-title":"Eur Respir J"},{"key":"10.1016\/j.tube.2010.12.006_bib13","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1046\/j.1365-2958.1999.01279.x","article-title":"Mycobacterium tuberculosis phagosome","volume":"31","author":"Deretic","year":"1999","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.tube.2010.12.006_bib14","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.8303277","article-title":"Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase","volume":"263","author":"Sturgill-Koszycki","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.tube.2010.12.006_bib15","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.4049\/jimmunol.153.6.2568","article-title":"Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages","volume":"153","author":"Xu","year":"1994","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2010.12.006_bib16","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/jac\/dkg287","article-title":"Susceptibility of Mycobacterium tuberculosis to weak acids","volume":"52","author":"Zhang","year":"2003","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.tube.2010.12.006_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1574-6968.1996.tb08173.x","article-title":"Response of Mycobacterium smegmatis to acid stress","volume":"139","author":"O\u2019Brien","year":"1996","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.tube.2010.12.006_bib18","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1128\/JB.181.7.2044-2049.1999","article-title":"Role of pH and deficient efflux of pyrazinoic acid in the unique susceptibility of Mycobacterium tuberculosis to pyrazinamide","volume":"181","author":"Zhang","year":"1999","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.tube.2010.12.006_bib19","doi-asserted-by":"crossref","first-page":"4518","DOI":"10.1128\/IAI.68.8.4518-4522.2000","article-title":"Growth of Mycobacterium tuberculosis in a defined medium is very restricted by acid pH and Mg 2+ levels","volume":"68","author":"Piddington","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2010.12.006_bib20","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1099\/00221287-147-4-1017","article-title":"Intracellular pH regulation by Mycobacterium smegmatis and Mycobacterium bovis BCG","volume":"147","author":"Rao","year":"2001","journal-title":"Microbiology"},{"key":"10.1016\/j.tube.2010.12.006_bib21","doi-asserted-by":"crossref","first-page":"e6077","DOI":"10.1371\/journal.pone.0006077","article-title":"A\u00a0novel in vitro multiple-stress dormancy model for Mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen","volume":"4","author":"Deb","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2010.12.006_bib22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0091-679X(08)61848-8","article-title":"Mycobacterium: isolation, maintenance, transformation, and mutant selection","volume":"45","author":"Connell","year":"1994","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.tube.2010.12.006_bib23","series-title":"Current protocols in cytometry","article-title":"Approaches to the estimation of microbial viability using flow cytometry","volume":"vol. 11","author":"Davey","year":"1999"},{"key":"10.1016\/j.tube.2010.12.006_bib24","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1099\/00221287-148-10-2951","article-title":"Intracellular lipophilic inclusions of mycobacteria in vitro and in sputum","volume":"10","author":"Garton","year":"2002","journal-title":"Microbiol"},{"issue":"5","key":"10.1016\/j.tube.2010.12.006_bib25","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1128\/IAI.73.5.3038-3043.2005","article-title":"Mutants of Mycobacterium tuberculosis lacking three of the five rpf-like genes are defective for growth in vivo and for resuscitation in vitro","volume":"73","author":"Downing","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2010.12.006_bib26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF01880621","article-title":"The probability of most probable numbers","volume":"1","author":"de Man","year":"1975","journal-title":"Eur J Appl Microbiol"},{"issue":"12","key":"10.1016\/j.tube.2010.12.006_bib27","doi-asserted-by":"crossref","first-page":"e8174","DOI":"10.1371\/journal.pone.0008174","article-title":"Finding of the low molecular weight inhibitors of resuscitation promoting factor ensymatic and resuscitation activity","volume":"4","author":"Demina","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2010.12.006_bib28","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1099\/00221287-148-5-1581","article-title":"Formation and resuscitation of \"non-culturable\" cells of Rhodococcus rhodochrous and Mycobacterium tuberculosis in prolonged stationary phase","volume":"148","author":"Shleeva","year":"2002","journal-title":"Microbiol"},{"key":"10.1016\/j.tube.2010.12.006_bib29","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1099\/mic.0.023028-0","article-title":"Dormant forms of Mycobacterium smegmatis with distinct morphology","volume":"155","author":"Anuchin","year":"2009","journal-title":"Microbiol"},{"key":"10.1016\/j.tube.2010.12.006_bib30","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1134\/S0006297910010098","article-title":"Biochemical and morphological changes in dormant (\"nonculturable\") Mycobacterium smegmatis cells","volume":"75","author":"Salina","year":"2010","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.tube.2010.12.006_bib31","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nm.1795","article-title":"A\u00a0membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis","volume":"14","author":"Vandal","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.tube.2010.12.006_bib32","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1084\/jem.20030846","article-title":"Transcriptional Adaptation of Mycobacterium tuberculosis within macrophages: insights into the phagosomal environment","volume":"198","author":"Schnappinger","year":"2003","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.tube.2010.12.006_bib33","doi-asserted-by":"crossref","first-page":"40174","DOI":"10.1074\/jbc.M406796200","article-title":"The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action","volume":"279","author":"Boshoff","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.tube.2010.12.006_bib34","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1128\/JB.180.4.801-808.1998","article-title":"Mycobacterial stationary phase induced by low oxygen tension: cell wall thickening and localization of the 16-kilodalton alfa-crystallin homolog","volume":"180","author":"Cunningham","year":"1998","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.tube.2010.12.006_bib35","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.1128\/JB.182.22.6358-6365.2000","article-title":"Detection of mRNA transcripts and active transcription in persistent Mycobacterium tuberculosis induced by exposure to rifampin or pyrazinamide","volume":"182","author":"Hu","year":"2000","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.tube.2010.12.006_bib36","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1046\/j.1365-2958.2002.02779.x","article-title":"Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling","volume":"43","author":"Betts","year":"2002","journal-title":"Mol Microbiol"},{"issue":"4","key":"10.1016\/j.tube.2010.12.006_bib37","first-page":"516","article-title":"Ultrastructure of resting cells of some non-spore-forming bacteria","volume":"73","author":"Suzina","year":"2004","journal-title":"Mikrobiologiia"},{"key":"10.1016\/j.tube.2010.12.006_bib38","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1128\/IAI.64.6.2062-2069.1996","article-title":"An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through 2 stages of nonreplicating persistence","volume":"64","author":"Wayne","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2010.12.006_bib39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0065-2911(03)47002-1","article-title":"Adoption of the transiently non-culturable state - a bacterial survival strategy?","volume":"47","author":"Mukamolova","year":"2003","journal-title":"Adv Microb Physiol"},{"key":"10.1016\/j.tube.2010.12.006_bib40","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1099\/mic.0.26893-0","article-title":"Formation of \"non-culturable\" cells of Mycobacterium smegmatis in stationary phase in response to growth under sub-optimal conditions and their Rpf-mediated resuscitation","volume":"150","author":"Shleeva","year":"2004","journal-title":"Microbiol"},{"key":"10.1016\/j.tube.2010.12.006_bib41","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1128\/AEM.60.9.3284-3291.1994","article-title":"Influence of viable cells on the resuscitation of dormant cells in Micrococcus luteus cultures held in an extended stationary phase: the population effect","volume":"60","author":"Votyakova","year":"1994","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.tube.2010.12.006_bib42","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1365-2958.2007.06078.x","article-title":"The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro","volume":"67","author":"Kana","year":"2008","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.tube.2010.12.006_bib43","doi-asserted-by":"crossref","first-page":"7626","DOI":"10.1128\/JB.181.24.7626-7628.1999","article-title":"Spent culture supernatant of Mycobacterium tuberculosis H37Ra improves viability of aged cultures of this strain and allows small inocula to initiate growth","volume":"181","author":"Sun","year":"1999","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.tube.2010.12.006_bib44","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1006\/bbrc.2001.4993","article-title":"Resuscitation of dormant Mycobacterium tuberculosis by phospholipids or specific peptides","volume":"284","author":"Zhang","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.tube.2010.12.006_bib45","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1099\/00221287-26-1-97","article-title":"Spore formation and \u2019dimorphism\u2019 in the mycobacteria","volume":"26","author":"Csillag","year":"1961","journal-title":"J\u00a0Gen Microbiol"},{"key":"10.1016\/j.tube.2010.12.006_bib46","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0962-8479(93)90034-U","article-title":"DNA analysis demonstrates that mycococcus forms are not mycobacteria","volume":"74","author":"de Wit","year":"1993","journal-title":"Tuber Lung Dis"},{"key":"10.1016\/j.tube.2010.12.006_bib47","doi-asserted-by":"crossref","first-page":"10781","DOI":"10.1073\/pnas.0904104106","article-title":"Sporulation in mycobacteria","volume":"106","author":"Ghosh","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.tube.2010.12.006_bib48","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10482-010-9446-0","article-title":"Growth, cell division and sporulation in mycobacteria","volume":"98","author":"Singh","year":"2010","journal-title":"Antonie Leeuwenhoek"},{"key":"10.1016\/j.tube.2010.12.006_bib49","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1073\/pnas.0911299107","article-title":"Do mycobacteria produce endospores?","volume":"107","author":"Traag","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.tube.2010.12.006_bib50","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1084\/jem.123.3.445","article-title":"Microbial persistence. I. The capacity of tubercle bacilli to survive sterilization in mouse tissues","volume":"123","author":"McCune","year":"1966","journal-title":"J\u00a0Exp Med"},{"issue":"4","key":"10.1016\/j.tube.2010.12.006_bib51","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1440-1843.2010.01751.x","article-title":"Treatment of latent tuberculosis infection: an update","volume":"15","author":"Lobue","year":"2010","journal-title":"Respirology"},{"issue":"4","key":"10.1016\/j.tube.2010.12.006_bib52","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ddstr.2004.10.007","article-title":"Tuberculosis \u2013 strategies towards anti-infectives for a chronic disease","volume":"1","author":"Barry","year":"2004","journal-title":"Drug Discov Today Ther Strat"}],"container-title":["Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979210001459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979210001459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T23:25:36Z","timestamp":1685921136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472979210001459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S1472979210001459"],"URL":"https:\/\/doi.org\/10.1016\/j.tube.2010.12.006","relation":{},"ISSN":["1472-9792"],"issn-type":[{"value":"1472-9792","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}