{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T07:48:37Z","timestamp":1777967317127,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tuberculosis"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.tube.2012.11.011","type":"journal-article","created":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T22:48:13Z","timestamp":1357685293000},"page":"130-135","source":"Crossref","is-referenced-by-count":14,"title":["The dual face of central nervous system tuberculosis: A new Janus Bifrons?"],"prefix":"10.1016","volume":"93","author":[{"given":"Brenda","family":"S\u00e1enz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rogelio","family":"Hernandez-Pando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gladis","family":"Fragoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Bottasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graciela","family":"C\u00e1rdenas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tube.2012.11.011_bib1","series-title":"World Health Organization global tuberculosis control: surveillance, planning, financing","year":"2010"},{"key":"10.1016\/j.tube.2012.11.011_bib2","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1001\/archneurol.2011.169","article-title":"The many faces of central nervous system tuberculosis","volume":"68","author":"C\u00e1rdenas","year":"2011","journal-title":"Arch Neurol"},{"key":"10.1016\/j.tube.2012.11.011_bib3","doi-asserted-by":"crossref","first-page":"405310","DOI":"10.1155\/2011\/405310","article-title":"Innate immune recognition of Mycobacterium tuberculosis","volume":"2011","author":"Kleinnijenhuis","year":"2011","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.tube.2012.11.011_bib4","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1126\/science.1123933","article-title":"Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response","volume":"311","author":"Liu","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.tube.2012.11.011_bib5","doi-asserted-by":"crossref","first-page":"347594","DOI":"10.1155\/2011\/347594","article-title":"Innate immune effectors in mycobacterial infection","volume":"2011","author":"Saiga","year":"2011","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.tube.2012.11.011_bib6","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nrmicro2387","article-title":"Evasion of innate immunity by Mycobacterium tuberculosis: is death an exits strategy?","volume":"8","author":"Behar","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.tube.2012.11.011_bib7","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/ni1468","article-title":"Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages","volume":"8","author":"Pathak","year":"2007","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.tube.2012.11.011_bib8","doi-asserted-by":"crossref","first-page":"e6329","DOI":"10.1371\/journal.pone.0006329","article-title":"TLR2-dependent inhibition of macrophage responses to\u00a0IFN-gamma is mediated by distinct, gene-specific mechanisms","volume":"24","author":"Benson","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2012.11.011_bib9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/1471-2180-11-237","article-title":"Mycobacterium tuberculosis infection induces non-apoptotic cell death of human dendritic cells","volume":"11","author":"Ryan","year":"2011","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.tube.2012.11.011_bib10","doi-asserted-by":"crossref","first-page":"10961","DOI":"10.1073\/pnas.0801496105","article-title":"ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodes","volume":"105","author":"Reiley","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.tube.2012.11.011_bib11","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.tube.2010.05.002","article-title":"Specific bacterial genotypes of mycobacterium tuberculosis cause extensive dissemination and brain infection in an experimental model","volume":"90","author":"Hernandez Pando","year":"2010","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.tube.2012.11.011_bib12","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1164\/rccm.200508-1294OC","article-title":"Regulatory T-cells are expanded in blood and disease sites in patients with tuberculosis","volume":"173","author":"Guyot-Revol","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.tube.2012.11.011_bib13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2249.2006.03027.x","article-title":"A\u00a0role for CD4+CD25+T cells in regulation of the immune response during human tuberculosis","volume":"144","author":"Ribeiro-Rodrigues","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.tube.2012.11.011_bib14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.clim.2006.11.009","article-title":"CD4(+)CD25(+)FoxP3(+) regulatory T-cells suppress Mycobacterium tuberculosis immunity in patients with active disease","volume":"123","author":"Chen","year":"2007","journal-title":"Clin Immunol"},{"key":"10.1016\/j.tube.2012.11.011_bib15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/intimm\/dxp126","article-title":"Transient role of CD4+CD25+ regulatory T cells in mycobacterial infection in mice","volume":"22","author":"Ozeki","year":"2010","journal-title":"Int Immunol"},{"key":"10.1016\/j.tube.2012.11.011_bib16","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1084\/jem.20062105","article-title":"Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis","volume":"204","author":"Scott-Browne","year":"2007","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.tube.2012.11.011_bib17","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1365-2249.2009.03908.x","article-title":"Characterization of regulatory T cells identified as CD4(+)CD25(high)CD39(+) in patients with active tuberculosis","volume":"156","author":"Chiacchio","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.tube.2012.11.011_bib18","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.micinf.2007.06.004","article-title":"In\u00a0vitro expansion of CD4+CD25high FoxP3+CD127low\/-regulatory T-cells from peripheral blood lymphocytes of healthy Mycobacterium tuberculosis-infected humans","volume":"9","author":"Hougardy","year":"2007","journal-title":"Microbe Infect"},{"key":"10.1016\/j.tube.2012.11.011_bib19","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1084\/jem.20052056","article-title":"Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens","volume":"203","author":"Suffia","year":"2006","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.tube.2012.11.011_bib20","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev.immunol.021908.132723","article-title":"Regulatory T cells in the control of host\u2013microorganism interactions (*)","volume":"27","author":"Belkaid","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.tube.2012.11.011_bib21","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/ni.1731","article-title":"The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation","volume":"10","author":"Koch","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.tube.2012.11.011_bib22","doi-asserted-by":"crossref","first-page":"7048","DOI":"10.1073\/pnas.0601554103","article-title":"Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells","volume":"103","author":"Liu","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.tube.2012.11.011_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000061055","article-title":"Introduction: immune-endocrine network","volume":"29","author":"Besedovsky","year":"2002","journal-title":"Front Horm Res"},{"key":"10.1016\/j.tube.2012.11.011_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1999.79.1.1","article-title":"Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanism of action","volume":"79","author":"Turnbull","year":"1999","journal-title":"Physiol Rev"},{"key":"10.1016\/j.tube.2012.11.011_bib25","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1365-3083.2007.01962.x","article-title":"The immune-endocrine component in the pathogenesis of tuberculosis","volume":"66","author":"Bottasso","year":"2007","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.tube.2012.11.011_bib26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.bbi.2010.11.006","article-title":"mRNA expression of alpha and beta isoforms of glucocorticoid receptor in peripheral blood mononuclear cells of patients with\u00a0tuberculosis and its relation with components of the immunoendocrine response","volume":"25","author":"D\u2019Attilio","year":"2011","journal-title":"Brain Behav Immunol"},{"key":"10.1016\/j.tube.2012.11.011_bib27","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2174\/1568010054022079","article-title":"Dehydroepiandrosterone sulfate and related steroids: their role in inflammatory, allergic and immunological disorders","volume":"4","author":"Dilloin","year":"2005","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"10.1016\/j.tube.2012.11.011_bib28","doi-asserted-by":"crossref","first-page":"e33061","DOI":"10.1371\/journal.pone.0033061","article-title":"Dynamics of adrenal steroids are related to variations in Th1 and Treg populations during Mycobacterium tuberculosis infection in HIV positive persons","volume":"7","author":"Quiroga","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2012.11.011_bib29","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/08830738060210040801","article-title":"Intractable intracranial tuberculous infection responsive to thalidomide: report of four cases","volume":"21","author":"Schoeman","year":"2006","journal-title":"J\u00a0Child Neurol"},{"key":"10.1016\/j.tube.2012.11.011_bib30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s10096-003-0998-z","article-title":"Risk factors for development of paradoxical response during anti-tuberculous therapy in HIV-negative patients","volume":"22","author":"Cheng","year":"2003","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.tube.2012.11.011_bib31","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.jaci.2006.01.042","article-title":"Decreased CD4+ lymphocytes and innate immune responses in adults with previous extrapulmonary tuberculosis","volume":"117","author":"Antas","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.tube.2012.11.011_bib32","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1086\/322670","article-title":"Human immunodeficiency virus-seronegative adults with extrapulmonary tuberculosis have abnormal innate immune responses","volume":"33","author":"Sterling","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.tube.2012.11.011_bib33","doi-asserted-by":"crossref","first-page":"e96","DOI":"10.1086\/598988","article-title":"Neurologic manifestations of paradoxical tuberculosis associated immune reconstitution inflammatory syndrome: a case series","volume":"48","author":"Pepper","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.tube.2012.11.011_bib34","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/QAI.0b013e31822e0d15","article-title":"Natural Killer cell activation distinguishes Mycobacterium tuberculosis-mediated immune reconstitution syndrome from chronic HIV and HIV\/MTB coinfection","volume":"58","author":"Conradie","year":"2011","journal-title":"J\u00a0Acquir Immune Defic Syndr"},{"key":"10.1016\/j.tube.2012.11.011_bib35","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1097\/QAD.0b013e3283477d67","article-title":"Circulating inflammatory biomarkers can predict and characterize tuberculosis-associated immune reconstitution inflammatory syndrome","volume":"25","author":"Haddow","year":"2011","journal-title":"AIDS"},{"key":"10.1016\/j.tube.2012.11.011_bib36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1128\/CVI.05263-11","article-title":"Increased frequency of regulatory T cells and T lymphocyte activation in persons with previously treated extrapulmonary tuberculosis","volume":"19","author":"de Almeida","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.tube.2012.11.011_bib37","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.1073\/pnas.96.10.5657","article-title":"Tumor necrosis factor alpha is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous system","volume":"96","author":"Tsenova","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.tube.2012.11.011_bib38","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1086\/592695","article-title":"Therapeutic use of infliximab in tuberculosis to control severe paradoxical reaction of the brain and lymph nodes","volume":"47","author":"Blackmore","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.tube.2012.11.011_bib39","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.ccm.2009.08.009","article-title":"Advances in immunotherapy for tuberculosis treatment","volume":"30","author":"Churchyard","year":"2009","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.tube.2012.11.011_bib40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1084\/jem.20061531","article-title":"Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta","volume":"204","author":"Nadkarni","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2012.11.011_bib41","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1167\/iovs.10-5916","article-title":"Induction of regulatory T cells by infliximab in Behcet's disease","volume":"52","author":"Sugita","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.tube.2012.11.011_bib42","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.imbio.2011.07.006","article-title":"Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-\u03b3-producing NK cell and regulatory T cell subsets","volume":"216","author":"Aravena","year":"2011","journal-title":"Immunobiology"},{"key":"10.1016\/j.tube.2012.11.011_bib43","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/ibd.21308","article-title":"Therapy with anti-TNF\u03b1 antibody enhances number and function of Foxp3(+) regulatory T cells in inflammatory bowel diseases","volume":"17","author":"Boschetti","year":"2011","journal-title":"Inflamm Bowel Dis"}],"container-title":["Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979212002119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979212002119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T02:57:50Z","timestamp":1562554670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472979212002119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S1472979212002119"],"URL":"https:\/\/doi.org\/10.1016\/j.tube.2012.11.011","relation":{},"ISSN":["1472-9792"],"issn-type":[{"value":"1472-9792","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}