{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:01:09Z","timestamp":1767852069788,"version":"3.49.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004695","name":"Inyuvesi Yakwazulu-Natali","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004695","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tuberculosis"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.tube.2016.05.001","type":"journal-article","created":{"date-parts":[[2016,5,7]],"date-time":"2016-05-07T19:34:25Z","timestamp":1462649665000},"page":"92-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["TB\/HIV pleurisy reduces Th17 lymphocyte proportion independent of the cytokine microenvironment"],"prefix":"10.1016","volume":"99","author":[{"given":"Vanessa C.","family":"Korb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisa","family":"Phulukdaree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umesh G.","family":"Lalloo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil A.","family":"Chuturgoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devapregasan","family":"Moodley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tube.2016.05.001_bib1","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1002\/eji.201242619","article-title":"Life, death, and miracles: Th17 cells in the intestine","volume":"42","author":"Huber","year":"2012","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib2","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.1128\/IAI.00403-09","article-title":"Critical role of the interleukin-17\/interleukin-17 receptor axis in regulating host susceptibility to respiratory infection with chlamydia species","volume":"77","author":"Zhou","year":"2009","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2016.05.001_bib3","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.4049\/jimmunol.1002194","article-title":"Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice","volume":"186","author":"Kudva","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib4","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.4049\/jimmunol.0904013","article-title":"Cutting edge: mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate","volume":"184","author":"Schoenen","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib5","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1189\/jlb.1211619","article-title":"IL-17 and IFN-\u03b3 expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease","volume":"91","author":"Jurado","year":"2012","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.tube.2016.05.001_bib6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1710-1492-10-28","article-title":"The changes and its significance of Th17 and Treg cells and related cytokines in patients with tuberculosis pleurisy","volume":"10","author":"Wang","year":"2014","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib7","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.4049\/jimmunol.180.3.1962","article-title":"Distinct, specific IL-17-and IL-22-producing CD4+ T-cell subsets contribute to the human anti-mycobacterial immune response","volume":"180","author":"Scriba","year":"2008","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib8","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1002\/eji.201343680","article-title":"Phosphorylated STAT3 and PD-1 regulate IL-17 production and IL-23 receptor expression in Mycobacterium tuberculosis infection","volume":"44","author":"Bandaru","year":"2014","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pathophys.2014.12.005","article-title":"Tuberculosis in the African continent: a comprehensive review","volume":"22","author":"Chatterjee","year":"2015","journal-title":"Pathophysiol"},{"key":"10.1016\/j.tube.2016.05.001_bib10","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.1128\/JVI.02643-10","article-title":"CD4+ T-cells, including Th17 and cycling subsets, are intact in the gut mucosa of HIV-1-infected long-term nonprogressors","volume":"85","author":"Ciccone","year":"2011","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.tube.2016.05.001_bib11","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12977-015-0164-6","article-title":"Impaired Th17 polarization of phenotypically naive CD4+ T-cells during chronic HIV-1 infection and potential restoration with early ART","volume":"12","author":"DaFonseca","year":"2015","journal-title":"Retrovirology"},{"key":"10.1016\/j.tube.2016.05.001_bib12","doi-asserted-by":"crossref","first-page":"e852418","DOI":"10.1155\/2013\/852418","article-title":"Loss and dysregulation of Th17 cells during HIV infection","volume":"2013","author":"Bixler","year":"2013","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib13","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.mpmed.2012.03.002","article-title":"Clinical tuberculosis","volume":"40","author":"Barker","year":"2012","journal-title":"Medicine"},{"key":"10.1016\/j.tube.2016.05.001_bib14","doi-asserted-by":"crossref","first-page":"e1004603","DOI":"10.1371\/journal.ppat.1004603","article-title":"Variability in tuberculosis granuloma T-cell responses exists, but a balance of pro-and anti-inflammatory cytokines is associated with sterilization","volume":"11","author":"Gideon","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.tube.2016.05.001_bib15","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.tube.2016.05.001_bib16","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/mi.2012.135","article-title":"Interleukin-17-dependent CXCL13 mediates mucosal vaccine-induced immunity against tuberculosis","volume":"6","author":"Gopal","year":"2013","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib17","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nrd3794","article-title":"Targeting IL-17 and Th17 cells in chronic inflammation","volume":"11","author":"Miossec","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.tube.2016.05.001_bib18","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1084\/jem.20100265","article-title":"Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis","volume":"207","author":"Cruz","year":"2010","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.tube.2016.05.001_bib19","doi-asserted-by":"crossref","first-page":"10843","DOI":"10.1128\/JVI.01838-13","article-title":"Preferential HIV infection of CCR6+ Th17 cells is associated with higher levels of virus receptor expression and lack of CCR5 ligands","volume":"87","author":"Alvarez","year":"2013","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.tube.2016.05.001_bib20","doi-asserted-by":"crossref","first-page":"7093","DOI":"10.1128\/JVI.00600-13","article-title":"Suppressed Th17 levels correlate with elevated PIAS3, SHP2, and SOCS3 expression in CD4 T-cells during acute simian immunodeficiency virus infection","volume":"87","author":"Bixler","year":"2013","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.tube.2016.05.001_bib21","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/ni.1610","article-title":"The differentiation of human Th17 cells requires transforming growth factor-\u03b2 and induction of the nuclear receptor ROR-\u03b3t","volume":"9","author":"Manel","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib22","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ni1500","article-title":"The development of inflammatory Th17 cells requires interferon-regulatory factor 4","volume":"8","author":"Br\u00fcstle","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.immuni.2007.11.016","article-title":"T-helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR\u03b1 and ROR\u03b3","volume":"28","author":"Yang","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.tube.2016.05.001_bib24","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1749-6632.1993.tb35912.x","article-title":"TGF-\u03b2 and HIV infection","volume":"685","author":"Lotz","year":"1993","journal-title":"Ann N. Y Acad Sci"},{"key":"10.1016\/j.tube.2016.05.001_bib25","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1097\/COH.0b013e32833ed6f4","article-title":"Biomarkers of immune dysfunction in HIV","volume":"5","author":"Nixon","year":"2010","journal-title":"Curr Opin HIV AIDS"},{"key":"10.1016\/j.tube.2016.05.001_bib26","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1182\/blood-2009-08-236521","article-title":"Regulating human Th17 cells via differential expression of IL-1 receptor","volume":"115","author":"Lee","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.tube.2016.05.001_bib27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1189\/jlb.0809550","article-title":"Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1","volume":"88","author":"van de Veerdonk","year":"2010","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.tube.2016.05.001_bib28","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1186\/2193-1801-2-686","article-title":"Interleukin-6: a potent biomarker of mycobacterial infection","volume":"2","author":"Singh","year":"2013","journal-title":"Springerplus"},{"key":"10.1016\/j.tube.2016.05.001_bib29","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1054\/tuld.1999.0215","article-title":"Increased TNF-\u03b1, IL-1\u03b2 and IL-6 levels in the bronchoalveolar lavage fluid with the upregulation of their mRNA in macrophages lavaged from patients with active pulmonary tuberculosis","volume":"79","author":"Tsao","year":"1999","journal-title":"Tuber Lung Dis"},{"key":"10.1016\/j.tube.2016.05.001_bib30","doi-asserted-by":"crossref","first-page":"e203","DOI":"10.1371\/journal.pmed.0050203","article-title":"Inflammatory and coagulation biomarkers and mortality in patients with HIV infection","volume":"5","author":"Kuller","year":"2008","journal-title":"PLoS Med"},{"key":"10.1016\/j.tube.2016.05.001_bib31","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1136\/thx.2007.092205","article-title":"Gene expression of IL-17 and IL-23 in the lungs of patients with active tuberculosis","volume":"63","author":"Dheda","year":"2008","journal-title":"Thorax"},{"key":"10.1016\/j.tube.2016.05.001_bib32","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.4049\/jimmunol.170.9.4432","article-title":"Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection","volume":"170","author":"Happel","year":"2003","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib33","doi-asserted-by":"crossref","first-page":"4662","DOI":"10.4049\/jimmunol.177.7.4662","article-title":"IL-17 production is dominated by \u03b3\u03b4 T cells rather than CD4 T-cells during Mycobacterium tuberculosis infection","volume":"177","author":"Lockhart","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib34","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/cmi.2008.25","article-title":"Interleukin 17-producing \u03b3\u03b4 T-cells increased in patients with active pulmonary tuberculosis","volume":"5","author":"Peng","year":"2008","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib35","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1084\/jem.20061551","article-title":"Identification of an IL-17\u2013producing NK1. 1\u2212 iNKT cell population involved in airway neutrophilia","volume":"204","author":"Michel","year":"2007","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.tube.2016.05.001_bib36","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.4049\/jimmunol.170.4.2106","article-title":"IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger","volume":"170","author":"Ferretti","year":"2003","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.20072713","article-title":"Lymphoid tissue inducer\u2013like cells are an innate source of IL-17 and IL-22","volume":"206","author":"Takatori","year":"2009","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.tube.2016.05.001_bib38","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.4049\/jimmunol.0801967","article-title":"Genome-wide comparison between IL-17A-and IL-17F-induced effects in human rheumatoid arthritis synoviocytes","volume":"182","author":"Zrioual","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib39","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1097\/QAI.0b013e3182893f96","article-title":"Altered balance between IL-17A- and IL-17F-producing Th17 cells in HIV-infected patients","volume":"63","author":"Salem","year":"2013","journal-title":"J\u00a0Acquir Immune Defic Syndr"},{"key":"10.1016\/j.tube.2016.05.001_bib40","doi-asserted-by":"crossref","first-page":"e745483","DOI":"10.1155\/2012\/745483","article-title":"Role of TNF-\u03b1, IFN-\u03b3, and IL-10 in the development of pulmonary tuberculosis","volume":"2012","author":"Cavalcanti","year":"2012","journal-title":"Pulm Med"},{"key":"10.1016\/j.tube.2016.05.001_bib41","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1136\/ard.2005.042531","article-title":"Immunological control of tuberculosis: role of tumour necrosis factor and more","volume":"64","author":"Stenger","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.tube.2016.05.001_bib42","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1742-4690-10-123","article-title":"HIV-1 Tat protein binds to TLR4-MD2 and signals to induce TNF-\u03b1 and IL-10","volume":"10","author":"Haij","year":"2013","journal-title":"Retrovirology"},{"key":"10.1016\/j.tube.2016.05.001_bib43","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.4049\/jimmunol.177.3.1416","article-title":"Cutting edge: IFN-\u03b3 regulates the induction and expansion of IL-17-producing CD4 T-cells during mycobacterial infection","volume":"177","author":"Cruz","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib44","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.tube.2011.06.009","article-title":"Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis","volume":"91","author":"Matthews","year":"2011","journal-title":"Tuberculosis"},{"key":"10.1016\/j.tube.2016.05.001_bib45","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4049\/jimmunol.178.1.407","article-title":"IL-22 participates in an innate anti-HIV-1 host resistance network through acute-phase protein induction","volume":"178","author":"Miss\u00e9","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib46","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nature14189","article-title":"The biology of innate lymphoid cells","volume":"517","author":"Artis","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.tube.2016.05.001_bib47","doi-asserted-by":"crossref","first-page":"e57379","DOI":"10.1371\/journal.pone.0057379","article-title":"IL-22 is mainly produced by IFN-\u00e3 secreting cells but is dispensable for host protection against Mycobacterium tuberculosis infection","volume":"8","author":"Behrends","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2016.05.001_bib48","doi-asserted-by":"crossref","first-page":"5319","DOI":"10.4049\/jimmunol.1101044","article-title":"Dendritic cells activated by IFN-\u03b3\/STAT1 express IL-31 receptor and release proinflammatory mediators upon IL-31 treatment","volume":"188","author":"Horejs-Hoeck","year":"2012","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2016.05.001_bib49","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.cytogfr.2008.08.003","article-title":"Structures and biological functions of IL-31 and IL-31 receptors","volume":"19","author":"Zhang","year":"2008","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.tube.2016.05.001_bib50","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/nm1511","article-title":"Microbial translocation is a cause of systemic immune activation in chronic HIV infection","volume":"12","author":"Brenchley","year":"2006","journal-title":"Nat Med"}],"container-title":["Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979215302717?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979215302717?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T08:40:22Z","timestamp":1761468022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472979215302717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":50,"alternative-id":["S1472979215302717"],"URL":"https:\/\/doi.org\/10.1016\/j.tube.2016.05.001","relation":{},"ISSN":["1472-9792"],"issn-type":[{"value":"1472-9792","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TB\/HIV pleurisy reduces Th17 lymphocyte proportion independent of the cytokine microenvironment","name":"articletitle","label":"Article Title"},{"value":"Tuberculosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tube.2016.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}