{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:32:32Z","timestamp":1769632352672,"version":"3.49.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Key Technologies Research and\u00a0Development Program for Infectious Diseases of China","award":["2013ZX10003007001002"],"award-info":[{"award-number":["2013ZX10003007001002"]}]},{"name":"Key Technologies Research and\u00a0Development Program for Infectious Diseases of China","award":["2013ZX10003001-002"],"award-info":[{"award-number":["2013ZX10003001-002"]}]},{"name":"Key Technologies Research and\u00a0Development Program for Infectious Diseases of China","award":["2013ZX10003008-003"],"award-info":[{"award-number":["2013ZX10003008-003"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400007"],"award-info":[{"award-number":["81400007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301481"],"award-info":[{"award-number":["81301481"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373064"],"award-info":[{"award-number":["81373064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Specialized Project on Scientific Research","award":["201302010"],"award-info":[{"award-number":["201302010"]}]}],"content-domain":{"domain":["tuberculosisjournal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tuberculosis"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.tube.2016.06.001","type":"journal-article","created":{"date-parts":[[2016,6,11]],"date-time":"2016-06-11T12:18:15Z","timestamp":1465647495000},"page":"68-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Multiple cytokine responses in discriminating between active tuberculosis and latent tuberculosis infection"],"prefix":"10.1016","volume":"102","author":[{"given":"Jing","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanyi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyun","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zumo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tube.2016.06.001_bib1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nrmicro2236","article-title":"The spectrum of latent tuberculosis: rethinking the biology and intervention strategies","volume":"7","author":"Barry","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.tube.2016.06.001_bib2","first-page":"1985","article-title":"Evaluation of gamma interferon release assays using Mycobacterium tuberculosis antigens for diagnosis of latent and active tuberculosis in Mycobacterium bovis BCG-vaccinated populations","volume":"17","author":"Zhang","year":"2010"},{"key":"10.1016\/j.tube.2016.06.001_bib3","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1086\/506935","article-title":"Antirheumatic drugs and the risk of tuberculosis","volume":"43","author":"Brassard","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.tube.2016.06.001_bib4","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/art.22768","article-title":"Risk of tuberculosis in patients treated with tumor necrosis factor antagonists due to incomplete prevention of reactivation of latent infection","volume":"57","author":"Gomez-Reino","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.tube.2016.06.001_bib5","doi-asserted-by":"crossref","first-page":"e12365","DOI":"10.1371\/journal.pone.0012365","article-title":"Production of TNF-alpha, IL-12(p40) and IL-17 can discriminate between active TB disease and latent infection in a West African cohort","volume":"5","author":"Sutherland","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2016.06.001_bib6","doi-asserted-by":"crossref","first-page":"e38501","DOI":"10.1371\/journal.pone.0038501","article-title":"Potential of host markers produced by infection phase-dependent antigen-stimulated cells for the diagnosis of tuberculosis in a highly endemic area","volume":"7","author":"Chegou","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2016.06.001_bib7","doi-asserted-by":"crossref","first-page":"e26545","DOI":"10.1371\/journal.pone.0026545","article-title":"Multiple cytokines are released when blood from patients with tuberculosis is stimulated with Mycobacterium tuberculosis antigens","volume":"6","author":"Kellar","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2016.06.001_bib8","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1128\/CMR.00014-11","article-title":"Immunodiagnosis of tuberculosis: a dynamic view of biomarker discovery","volume":"24","author":"Kunnath-Velayudhan","year":"2011","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.tube.2016.06.001_bib9","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nri2960","article-title":"Immunological biomarkers of tuberculosis","volume":"11","author":"Walzl","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.tube.2016.06.001_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2172-10-31","article-title":"High-sensitive and rapid detection of Mycobacterium tuberculosis infection by IFN-gamma release assay among HIV-infected individuals in BCG-vaccinated area","volume":"10","author":"Jiang","year":"2009","journal-title":"BMC Immunol"},{"key":"10.1016\/j.tube.2016.06.001_bib11","doi-asserted-by":"crossref","first-page":"e32652","DOI":"10.1371\/journal.pone.0032652","article-title":"Interferon-gamma release assay performance in pulmonary and extrapulmonary tuberculosis","volume":"7","author":"Feng","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2016.06.001_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.humimm.2011.10.003","article-title":"Analysis of microRNA expression profiling identifies miR-155 and miR-155\u2217 as potential diagnostic markers for active tuberculosis: a preliminary study","volume":"73","author":"Wu","year":"2012","journal-title":"Hum Immunol"},{"key":"10.1016\/j.tube.2016.06.001_bib13","doi-asserted-by":"crossref","first-page":"e24290","DOI":"10.1371\/journal.pone.0024290","article-title":"Novel biomarkers distinguishing active tuberculosis from latent infection identified by gene expression profile of peripheral blood mononuclear cells","volume":"6","author":"Lu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2016.06.001_bib14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev.immunol.19.1.93","article-title":"Immunology of tuberculosis","volume":"19","author":"Flynn","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.tube.2016.06.001_bib15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/35095558","article-title":"How can immunology contribute to the control of tuberculosis?","volume":"1","author":"Kaufmann","year":"2001","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.tube.2016.06.001_bib16","first-page":"1112","article-title":"Risk factors for developing tuberculosis: a 12-year follow-up of contacts of tuberculosis cases","volume":"14","author":"Moran-Mendoza","year":"2010","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.tube.2016.06.001_bib17","first-page":"93","article-title":"Risk of active tuberculosis in adult household contacts of smear-positive pulmonary tuberculosis cases","volume":"13","author":"Kilicaslan","year":"2009","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.tube.2016.06.001_bib18","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1183\/09031936.00055508","article-title":"Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of tuberculosis","volume":"32","author":"Ruhwald","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.tube.2016.06.001_bib19","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.tube.2011.02.006","article-title":"Discriminating between latent and active tuberculosis with multiple biomarker responses","volume":"91","author":"Frahm","year":"2011","journal-title":"Tuberculosis"},{"key":"10.1016\/j.tube.2016.06.001_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2466-9-21","article-title":"Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report","volume":"9","author":"Chegou","year":"2009","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.tube.2016.06.001_bib21","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1164\/rccm.201501-0059OC","article-title":"Mycobacteria-specific cytokine responses detect tuberculosis infection and distinguish latent from active tuberculosis","volume":"192","author":"Tebruegge","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.tube.2016.06.001_bib22","doi-asserted-by":"crossref","first-page":"e17813","DOI":"10.1371\/journal.pone.0017813","article-title":"Whole-blood flow-cytometric analysis of antigen-specific CD4 T-cell cytokine profiles distinguishes active tuberculosis from non-active states","volume":"6","author":"Sester","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2016.06.001_bib23","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.humimm.2010.07.006","article-title":"In\u00a0vitro levels of cytokines in response to purified protein derivative (PPD) antigen in a population with high prevalence of pulmonary tuberculosis","volume":"71","author":"Giampietro","year":"2010","journal-title":"Hum Immunol"},{"key":"10.1016\/j.tube.2016.06.001_bib24","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.coi.2011.08.003","article-title":"IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation","volume":"23","author":"Liao","year":"2011","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.tube.2016.06.001_bib25","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1084\/jem.163.5.1162","article-title":"Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis","volume":"163","author":"Toossi","year":"1986","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.tube.2016.06.001_bib26","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.4049\/jimmunol.1101291","article-title":"IL-2 simultaneously expands Foxp3+ T regulatory and T effector cells and confers resistance to severe tuberculosis (TB): implicative Treg-T effector cooperation in immunity to TB","volume":"188","author":"Chen","year":"2012","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2016.06.001_bib27","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1111\/j.1469-0691.2009.03104.x","article-title":"Detection of interleukin-2 in addition to interferon-gamma discriminates active tuberculosis patients, latently infected individuals, and controls","volume":"16","author":"Biselli","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.tube.2016.06.001_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1471-2334-9-99","article-title":"Cytometric detection of antigen-specific IFN-gamma\/IL-2 secreting cells in the diagnosis of tuberculosis","volume":"9","author":"Sargentini","year":"2009","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.tube.2016.06.001_bib29","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1365-2567.2003.01645.x","article-title":"Increased interleukin-10 expression is not responsible for failure of T helper 1 immunity to resolve airborne Mycobacterium tuberculosis infection in mice","volume":"109","author":"Jung","year":"2003","journal-title":"Immunology"},{"key":"10.1016\/j.tube.2016.06.001_bib30","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1006\/clim.1999.4752","article-title":"CD4(+) T cell clones producing both interferon-gamma and interleukin-10 predominate in bronchoalveolar lavages of active pulmonary tuberculosis patients","volume":"92","author":"Gerosa","year":"1999","journal-title":"Clin Immunol"},{"key":"10.1016\/j.tube.2016.06.001_bib31","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1002\/eji.201040455","article-title":"Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection","volume":"40","author":"Caccamo","year":"2010","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.tube.2016.06.001_bib32","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nri1840","article-title":"Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases","volume":"6","author":"Pantaleo","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.tube.2016.06.001_bib33","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1128\/CVI.05013-11","article-title":"Mycobacterium tuberculosis specific T-cell signatures: clinical significance of IL-2\/IFN-gamma ratios","volume":"18","author":"Suter-Riniker","year":"2011","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.tube.2016.06.001_bib34","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.4049\/jimmunol.178.8.5217","article-title":"Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load","volume":"178","author":"Millington","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2016.06.001_bib35","doi-asserted-by":"crossref","first-page":"e51338","DOI":"10.1371\/journal.pone.0051338","article-title":"Evaluation of the diagnostic potential of IP-10 and IL-2 as biomarkers for the diagnosis of active and latent tuberculosis in a BCG-vaccinated population","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2016.06.001_bib36","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1365-3083.2012.02776.x","article-title":"The responses of multiple cytokines following incubation of whole blood from TB patients, latently infected individuals and controls with the TB antigens ESAT-6, CFP-10 and TB7.7","volume":"76","author":"Kim","year":"2012","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.tube.2016.06.001_bib37","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/imr.12269","article-title":"The human immune response to tuberculosis and its treatment: a view from the blood","volume":"264","author":"Cliff","year":"2015","journal-title":"Immunol Rev"}],"container-title":["Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979215302857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979215302857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T16:37:02Z","timestamp":1568047022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472979215302857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":37,"alternative-id":["S1472979215302857"],"URL":"https:\/\/doi.org\/10.1016\/j.tube.2016.06.001","relation":{},"ISSN":["1472-9792"],"issn-type":[{"value":"1472-9792","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple cytokine responses in discriminating between active tuberculosis and latent tuberculosis infection","name":"articletitle","label":"Article Title"},{"value":"Tuberculosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tube.2016.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}