{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T02:57:02Z","timestamp":1771383422976,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,7,2]],"date-time":"2017-07-02T00:00:00Z","timestamp":1498953600000},"content-version":"am","delay-in-days":304,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Grand Challenges in Global Health Initiative (GCGH)","award":["37772"],"award-info":[{"award-number":["37772"]}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Grand Challenges in Global Health Initiative (GCGH)","award":["37772"],"award-info":[{"award-number":["37772"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tuberculosis"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.tube.2016.06.003","type":"journal-article","created":{"date-parts":[[2016,6,18]],"date-time":"2016-06-18T07:51:16Z","timestamp":1466236276000},"page":"25-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Discriminative expression of whole blood genes in HIV patients with latent and active TB in Ethiopia"],"prefix":"10.1016","volume":"100","author":[{"given":"Desta","family":"Kassa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonie","family":"Ran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilco de","family":"Jager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo","family":"van den Broek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Jacobi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muluberhan","family":"Mekonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsehaynesh","family":"Messele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u00eblle C.","family":"Haks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom H.M.","family":"Ottenhoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie","family":"van Baarle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tube.2016.06.003_bib1","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1172\/JCI34614","article-title":"Confronting the scientific obstacles to global control of tuberculosis","volume":"118","author":"Young","year":"2008","journal-title":"J\u00a0Clin Investig"},{"issue":"5","key":"10.1016\/j.tube.2016.06.003_bib2","doi-asserted-by":"crossref","first-page":"e1002607","DOI":"10.1371\/journal.ppat.1002607","article-title":"Vaccines against tuberculosis: where are we and where do we need to go?","volume":"8","author":"Ottenhoff","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.tube.2016.06.003_bib3","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jama.1994.03510330076038","article-title":"Efficacy of BCG vaccine in the prevention of tuberculosis. Met-analyisi of the published literature","volume":"271","author":"Colditz","year":"1994","journal-title":"JAMA"},{"key":"10.1016\/j.tube.2016.06.003_bib4","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev-immunol-032712-095939","article-title":"The immune response in tuberculosis","volume":"31","author":"O'Garra","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.tube.2016.06.003_bib5","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1016\/S0140-6736(10)60359-5","article-title":"Biomarkers and diagnostics for tuberculosis: progress, needs and translation in to practice","volume":"375","author":"Wallis","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.tube.2016.06.003_bib6","doi-asserted-by":"crossref","unstructured":"Gerhard W, Katharina R, Willem H, Thomas JS, and Alimuddin Z. Immunological biomarkers of tuberculosis. Natur Rev Immunol. 200; 11: 343\u2013354","DOI":"10.1038\/nri2960"},{"issue":"10","key":"10.1016\/j.tube.2016.06.003_bib7","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.3748\/wjg.v12.i10.1536","article-title":"Identification of serum proteins discriminating colorectal cancer patients and healthy controls using surface-enhanced laser desorption ionisation-time of flight mass spectrometry","volume":"12","author":"Engwegen","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.tube.2016.06.003_bib8","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00109-007-0157-6","article-title":"Candidate biomarkers for discrimination between infection and disease caused by Mycobacterium tuberculosis","volume":"85","author":"Jacobsen","year":"2007","journal-title":"J\u00a0Mol Med"},{"key":"10.1016\/j.tube.2016.06.003_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/gene.2010.51","article-title":"Human gene expression profiles of susceptibility and resistance in tuberculosis","volume":"12","author":"Maertzdorf","year":"2011","journal-title":"Genes Immun"},{"key":"10.1016\/j.tube.2016.06.003_bib10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/gene.2011.64","article-title":"Identification of biomarkers for tuberculosis disease using a novel dual-color RT-MLPA assay","volume":"13","author":"Joosten","year":"2012","journal-title":"Genes Immun"},{"issue":"7309","key":"10.1016\/j.tube.2016.06.003_bib11","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nature09247","article-title":"An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis","volume":"466","author":"Berry","year":"2010","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.tube.2016.06.003_bib12","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S1473-3099(07)70108-1","article-title":"Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development","volume":"7","author":"Gagneux","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.tube.2016.06.003_bib13","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1128\/CMR.15.2.294-309.2002","article-title":"Innate immunity to Mycobacterium tuberculosis","volume":"15","author":"Van Crevel","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.tube.2016.06.003_bib14","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/S1472-9792(12)70007-0","article-title":"Ten challenges for TB biomarkers","volume":"92S1","author":"Ottenhoff","year":"2012","journal-title":"Tuberculosis"},{"key":"10.1016\/j.tube.2016.06.003_bib15","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ccm.2009.08.008","article-title":"Biomarkers of disease activity, cure, and relapse in tuberculosis","author":"Doherty","year":"2009","journal-title":"Clin Chest Med"},{"issue":"5","key":"10.1016\/j.tube.2016.06.003_bib16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nri2960","article-title":"Immunological biomarkers of tuberculosis","volume":"11","author":"Walzl","year":"2011","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"10.1016\/j.tube.2016.06.003_bib17","doi-asserted-by":"crossref","first-page":"e74080","DOI":"10.1371\/journal.pone.0074080","article-title":"Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa","volume":"8","author":"Sutherland","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2016.06.003_bib18","series-title":"Guidline for clinical and programatic managment of TB, TB\/HIV and Leprosy in Ethiopia","author":"Federal Ministry of Hearlth (FMOH)","year":"2013"},{"key":"10.1016\/j.tube.2016.06.003_bib19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.tube.2003.08.010","article-title":"Immunology of tuberculosis and implications in vaccine development","volume":"4","author":"Flynn","year":"2004","journal-title":"Tuberculosis"},{"key":"10.1016\/j.tube.2016.06.003_bib20","doi-asserted-by":"crossref","first-page":"193923","DOI":"10.1155\/2012\/193923","article-title":"Cellular and humoral mechanisms involved in the control of tuberculosis","volume":"2012","author":"Zuniga","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.tube.2016.06.003_bib21","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1128\/IAI.72.5.2628-2634.2004","article-title":"Down-modulation of lung immune responses by interleukin-10 and transforming growth factor beta (TGF-beta) and analysis of TGF-beta receptors I and II in active tuberculosis","volume":"72","author":"Bonecini-Almeida","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2016.06.003_bib22","first-page":"1485","article-title":"Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia","volume":"12","author":"Buijtels","year":"2008","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.tube.2016.06.003_bib23","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.tube.2008.10.001","article-title":"Hoal EG Investigation of chromosome 17 candidate genes in susceptibility to TB in a South African population","volume":"89","author":"Moller","year":"2009","journal-title":"Tuberc"},{"issue":"1","key":"10.1016\/j.tube.2016.06.003_bib24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/infdis\/jis499","article-title":"Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response","volume":"207","author":"Cliff","year":"2013","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.tube.2016.06.003_bib25","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1086\/313516","article-title":"Spectrum of opportunistic infections and malignancies in patients with human immunodeficiency virus infection in South Korea","volume":"29","author":"Oh","year":"1999","journal-title":"Clin Infect Dis"},{"issue":"4","key":"10.1016\/j.tube.2016.06.003_bib26","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ijid.2007.02.001","article-title":"Correlates for disease progression and prognosis during concurrent HIV\/TB infection: review","volume":"11","author":"Siawaya","year":"2007","journal-title":"Int J Infect Dis"},{"issue":"3","key":"10.1016\/j.tube.2016.06.003_bib27","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.tube.2009.02.003","article-title":"Prophylactic effect of administration of human gamma globulins in a mouse model of tuberculosis","volume":"89","author":"Olivares","year":"2009","journal-title":"Tuberculosis"},{"issue":"5","key":"10.1016\/j.tube.2016.06.003_bib28","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.4049\/jimmunol.180.5.3329","article-title":"Fc gamma receptors regulate immune activation and susceptibility during Mycobacterium tuberculosis infection","volume":"180","author":"Maglione","year":"2008","journal-title":"J\u00a0Immunol"},{"issue":"2","key":"10.1016\/j.tube.2016.06.003_bib29","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nri3582","article-title":"The function of Fc\u03b3 receptors in dendritic cells and macrophages","volume":"14","author":"Guilliams","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.tube.2016.06.003_bib30","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1183\/09031936.00127807","article-title":"High MMP9 activity characterises pleural tuberculosis correlating with granuloma formation","volume":"33","author":"Sheen","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.tube.2016.06.003_bib31","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.4049\/jimmunol.166.6.4223","article-title":"Identification of a matrix-degrading phenotype in human tuberculosis in\u00a0vitro and in\u00a0vivo","volume":"166","author":"Price","year":"2001","journal-title":"J\u00a0Immunol"},{"issue":"4","key":"10.1016\/j.tube.2016.06.003_bib32","doi-asserted-by":"crossref","first-page":"e61002","DOI":"10.1371\/journal.pone.0061002","article-title":"Elucidating novel serum biomarkers associated with pulmonary tuberculosis treatment","volume":"8","author":"De Groote","year":"2013","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.tube.2016.06.003_bib33","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1128\/IAI.02048-05","article-title":"Role for matrix metalloproteinase 9 in granuloma formation during pulmonary Mycobacterium tuberculosis infection","volume":"74","author":"Taylor","year":"2006","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.tube.2016.06.003_bib34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/intimm\/11.1.81","article-title":"Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine","volume":"11","author":"Imai","year":"1999","journal-title":"Int Immunol"},{"key":"10.1016\/j.tube.2016.06.003_bib35","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1086\/422534","article-title":"Association of IL12RB1 polymorphisms with pulmonary tuberculosis in adults in Morocco","volume":"190","author":"Remus","year":"2004","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.tube.2016.06.003_bib36","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3389\/fimmu.2015.00217","article-title":"Regulatory t-cells at the interface between human host and pathogens in infectious diseases and vaccination","volume":"6","author":"Boer","year":"2015","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.tube.2016.06.003_bib37","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/imm.12097","article-title":"Tumour necrosis factor receptors and apoptosis of alveolar macrophages during early infection with attenuated and virulent Mycobacterium bovis","volume":"139","author":"Rodrigues","year":"2013","journal-title":"Immunology"},{"key":"10.1016\/j.tube.2016.06.003_bib38","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1164\/rccm.200601-088OC","article-title":"Polymorphism within the interferon-gamma\/receptor complex is associated with pulmonary tuberculosis","volume":"174","author":"Cooke","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.tube.2016.06.003_bib39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/(SICI)1096-9896(199701)181:1<31::AID-PATH722>3.0.CO;2-G","article-title":"Apoptosis of human monocytes\/macrophages in Mycobacterium tuberculosis infection","volume":"181","author":"Placido","year":"1997","journal-title":"J\u00a0Pathol"},{"issue":"3","key":"10.1016\/j.tube.2016.06.003_bib40","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/mi.2011.3","article-title":"Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis","volume":"4","author":"Behar","year":"2011","journal-title":"Mucosal Immunol"},{"issue":"3","key":"10.1016\/j.tube.2016.06.003_bib41","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1440-1843.2010.01719.x","article-title":"CCL22 is involved in the recruitment of CD4+CD25 high T cells into tuberculous pleural effusions","volume":"15","author":"Wu","year":"2010","journal-title":"Respirology"},{"key":"10.1016\/j.tube.2016.06.003_bib42","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/1521-4141(200001)30:1<204::AID-IMMU204>3.0.CO;2-G","article-title":"Macrophage-derived chemokine production by activated human T cells in\u00a0vitro and in\u00a0vivo: preferential association with the production of type 2 cytokines","volume":"30","author":"Galli","year":"2000","journal-title":"Eur J Immunol"},{"issue":"12","key":"10.1016\/j.tube.2016.06.003_bib43","doi-asserted-by":"crossref","first-page":"8004","DOI":"10.4049\/jimmunol.0901937","article-title":"In a murine tuberculosis model, the absence of homeostatic chemokines delays granuloma formation and protective immunity","volume":"183","author":"Khader","year":"2009","journal-title":"J\u00a0Immunol"},{"issue":"3","key":"10.1016\/j.tube.2016.06.003_bib44","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.chom.2008.08.002","article-title":"Tuberculosis in Africa: learning from pathogenesis for biomarker identification","volume":"4","author":"Kaufmann","year":"2008","journal-title":"Cell Host Microbe"}],"container-title":["Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979216300567?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979216300567?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T08:39:26Z","timestamp":1761467966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472979216300567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":44,"alternative-id":["S1472979216300567"],"URL":"https:\/\/doi.org\/10.1016\/j.tube.2016.06.003","relation":{},"ISSN":["1472-9792"],"issn-type":[{"value":"1472-9792","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discriminative expression of whole blood genes in HIV patients with latent and active TB in Ethiopia","name":"articletitle","label":"Article Title"},{"value":"Tuberculosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tube.2016.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}