{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:44:44Z","timestamp":1787499884101,"version":"build-2736575974"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501359"],"award-info":[{"award-number":["81501359"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671553"],"award-info":[{"award-number":["81671553"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tuberculosis"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.tube.2017.08.009","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T03:31:21Z","timestamp":1503631881000},"page":"95-103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The expressions and roles of different forms of IL-22 in Mycobacterium tuberculosis infection"],"prefix":"10.1016","volume":"107","author":[{"given":"Yuanyuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinfang","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tube.2017.08.009_bib1","author":"WHO"},{"key":"10.1016\/j.tube.2017.08.009_bib2","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nri1704","article-title":"Tuberculosis control in the era of HIV","volume":"5","author":"Nunn","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.tube.2017.08.009_bib3","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.4049\/jimmunol.164.4.1814","article-title":"Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9","volume":"164","author":"Dumoutier","year":"2000","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2017.08.009_bib4","doi-asserted-by":"crossref","first-page":"10144","DOI":"10.1073\/pnas.170291697","article-title":"Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor","volume":"97","author":"Dumoutier","year":"2000","journal-title":"Proc Natl Acad Sci U. S. A"},{"key":"10.1016\/j.tube.2017.08.009_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-381300-8.00001-0","article-title":"Functional biology of the IL-22-IL-22R pathway in regulating immunity and inflammation at barrier surfaces","volume":"107","author":"Sonnenberg","year":"2010","journal-title":"Adv Immunol"},{"key":"10.1016\/j.tube.2017.08.009_bib6","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1084\/jem.20082683","article-title":"STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing","volume":"206","author":"Pickert","year":"2009","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.tube.2017.08.009_bib7","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.immuni.2008.11.003","article-title":"Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease","volume":"29","author":"Zenewicz","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.tube.2017.08.009_bib8","first-page":"597","article-title":"IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation","volume":"118","author":"Ma","year":"2008","journal-title":"J\u00a0Clin Investig"},{"key":"10.1016\/j.tube.2017.08.009_bib9","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nature05505","article-title":"Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis","volume":"445","author":"Zheng","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.tube.2017.08.009_bib10","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/art.24220","article-title":"Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL\/6 mice","volume":"60","author":"Geboes","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.tube.2017.08.009_bib11","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/ni.2025","article-title":"Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22","volume":"12","author":"Sonnenberg","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.tube.2017.08.009_bib12","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nm1720","article-title":"Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens","volume":"14","author":"Zheng","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.tube.2017.08.009_bib13","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nm1710","article-title":"IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia","volume":"14","author":"Aujla","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.tube.2017.08.009_bib14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/mi.2010.22","article-title":"IL-22 defines a novel immune pathway of antifungal resistance","volume":"3","author":"De Luca","year":"2010","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.tube.2017.08.009_bib15","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1086\/592448","article-title":"Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22, MIP-1alpha, CCL27, IP-10, CCR4, CCR5, CXCR3, PD1, PDL2, IL-3, IFN-beta, TIM1, and TLR2 but low antigen-specific cellular responses","volume":"198","author":"Qiu","year":"2008","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.tube.2017.08.009_bib16","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.4049\/jimmunol.180.3.1962","article-title":"Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response","volume":"180","author":"Scriba","year":"2008","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2017.08.009_bib17","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4049\/jimmunol.1004129","article-title":"Membrane-bound IL-22 after de novo production in tuberculosis and anti-Mycobacterium tuberculosis effector function of IL-22+ CD4+ T cells","volume":"187","author":"Zeng","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2017.08.009_bib18","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nm1585","article-title":"TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27\/STAT1","volume":"13","author":"Amadi-Obi","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.tube.2017.08.009_bib19","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.4049\/jimmunol.1301373","article-title":"CD4+ T cells contain early extrapulmonary tuberculosis (TB) dissemination and rapid TB progression and sustain multieffector functions of CD8+ T and CD3- lymphocytes: mechanisms of CD4+ T cell immunity","volume":"192","author":"Yao","year":"2014","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2017.08.009_bib20","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1089\/aid.2012.0028","article-title":"CD4 T cell depletion exacerbates acute Mycobacterium tuberculosis while reactivation of latent infection is dependent on severity of tissue depletion in cynomolgus macaques","volume":"28","author":"Lin","year":"2012","journal-title":"AIDS Res Hum Retroviruses"},{"key":"10.1016\/j.tube.2017.08.009_bib21","doi-asserted-by":"crossref","first-page":"e1000392","DOI":"10.1371\/journal.ppat.1000392","article-title":"A\u00a0critical role for CD8 T cells in a nonhuman primate model of tuberculosis","volume":"5","author":"Chen","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.tube.2017.08.009_bib22","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/S0140-6736(03)13491-5","article-title":"Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene","volume":"361","author":"Rossouw","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.tube.2017.08.009_bib23","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/eji.201243090","article-title":"Lack of Mycobacterium tuberculosis-specific interleukin-17A-producing CD4+ T cells in active disease","volume":"43","author":"Perreau","year":"2013","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.tube.2017.08.009_bib24","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1189\/jlb.1211619","article-title":"IL-17 and IFN-gamma expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease","volume":"91","author":"Jurado","year":"2012","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.tube.2017.08.009_bib25","doi-asserted-by":"crossref","first-page":"6639","DOI":"10.4049\/jimmunol.0902587","article-title":"IL-22 produced by human NK cells inhibits growth of Mycobacterium tuberculosis by enhancing phagolysosomal fusion","volume":"183","author":"Dhiman","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.tube.2017.08.009_bib26","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.immuni.2007.07.023","article-title":"Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation","volume":"27","author":"Zenewicz","year":"2007","journal-title":"Immunity"}],"container-title":["Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979217301452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979217301452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T08:40:07Z","timestamp":1761468007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472979217301452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":26,"alternative-id":["S1472979217301452"],"URL":"https:\/\/doi.org\/10.1016\/j.tube.2017.08.009","relation":{},"ISSN":["1472-9792"],"issn-type":[{"value":"1472-9792","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The expressions and roles of different forms of IL-22 in Mycobacterium tuberculosis infection","name":"articletitle","label":"Article Title"},{"value":"Tuberculosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tube.2017.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}