{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T23:13:29Z","timestamp":1781565209378,"version":"3.54.5"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100008688","name":"CINVESTAV","doi-asserted-by":"publisher","award":["2015-2 1256"],"award-info":[{"award-number":["2015-2 1256"]}],"id":[{"id":"10.13039\/501100008688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Conacyt","doi-asserted-by":"publisher","award":["2015"],"award-info":[{"award-number":["2015"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tuberculosis"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.tube.2018.02.005","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T08:06:02Z","timestamp":1519113962000},"page":"109-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Immunoendocrine abnormalities in the male reproductive system during experimental pulmonary tuberculosis"],"prefix":"10.1016","volume":"109","author":[{"given":"Brenda","family":"Ramos Robles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo A.","family":"Valdez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uriel Ju\u00e1rez","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Marquina Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulce","family":"Mata Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Barrios Payan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Hern\u00e1ndez Pando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta C.","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.tube.2018.02.005_bib1","first-page":"74","article-title":"The tuberculosis pandemic: implications for health in the tropics","volume":"38","author":"Zumla","year":"1999","journal-title":"Trans R Soc Trop Med Hyq"},{"key":"10.1016\/j.tube.2018.02.005_bib2","series-title":"Global tuberculosis report","author":"WHO","year":"2016"},{"key":"10.1016\/j.tube.2018.02.005_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000199","article-title":"Sexual inequality in tuberculosis","volume":"6","author":"Neyrolles","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.tube.2018.02.005_bib4","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/thx.2005.049452","article-title":"Gender differentials of pulmonary tuberculosis transmission and reactivation in an endemic area","volume":"61","author":"Jim\u00e9nez Corona","year":"2006","journal-title":"Thorax"},{"issue":"4","key":"10.1016\/j.tube.2018.02.005_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093831","article-title":"The influence of sex steroid hormones in the immunopathology of experimental pulmonary tuberculosis","volume":"9","author":"Bini","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2018.02.005_bib6","series-title":"Nobil and Neill's physiology of reproduction","first-page":"1149","article-title":"Physiology of the male accessory sex structures: the prostate gland, seminal vesicles and bulbourethral glands'","author":"Risbridger","year":"2006"},{"issue":"9924","key":"10.1016\/j.tube.2018.02.005_bib7","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/S0140-6736(13)61126-5","article-title":"Male hipogonadism","volume":"383","author":"Basaria","year":"2014","journal-title":"Lancet"},{"issue":"876","key":"10.1016\/j.tube.2018.02.005_bib8","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1749-6632.1999.tb07667.x","article-title":"Sex hormones modulated inflammatory mediators produced by macrophages","volume":"22","author":"D'Agostino","year":"1999","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.tube.2018.02.005_bib9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.0141-9838.2004.00710.x","article-title":"Hormonal and immunological mechanisms mediating sex differences in parasite infection","volume":"26","author":"Klein","year":"2004","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.tube.2018.02.005_bib10","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.4049\/jimmunol.167.4.2060","article-title":"Testosterone acts directly on CD4+ T lymphocytes to increase IL-10 production","volume":"167","author":"Liva","year":"2001","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.tube.2018.02.005_bib11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bbi.2006.06.005","article-title":"Endocrine and cytokine responses in humans with pulmonary tuberculosis","volume":"21","author":"del Rey","year":"2007","journal-title":"Brain Behav Immun"},{"issue":"20","key":"10.1016\/j.tube.2018.02.005_bib12","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1056\/NEJM199505183322008","article-title":"The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation","volume":"332","author":"Chrousos","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tube.2018.02.005_bib13","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1210\/edrv-17-1-64","article-title":"Immune-neuro-endocrine interactions: facts and hypotheses","volume":"1","author":"Besedovsky","year":"1996","journal-title":"Endocr Rev"},{"key":"10.1016\/j.tube.2018.02.005_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1999.79.1.1","article-title":"Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action","volume":"79","author":"Turnbull","year":"1999","journal-title":"Physiol Rev"},{"issue":"1","key":"10.1016\/j.tube.2018.02.005_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-0378(02)00060-8","article-title":"Cytokines and the immune-testicular axis","volume":"58","author":"Hedger","year":"2003","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.tube.2018.02.005_bib16","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3389\/fendo.2017.00307","article-title":"Cytokines in male fertility and reproductive pathologies: immunoregulation and beyond","volume":"8","author":"Loveland","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"10.1016\/j.tube.2018.02.005_bib17","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1006\/dbio.1998.9068","article-title":"Sertoli cells of the mouse testis originate from the coelomic epithelium","volume":"203","author":"Karl","year":"1998","journal-title":"Dev Biol"},{"issue":"12","key":"10.1016\/j.tube.2018.02.005_bib18","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/S0960-9822(06)00415-5","article-title":"Male-specific cell migration into the developing gonad","volume":"7","author":"Martineau","year":"1997","journal-title":"Curr Biol"},{"key":"10.1016\/j.tube.2018.02.005_bib19","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1095\/biolreprod.107.066605","article-title":"Functional redundancy of TGF-\u03b2 family type I receptors and receptor-smads in mediating anti-Mullerian hormone-induced Mullerian duct regression in the mouse","volume":"78","author":"Orvis","year":"2008","journal-title":"Biol Reprod"},{"issue":"3","key":"10.1016\/j.tube.2018.02.005_bib20","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/sj.cdd.4400799","article-title":"Developmental regulation of the bcl-2 family during spermatogenesis. Insights into the sterility of bcl-w-\/- male mice","volume":"8","author":"Meehan","year":"2001","journal-title":"Cell Death Differ"},{"issue":"12","key":"10.1016\/j.tube.2018.02.005_bib21","article-title":"Activin stimulates Sertoli cell proliferation in a defined period of rat testis development","volume":"136","author":"Boitani","year":"2011","journal-title":"Mol Phys B Endo Health Dis"},{"key":"10.1016\/j.tube.2018.02.005_bib22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.semcdb.2015.10.029","article-title":"TGF-\u03b2 superfamily signaling in testis formation and early male germline development","volume":"45","author":"Young","year":"2015","journal-title":"Semin Cell Devl Biol"},{"key":"10.1016\/j.tube.2018.02.005_bib23","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1210\/endo.134.5.8156916","article-title":"Interleukin-6 secretion from rat Leydig cells in culture","volume":"134","author":"Boockfor","year":"1994","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.tube.2018.02.005_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/j.1939-4640.1996.tb00585.x","article-title":"Secretion of bioactive interleukine 1 by rat testicular macrophages in vitro","volume":"17","author":"Hayes","year":"1996","journal-title":"J Androl"},{"issue":"Pt 1","key":"10.1016\/j.tube.2018.02.005_bib25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1242\/jcs.113.1.161","article-title":"Stem cell factor protects germ cells from apoptosis in vitro","volume":"113","author":"Yan","year":"2000","journal-title":"J Cell Sci"},{"key":"10.1016\/j.tube.2018.02.005_bib26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0303-7207(01)00554-8","article-title":"Age-dependent stimulation of Leydig cell steroidogenesis by interleukin-1 isoforms","volume":"182","author":"Svechnikov","year":"2001","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.tube.2018.02.005_bib27","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1095\/biolreprod.107.064501","article-title":"Interleukin 1\u03b1 (IL-1A) is a novel regulator of the blood testis barrier in the rat","volume":"78","author":"Sarkar","year":"2008","journal-title":"Biol Reprod"},{"key":"10.1016\/j.tube.2018.02.005_bib28","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cytogfr.2007.04.009","article-title":"Regulation of cell junction dynamics by cytokines in the testis: a molecular and biochemical perspective'","volume":"18","author":"Lui","year":"2007","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.tube.2018.02.005_bib29","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1096\/fj.06-070342","article-title":"Blood testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells","volume":"22","author":"Yan","year":"2008","journal-title":"Faseb J"},{"issue":"8","key":"10.1016\/j.tube.2018.02.005_bib30","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/jemt.20704","article-title":"Cytokines and chemokines in testicular inflammation: a brief review","volume":"72","author":"Guazzone","year":"2009","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.tube.2018.02.005_bib31","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0015-0282(02)03206-5","article-title":"Number, distribution pattern, and identification of macrophages in the testes of infertile men","volume":"78","author":"Frungieri","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.tube.2018.02.005_bib32","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2164\/jandrol.111.012989","article-title":"Immunophysiology and pathology of inflammation in the testis and epididymis","volume":"32","author":"Hedger","year":"2011","journal-title":"J Androl"},{"issue":"1","key":"10.1016\/j.tube.2018.02.005_bib33","first-page":"26","article-title":"Correlation between the kinetics of Th1, Th2 cells and pathology in a murine model of experimental pulmonary tuberculosis","volume":"81","author":"Hern\u00e1ndez-Pando","year":"1996","journal-title":"Immunology"},{"key":"10.1016\/j.tube.2018.02.005_bib34","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0739-7240(94)90017-5","article-title":"The effects of fetal serum and gonadotropins on testosterone production by cultured chick testicular cells","volume":"11","author":"Castro","year":"1994","journal-title":"Domest Anim Endocrinol"},{"issue":"6","key":"10.1016\/j.tube.2018.02.005_bib35","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00436-004-1160-2","article-title":"Reduction in testosterone concentration and its effect on the reproductive output of chronic malaria-infected male mice","volume":"93","author":"Barthelemy","year":"2004","journal-title":"Parasitol Res"},{"key":"10.1016\/j.tube.2018.02.005_bib36","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1111\/j.1365-3156.2006.01692.x","article-title":"Pituitary-gonadal hormones and interleukin patterns in leprosy","volume":"11","author":"Leal","year":"2006","journal-title":"Trop Med Int Health"},{"issue":"2","key":"10.1016\/j.tube.2018.02.005_bib37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijpara.2011.11.009","article-title":"Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parameters","volume":"42","author":"Cardenas","year":"2012","journal-title":"Int J Parasitol"},{"issue":"Suppl 1","key":"10.1016\/j.tube.2018.02.005_bib38","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1016\/S0306-4530(97)00014-0","article-title":"Pathogenic role, in human and murine tuberculosis, of changes in the peripheral metabolism of glucocorticoids and antiglucocorticoids","volume":"22","author":"Rook","year":"1997","journal-title":"Psychoneuroendocrinology"},{"issue":"5","key":"10.1016\/j.tube.2018.02.005_bib39","first-page":"419","article-title":"Adrenal function during tuberculous infection and effects of antituberculosis treatment on endogenous and exogenous steroids","author":"Keven","year":"1998","journal-title":"Int J Tubercul Lung Dis"},{"issue":"1","key":"10.1016\/j.tube.2018.02.005_bib40","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00441-005-0006-2","article-title":"Stress hormone and male reproductive function","volume":"322","author":"Hardy","year":"2005","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.tube.2018.02.005_bib41","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.steroids.2014.05.010","article-title":"Adverse health affects of testosterone deficiency (TD) in men","volume":"88","author":"Traish","year":"2014","journal-title":"Steroids"},{"key":"10.1016\/j.tube.2018.02.005_bib42","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1046\/j.1365-2567.1997.00193.x","article-title":"Analysis of the local kinetics and localization of interleukin 1 alpha, tumor necrosis factor alpha and transforming growth factor beta, during the course of experimental pulmonary tuberculosis","volume":"90","author":"Hern\u00e1ndez Pando","year":"1997","journal-title":"Immunology"},{"key":"10.1016\/j.tube.2018.02.005_bib43","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1002\/cncr.21889","article-title":"Hypogonadism in male patients with cancer","volume":"106","author":"Garcia","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.tube.2018.02.005_bib44","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1749-6632.2002.tb04213.x","article-title":"Influence of cytokines and growth factors on distinct steroidogenic enzymes in vitro: a short tabular data collection","volume":"966","author":"Hermann","year":"2002","journal-title":"Ann NY Acad Sci"},{"issue":"3","key":"10.1016\/j.tube.2018.02.005_bib45","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1152\/physrev.00018.2016","article-title":"Estrogens in male physiology","volume":"97","author":"Cooke","year":"2017","journal-title":"Physiol Rev"},{"issue":"4","key":"10.1016\/j.tube.2018.02.005_bib46","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/j.1939-4640.1989.tb00100.x","article-title":"The effect of tumor necrosis factor on human sperm motility in vitro","volume":"10","author":"Eisermann","year":"1989","journal-title":"J Androl"},{"key":"10.1016\/j.tube.2018.02.005_bib47","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1053\/gast.2001.22158","article-title":"Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin","volume":"120","author":"Asakawa","year":"2001","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.tube.2018.02.005_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054564","article-title":"Gut hormones, appetite suppression and cachexia in patients with pulmonary TB","volume":"8","author":"Chang","year":"2013","journal-title":"PLoS One"}],"container-title":["Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979217303487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979217303487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T10:02:46Z","timestamp":1719828166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472979217303487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":48,"alternative-id":["S1472979217303487"],"URL":"https:\/\/doi.org\/10.1016\/j.tube.2018.02.005","relation":{},"ISSN":["1472-9792"],"issn-type":[{"value":"1472-9792","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunoendocrine abnormalities in the male reproductive system during experimental pulmonary tuberculosis","name":"articletitle","label":"Article Title"},{"value":"Tuberculosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tube.2018.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}