{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T02:11:51Z","timestamp":1768961511383,"version":"3.49.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003069","name":"National Polytechnic Institute","doi-asserted-by":"publisher","award":["20141136"],"award-info":[{"award-number":["20141136"]}],"id":[{"id":"10.13039\/501100003069","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mexican National Commission of Science and Technology","award":["21641\/250395"],"award-info":[{"award-number":["21641\/250395"]}]}],"content-domain":{"domain":["tuberculosisjournal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tuberculosis"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.tube.2018.02.007","type":"journal-article","created":{"date-parts":[[2018,2,25]],"date-time":"2018-02-25T10:29:55Z","timestamp":1519554595000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Experimental animal models of central nervous system tuberculosis: A historical review"],"prefix":"10.1016","volume":"110","author":[{"given":"Carlos","family":"S\u00e1nchez-Garibay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Elena","family":"Hern\u00e1ndez-Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha Lilia","family":"Tena-Suck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Citlaltepetl","family":"Salinas-Lara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tube.2018.02.007_bib1","series-title":"Global tuberculosis control report","author":"WHO World Health Organization","year":"2014"},{"issue":"2","key":"10.1016\/j.tube.2018.02.007_bib2","article-title":"Central nervous system tuberculosis","volume":"5","author":"Leonard","year":"2017","journal-title":"Microbiol Spectr Mar"},{"key":"10.1016\/j.tube.2018.02.007_bib3","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1086\/515327","article-title":"A combination of thalidomide plus antibiotics protects rabbits from mycobacterial meningitis-associated death","volume":"177","author":"Tsenova","year":"1998","journal-title":"J Infect Dis"},{"key":"10.1016\/j.tube.2018.02.007_bib4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1128\/CMR.00042-07","article-title":"Central nervous system tuberculosis: pathogenesis and clinical aspects","volume":"21","author":"Rock","year":"2008","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"10.1016\/j.tube.2018.02.007_bib5","first-page":"116","article-title":"Central nervous system tuberculosis","volume":"11","author":"Cherian","year":"2011","journal-title":"Afr Health Sci"},{"issue":"9","key":"10.1016\/j.tube.2018.02.007_bib6","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.2217\/fmb.12.86","article-title":"Tuberculous meningitis in adults: a review of a decade of developments focusing on prognostic factors for outcome","volume":"7","author":"Brancusi","year":"2012","journal-title":"Future Microbiol."},{"key":"10.1016\/j.tube.2018.02.007_bib7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jmii.2013.06.008","article-title":"Childhood tuberculosis in southern Taiwan, with emphasis on central nervous system complications","volume":"47","author":"Cho","year":"2014","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.tube.2018.02.007_bib8","series-title":"StatPearls","article-title":"Tuberculosis","author":"Adigun","year":"2017"},{"key":"10.1016\/j.tube.2018.02.007_bib9","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2174\/156652409787581655","article-title":"Pathogenesis of central nervous system tuberculosis","volume":"9","author":"Be","year":"2009","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.tube.2018.02.007_bib10","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.tcb.2005.03.009","article-title":"The Trojan horse: survival tactics of pathogenic mycobacteria in macrophages","volume":"15","author":"Nguyen","year":"2005","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.tube.2018.02.007_bib11","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1128\/CMR.16.3.463-496.2003","article-title":"Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence","volume":"16","author":"Smith","year":"2003","journal-title":"Clin Microbiol Rev"},{"issue":"3","key":"10.1016\/j.tube.2018.02.007_bib12","first-page":"4","article-title":"The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis","volume":"28","author":"Caws","year":"2008","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.tube.2018.02.007_bib13","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1212\/WNL.50.6.1827","article-title":"M. tuberculosis molecular variation in CNS infection: evidence for strain-dependent neurovirulence","volume":"50","author":"Arvanitakis","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.tube.2018.02.007_bib14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/47042","article-title":"Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice","volume":"402","author":"Cox","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.tube.2018.02.007_bib15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2567.2008.03004.x","article-title":"Virulence, immunopathology and transmissibility of selected strains of Mycobacterium tuberculosis in a murine model","volume":"128","author":"Marquina-Castillo","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.tube.2018.02.007_bib16","doi-asserted-by":"crossref","first-page":"6740","DOI":"10.4049\/jimmunol.162.11.6740","article-title":"Mycobacterium tuberculosis CDC1551 induces a more vigorous host response in vivo and in vitro, but is not more virulent than other clinical isolates","volume":"162","author":"Manca","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2018.02.007_bib17","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jneumeth.2012.02.015","article-title":"The contribution of a murine CNS-TB model for the understanding of the host\u2013pathogen interactions in the formation of granulomas","volume":"206","author":"Zucchi","year":"2012","journal-title":"J Neuro Sci Methods"},{"key":"10.1016\/j.tube.2018.02.007_bib18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1054\/tuld.1999.0214","article-title":"Growth of a highly virulent strain of Mycobacterium tuberculosis in mice of differing susceptibility to tuberculous challenge","volume":"79","author":"Kelley","year":"1999","journal-title":"Tuber Lung Dis"},{"key":"10.1016\/j.tube.2018.02.007_bib19","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1084\/jem.50.3.365","article-title":"A paralytic disease of Guinea pigs due to the tubercle bacillus","volume":"50","author":"Shope","year":"1929","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2018.02.007_bib20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1084\/jem.56.2.203","article-title":"The role of hypersensitivity in the production of experimental meningitis: experimental meningitis in tuberculous animals","volume":"56","author":"Burn","year":"1932","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2018.02.007_bib21","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1084\/jem.141.2.346","article-title":"Primary demyelination as a nonspecific consequence of a cell-mediated immune reaction","volume":"141","author":"Wisniewski","year":"1975","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2018.02.007_bib22","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/CDLI.10.4.564-572.2003","article-title":"Infection with Mycobacterium bovis BCG diverts traffic of myelin oligodendroglial glycoprotein autoantigen-specific T cells away from the central nervous system and ameliorates experimental autoimmune encephalomyelitis","volume":"10","author":"Sewell","year":"2003","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.tube.2018.02.007_bib23","first-page":"5","article-title":"The pathogenesis of tubercular meningitis","volume":"52","author":"Rich","year":"1933","journal-title":"Bull John Hopkins Hosp"},{"key":"10.1016\/j.tube.2018.02.007_bib24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1084\/jem.86.2.159","article-title":"Infection of mice with mammalian tubercle bacilli grown in tween-albumin liquid medium","volume":"86","author":"Pierce","year":"1947","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2018.02.007_bib25","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jneuroim.2009.05.008","article-title":"Intracerebral Mycobacterium bovis bacilli Calmette-Guerin infection-induced immune responses in the CNS","volume":"213","author":"Lee","year":"2009","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.tube.2018.02.007_bib26","doi-asserted-by":"crossref","first-page":"11695","DOI":"10.1073\/pnas.0601347103","article-title":"Regulation of T cell activation and tolerance by PDL2","volume":"103","author":"Zhang","year":"2006","journal-title":"Proc Natl Acad Sci."},{"key":"10.1016\/j.tube.2018.02.007_bib27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1574-695X.2002.tb00547.x","article-title":"Differential microbial clearance and immunoresponse of BALB\/c (Nramp1 susceptible) and DBA2 (Nramp1 resistant) mice intracerebrally infected with Mycobacterium bovis BCG (BCG)","volume":"32","author":"Mazzolla","year":"2002","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.tube.2018.02.007_bib28","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1086\/511273","article-title":"A new murine model to study the pathogenesis of tuberculous meningitis","volume":"195","author":"van Well","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.tube.2018.02.007_bib29","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1542\/peds.2008-1353","article-title":"Twenty years of pediatric tuberculous meningitis: a retrospective cohort study in the western cape of South Africa","volume":"123","author":"van Well","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.tube.2018.02.007_bib30","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S1473-3099(10)70138-9","article-title":"Tuberculous meningitis: a uniform case definition for use in clinical research","volume":"10","author":"Marais","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.tube.2018.02.007_bib31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1574-695X.2000.tb01528.x","article-title":"Culturability of Mycobacterium tuberculosis cells isolated from murine macrophages: a bacterial growth factor promotes recovery","volume":"29","author":"Biketov","year":"2000","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.tube.2018.02.007_bib32","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1093\/infdis\/jis381","article-title":"Extrapulmonary locations of Mycobacterium tuberculosis DNA during latent infection","volume":"206","author":"Barrios-Pay\u00e1n","year":"2012","journal-title":"J Infect Dis"},{"key":"10.1016\/j.tube.2018.02.007_bib33","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1086\/592447","article-title":"Murine model to study the invasion and survival of Mycobacterium tuberculosis in the central nervoussystem","volume":"198","author":"Be","year":"2008","journal-title":"J Infect Dis"},{"issue":"5","key":"10.1016\/j.tube.2018.02.007_bib34","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.tube.2011.07.003","article-title":"Tuberculosis Strain-dependent CNS dissemination in Guinea pigs after Mycobacterium tuberculosis aerosol challenge","volume":"91","author":"Be","year":"2011","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.tube.2018.02.007_bib35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2180-12-7","article-title":"Role of Mycobacterium tuberculosis PknD in the pathogenesis of central nervous systemtuberculosis","volume":"12","author":"Be","year":"2012","journal-title":"BMC Microbiol"},{"issue":"6","key":"10.1016\/j.tube.2018.02.007_bib36","doi-asserted-by":"crossref","first-page":"e66310","DOI":"10.1371\/journal.pone.0066310","article-title":"Vaccination with recombinant Mycobacterium tuberculosis PknD attenuates bacterial dissemination to the brain in Guinea pigs","volume":"8","author":"Skerry","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2018.02.007_bib37","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.tube.2009.02.003","article-title":"Prophylactic effect of administration of human gamma globulins in a mouse model of tuberculosis","volume":"89","author":"Olivares","year":"2008","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.tube.2018.02.007_bib38","first-page":"176","article-title":"The protective effect of immunoglobulin in murine tuberculosis is dependent on IgG glycosylation","volume":"69","author":"Olivares","year":"2013","journal-title":"PathogDis"},{"issue":"2","key":"10.1016\/j.tube.2018.02.007_bib39","first-page":"9","article-title":"The human antibody response to the surface of Mycobacterium tuberculosis","volume":"11","author":"Perley","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2018.02.007_bib40","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.tube.2010.05.002","article-title":"Specific bacterial genotypes of Mycobacterium tuberculosis cause extensive dissemination and brain infection in an experimental model","volume":"90","author":"Hernandez-Pando","year":"2010","journal-title":"Tuberculosis"},{"key":"10.1016\/j.tube.2018.02.007_bib41","doi-asserted-by":"crossref","first-page":"783698","DOI":"10.1155\/2013\/783698","article-title":"Pediatric tuberculosis in young children in India: a prospective study","volume":"2013","author":"Jain","year":"2013","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.tube.2018.02.007_bib42","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1086\/514155","article-title":"Infection of swine with Mycobacterium bovis as a model of human tuberculosis","volume":"176","author":"Bolin","year":"1997","journal-title":"J Infect Dis"},{"key":"10.1016\/j.tube.2018.02.007_bib43","series-title":"Proceedings of the 26th annual meeting of the American association of veterinary laboratory diagnosticians (Las Vegas)","first-page":"63","article-title":"Swine tuberculosis: histologic similarities of lesions from which Mycobacterium tuberculosis, M. avium complex, or M. bovis was identified","author":"Himes","year":"1983"},{"key":"10.1016\/j.tube.2018.02.007_bib44","first-page":"129","article-title":"Inmunopatologia De La tuberculosis pulmonar experimental","volume":"28","author":"Hern\u00e1ndez Pando","year":"2004","journal-title":"Mensaje Bioqu\u00edmico"},{"issue":"5","key":"10.1016\/j.tube.2018.02.007_bib45","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/glia.22780","article-title":"Immune cell dynamics in the CNS: learning from the zebrafish","volume":"63","author":"Oosterhof","year":"2014","journal-title":"Glia"},{"issue":"3","key":"10.1016\/j.tube.2018.02.007_bib46","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a018580","article-title":"Animal models of tuberculosis: zebrafish","volume":"5","author":"van Leeuwen","year":"2014","journal-title":"Cold Spring Harbor Perspect Med"},{"issue":"5","key":"10.1016\/j.tube.2018.02.007_bib47","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nrg2091","article-title":"Animal models of human disease: zebrafish swim into view","volume":"8","author":"Lieschke","year":"2007","journal-title":"Nat Rev Genet"},{"issue":"11","key":"10.1016\/j.tube.2018.02.007_bib48","doi-asserted-by":"crossref","first-page":"6108","DOI":"10.1128\/IAI.00887-06","article-title":"Mycobacterium marinum infection of adult zebrafish causes caseating granulomatous tuberculosis and is moderated by adaptive immunity","volume":"74","author":"Swaim","year":"2006","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.tube.2018.02.007_bib49","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S1074-7613(02)00475-2","article-title":"Real-time visualization of Mycobacterium-Macrophage interactions leading to initiation of granuloma formation in zebrafish embryos","volume":"17","author":"Davis","year":"2002","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.tube.2018.02.007_bib50","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1128\/IAI.74.4.2392-2401.2006","article-title":"Evaluation of the Mtb72F polyprotein vaccine in a rabbit model of tuberculous meningitis","volume":"74","author":"Tsenova","year":"2006","journal-title":"Infect Immun"},{"issue":"28","key":"10.1016\/j.tube.2018.02.007_bib51","doi-asserted-by":"crossref","first-page":"5126","DOI":"10.1016\/j.vaccine.2006.11.024","article-title":"BCG vaccination confers poor protection against M. tuberculosis HN878-induced central nervous system disease","volume":"25","author":"Tsenova","year":"2007","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.tube.2018.02.007_bib52","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.tube.2013.02.002","article-title":"Modulation of angiogenic factor VEGF by DNA-hsp65 vaccination in a murine CNS tuberculosis model","volume":"93","author":"Zucchi","year":"2013","journal-title":"Tuberculosis"},{"key":"10.1016\/j.tube.2018.02.007_bib53","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.1073\/pnas.96.10.5657","article-title":"Tumor necrosis factor alpha is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous system","volume":"96","author":"Tsenova","year":"1999","journal-title":"ProcNatlAcadSci"},{"key":"10.1016\/j.tube.2018.02.007_bib54","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1128\/AAC.46.6.1887-1895.2002","article-title":"Use of IMiD3, a thalidomide analog, as an adjunct to therapy for experimental tuberculous meningitis","volume":"46","author":"Tsenova","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.tube.2018.02.007_bib55","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1086\/430614","article-title":"Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli","volume":"192","author":"Tsenova","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1016\/j.tube.2018.02.007_bib56","first-page":"357","article-title":"Nanotechnology based drug delivery system(s) for the management of tuberculosis Indian","volume":"44","author":"Pandey","year":"2003","journal-title":"J Exp Biol"},{"issue":"1","key":"10.1016\/j.tube.2018.02.007_bib57","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijantimicag.2017.08.020","article-title":"Clofazimine protects against Mycobacterium tuberculosis dissemination in the central nervous system following aerosol challenge in a murine model","volume":"51","author":"Baijnath","year":"2017","journal-title":"Int J Antimicrob Agents"}],"container-title":["Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979217302196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979217302196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T04:33:04Z","timestamp":1693542784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472979217302196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":57,"alternative-id":["S1472979217302196"],"URL":"https:\/\/doi.org\/10.1016\/j.tube.2018.02.007","relation":{},"ISSN":["1472-9792"],"issn-type":[{"value":"1472-9792","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Experimental animal models of central nervous system tuberculosis: A historical review","name":"articletitle","label":"Article Title"},{"value":"Tuberculosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tube.2018.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}