{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:56:41Z","timestamp":1791946601737,"version":"4.3.4"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100011349","name":"University of Texas at El Paso","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001820","name":"Alice Kleberg Reynolds Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001820","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tuberculosis"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.tube.2019.04.009","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T12:25:51Z","timestamp":1556281551000},"page":"S34-S41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"S","title":["Enhanced delivery of Mycobacterium tuberculosis antigens to antigen presenting cells using RVG peptide"],"prefix":"10.1016","volume":"116","author":[{"given":"Omar","family":"Garnica","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhi","family":"Devasundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramanian","family":"Dhandayuthapani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tube.2019.04.009_bib1","series-title":"Global tuberculosis report 2015","author":"WHO","year":"2016"},{"key":"10.1016\/j.tube.2019.04.009_bib2","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrmicro1211","article-title":"The success and failure of BCG - implications for a novel tuberculosis vaccine","volume":"3","author":"Andersen","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.tube.2019.04.009_bib3","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0140-6736(95)92348-9","article-title":"Variation in protection by BCG: implications of and for heterologous immunity","volume":"346","author":"Fine","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.tube.2019.04.009_bib4","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S1471-4906(01)01865-8","article-title":"TB vaccines: progress and problems","volume":"22","author":"Andersen","year":"2001","journal-title":"Trends Immunol"},{"key":"10.1016\/j.tube.2019.04.009_bib5","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrmicro1703","article-title":"Tuberculosis vaccines - an update","volume":"5","author":"Andersen","year":"2007","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.tube.2019.04.009_bib6","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.copbio.2012.03.007","article-title":"Recombinant live vaccine candidates against tuberculosis","volume":"23","author":"Kaufmann","year":"2012","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.tube.2019.04.009_bib7","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.coi.2010.04.006","article-title":"Novel tuberculosis vaccines on the horizon","volume":"22","author":"Parida","year":"2010","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.tube.2019.04.009_bib8","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1517\/14712598.2014.951630","article-title":"DNA vaccines against tuberculosis","volume":"14","author":"Bruffaerts","year":"2014","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.tube.2019.04.009_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036198","article-title":"The fbpA\/sapM double knock out strain of Mycobacterium tuberculosis is highly attenuated and immunogenic in macrophages","volume":"7","author":"Saikolappan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2019.04.009_bib10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nm.1928","article-title":"Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells","volume":"15","author":"Jagannath","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.tube.2019.04.009_bib11","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a018523","article-title":"Novel vaccination strategies against tuberculosis","volume":"4","author":"Andersen","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.tube.2019.04.009_bib12","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.smim.2013.04.006","article-title":"Tuberculosis vaccines: time to think about the next generation","volume":"25","author":"Kaufmann","year":"2013","journal-title":"Semin Immunol"},{"key":"10.1016\/j.tube.2019.04.009_bib13","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.0818-9641.2004.01271.x","article-title":"Vaccines that facilitate antigen entry into dendritic cells","volume":"82","author":"Gamvrellis","year":"2004","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.tube.2019.04.009_bib14","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1615\/CritRevImmunol.2013008033","article-title":"Therapeutic dendritic cell-based cancer vaccines: the state of the art","volume":"33","author":"Strioga","year":"2013","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.tube.2019.04.009_bib15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2796.2011.02496.x","article-title":"Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity","volume":"271","author":"Trumpfheller","year":"2012","journal-title":"J Intern Med"},{"key":"10.1016\/j.tube.2019.04.009_bib16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.micpath.2012.11.010","article-title":"Dendritic cells and vaccine design for sexually-transmitted diseases","volume":"58","author":"Duluc","year":"2013","journal-title":"Microb Pathog"},{"key":"10.1016\/j.tube.2019.04.009_bib17","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1073\/pnas.0711976105","article-title":"The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine","volume":"105","author":"Trumpfheller","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.tube.2019.04.009_bib18","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1084\/jem.20052005","article-title":"Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine","volume":"203","author":"Trumpfheller","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2019.04.009_bib19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fimmu.2014.00255","article-title":"Dendritic cell-targeted vaccines","volume":"5","author":"Cohn","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.tube.2019.04.009_bib20","doi-asserted-by":"crossref","first-page":"7098","DOI":"10.1016\/j.vaccine.2014.10.036","article-title":"A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human","volume":"32","author":"van Dissel","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.tube.2019.04.009_bib21","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1016\/j.vaccine.2010.02.094","article-title":"Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naive human volunteers","volume":"28","author":"van Dissel","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.tube.2019.04.009_bib22","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1128\/IAI.69.5.2773-2778.2001","article-title":"Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6","volume":"69","author":"Weinrich Olsen","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2019.04.009_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080579","article-title":"ESAT-6 (EsxA) and TB10.4 (EsxH) based vaccines for pre- and post-exposure tuberculosis vaccination","volume":"8","author":"Hoang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2019.04.009_bib24","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.molimm.2016.04.014","article-title":"A novel dendritic cell-targeted lentiviral vector, encoding Ag85A-ESAT6 fusion gene of Mycobacterium tuberculosis, could elicit potent cell-mediated immune responses in mice","volume":"75","author":"Shakouri","year":"2016","journal-title":"Mol Immunol"},{"key":"10.1016\/j.tube.2019.04.009_bib25","doi-asserted-by":"crossref","first-page":"5368","DOI":"10.1128\/IAI.00322-07","article-title":"Effects of DNA- and Mycobacterium bovis BCG-based delivery of the Flt3 ligand on protective immunity to Mycobacterium tuberculosis","volume":"75","author":"Triccas","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2019.04.009_bib26","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1084\/jem.20021598","article-title":"Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance","volume":"196","author":"Bonifaz","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2019.04.009_bib27","doi-asserted-by":"crossref","first-page":"17280","DOI":"10.1073\/pnas.1010263107","article-title":"Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells","volume":"107","author":"Stern","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.tube.2019.04.009_bib28","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.immuni.2004.05.002","article-title":"Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo","volume":"20","author":"Hawiger","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.tube.2019.04.009_bib29","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/13550280590900427","article-title":"Rabies virus receptors","volume":"11","author":"Lafon","year":"2005","journal-title":"J Neurovirol"},{"key":"10.1016\/j.tube.2019.04.009_bib30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nature05901","article-title":"Transvascular delivery of small interfering RNA to the central nervous system","volume":"448","author":"Kumar","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.tube.2019.04.009_bib31","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/1061186X.2016.1223676","article-title":"The potential use of rabies virus glycoprotein-derived peptides to facilitate drug delivery into the central nervous system: a mini review","volume":"25","author":"Huey","year":"2017","journal-title":"J Drug Target"},{"key":"10.1016\/j.tube.2019.04.009_bib32","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1016\/j.biomaterials.2009.02.051","article-title":"Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles","volume":"30","author":"Liu","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.tube.2019.04.009_bib33","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/mt.2010.27","article-title":"Targeted delivery of siRNA to macrophages for anti-inflammatory treatment","volume":"18","author":"Kim","year":"2010","journal-title":"Mol Ther J Am Soc Gene Ther"},{"key":"10.1016\/j.tube.2019.04.009_bib34","doi-asserted-by":"crossref","first-page":"21052","DOI":"10.1073\/pnas.1216195109","article-title":"Human macrophage and dendritic cell-specific silencing of high-mobility group protein B1 ameliorates sepsis in a humanized mouse model","volume":"109","author":"Ye","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.tube.2019.04.009_bib35","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/eji.201445010","article-title":"Targeting DNA vaccines to myeloid cells using a small peptide","volume":"45","author":"Ye","year":"2015","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.tube.2019.04.009_bib36","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1093\/intimm\/dxg115","article-title":"Immunogenicity of Peptide-25 of Ag85B in Th1 development: role of IFN-gamma","volume":"15","author":"Kariyone","year":"2003","journal-title":"Int Immunol"},{"key":"10.1016\/j.tube.2019.04.009_bib37","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3389\/fimmu.2014.00321","article-title":"The immunodominant T-cell epitopes of the mycolyl-transferases of the antigen 85 complex of M. tuberculosis","volume":"5","author":"Huygen","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.tube.2019.04.009_bib38","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1002\/eji.200636128","article-title":"Alteration of epitope recognition pattern in Ag85B and ESAT-6 has a profound influence on vaccine-induced protection against Mycobacterium tuberculosis","volume":"36","author":"Bennekov","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.tube.2019.04.009_bib39","doi-asserted-by":"crossref","first-page":"910","DOI":"10.4049\/jimmunol.167.2.910","article-title":"Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis","volume":"167","author":"Noss","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.tube.2019.04.009_bib40","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1128\/IAI.74.3.1621-1630.2006","article-title":"Role of phagosomes and major histocompatibility complex class II (MHC-II) compartment in MHC-II antigen processing of Mycobacterium tuberculosis in human macrophages","volume":"74","author":"Torres","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.tube.2019.04.009_bib41","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1182\/blood.V90.5.1920","article-title":"Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype","volume":"90","author":"Hilkens","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.tube.2019.04.009_bib42","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1084\/jem.189.3.541","article-title":"Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta 1 and beta 2 chain expression","volume":"189","author":"Braun","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.tube.2019.04.009_bib43","first-page":"1408","article-title":"The prediction of T- and B-combined epitope of Ag85B antigen of Mycobacterium tuberculosis","volume":"9","author":"Zhang","year":"2016","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.tube.2019.04.009_bib44","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/gt.2011.140","article-title":"Mtb32 is a promising tuberculosis antigen for DNA vaccination in pre- and post-exposure mouse models","volume":"19","author":"Ahn","year":"2012","journal-title":"Gene Ther"},{"key":"10.1016\/j.tube.2019.04.009_bib45","series-title":"Pharmacology","author":"Rang","year":"2003"},{"key":"10.1016\/j.tube.2019.04.009_bib46","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev.immunol.021908.132703","article-title":"Cell-mediated immune responses in tuberculosis","volume":"27","author":"Cooper","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.tube.2019.04.009_bib47","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nm.2285","article-title":"A multistage tuberculosis vaccine that confers efficient protection before and after exposure","volume":"17","author":"Aagaard","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.tube.2019.04.009_bib48","series-title":"Report of the consultation on immunotherapeutic interventions for tuberculosis","first-page":"1","author":"WHO","year":"2007"},{"key":"10.1016\/j.tube.2019.04.009_bib49","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.tube.2006.01.024","article-title":"RUTI: a new chance to shorten the treatment of latent tuberculosis infection","volume":"86","author":"Cardona","year":"2006","journal-title":"Tuberculosis"},{"key":"10.1016\/j.tube.2019.04.009_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039215","article-title":"Efficacy of Mycobacterium indicus pranii immunotherapy as an adjunct to chemotherapy for tuberculosis and underlying immune responses in the lung","volume":"7","author":"Gupta","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.tube.2019.04.009_bib51","doi-asserted-by":"crossref","first-page":"6198","DOI":"10.1016\/j.vaccine.2012.07.061","article-title":"Protective efficacy of Mycobacterium indicus pranii against tuberculosis and underlying local lung immune responses in Guinea pig model","volume":"30","author":"Gupta","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.tube.2019.04.009_bib52","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/S0140-6736(02)11141-X","article-title":"Mycobacterium vaccae (SRL172) immunotherapy as an adjunct to standard antituberculosis treatment in HIV-infected adults with pulmonary tuberculosis: a randomised placebo-controlled trial","volume":"360","author":"Mwinga","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.tube.2019.04.009_bib53","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/22326","article-title":"Therapy of tuberculosis in mice by DNA vaccination","volume":"400","author":"Lowrie","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.tube.2019.04.009_bib54","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/gt.2008.13","article-title":"Efficient tuberculosis treatment in mice using chemotherapy and immunotherapy with the combined DNA vaccine encoding Ag85B, MPT-64 and MPT-83","volume":"15","author":"Yu","year":"2008","journal-title":"Gene Ther"}],"container-title":["Tuberculosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979219301489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1472979219301489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T08:43:08Z","timestamp":1761468188000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1472979219301489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":54,"alternative-id":["S1472979219301489"],"URL":"https:\/\/doi.org\/10.1016\/j.tube.2019.04.009","relation":{},"ISSN":["1472-9792"],"issn-type":[{"value":"1472-9792","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced delivery of Mycobacterium tuberculosis antigens to antigen presenting cells using RVG peptide","name":"articletitle","label":"Article Title"},{"value":"Tuberculosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tube.2019.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}