{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:12:21Z","timestamp":1792761141070,"version":"4.5.0"},"reference-count":162,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Veterinary Journal"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.tvjl.2009.04.010","type":"journal-article","created":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T07:19:34Z","timestamp":1252048774000},"page":"146-155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":196,"title":["Pathogenesis of bovine brucellosis"],"prefix":"10.1016","volume":"184","author":[{"given":"Alcina V. Carvalho","family":"Neta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana P.S.","family":"Mol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana N.","family":"Xavier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiane A.","family":"Paix\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey P.","family":"Lage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato L.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tvjl.2009.04.010_bib1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1177\/030098588802500104","article-title":"Bovine ileal dome lymphoepithelial cell: endocytosis and transport of Brucella abortus strain 19","volume":"25","author":"Ackermann","year":"1988","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0378-1135(02)00235-3","article-title":"The pathology of brucellosis reflects the outcome of the battle between the host genome and the Brucella genome","volume":"90","author":"Adams","year":"2002","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib3","doi-asserted-by":"crossref","first-page":"200","DOI":"10.20506\/rst.17.1.1085","article-title":"Genetic resistance to bacterial diseases of animals","volume":"17","author":"Adams","year":"1998","journal-title":"Revue Scientifique et Technique de l\u2019Office International des Epizooties"},{"key":"10.1016\/j.tvjl.2009.04.010_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1017\/S0022172400055182","article-title":"A quantitative comparison of the sensitivity of serological tests for bovine brucellosis to different antibody classes","volume":"76","author":"Allan","year":"1976","journal-title":"Journal of Hygiene"},{"key":"10.1016\/j.tvjl.2009.04.010_bib5","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1128\/IAI.66.3.1008-1016.1998","article-title":"Transposon-derived Brucella abortus rough mutants are attenuated and exhibit reduced intracellular survival","volume":"66","author":"Allen","year":"1998","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/030098588602300301","article-title":"Pathogenesis of placentitis in the goat inoculated with Brucella abortus. I. Gross and histologic lesions","volume":"23","author":"Anderson","year":"1986","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/030098588602300302","article-title":"Pathogenesis of placentitis in the goat inoculated with Brucella abortus. II. Ultrastructural studies","volume":"23","author":"Anderson","year":"1986","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib8","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/ni1202","article-title":"Cyclic beta-1, 2-glucan is a Brucella virulence factor required for intracellular survival","volume":"6","author":"Arellano-Reynoso","year":"2005","journal-title":"Nature Immunology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib9","first-page":"e.7","article-title":"Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection","volume":"18","author":"Barquero-Calvo","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tvjl.2009.04.010_bib10","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1128\/IAI.69.5.3110-3119.2001","article-title":"Stable transfection of the bovine Nramp1 gene into murine RAW264.7 cells: effect on Brucella abortus survival","volume":"69","author":"Barthel","year":"2001","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0034-5288(18)33699-3","article-title":"Quantitative distribution of Brucella antibody amongst immunoglobulin classes in vaccinated and infected cattle","volume":"17","author":"Beh","year":"1974","journal-title":"Research in Veterinary Science"},{"key":"10.1016\/j.tvjl.2009.04.010_bib12","doi-asserted-by":"crossref","first-page":"5916","DOI":"10.1128\/IAI.00931-07","article-title":"Interaction of Brucella suis and Brucella abortus rough strains with human dendritic cells","volume":"75","author":"Billard","year":"2007","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib13","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S1369-5274(00)00165-X","article-title":"Brucellosis: a worldwide zoonosis","volume":"4","author":"Boschiroli","year":"2001","journal-title":"Current Opinion in Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0378-1135(02)00219-5","article-title":"Type IV secretion and Brucella virulence","volume":"90","author":"Boschiroli","year":"2002","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib15","first-page":"483","article-title":"Human exposure to Brucella recovered from a sea mammal","volume":"144","author":"Brew","year":"1999","journal-title":"Veterinary Record"},{"key":"10.1016\/j.tvjl.2009.04.010_bib16","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0378-1135(02)00228-6","article-title":"PCR as a diagnostic tool for brucellosis","volume":"90","author":"Bricker","year":"2002","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2180-3-15","article-title":"Brucella \u2018HOOF-Prints\u2019: strain typing by multi-locus analysis of variable number tandem repeats (VNTRs)","volume":"3","author":"Bricker","year":"2003","journal-title":"BMC Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib18","doi-asserted-by":"crossref","first-page":"4528","DOI":"10.1128\/IAI.69.7.4528-4535.2001","article-title":"Brucella abortus cyclic beta-1, 2-glucan mutants have reduced virulence in mice and are defective in intracellular replication in HeLa cells","volume":"69","author":"Briones","year":"2001","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib19","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.2460\/ajvr.1986.47.06.1258","article-title":"Preliminary evidence for a diagnostic immunoglobulin G1 antibody response among culture-positive cows vaccinated with Brucella abortus strain 19 and challenge exposed with strain 2308","volume":"47","author":"Butler","year":"1986","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2009.04.010_bib20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0165-2427(94)90103-1","article-title":"Mechanism of binding of Brucella abortus to mononuclear phagocytes from cows naturally resistant or susceptible to brucellosis","volume":"41","author":"Campbell","year":"1994","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0165-2427(92)90171-L","article-title":"The long-term culture of bovine monocyte-derived macrophages and their use in the study of intracellular proliferation of Brucella abortus","volume":"34","author":"Campbell","year":"1992","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib22","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0165-2427(90)90039-U","article-title":"Immunopathology of experimental Brucella abortus strain 19 infection of the genitalia of bulls","volume":"24","author":"Campero","year":"1990","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib23","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1128\/IAI.72.1.176-186.2004","article-title":"Role of Toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in mice","volume":"72","author":"Campos","year":"2004","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib24","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1128\/IAI.01554-07","article-title":"Modulation of bovine trophoblastic innate immune response by Brucella abortus","volume":"76","author":"Carvalho Neta","year":"2008","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib25","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1111\/j.1462-5822.2006.00754.x","article-title":"Characterization of SP41, a surface protein of Brucella associated with adherence and invasion of host epithelial cells","volume":"8","author":"Casta\u00f1eda-Rold\u00e1n","year":"2006","journal-title":"Cell Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.resmic.2005.10.002","article-title":"Surviving inside a macrophage: the many ways of Brucella","volume":"157","author":"Celli","year":"2006","journal-title":"Research in Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib27","doi-asserted-by":"crossref","first-page":"8353","DOI":"10.1128\/IAI.73.12.8353-8361.2005","article-title":"Whole-genome analyses of speciation events in pathogenic Brucella","volume":"73","author":"Chain","year":"2005","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib28","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1046\/j.1462-5822.2002.00221.x","article-title":"Activation of Rho and Rab GTPases dissociate Brucella abortus internalization from intracellular trafficking","volume":"4","author":"Chaves-Olarte","year":"2002","journal-title":"Cell Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib29","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.2460\/ajvr.1993.54.10.1591","article-title":"Immune responses and protection against infection and abortion in cattle experimentally vaccinated with mutant strains of Brucella abortus","volume":"54","author":"Cheville","year":"1993","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2009.04.010_bib30","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nm1734","article-title":"Subversion of Toll-like receptor signalling by a unique family of bacterial Toll\/interleukin-1 receptor domain-containing proteins","volume":"14","author":"Cirl","year":"2008","journal-title":"Nature Medicine"},{"key":"10.1016\/j.tvjl.2009.04.010_bib31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1046\/j.1462-5822.2001.00102.x","article-title":"Essential role of the VirB machinery in the maturation of the Brucella abortus-containing vacuole","volume":"3","author":"Comerci","year":"2001","journal-title":"Cell Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib32","doi-asserted-by":"crossref","first-page":"5182","DOI":"10.4049\/jimmunol.178.8.5182","article-title":"MyD88-dependent activation of B220-CD11b+LY-6C+ dendritic cells during Brucella melitensis infection","volume":"178","author":"Copin","year":"2007","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib33","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1128\/iai.56.12.3251-3261.1988","article-title":"Killing of Brucella abortus by bovine serum","volume":"56","author":"Corbeil","year":"1988","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib34","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3201\/eid0302.970219","article-title":"Brucellosis: an overview","volume":"3","author":"Corbel","year":"1997","journal-title":"Emerging Infectious Diseases"},{"key":"10.1016\/j.tvjl.2009.04.010_bib35","series-title":"Animal Brucellosis","first-page":"131","article-title":"Epidemiology and surveillance","author":"Crawford","year":"1990"},{"key":"10.1016\/j.tvjl.2009.04.010_bib36","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1046\/j.1462-5822.2001.00131.x","article-title":"Identification of Brucella spp. genes involved in intracellular trafficking","volume":"3","author":"Delrue","year":"2001","journal-title":"Cell Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib37","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0378-1135(02)00238-9","article-title":"The genome of Brucella melitensis","volume":"90","author":"Delvecchio","year":"2002","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib38","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1073\/pnas.221575398","article-title":"The genome sequence of the facultative intracellular pathogen Brucella melitensis","volume":"99","author":"Delvecchio","year":"2002","journal-title":"Proceedings of the National Academy of Science of the United States of America"},{"key":"10.1016\/j.tvjl.2009.04.010_bib39","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1128\/IAI.72.9.5143-5149.2004","article-title":"Differential requirements for VirB1 and VirB2 during Brucella abortus infection","volume":"72","author":"Den Hartigh","year":"2004","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib40","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1128\/JB.00406-08","article-title":"VirB3 to VirB6 and VirB8 to VirB11, but not VirB7, are essential for mediating persistence of Brucella in the reticuloendothelial system","volume":"190","author":"Den Hartigh","year":"2008","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib41","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1128\/iai.58.7.2320-2328.1990","article-title":"Penetration and intracellular growth of Brucella abortus in non phagocytic cells in vitro","volume":"58","author":"Detilleux","year":"1990","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib42","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1177\/030098589002700503","article-title":"Entry and intracellular localization of Brucella spp. in Vero cells: fluorescence and electron microscopy","volume":"27","author":"Detilleux","year":"1990","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib43","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1093\/intimm\/dxh148","article-title":"Interaction of endotoxins with Toll-like receptor 4 correlates with their endotoxic potential and may explain the proinflammatory effect of Brucella spp. LPS","volume":"16","author":"Due\u00f1as","year":"2004","journal-title":"International Immunology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib44","first-page":"100","article-title":"The effect of Brucella abortus on the bovine udder and its secretion","volume":"4","author":"Emminger","year":"1943","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2009.04.010_bib45","doi-asserted-by":"crossref","first-page":"424","DOI":"10.2460\/ajvr.1984.45.03.424","article-title":"Cellular and humoral responses of Brucella abortus-infected bovine fetuses","volume":"45","author":"Enright","year":"1984","journal-title":"American. Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2009.04.010_bib46","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1177\/104063879700900414","article-title":"Brucella suis biovar 1 in naturally infected cattle: a bacteriological, serological and histological study","volume":"9","author":"Ewalt","year":"1997","journal-title":"Journal of Veterinary Diagnostic Investigation"},{"key":"10.1016\/j.tvjl.2009.04.010_bib47","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1099\/ijs.0.65269-0","article-title":"Brucella ceti sp. Nov. and Brucella pinnipedialis sp. nov. for Brucella strains with cetaceans and seals as their preferred hosts","volume":"57","author":"Foster","year":"2007","journal-title":"International Journal of Systematic and Evolutionary Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib48","series-title":"Bergey\u2019s Manual of Systematic Bacteriology","author":"Garrity","year":"2001"},{"key":"10.1016\/j.tvjl.2009.04.010_bib49","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0378-1135(02)00217-1","article-title":"Brucellosis in the European Union and Norway at the turn of the twenty-first century","volume":"90","author":"Godfroid","year":"2002","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib50","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1286-4579(00)01350-2","article-title":"Immunity and protection against Brucella abortus","volume":"3","author":"Golding","year":"2001","journal-title":"Microbes and Infection"},{"key":"10.1016\/j.tvjl.2009.04.010_bib51","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1177\/030098588602300317","article-title":"Morphologic lesions in Brucella abortus infected ovine fetuses","volume":"23","author":"Gorham","year":"1986","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib52","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0378-1135(02)00214-6","article-title":"Brucella intracellular life: from invasion to intracellular replication","volume":"90","author":"Gorvel","year":"2002","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib53","doi-asserted-by":"crossref","first-page":"44435","DOI":"10.1074\/jbc.M105606200","article-title":"GTPases of the Rho subfamily are required for Brucella abortus internalization in non professional phagocytes: direct activation of CDC42","volume":"276","author":"Guzm\u00e1n-Verri","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.tvjl.2009.04.010_bib54","doi-asserted-by":"crossref","first-page":"12375","DOI":"10.1073\/pnas.192439399","article-title":"The two-component system BvrR\u2013BvrS essential for Brucella abortus virulence regulates the expression of the outer membrane proteins with counterparts in members of the Rizhobiaceae","volume":"99","author":"Guzm\u00e1n-Verri","year":"2002","journal-title":"Proceedings of the National Academy of Science of the United States of America"},{"key":"10.1016\/j.tvjl.2009.04.010_bib55","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1128\/JB.187.8.2715-2726.2005","article-title":"Completions of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis","volume":"187","author":"Halling","year":"2005","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib56","first-page":"179","article-title":"Human brucellosis: epidemiology and clinical manifestations","volume":"50","author":"Hartigan","year":"1997","journal-title":"Irish Veterinary Journal"},{"key":"10.1016\/j.tvjl.2009.04.010_bib57","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.3201\/eid1409.071056","article-title":"Neurobrucellosis in stranded dolphins, Costa Rica","volume":"14","author":"Hern\u00e1ndez-Mora","year":"2008","journal-title":"Emerging Infectious Diseases"},{"key":"10.1016\/j.tvjl.2009.04.010_bib58","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/10408419509113538","article-title":"Contradictory holes for antibody and complement in the interaction of Brucella abortus with its host","volume":"21","author":"Hoffmann","year":"1995","journal-title":"Critical Reviews in Microbiology."},{"key":"10.1016\/j.tvjl.2009.04.010_bib59","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1177\/030098589102800605","article-title":"Brucella abortus-associated meningitis in aborted bovine fetuses","volume":"28","author":"Hong","year":"1991","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib60","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1128\/IAI.68.7.4102-4107.2000","article-title":"Identification of genes required for chronic persistence of Brucella abortus in mice","volume":"68","author":"Hong","year":"2000","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib61","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.4049\/jimmunol.171.3.1441","article-title":"Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent","volume":"171","author":"Huang","year":"2003","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib62","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.4049\/jimmunol.175.6.3964","article-title":"Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering TLR9","volume":"175","author":"Huang","year":"2005","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib63","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1146\/annurev.iy.10.040192.003241","article-title":"The T-cell receptor as multicomponent signalling machine: CD4\/CD8 coreceptors and CD45 in T-cell activation","volume":"10","author":"Janeway","year":"1992","journal-title":"Annual Review of Immunology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib64","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1128\/iai.61.1.124-134.1993","article-title":"Effects of cytokines on intracellular growth of Brucella abortus","volume":"61","author":"Jiang","year":"1993","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib65","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/cimm.1993.1241","article-title":"Macrophage control of Brucella abortus: role of reactive oxygen intermediates and nitric oxide","volume":"151","author":"Jiang","year":"1993","journal-title":"Cellular Immunology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib66","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1128\/IAI.72.4.2429-2433.2004","article-title":"Different responses of macrophages to smooth and rough Brucella spp.: relationship to virulence","volume":"72","author":"Jimenez de Bagues","year":"2004","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib67","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1128\/iai.60.7.3011-3014.1992","article-title":"Survival of virulent and attenuated strains of Brucella abortus in normal and gamma interferon-activated murine peritoneal macrophages","volume":"60","author":"Jones","year":"1992","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib68","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1128\/iai.10.1.282-283.1974","article-title":"Interferon inducing in mice by lipopolysaccharide from Brucella abortus","volume":"10","author":"Keleti","year":"1974","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2144\/04363ST02","article-title":"Annealing control primer system for identification of differentially expressed genes on agarose gels","volume":"36","author":"Kim","year":"2004","journal-title":"Biotechniques"},{"key":"10.1016\/j.tvjl.2009.04.010_bib70","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1128\/CMR.16.1.65-78.2003","article-title":"Molecular host\u2013pathogen interaction in brucellosis: current understanding and future approaches to vaccine development for mice and humans","volume":"6","author":"Ko","year":"2003","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1016\/j.tvjl.2009.04.010_bib71","doi-asserted-by":"crossref","first-page":"7004","DOI":"10.1128\/IAI.70.12.7004-7012.2002","article-title":"Virulence criteria for Brucella abortus strains as determined by interferon regulatory factor 1-deficient mice","volume":"70","author":"Ko","year":"2002","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib72","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0952-7915(99)80003-X","article-title":"The Toll-receptor family and control of innate immunity","volume":"11","author":"Kopp","year":"1999","journal-title":"Current Opinion in Immunology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib74","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1128\/iai.26.1.240-247.1979","article-title":"Enzyme linked immunosorbent assay for bovine immunoglobulin subclass-specific response to Brucella abortus lipopolysaccharides","volume":"26","author":"Lamb","year":"1979","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib75","first-page":"1153","article-title":"Studies on Brucella abortus infection in bulls","volume":"24","author":"Lambert","year":"1963","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2009.04.010_bib76","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mib.2004.12.003","article-title":"Brucella lipopolysaccharide acts as a virulence factor","volume":"8","author":"Lapaque","year":"2005","journal-title":"Current Opinion in Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib77","first-page":"263","article-title":"Molecular detection of Brucella spp: rapid identification of B. abortus biovar 1 using PCR","volume":"26","author":"Leal-Klevezas","year":"1995","journal-title":"Archives of Medical Research"},{"key":"10.1016\/j.tvjl.2009.04.010_bib78","first-page":"275","article-title":"Lung lesions in bovine fetuses aborted by Brucella abortus","volume":"48","author":"L\u00f3pez","year":"1984","journal-title":"Canadian Journal of Comparative Medicine"},{"key":"10.1016\/j.tvjl.2009.04.010_bib79","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0378-1135(02)00218-3","article-title":"Regulation of Brucella virulence by the two-component system BvrR\/BvrS","volume":"90","author":"L\u00f3pez-Go\u00f1i","year":"2002","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib80","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1017\/S0950268807008795","article-title":"Brucella isolated in humans and animals in Latin America from 1968 to 2006","volume":"136","author":"Lucero","year":"2008","journal-title":"Epidemiology and Infection"},{"key":"10.1016\/j.tvjl.2009.04.010_bib81","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.4049\/jimmunol.180.2.1080","article-title":"Central role of MyD88-dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infection","volume":"180","author":"Macedo","year":"2008","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib82","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1439-0388.2007.00690.x","article-title":"Novel variants within the coding regions of the Slc11A1 gene identified in Bos taurus and Bos indicus breeds","volume":"125","author":"Mart\u00ednez","year":"2008","journal-title":"Journal of Animal Breeding and Genetics"},{"key":"10.1016\/j.tvjl.2009.04.010_bib83","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1136\/vr.93.12.336","article-title":"Brucellosis in bull","volume":"93","author":"McCaughey","year":"1973","journal-title":"Veterinary Record"},{"key":"10.1016\/j.tvjl.2009.04.010_bib84","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1128\/JCM.00680-06","article-title":"Characterization of a Brucella sp. strain as a marine-mammal type despite isolation from a patient with spinal osteomyelitis in New Zealand","volume":"44","author":"McDonald","year":"2006","journal-title":"Journal of Clinical Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib85","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1177\/030098588902600609","article-title":"Intracellular localization of Brucella abortus in bovine placenta","volume":"26","author":"Meador","year":"1989","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib86","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.2460\/ajvr.1986.47.10.2147","article-title":"Identification of Brucella abortus in formalin-fixed, paraffin-embedded tissues of cows, goats, and mice with an avidin\u2013biotin\u2013peroxidase complex immunoenzymatic staining technique","volume":"47","author":"Meador","year":"1986","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2009.04.010_bib87","doi-asserted-by":"crossref","first-page":"274","DOI":"10.2460\/ajvr.1988.49.02.274","article-title":"Histopathologic findings in Brucella abortus-infected, pregnant goats","volume":"49","author":"Meador","year":"1988","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2009.04.010_bib88","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1177\/030098588902600501","article-title":"Pathogenesis of Brucella abortus infection of the mammary gland and supramammary lymph node of the goat","volume":"26","author":"Meador","year":"1989","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib89","series-title":"The Prokaryotes","article-title":"The genus Brucella","author":"Moreno","year":"2001"},{"key":"10.1016\/j.tvjl.2009.04.010_bib90","first-page":"69","article-title":"The epidemiology of bovine brucellosis","volume":"24","author":"Nicoletti","year":"1980","journal-title":"Advances in Veterinary Science and Comparative Medicine"},{"key":"10.1016\/j.tvjl.2009.04.010_bib91","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0378-1135(02)00229-8","article-title":"Diagnosis of brucellosis by serology","volume":"90","author":"Nielsen","year":"2002","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib92","article-title":"Bovine Brucellosis. Office International des Epizooties. Manual of Standards for Diagnostic Tests and Vaccines","author":"Nielsen","year":"2004"},{"key":"10.1016\/j.tvjl.2009.04.010_bib93","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0167-5877(84)90063-1","article-title":"Comparative assessment of antibody isotypes to Brucella by primary and secondary binding assays","volume":"2","author":"Nielsen","year":"1984","journal-title":"Preventive Veterinary Medicine"},{"key":"10.1016\/j.tvjl.2009.04.010_bib94","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1046\/j.1365-2958.1999.01569.x","article-title":"A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis","volume":"33","author":"O\u2019Callaghan","year":"1999","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib95","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1002\/eji.1830250922","article-title":"CD8+ type 1 CD44hi CD45Rblo T lymphocytes control intracellular Brucella abortus infection as demonstrated in major histocompatibility complex class I and class II deficient mice","volume":"25","author":"Oliveira","year":"1995","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib96","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1590\/S0100-879X1998000100010","article-title":"The role of T-cell subsets and cytokines in the regulation of intracellular bacterial infection","volume":"31","author":"Oliveira","year":"1998","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"10.1016\/j.tvjl.2009.04.010_bib97","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0378-1135(02)00225-0","article-title":"Molecular and cellular interactions between Brucella abortus antigens and host immune responses","volume":"90","author":"Oliveira","year":"2002","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib98","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1099\/ijs.0.64349-0","article-title":"International Committee on Systematics of Prokaryotes Subcommittee on the taxonomy of Brucella","volume":"56","author":"Osterman","year":"2006","journal-title":"International Journal of Systematic and Evolutionary Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib99","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1046\/j.1365-2567.2000.00024.x","article-title":"Activation of human V\u03b39V\u03b42 T-cells by a Brucella suis non-peptidic fraction impairs bacterial intracellular multiplication in monocytic infected cells","volume":"100","author":"Ottones","year":"2000","journal-title":"Immunology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib100","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.vetimm.2005.07.018","article-title":"Frequency of bovine Nramp1 (Slc11a1) alleles in Holstein and Zebu breeds","volume":"109","author":"Paix\u00e3o","year":"2006","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib101","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1128\/IAI.01855-06","article-title":"NRAMP1 3\u2019UTR polymorphisms are not associated with natural resistance to Brucella abortus in cattle","volume":"75","author":"Paix\u00e3o","year":"2007","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib102","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1473-3099(06)70382-6","article-title":"The new global map of human brucellosis","volume":"6","author":"Pappas","year":"2006","journal-title":"Lancet Infectious Diseases"},{"key":"10.1016\/j.tvjl.2009.04.010_bib103","doi-asserted-by":"crossref","first-page":"13148","DOI":"10.1073\/pnas.192319099","article-title":"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts","author":"Paulsen","year":"2002","journal-title":"Proceedings of the National Academy of Science of the United States of America 99"},{"key":"10.1016\/j.tvjl.2009.04.010_bib104","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/path.1700780211","article-title":"The pathogenesis of experimental brucellosis in the pregnant cow","volume":"78","author":"Payne","year":"1959","journal-title":"Journal of Pathology and Bacteriology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib105","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1128\/IAI.72.1.440-450.2004","article-title":"Brucella abortus rough mutants are cytopathic for macrophages in culture","volume":"72","author":"Pei","year":"2004","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib106","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1128\/IAI.74.5.2667-2675.2006","article-title":"Brucella abortus rough mutants induce macrophage oncosis that requires bacterial protein synthesis and direct interaction with the macrophage","volume":"74","author":"Pei","year":"2006","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib107","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.2460\/ajvr.1989.50.12.2158","article-title":"Protection of mice against Brucella abortus infection by inoculation with monoclonal antibodies recognizing Brucella O-antigen","volume":"50","author":"Phillips","year":"1989","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2009.04.010_bib108","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1128\/IAI.66.5.2387-2392.1998","article-title":"Virulent Brucella abortus prevents lysosome fusion and is distributed within autophagosome-like compartments","volume":"66","author":"Pizarro-Cerd\u00e1","year":"1998","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib109","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1128\/IAI.66.12.5711-5724.1998","article-title":"Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes","volume":"66","author":"Pizarro-Cerd\u00e1","year":"1998","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib110","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.4049\/jimmunol.162.6.3519","article-title":"Modulation of endocytosis in nuclear factor IL6 (-\/-) macrophages is responsible for high susceptibility to intracellular bacterial infection","volume":"162","author":"Pizarro-Cerd\u00e1","year":"1999","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib111","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S1286-4579(00)90368-X","article-title":"Invasion and intracellular trafficking of Brucella abortus in non phagocytic cells","volume":"2","author":"Pizarro-Cerd\u00e1","year":"2000","journal-title":"Review Microbes and Infection"},{"key":"10.1016\/j.tvjl.2009.04.010_bib112","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0378-1135(02)00245-6","article-title":"Brucellosis in Brazil","volume":"90","author":"Poester","year":"2002","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib113","first-page":"13","article-title":"Diagn\u00f3stico da Brucelose Bovina","volume":"47","author":"Poester","year":"2005","journal-title":"Cadernos T\u00e9cnicos de Veterin\u00e1ria e Zootecnia"},{"key":"10.1016\/j.tvjl.2009.04.010_bib114","doi-asserted-by":"crossref","first-page":"5327","DOI":"10.1016\/j.vaccine.2006.04.020","article-title":"Efficacy of strain RB51 vaccine in heifers against experimental brucellosis","volume":"24","author":"Poester","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.tvjl.2009.04.010_bib115","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1128\/IAI.67.8.4041-4047.1999","article-title":"Early acidification of phagosomes containing Brucella suis is essential for intracellular survival in murine macrophages","volume":"67","author":"Porte","year":"1999","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib116","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1128\/IAI.71.3.1481-1490.2003","article-title":"Role of the Brucella suis lipopolysaccharide O antigen in phagosomal genesis and in inhibition of phagosome\u2013lysosome fusion in murine macrophages","volume":"71","author":"Porte","year":"2003","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib117","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-2427(95)05492-8","article-title":"Intracellular survival of Brucella abortus, Mycobacterium bovis BCG, Salmonella Dublin and Salmonella typhimurium in macrophages from cattle genetically resistant to Brucella abortus","volume":"50","author":"Qureshi","year":"1996","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib118","doi-asserted-by":"crossref","first-page":"5040","DOI":"10.1128\/JB.186.15.5040-5051.2004","article-title":"Comparative whole-genome hybridization reveals genomic islands in Brucella species","volume":"186","author":"Rajashekara","year":"2004","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib119","first-page":"132","article-title":"Brucella abortus in bull: a study of twelve naturally-infected cases","volume":"77","author":"Rankin","year":"1965","journal-title":"Veterinary Record"},{"key":"10.1016\/j.tvjl.2009.04.010_bib120","doi-asserted-by":"crossref","first-page":"182","DOI":"10.2460\/javma.1988.192.02.182","article-title":"Bovine brucellosis: an investigation of latency in progeny of culture-positive cows","volume":"192","author":"Ray","year":"1988","journal-title":"Journal of American Veterinary Medical Association"},{"key":"10.1016\/j.tvjl.2009.04.010_bib121","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0378-1135(02)00253-5","article-title":"Epidemiology, zoonotic aspects, vaccination and control\/eradication of brucellosis in India","volume":"90","author":"Renukaradhya","year":"2002","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib122","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1189\/jlb.0103015","article-title":"Smooth and rough lipopolysaccharide phenotypes of Brucella induce different intracellular trafficking and cytokine\/chemokine release in human monocytes","volume":"74","author":"Ritting","year":"2003","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib123","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1073\/pnas.95.2.588","article-title":"A family of human receptors structurally related to Drosophila Toll","volume":"95","author":"Rock","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.tvjl.2009.04.010_bib124","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1751-0813.1989.tb09748.x","article-title":"An Evaluation of three serological tests for antibody to Brucella suis in pigs","volume":"66","author":"Rogers","year":"1989","journal-title":"Australian Veterinary Journal"},{"key":"10.1016\/j.tvjl.2009.04.010_bib125","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1128\/IAI.01896-06","article-title":"Mice lacking components of adaptive immunity show increased Brucella abortus virB mutant colonization","volume":"75","author":"Rol\u00e1n","year":"2007","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib126","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1128\/IAI.00203-08","article-title":"Inactivation of the type IV secretion system reduces the Th1 polarization of the immune response to Brucella abortus infection","volume":"76","author":"Rol\u00e1n","year":"2008","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib127","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1111\/j.1462-5822.2007.00922.x","article-title":"Brucella requires a functional Type IV secretion system to elicit innate immune responses in mice","volume":"9","author":"Roux","year":"2007","journal-title":"Cell Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib128","doi-asserted-by":"crossref","unstructured":"Salcedo, S.P., Maechesini, M.I., Lelouard, H., Fugier, E., Jolly, G., Balor, S., Muller, A., Lapaque, N., Demaria, O., Alexopoulou, L., Comerci, D.J., Ugalde. R.A., Pierre, P., Gorvel, J.P., 2008. Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1. PLoS Pathogens 4 e21.","DOI":"10.1371\/journal.ppat.0040021"},{"key":"10.1016\/j.tvjl.2009.04.010_bib129","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1093\/clind\/15.5.764","article-title":"Impaired activity of natural killer cells in patients with acute brucellosis","author":"Salmeron","year":"1992","journal-title":"Clinical Infectious Diseases 15"},{"key":"10.1016\/j.tvjl.2009.04.010_bib130","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0147-9571(93)90001-L","article-title":"Pathogenesis of abortion of bovine brucellosis","volume":"16","author":"Samartino","year":"1993","journal-title":"Comparative Immunology Microbiology and Infectious Diseases"},{"key":"10.1016\/j.tvjl.2009.04.010_bib131","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0147-9571(95)00018-6","article-title":"Brucella abortus differs in the multiplication within bovine chorioallantoic membrane explants from early and late gestation","volume":"19","author":"Samartino","year":"1996","journal-title":"Comparative Immunology Microbiology and Infectious Diseases"},{"key":"10.1016\/j.tvjl.2009.04.010_bib132","first-page":"229","article-title":"Invasion and replication of Brucella abortus in three different trophoblastic cell lines","volume":"41","author":"Samartino","year":"1994","journal-title":"Zentralblatt fur Veterinarmedizin B"},{"key":"10.1016\/j.tvjl.2009.04.010_bib133","first-page":"207","article-title":"Molecular basis of Brucella pathogenicity an update","volume":"12","author":"Sangari","year":"1996","journal-title":"Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib134","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ijmm.2004.06.029","article-title":"Cell tropism of Salmonella enterica","volume":"294","author":"Santos","year":"2004","journal-title":"International Journal of Medical Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib135","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0093-691X(96)00272-5","article-title":"Erythrophagocytosis in caprine trophoblast","volume":"46","author":"Santos","year":"1996","journal-title":"Theriogenology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib136","first-page":"34","article-title":"Detecci\u00f3n de Brucella abortus (muestra B19) por el complejo inmunoenzim\u00e1tico avidina\u2013biotina\u2013peroxidasa en el test\u00edculo y en el epid\u00eddimo de bovinos inoculados experimentalmente","volume":"6","author":"Santos","year":"1998","journal-title":"Archivos de Reproduccion Animal"},{"key":"10.1016\/j.tvjl.2009.04.010_bib137","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1590\/S0100-879X2003000100002","article-title":"Pathogenesis of Salmonella-induced enteritis: a review","volume":"36","author":"Santos","year":"2003","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"10.1016\/j.tvjl.2009.04.010_bib138","first-page":"401","article-title":"Human brucellosis review","volume":"15","author":"Sauret","year":"2002","journal-title":"The Journal of the American Board of Family Practice"},{"key":"10.1016\/j.tvjl.2009.04.010_bib139","first-page":"429","article-title":"Female genital system","volume":"Vol.3","author":"Schlafer","year":"2007"},{"key":"10.1016\/j.tvjl.2009.04.010_bib140","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1099\/ijs.0.65356-0","article-title":"Brucella microti sp. nov., isolated from the common vole Microtus arvalis","volume":"58","author":"Scholz","year":"2008","journal-title":"International Journal of Systematic and Evolutionary Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib141","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0378-1135(91)90091-S","article-title":"Biological properties of RB51: a stable rough strain of Brucella abortus","volume":"28","author":"Schurig","year":"1991","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib142","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1128\/JB.182.17.4849-4855.2000","article-title":"A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication","volume":"182","author":"Sieira","year":"2000","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib143","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3201\/eid0904.020576","article-title":"Human neurobrucellosis with intracerebral granuloma caused by a marine mammal Brucella spp","volume":"9","author":"Sohn","year":"2003","journal-title":"Emerging Infectious Diseases"},{"key":"10.1016\/j.tvjl.2009.04.010_bib144","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1046\/j.1365-2958.1998.00913.x","article-title":"A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence","volume":"29","author":"Sola-Landa","year":"1998","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib145","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1128\/iai.60.10.4407-4409.1992","article-title":"Effects of gamma interferon and indomethacin in preventing Brucella abortus infections in mice","volume":"60","author":"Stevens","year":"1992","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib146","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1128\/IAI.70.9.4826-4832.2002","article-title":"Vir-B mediated survival of Brucella abortus in mice and macrophages is independent of a functional inducible nitric oxide synthase or macrophage NADPH oxidase in macrophages","volume":"70","author":"Sun","year":"2002","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib147","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/intimm\/dxh186","article-title":"Toll-like receptors in innate immunity","volume":"17","author":"Takeda","year":"2005","journal-title":"International Immunology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib148","first-page":"60","article-title":"Unilateral orchitis in a bull caused by Brucella abortus biotype 1","volume":"53","author":"Trichard","year":"1982","journal-title":"Journal of South African Veterinary Association"},{"key":"10.1016\/j.tvjl.2009.04.010_bib149","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0891-5520(20)30581-X","article-title":"Brucellosis infection","volume":"8","author":"Trujillo","year":"1994","journal-title":"Infectious Disease Clinics of North America"},{"key":"10.1016\/j.tvjl.2009.04.010_bib150","doi-asserted-by":"crossref","first-page":"12503","DOI":"10.1073\/pnas.212508599","article-title":"Comparative genome analysis of the \u03b1-proteobacteria: relationships between plant and animal pathogens and host specificity","volume":"99","author":"Tsolis","year":"2002","journal-title":"Proceedings of the National Academy of Science of the United States of America"},{"key":"10.1016\/j.tvjl.2009.04.010_bib151","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1099\/00207713-35-3-292","article-title":"Brucella, a monospecific genus as shown by deoxyribonucleic acid hybridization","volume":"35","author":"Verger","year":"1985","journal-title":"International Journal of Systematic Bacteriology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib152","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0769-2609(87)90199-2","article-title":"Taxonomy of the genus Brucella","volume":"138","author":"Verger","year":"1987","journal-title":"Annual Institute Pasteur Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib153","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/mpat.2001.0463","article-title":"High levels of nitric oxide production decrease early but increase late survival of Brucella abortus in macrophages","volume":"31","author":"Wang","year":"2001","journal-title":"Microbial Pathology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib154","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.1128\/IAI.70.9.4818-4825.2002","article-title":"Macrophage plasma membrane cholesterol contributes to Brucella abortus infection of mice","volume":"70","author":"Watarai","year":"2002","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib155","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/9018","article-title":"Microtubule growth activates Rac 1 to promote lamelliopodial protrusion in fibroblasts","volume":"1","author":"Waterman-Storer","year":"1999","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib156","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1128\/IAI.73.8.5137-5143.2005","article-title":"MyD88, but not Toll like receptors 4 and 2, is required for efficient clearance of Brucella abortus","volume":"73","author":"Weiss","year":"2005","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib157","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1136\/vr.103.8.149","article-title":"The persistence of Brucella abortus in calves: a retrospective study of heavily infected herds","volume":"103","author":"Wilesmith","year":"1978","journal-title":"Veterinary Record"},{"key":"10.1016\/j.tvjl.2009.04.010_bib158","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0378-1135(02)00224-9","article-title":"Bovine T lymphocyte responses to Brucella abortus","volume":"90","author":"Wyckoff","year":"2002","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2009.04.010_bib159","doi-asserted-by":"crossref","unstructured":"Xavier, M.N., Paix\u00e3o, T.A., Poester, F.P., Lage, A.P., Santos, R.L., in press. Pathology, immunohistochemistry, and bacteriology of tissues and milk of cows and fetuses experimentally infected with Brucella abortus. Journal of Comparative Pathology. doi:10.1016\/j.jcpa.2008.10.004.","DOI":"10.1016\/j.jcpa.2008.10.004"},{"key":"10.1016\/j.tvjl.2009.04.010_bib160","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1093\/clinids\/5.5.821","article-title":"Human brucellosis","volume":"5","author":"Young","year":"1983","journal-title":"Reviews of Infectious Diseases"},{"key":"10.1016\/j.tvjl.2009.04.010_bib161","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1128\/iai.59.5.1790-1794.1991","article-title":"Prophylaxis or treatment of experimental brucellosis with interleukin-1","volume":"59","author":"Zhan","year":"1991","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib162","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1128\/iai.61.7.2841-2847.1993","article-title":"Cytokine response of T-cell subsets from Brucella abortus-infected mice to soluble Brucella proteins","volume":"61","author":"Zhan","year":"1993","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2009.04.010_bib163","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1128\/iai.64.7.2782-2786.1996","article-title":"Tumor necrosis factor alpha and interleukin 12 contribute to resistance to the intracellular bacterium Brucella abortus by different mechanisms","volume":"64","author":"Zhan","year":"1996","journal-title":"Infection and Immunity"}],"container-title":["The Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023309001518?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023309001518?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:25:10Z","timestamp":1761071110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090023309001518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":162,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S1090023309001518"],"URL":"https:\/\/doi.org\/10.1016\/j.tvjl.2009.04.010","relation":{},"ISSN":["1090-0233"],"issn-type":[{"value":"1090-0233","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathogenesis of bovine brucellosis","name":"articletitle","label":"Article Title"},{"value":"The Veterinary Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tvjl.2009.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}