{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T07:07:43Z","timestamp":1786604863853,"version":"build-2736575974"},"reference-count":22,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Veterinary Journal"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.tvjl.2011.07.007","type":"journal-article","created":{"date-parts":[[2011,8,29]],"date-time":"2011-08-29T11:58:39Z","timestamp":1314619119000},"page":"317-322","source":"Crossref","is-referenced-by-count":86,"title":["Continuous intravenous infusion of glucose induces endogenous hyperinsulinaemia and lamellar histopathology in Standardbred horses"],"prefix":"10.1016","volume":"191","author":[{"given":"Melody A.","family":"de Laat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin N.","family":"Sillence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"McGowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Pollitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tvjl.2011.07.007_b0005","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.tvjl.2007.07.003","article-title":"Induction of laminitis by prolonged hyperinsulinaemia in clinically normal ponies","volume":"174","author":"Asplin","year":"2007","journal-title":"The Veterinary Journal"},{"key":"10.1016\/j.tvjl.2011.07.007_b0010","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.2460\/javma.231.9.1365","article-title":"Effect of dietary fructans and dexamethasone administration on the insulin response of ponies predisposed to laminitis","volume":"231","author":"Bailey","year":"2007","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"10.1016\/j.tvjl.2011.07.007_b0015","doi-asserted-by":"crossref","first-page":"E251","DOI":"10.1152\/ajpendo.1996.270.2.E251","article-title":"Effects of prolonged glucose infusion on insulin secretion, clearance, and action in normal subjects","volume":"270","author":"Boden","year":"1996","journal-title":"American Journal of Physiology \u2013 Endocrinology and Metabolism"},{"key":"10.1016\/j.tvjl.2011.07.007_b0020","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2746\/042516408X342975","article-title":"Prediction of incipient pasture-associated laminitis from hyperinsulinaemia, hyperleptinaemia and generalised and localised obesity in a cohort of ponies","volume":"41","author":"Carter","year":"2009","journal-title":"Equine Veterinary Journal"},{"key":"10.1016\/j.tvjl.2011.07.007_b0025","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2746\/042516409X475779","article-title":"Equine laminitis: Induced by 48 h hyperinsulinaemia in Standardbred horses","volume":"42","author":"de Laat","year":"2010","journal-title":"Equine Veterinary Journal"},{"key":"10.1016\/j.tvjl.2011.07.007_b0030","doi-asserted-by":"crossref","unstructured":"de Laat, M.A., van Eps, A.W., McGowan, C.M., Sillence, M.N., Pollitt, C.C., 2011. Equine laminitis: Comparative histopathology 48hours after experimental induction with insulin or alimentary oligofructose in standardbred horses. Journal of Comparative Pathology, in press. doi:10.1016\/j.jcpa.2011.02.001.","DOI":"10.1016\/j.jcpa.2011.02.001"},{"key":"10.1016\/j.tvjl.2011.07.007_b0035","first-page":"E214","article-title":"Glucose clamp technique: A method for quantifying insulin secretion and resistance","volume":"237","author":"DeFronzo","year":"1979","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.tvjl.2011.07.007_b0040","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2746\/042516407X238512","article-title":"Factors affecting clinical assessment of insulin sensitivity in horses","volume":"39","author":"Firshman","year":"2007","journal-title":"Equine Veterinary Journal"},{"key":"10.1016\/j.tvjl.2011.07.007_b0045","first-page":"441","article-title":"Equine laminitis of alimentary origin: An experimental model","volume":"36","author":"Garner","year":"1975","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2011.07.007_b0050","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cveq.2009.01.004","article-title":"Pasture-associated laminitis","volume":"25","author":"Geor","year":"2009","journal-title":"Veterinary Clinics of North America: Equine Practice"},{"key":"10.1016\/j.tvjl.2011.07.007_b0055","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.2042-3306.1983.tb01826.x","article-title":"Relationship between condition score, physical measurements and body-fat percentage in mares","volume":"15","author":"Henneke","year":"1983","journal-title":"Equine Veterinary Journal"},{"key":"10.1016\/j.tvjl.2011.07.007_b0060","doi-asserted-by":"crossref","DOI":"10.1111\/j.1439-0396.2005.00611_9.x","article-title":"Laminitic metabolic profile in genetically predisposed ponies involves exaggerated compensated insulin resistance","volume":"89","author":"Hess","year":"2005","journal-title":"Journal of Animal Physiology and Animal Nutrition"},{"key":"10.1016\/j.tvjl.2011.07.007_b0065","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2460\/ajvr.70.2.186","article-title":"Histologic evaluation of the diversity of epidermal laminae in hooves of horses without clinical signs of laminitis","volume":"70","author":"Kawasako","year":"2009","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2011.07.007_b0070","first-page":"655","article-title":"The graded glucose infusion is comparable to the hyperglycaemic clamp as a tool for measurement of glucose-dependent insulin secretion","volume":"53","author":"Kelley","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.tvjl.2011.07.007_b0075","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cveq.2010.04.009","article-title":"Endocrinopathic laminitis","volume":"26","author":"McGowan","year":"2010","journal-title":"Veterinary Clinics of North America \u2013 Equine Practice"},{"key":"10.1016\/j.tvjl.2011.07.007_b0080","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2746\/0425164044877288","article-title":"Serum insulin concentrations in horses with equine Cushing\u2019s syndrome: Response to a cortisol inhibitor and prognostic value","volume":"36","author":"McGowan","year":"2004","journal-title":"Equine Veterinary Journal"},{"key":"10.1016\/j.tvjl.2011.07.007_b0085","first-page":"115","article-title":"Comparison of 4 assays for serum insulin analysis in the horse","volume":"22","author":"McGowan","year":"2008","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"10.1016\/j.tvjl.2011.07.007_b0090","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.diabres.2007.01.031","article-title":"Impact of mitochondrial ROS production on diabetic vascular complications","volume":"77","author":"Nishikawa","year":"2007","journal-title":"Diabetes Research and Clinical Practice"},{"key":"10.1016\/j.tvjl.2011.07.007_b0095","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.2042-3306.2006.tb05608.x","article-title":"Effects of dietary energy source and physical conditioning on insulin sensitivity and glucose tolerance in Standardbred horses","volume":"38","author":"Pratt","year":"2006","journal-title":"Equine Veterinary Journal"},{"key":"10.1016\/j.tvjl.2011.07.007_b0100","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.2460\/ajvr.2003.64.1260","article-title":"Determination of reference range values indicative of glucose metabolism and insulin resistance by use of glucose clamp techniques in horses and ponies","volume":"64","author":"Rijnen","year":"2003","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2011.07.007_b0105","doi-asserted-by":"crossref","first-page":"2094S","DOI":"10.1093\/jn\/136.7.2094S","article-title":"Insulin resistance in equids: A possible role in laminitis","author":"Treiber","year":"2006","journal-title":"The Journal of Nutrition"},{"key":"10.1016\/j.tvjl.2011.07.007_b0110","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.2460\/javma.228.10.1538","article-title":"Evaluation of genetic and metabolic predispositions and nutritional risk factors for pasture-associated laminitis in ponies","volume":"228","author":"Treiber","year":"2006","journal-title":"Journal of the American Veterinary Medical Association"}],"container-title":["The Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023311002784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023311002784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T15:00:39Z","timestamp":1560524439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090023311002784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S1090023311002784"],"URL":"https:\/\/doi.org\/10.1016\/j.tvjl.2011.07.007","relation":{},"ISSN":["1090-0233"],"issn-type":[{"value":"1090-0233","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}