{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T18:53:56Z","timestamp":1774292036658,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Veterinary Journal"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.tvjl.2012.01.017","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T10:17:28Z","timestamp":1330424248000},"page":"420-425","source":"Crossref","is-referenced-by-count":26,"title":["Involvement of matrix metalloproteinase-2 in medial hypertrophy of pulmonary arterioles in broiler chickens with pulmonary arterial hypertension"],"prefix":"10.1016","volume":"193","author":[{"given":"Xun","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Cheng","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Yong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tvjl.2012.01.017_b0005","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1161\/01.CIR.102.22.2781","article-title":"Primary pulmonary hypertension: A vascular biology and translational research \u201cwork in progress\u201d","volume":"102","author":"Archer","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.tvjl.2012.01.017_b0010","doi-asserted-by":"crossref","first-page":"H1778","DOI":"10.1152\/ajpheart.00494.2002","article-title":"Uniaxial strain upregulates matrix-degrading enzymes produced by human vascular smooth muscle cells","volume":"284","author":"Asanuma","year":"2003","journal-title":"American Journal of Physiology Heart and Circulatory Physiology"},{"key":"10.1016\/j.tvjl.2012.01.017_b0015","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.atherosclerosis.2007.10.011","article-title":"Metalloproteinase inhibition ameliorates hypertension and prevents vascular dysfunction and remodeling in renovascular hypertensive rats","volume":"198","author":"Castro","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.tvjl.2012.01.017_b0020","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.phrs.2011.04.002","article-title":"Matrix metalloproteinases: Targets for doxycycline to prevent the vascular alterations of hypertension","volume":"64","author":"Castro","year":"2011","journal-title":"Pharmacology Research"},{"key":"10.1016\/j.tvjl.2012.01.017_b0025","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000178814","article-title":"Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses 5-hydroxytryptamine-induced pulmonary artery smooth muscle cell proliferation via JNK and ERK1\/2 pathway","volume":"83","author":"Chen","year":"2009","journal-title":"Pharmacology"},{"key":"10.1016\/j.tvjl.2012.01.017_b0030","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1172\/JCI6539","article-title":"Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease","volume":"105","author":"Cowan","year":"2000","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.tvjl.2012.01.017_b0035","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1164\/ajrccm.165.3.2104059","article-title":"ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells","volume":"165","author":"Davie","year":"2002","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.tvjl.2012.01.017_b0040","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.3382\/ps.0741677","article-title":"Pulmonary arteriole hypertrophy in broilers with pulmonary hypertension syndrome (ascites)","volume":"74","author":"Enkvetchakul","year":"1995","journal-title":"Poultry Science"},{"key":"10.1016\/j.tvjl.2012.01.017_b0045","doi-asserted-by":"crossref","first-page":"H222","DOI":"10.1152\/ajpheart.00133.2003","article-title":"Stress upregulates arterial matrix metalloproteinase expression and activity via endothelin A receptor activation","volume":"285","author":"Ergul","year":"2003","journal-title":"American Journal of Physiology Heart and Circulatory Physiology"},{"key":"10.1016\/j.tvjl.2012.01.017_b0050","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1161\/01.RES.85.10.906","article-title":"Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor","volume":"85","author":"Fernandez-Patron","year":"1999","journal-title":"Circulation Research"},{"key":"10.1016\/j.tvjl.2012.01.017_b0055","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1242\/dmm.003616","article-title":"Idiopathic pulmonary arterial hypertension","volume":"3","author":"Firth","year":"2010","journal-title":"Disease Modes and Mechanisms"},{"key":"10.1016\/j.tvjl.2012.01.017_b0060","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1183\/09031936.01.00084601","article-title":"Gelatinase expression in pulmonary arteries during experimental pulmonary hypertension","volume":"18","author":"Frisdal","year":"2001","journal-title":"European Respiratory Journal"},{"key":"10.1016\/j.tvjl.2012.01.017_b0065","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cardiores.2003.11.026","article-title":"The endothelin system in pulmonary arterial hypertension","volume":"61","author":"Galie","year":"2004","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.tvjl.2012.01.017_b0070","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1161\/01.RES.75.1.181","article-title":"Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion","volume":"75","author":"Galis","year":"1994","journal-title":"Circulation Research"},{"key":"10.1016\/j.tvjl.2012.01.017_b0075","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1183\/09059180.00003309","article-title":"Pulmonary arterial hypertension in paediatric and adult patients with congenital heart disease","volume":"18","author":"Gatzoulis","year":"2009","journal-title":"European Respiratory Review"},{"key":"10.1016\/j.tvjl.2012.01.017_b0080","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/ps\/86.5.909","article-title":"Endothelin 1, its endothelin type A receptor, connective tissue growth factor, platelet-derived growth factor, and adrenomedullin expression in lungs of pulmonary hypertensive and nonhypertensive chickens","volume":"86","author":"Gomez","year":"2007","journal-title":"Poultry Science"},{"key":"10.1016\/j.tvjl.2012.01.017_b0085","doi-asserted-by":"crossref","first-page":"R235","DOI":"10.1152\/ajpregu.00451.2009","article-title":"Differential expression of vasoactive mediators in microparticle-challenged lungs of chickens that differ in susceptibility to pulmonary arterial hypertension","volume":"298","author":"Hamal","year":"2010","journal-title":"American Journal of Physiology Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.tvjl.2012.01.017_b0090","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1042\/bj2960803","article-title":"Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Effects of tumour necrosis factor alpha, interleukin 1 and phorbol ester","volume":"296","author":"Hanemaaijer","year":"1993","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.tvjl.2012.01.017_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-7258(01)00157-7","article-title":"Pulmonary vascular remodeling: A target for therapeutic intervention in pulmonary hypertension","volume":"92","author":"Jeffery","year":"2001","journal-title":"Pharmacology and Therapeutics"},{"key":"10.1016\/j.tvjl.2012.01.017_b0100","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.bbrc.2010.12.106","article-title":"ARP101, a selective MMP-2 inhibitor, induces autophagy-associated cell death in cancer cells","volume":"404","author":"Jo","year":"2011","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.tvjl.2012.01.017_b0105","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ajpath.2011.03.040","article-title":"Plexiform lesions in pulmonary arterial hypertension: Composition, architecture, and microenvironment","volume":"179","author":"Jonigk","year":"2011","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.tvjl.2012.01.017_b0110","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1080\/03079450020016751","article-title":"Physiological, management and environmental triggers of the ascites syndrome: A review","volume":"29","author":"Julian","year":"2000","journal-title":"Avian Pathology"},{"key":"10.1016\/j.tvjl.2012.01.017_b0115","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/03079458908418588","article-title":"Right ventricular hypertrophy, right ventricular failure and ascites in broiler chickens caused by amiodarone-induced lung pathology","volume":"18","author":"Julian","year":"1989","journal-title":"Avian Pathology"},{"key":"10.1016\/j.tvjl.2012.01.017_b0120","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1183\/09031936.05.00072504","article-title":"Smooth muscle cell matrix metalloproteinases in idiopathic pulmonary arterial hypertension","volume":"25","author":"Lepetit","year":"2005","journal-title":"European Respiratory Journal"},{"key":"10.1016\/j.tvjl.2012.01.017_b0125","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.rvsc.2009.05.023","article-title":"Expression of PDGF-beta receptor in broilers with pulmonary hypertension induced by cold temperature and its association with pulmonary vascular remodeling","volume":"88","author":"Li","year":"2010","journal-title":"Research in Veterinary Science"},{"key":"10.1016\/j.tvjl.2012.01.017_b0130","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/ps\/85.5.899","article-title":"Pulmonary arteriole remodeling in hypoxic broilers expressing different amounts of endothelial nitric oxide synthase","volume":"85","author":"Moreno de Sandino","year":"2006","journal-title":"Poultry Science"},{"key":"10.1016\/j.tvjl.2012.01.017_b0135","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.cardiores.2005.08.002","article-title":"Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates","volume":"69","author":"Newby","year":"2006","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.tvjl.2012.01.017_b0140","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1080\/03079450500368508","article-title":"The identification of matrix metalloproteinases and their tissue inhibitors in broiler chickens by immunohistochemistry","volume":"34","author":"Ozyigit","year":"2005","journal-title":"Avian Pathology"},{"key":"10.1016\/j.tvjl.2012.01.017_b0145","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1080\/00071660500098152","article-title":"Effects of early feed restriction and cold temperature on lipid peroxidation, pulmonary vascular remodelling and ascites morbidity in broilers under normal and cold temperature","volume":"46","author":"Pan","year":"2005","journal-title":"British Poultry Science"},{"key":"10.1016\/j.tvjl.2012.01.017_b0150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/07853890600622143","article-title":"Pulmonary arterial hypertension","volume":"38","author":"Raiesdana","year":"2006","journal-title":"Annals of Medicine"},{"key":"10.1016\/j.tvjl.2012.01.017_b0155","doi-asserted-by":"crossref","first-page":"25915","DOI":"10.1074\/jbc.M513513200","article-title":"Matrix metalloproteinase-2 expression by vascular smooth muscle cells is mediated by both stimulatory and inhibitory signals in response to growth factors","volume":"281","author":"Risinger","year":"2006","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.tvjl.2012.01.017_b0160","doi-asserted-by":"crossref","first-page":"L1013","DOI":"10.1152\/ajplung.00217.2009","article-title":"Animal models of pulmonary arterial hypertension: The hope for etiological discovery and pharmacological cure","volume":"297","author":"Stenmark","year":"2009","journal-title":"American Journal of Physiology. Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.tvjl.2012.01.017_b0165","doi-asserted-by":"crossref","first-page":"L819","DOI":"10.1152\/ajplung.00062.2003","article-title":"Bovine distal pulmonary arterial media is composed of a uniform population of well-differentiated smooth muscle cells with low proliferative capabilities","volume":"285","author":"Stiebellehner","year":"2003","journal-title":"American Journal of Physiology. Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.tvjl.2012.01.017_b0175","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.rvsc.2004.11.014","article-title":"Activation of PKC\u03b1 and pulmonary vascular remodelling in broilers","volume":"79","author":"Tan","year":"2005","journal-title":"Research in Veterinary Science"},{"key":"10.1016\/j.tvjl.2012.01.017_b0180","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.rvsc.2004.12.004","article-title":"L-Arginine inhibiting pulmonary vascular remodelling is associated with promotion of apoptosis in pulmonary arterioles smooth muscle cells in broilers","volume":"79","author":"Tan","year":"2005","journal-title":"Research in Veterinary Science"},{"key":"10.1016\/j.tvjl.2012.01.017_b0185","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/03079450701460765","article-title":"Possible role of nitric oxide in the pathogenesis of pulmonary hypertension in broilers","volume":"36","author":"Tan","year":"2007","journal-title":"Avian Pathology"},{"key":"10.1016\/j.tvjl.2012.01.017_b0170","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1439-0396.2007.00727.x","article-title":"The effect of dietary l-carnitine supplementation on pulmonary hypertension syndrome mortality in broilers exposed to low temperatures","volume":"92","author":"Tan","year":"2008","journal-title":"Journal of Animal Physiology and Animal Nutrition"},{"key":"10.1016\/j.tvjl.2012.01.017_b0190","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3109\/14653249.2010.536215","article-title":"Suppression of tissue inhibitors of metalloproteinases may reverse severe pulmonary arterial hypertension","volume":"13","author":"Tang","year":"2011","journal-title":"Cytotherapy"},{"key":"10.1016\/j.tvjl.2012.01.017_b0195","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1101\/gad.815400","article-title":"Matrix metalloproteinases: Effectors of development and normal physiology","volume":"14","author":"Vu","year":"2000","journal-title":"Genes and Development"},{"key":"10.1016\/j.tvjl.2012.01.017_b0205","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1080\/0007166022000004534","article-title":"Effect of L-NAME on pulmonary arterial pressure, plasma nitric oxide and pulmonary hypertension syndrome morbidity in broilers","volume":"43","author":"Wang","year":"2002","journal-title":"British Poultry Science"},{"key":"10.1016\/j.tvjl.2012.01.017_b0200","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1439-0442.2007.00988.x","article-title":"Proliferation of pulmonary artery smooth muscle cells in the development of ascites syndrome in broilers induced by low ambient temperature","volume":"54","author":"Wang","year":"2007","journal-title":"Journal of Veterinary Medicine A"},{"key":"10.1016\/j.tvjl.2012.01.017_b0210","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2174\/138920011795202901","article-title":"Matrix metalloproteinase inhibitors: A review on bioanalytical methods, pharmacokinetics and metabolism","volume":"12","author":"Wang","year":"2011","journal-title":"Current Drug Metabolism"},{"key":"10.1016\/j.tvjl.2012.01.017_b0220","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1079\/WPS20010021","article-title":"Pathophysiology of heart\/lung disorders: Pulmonary hypertension syndrome in broiler chickens","volume":"57","author":"Wideman","year":"2001","journal-title":"World\u2019s Poultry Science Journal"},{"key":"10.1016\/j.tvjl.2012.01.017_b0215","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.vascn.2011.01.002","article-title":"Idiopathic pulmonary arterial hypertension: An avian model for plexogenic arteriopathy and serotonergic vasoconstriction","volume":"63","author":"Wideman","year":"2011","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.tvjl.2012.01.017_b0225","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1093\/ps\/86.5.984","article-title":"An inadequate pulmonary vascular capacity and susceptibility to pulmonary arterial hypertension in broilers","volume":"86","author":"Wideman","year":"2007","journal-title":"Poultry Science"},{"key":"10.1016\/j.tvjl.2012.01.017_b0230","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/ar.21369","article-title":"Plexiform lesions in the lungs of domestic fowl selected for susceptibility to pulmonary arterial hypertension: Incidence and histology","volume":"294","author":"Wideman","year":"2011","journal-title":"Anatomical Record (Hoboken)"},{"key":"10.1016\/j.tvjl.2012.01.017_b0235","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1165\/ajrcmb\/9.4.429","article-title":"BQ123, an ETA receptor antagonist, inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells","volume":"9","author":"Zamora","year":"1993","journal-title":"American Journal of Respiratory Cell and Molecular Biology"}],"container-title":["The Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023312000354?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023312000354?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,25]],"date-time":"2018-11-25T18:57:37Z","timestamp":1543172257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090023312000354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S1090023312000354"],"URL":"https:\/\/doi.org\/10.1016\/j.tvjl.2012.01.017","relation":{},"ISSN":["1090-0233"],"issn-type":[{"value":"1090-0233","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}