{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:01:33Z","timestamp":1762542093088},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Veterinary Journal"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.tvjl.2012.07.030","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T19:00:20Z","timestamp":1346180420000},"page":"40-46","source":"Crossref","is-referenced-by-count":26,"title":["Upregulation of articular synovial membrane \u03bc-opioid-like receptors in an acute equine synovitis model"],"prefix":"10.1016","volume":"196","author":[{"given":"J.P.A.M.","family":"van Loon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.","family":"de Grauw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Brunott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.A.W.S.","family":"Weerts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.R.","family":"van Weeren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tvjl.2012.07.030_b0005","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1523\/JNEUROSCI.15-01-00165.1995","article-title":"Perineural defect and peripheral opioid analgesia in inflammation","volume":"15","author":"Antonijevic","year":"1995","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.tvjl.2012.07.030_b0010","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.rvsc.2007.10.011","article-title":"Development of a composite orthopaedic pain scale in horses","volume":"85","author":"Bussi\u00e8res","year":"2008","journal-title":"Research in Veterinary Science"},{"key":"10.1016\/j.tvjl.2012.07.030_b0015","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1006\/bbrc.1995.2709","article-title":"Mu-opioid receptor gene expression in immune cells","volume":"216","author":"Chuang","year":"1995","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.tvjl.2012.07.030_b0020","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2746\/042516409X436286","article-title":"In vivo effects of meloxicam on inflammatory mediators, MMP activity and cartilage biomarkers in equine joints with acute synovitis","volume":"41","author":"De Grauw","year":"2009","journal-title":"Equine Veterinary Journal"},{"key":"10.1016\/j.tvjl.2012.07.030_b0025","first-page":"42","article-title":"Perineal analgesia and hemodynamic effects of the epidural administration of meperidine or hyperbaric bupivacaine in conscious horses","volume":"45","author":"DeRossi","year":"2004","journal-title":"Canadian Veterinary Journal"},{"key":"10.1016\/j.tvjl.2012.07.030_b0030","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1097\/00000539-200109000-00042","article-title":"A systematic review of the peripheral analgesic effects of intra-articular morphine","volume":"93","author":"Gupta","year":"2001","journal-title":"Anesthesia Analgesia"},{"key":"10.1016\/j.tvjl.2012.07.030_b0035","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0306-4522(93)90465-R","article-title":"Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue","volume":"55","author":"Hassan","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.tvjl.2012.07.030_b0040","first-page":"169","article-title":"Modulation of transmitter and hormone release by multiple neuronal opioid receptors","volume":"112","author":"Illes","year":"1989","journal-title":"Reviews of Physiology, Biochemistry and Pharmacology"},{"key":"10.1016\/j.tvjl.2012.07.030_b0045","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0304-3940(94)90048-5","article-title":"Il-1 beta-like Freund\u2019s adjuvant enhances axonal transport of opiate receptors in sensory neurons","volume":"177","author":"Jeanjean","year":"1994","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.tvjl.2012.07.030_b0050","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0304-3959(02)00019-2","article-title":"No pain, no gain: Clinical excellence and scientific rigour \u2013 Lessons learned from IA morphine","volume":"98","author":"Kalso","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.tvjl.2012.07.030_b0055","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","article-title":"Synovitis score: Discrimination between chronic low-grade and high-grade synovitis","volume":"49","author":"Krenn","year":"2006","journal-title":"Histopathology"},{"key":"10.1016\/j.tvjl.2012.07.030_b0060","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.lungcan.2010.02.005","article-title":"The immunohistochemical overexpression of ribonucleotide reductase regulatory subunit M1 (RRM1) protein is a predictor of shorter survival to gemcitabine-based chemotherapy in advanced non-small cell lung cancer (NSCLC)","volume":"70","author":"Lee","year":"2010","journal-title":"Lung Cancer"},{"key":"10.1016\/j.tvjl.2012.07.030_b0065","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0306-4522(89)90279-0","article-title":"Involvement of the mu-opiate receptor in peripheral analgesia","volume":"32","author":"Levine","year":"1989","journal-title":"Neuroscience"},{"key":"10.1016\/j.tvjl.2012.07.030_b0070","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1213\/00000539-199706000-00025","article-title":"Intra-articular morphine analgesia in chronic pain patients with osteoarthritis","volume":"84","author":"Likar","year":"1997","journal-title":"Anesthesia Analgesia"},{"key":"10.1016\/j.tvjl.2012.07.030_b0075","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1467-2995.2009.00521.x","article-title":"Analgesic efficacy of intra-articular morphine in experimentally induced radiocarpal synovitis in horses","volume":"37","author":"Lindegaard","year":"2010","journal-title":"Veterinary Anaesthesia Analgesia"},{"key":"10.1016\/j.tvjl.2012.07.030_b0080","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2460\/ajvr.71.1.69","article-title":"Anti-inflammatory effects of intra-articular administration of morphine in horses with experimentally induced synovitis","volume":"71","author":"Lindegaard","year":"2010","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2012.07.030_b0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0165-5728(01)00271-5","article-title":"\u03b2-Endorphin-containing memory-cells and \u03bc-opioid receptors undergo transport to peripheral inflamed tissue","volume":"115","author":"Mousa","year":"2001","journal-title":"Journal of Neuroimmunology"},{"key":"10.1016\/j.tvjl.2012.07.030_b0090","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0165-5728(02)00049-8","article-title":"Immunohistochemical localisation of endomorphin-1 and endomorphin-2 in immune cells and spinal cord in a model of inflammatory pain","volume":"126","author":"Mousa","year":"2002","journal-title":"Journal of Neuroimmunology"},{"key":"10.1016\/j.tvjl.2012.07.030_b0095","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2746\/0425164054223831","article-title":"Pain therapy in horses","volume":"37","author":"Muir","year":"2005","journal-title":"Equine Veterinary Journal"},{"key":"10.1016\/j.tvjl.2012.07.030_b0100","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0304-3959(90)91112-V","article-title":"Peripheral opioid receptors mediating antinociception in inflammation. Activation by endogenous opioids and role of the pituitary\u2013adrenal axis","volume":"41","author":"Parsons","year":"1990","journal-title":"Pain"},{"key":"10.1016\/j.tvjl.2012.07.030_b0105","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.neuroscience.2004.06.086","article-title":"Rapid upregulation of \u03bc opioid receptor mRNA in dorsal root ganglia in response to peripheral inflammation depends on neuronal conduction","volume":"129","author":"Puehler","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.tvjl.2012.07.030_b0110","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0749-0739(02)00010-X","article-title":"Epidural anesthesia and analgesia in horses","volume":"18","author":"Robinson","year":"2002","journal-title":"Veterinary Clinics of North American Equine Practice"},{"key":"10.1016\/j.tvjl.2012.07.030_b0115","unstructured":"Ross, M.W., Dyson, S.J., 2003. The lameness score: Quantification of lameness severity. In: Ross, M.W., Dyson, S.J. (Eds.), Diagnosis and Management of Lameness in the Horse. W.B. Saunders, Philadelphia, pp. 66\u201367."},{"key":"10.1016\/j.tvjl.2012.07.030_b0120","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1467-2995.2009.00452.x","article-title":"Effects of intraarticular ropivacaine and morphine on lipopolysaccharide-induced synovitis in horses","volume":"36","author":"Santos","year":"2009","journal-title":"Veterinary Anesthesia and Analgesia"},{"key":"10.1016\/j.tvjl.2012.07.030_b0125","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.2460\/ajvr.2001.62.1408","article-title":"Evaluation of opioid receptors in synovial membranes of horses","volume":"62","author":"Sheehy","year":"2001","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2012.07.030_b0130","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1002\/art.21141","article-title":"Kappa and delta opioid receptors are expressed but down-regulated in fibroblast-like synoviocytes of patients with rheumatoid arthritis and osteoarthritis","volume":"52","author":"Shen","year":"2005","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.tvjl.2012.07.030_b0135","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev.iy.06.040188.001251","article-title":"Opioid peptides and opioid receptors in cells of the immune system","volume":"6","author":"Sibinga","year":"1988","journal-title":"Annual Review of Immunology"},{"key":"10.1016\/j.tvjl.2012.07.030_b0140","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/s00393-008-0354-x","article-title":"Periphere mechanismen von Gelenkschmerzen mit speziellem Fokus auf den Synovialen Fibroblasten","volume":"67","author":"Sprott","year":"2008","journal-title":"Zeitschrift f\u00fcr Rheumatology"},{"key":"10.1016\/j.tvjl.2012.07.030_b0145","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0140-6736(93)91471-W","article-title":"Local analgesic effect of endogenous opioid peptides","volume":"342","author":"Stein","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.tvjl.2012.07.030_b0150","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1213\/00000539-199301000-00031","article-title":"Peripheral mechanisms of opioid analgesia","volume":"76","author":"Stein","year":"1993","journal-title":"Anesthesia and Analgesia"},{"key":"10.1016\/j.tvjl.2012.07.030_b0155","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJM199506223322506","article-title":"The control of pain in peripheral tissue by opioids","volume":"332","author":"Stein","year":"1995","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.tvjl.2012.07.030_b0160","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2746\/0425164054530740","article-title":"Influence of repeated arthrocentesis and exercise on synovial fluid concentration of nitric oxide, prostaglandin E2 and glycosaminoglycans in healthy equine joints","volume":"37","author":"Van den Boom","year":"2005","journal-title":"Equine Veterinary Journal"},{"key":"10.1016\/j.tvjl.2012.07.030_b0165","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.2042-3306.2010.00077.x","article-title":"Intra-articular opioid analgesia is effective in reducing pain and inflammation in an equine LPS induced synovitis model","volume":"42","author":"Van Loon","year":"2010","journal-title":"Equine Veterinary Journal"}],"container-title":["The Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023312003401?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023312003401?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T05:28:12Z","timestamp":1562131692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090023312003401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S1090023312003401"],"URL":"https:\/\/doi.org\/10.1016\/j.tvjl.2012.07.030","relation":{},"ISSN":["1090-0233"],"issn-type":[{"value":"1090-0233","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}