{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:19:59Z","timestamp":1791350399646,"version":"4.3.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Veterinary Journal"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.tvjl.2013.03.003","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T19:01:58Z","timestamp":1365534118000},"page":"468-473","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Urinary excretion of copper, zinc and iron with and without D-penicillamine administration in relation to hepatic copper concentration in dogs"],"prefix":"10.1016","volume":"197","author":[{"given":"H.","family":"Fieten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hugen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.S.G.A.M.","family":"van den Ingh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.H.","family":"Hendriks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.M.","family":"Vernooij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.L.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.A.J.","family":"Leegwater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rothuizen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tvjl.2013.03.003_b0005","first-page":"139","article-title":"Instrumental neutron activation analysis in a routine way","volume":"8","author":"Bode","year":"1990","journal-title":"Journal of Trace and Microprobe Techniques"},{"key":"10.1016\/j.tvjl.2013.03.003_b0010","first-page":"289","article-title":"Studies on metal complexes of drugs; D-penicillamine and N-acetyl-D-penicillamine","volume":"99","author":"Doornbos","year":"1964","journal-title":"Pharmaceutisch Weekblad"},{"key":"10.1016\/j.tvjl.2013.03.003_b0015","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s00335-004-2457-2","article-title":"Quantitative PCR method to detect a 13-kb deletion in the MURR1 gene associated with copper toxicosis and HIV-1 replication","volume":"16","author":"Favier","year":"2005","journal-title":"Mammalian Genome"},{"key":"10.1016\/j.tvjl.2013.03.003_b0025","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s00335-011-9378-7","article-title":"Canine models of copper toxicosis for understanding mammalian copper metabolism","volume":"23","author":"Fieten","year":"2012","journal-title":"Mammalian Genome"},{"key":"10.1016\/j.tvjl.2013.03.003_b0020","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.tvjl.2012.12.013","article-title":"D-penicillamine treatment of copper associated hepatitis in Labrador retrievers","volume":"196","author":"Fieten","year":"2013","journal-title":"The Veterinary Journal"},{"key":"10.1016\/j.tvjl.2013.03.003_b0030","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1080\/00365520701847044","article-title":"Usefulness of penicillamine-stimulated urinary copper excretion in the diagnosis of adult Wilson\u2019s disease","volume":"43","author":"Foruny","year":"2008","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1016\/j.tvjl.2013.03.003_b0035","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1039\/an9648900713","article-title":"High-pressure plasmas as spectroscopic emission sources","volume":"89","author":"Greenfield","year":"1964","journal-title":"Analyst"},{"key":"10.1016\/j.tvjl.2013.03.003_b0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2885.1993.tb00294.x","article-title":"Urinary excretion of metals during treatment with D-penicillamine and 2-mercaptopropionylglycine in normal and cystinuric dogs","volume":"16","author":"Hoppe","year":"1993","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"10.1016\/j.tvjl.2013.03.003_b0045","doi-asserted-by":"crossref","first-page":"2680S","DOI":"10.1093\/jn\/128.12.2680S","article-title":"Body composition of puppies and young dogs","volume":"128","author":"Kienzle","year":"1998","journal-title":"The Journal of Nutrition"},{"key":"10.1016\/j.tvjl.2013.03.003_b0050","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0003-9861(62)90090-5","article-title":"Metal chelates of DL-penicillamine","volume":"97","author":"Kuchinskas","year":"1962","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.tvjl.2013.03.003_b0055","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1021\/bi00894a001","article-title":"Metal chelates of some sulfur-containing amino acids","volume":"3","author":"Lenz","year":"1964","journal-title":"Biochemistry"},{"key":"10.1016\/j.tvjl.2013.03.003_b0060","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/hep.1840150410","article-title":"Value of urinary copper excretion after penicillamine challenge in the diagnosis of Wilson\u2019s disease","volume":"15","author":"Martins da Costa","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.tvjl.2013.03.003_b0065","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jhep.2007.03.011","article-title":"Re-evaluation of the penicillamine challenge test in the diagnosis of Wilson\u2019s disease in children","volume":"47","author":"Muller","year":"2007","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.tvjl.2013.03.003_b0075","unstructured":"R Development Core Team, 2011. R: A Language and Environment for Statistical Computing. Vienna, Austria."},{"key":"10.1016\/j.tvjl.2013.03.003_b0080","series-title":"WSAVA Standards for Clinical and Histological Diagnosis Fo Canine and Feline Liver Disease \u2013 WSAVA Liver Standardization Group","first-page":"5","article-title":"Sampling and handling of liver tissue","author":"Rothuizen","year":"2006"},{"key":"10.1016\/j.tvjl.2013.03.003_b0085","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/hmg\/11.2.165","article-title":"Identification of a new copper metabolism gene by positional cloning in a purebred dog population","volume":"11","author":"Van de Sluis","year":"2002","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.tvjl.2013.03.003_b0090","doi-asserted-by":"crossref","unstructured":"van den Ingh, T.S.G.A.M., Van Winkle, T., Cullen, J.M., Charles, J.A., Desmet, V.J., 2006. Morphological classification of parenchymal disorders of the canine and feline liver, 2. Hepatocellular death, hepatitis and cirrhosis. In: WSAVA Liver Standardization Group. (Ed.), WSAVA Standards for Clinical and Histological Diagnosis of Canine Liver Diseases. Elsevier, Philadelphia, pp. 85\u2013101.","DOI":"10.1016\/B978-0-7020-2791-8.50011-3"},{"key":"10.1016\/j.tvjl.2013.03.003_b0095","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s12519-010-0023-4","article-title":"Urinary copper\/zinc ratio: a promising parameter for replacement of 24-hour urinary copper excretion for diagnosis of Wilson\u2019s disease in children","volume":"6","author":"Wang","year":"2010","journal-title":"World Journal of Pediatrics"}],"container-title":["The Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023313001056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023313001056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:26:47Z","timestamp":1761071207000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090023313001056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S1090023313001056"],"URL":"https:\/\/doi.org\/10.1016\/j.tvjl.2013.03.003","relation":{},"ISSN":["1090-0233"],"issn-type":[{"value":"1090-0233","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urinary excretion of copper, zinc and iron with and without D-penicillamine administration in relation to hepatic copper concentration in dogs","name":"articletitle","label":"Article Title"},{"value":"The Veterinary Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tvjl.2013.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}