{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:20:23Z","timestamp":1790040023908,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Veterinary Journal"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.tvjl.2013.06.022","type":"journal-article","created":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T19:45:28Z","timestamp":1374954328000},"page":"109-115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Big-endothelin 1 (big ET-1) and homocysteine in the serum of dogs with chronic kidney disease"],"prefix":"10.1016","volume":"198","author":[{"given":"Gabriele","family":"Rossi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Breda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Lisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Roura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Zatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Paltrinieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tvjl.2013.06.022_b0005","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1139\/Y08-059","article-title":"Endothelin: 20 years from discovery to therapy","volume":"86","author":"Barton","year":"2008","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"key":"10.1016\/j.tvjl.2013.06.022_b0010","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.2460\/javma.236.11.1221","article-title":"Comparison of urine protein-to-creatinine ratio in urine samples collected by cystocentesis versus free catch in dogs","volume":"236","author":"Beatrice","year":"2010","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"10.1016\/j.tvjl.2013.06.022_b0015","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1939-165X.2003.tb00334.x","article-title":"Comparative sequences of canine and feline endothelin-1","volume":"32","author":"Biondo","year":"2003","journal-title":"Veterinary Clinical Pathology"},{"key":"10.1016\/j.tvjl.2013.06.022_b0020","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1939-1676.2007.tb03005.x","article-title":"Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats","volume":"21","author":"Brown","year":"2007","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"10.1016\/j.tvjl.2013.06.022_b0025","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1939-165X.2005.tb00019.x","article-title":"Acute phase proteins in dogs and cats: Current knowledge and future perspectives","volume":"34","author":"Ceron","year":"2005","journal-title":"Veterinary Clinical Pathology"},{"key":"10.1016\/j.tvjl.2013.06.022_b0030","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1748-5827.2006.00173.x","article-title":"Prospective evaluation of a peripherally administered three-in-one parenteral nutrition product in dogs","volume":"47","author":"Chandler","year":"2006","journal-title":"Journal of Small Animal Practice"},{"key":"10.1016\/j.tvjl.2013.06.022_b0035","first-page":"219","article-title":"Update on endothelin receptor nomenclature","volume":"54","author":"Davenport","year":"2002","journal-title":"Pharmacology"},{"key":"10.1016\/j.tvjl.2013.06.022_b0040","series-title":"Kirk\u2019s Current Veterinary Therapy","first-page":"883","article-title":"Chronic kidney disease: Staging and management","author":"Elliott","year":"2008"},{"key":"10.1016\/j.tvjl.2013.06.022_b0045","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1939-1676.2004.tb02547.x","article-title":"Association of systemic hypertension with renal injury in dogs with induced renal failure","volume":"18","author":"Finco","year":"2004","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"10.1016\/j.tvjl.2013.06.022_b0050","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1939-165X.2009.00179.x","article-title":"Reference values: A review","volume":"38","author":"Geffr\u00e9","year":"2009","journal-title":"Veterinary Clinical Pathology"},{"key":"10.1016\/j.tvjl.2013.06.022_b0055","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1161\/01.HYP.27.4.885","article-title":"Effects and interactions of endothelin-1 and angiotensin II on matrix protein expression and synthesis and mesangial cell growth","volume":"27","author":"Gomez-Garre","year":"1996","journal-title":"Hypertension"},{"key":"10.1016\/j.tvjl.2013.06.022_b0060","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ki.1997.359","article-title":"Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure","volume":"52","author":"Guttormsen","year":"1997","journal-title":"Kidney International"},{"key":"10.1016\/j.tvjl.2013.06.022_b0065","doi-asserted-by":"crossref","first-page":"322","DOI":"10.2460\/javma.2003.222.322","article-title":"Association between initial systolic blood pressure and risk of developing a uremic crisis or of dying in dogs with chronic renal failure","volume":"222","author":"Jacob","year":"2003","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"10.1016\/j.tvjl.2013.06.022_b0070","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/vr.100864","article-title":"Evaluation of homocysteine levels in dogs with chronic mitral valve insufficiency","volume":"171","author":"Lee","year":"2012","journal-title":"Veterinary Record"},{"key":"10.1016\/j.tvjl.2013.06.022_b0075","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1681\/ASN.V12112321","article-title":"Renal endothelin-1 and endothelin receptor type B expression in glomerular disease with proteinuria","volume":"12","author":"Lehrke","year":"2001","journal-title":"Journal of the American Society of Nephrology"},{"key":"10.1016\/j.tvjl.2013.06.022_b0080","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.2460\/ajvr.73.8.1194","article-title":"Serum cobalamin, urine methylmalonic acid, and plasma total homocysteine concentrations in Border Collies and dogs of other breeds","volume":"73","author":"Lutz","year":"2012","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2013.06.022_b0085","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1939-1676.2000.tb02268.x","article-title":"Plasma homocysteine, B vitamins, and amino acid concentrations in cats with cardiomyopathy and arterial thromboembolism","volume":"14","author":"McMichael","year":"2000","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"10.1016\/j.tvjl.2013.06.022_b0090","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1939-1676.2007.tb02933.x","article-title":"Plasma big endothelin-1, atrial natriuretic peptide, aldosterone, and norepinephrine concentrations in normal Doberman pinschers and Doberman pinschers with dilated cardiomyopathy","volume":"21","author":"O\u2019Sullivan","year":"2007","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"10.1016\/j.tvjl.2013.06.022_b0095","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/ki.1991.38","article-title":"Urinary excretion of endothelin-1 in normal subjects and patients with renal disease","volume":"39","author":"Ohta","year":"1991","journal-title":"Kidney International"},{"key":"10.1016\/j.tvjl.2013.06.022_b0100","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.tvjl.2009.08.019","article-title":"Serum concentration of the derivative of reactive oxygen metabolites (d-ROMs) in dogs with leishmaniosis","volume":"186","author":"Paltrinieri","year":"2010","journal-title":"The Veterinary Journal"},{"key":"10.1016\/j.tvjl.2013.06.022_b0105","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/S0026-0495(98)90314-6","article-title":"Urinary endothelin in adolescents and young adults with insulin-dependent diabetes mellitus: Relation to urinary albumin, blood pressure and other factors","volume":"47","author":"Peppa-Patrikiou","year":"1998","journal-title":"Metabolism"},{"key":"10.1016\/j.tvjl.2013.06.022_b0110","first-page":"396","article-title":"Endothelin-1 plasma immunoreactivity in cats with myocardial disease (Abstract)","volume":"2003","author":"Prosek","year":"2003","journal-title":"Veterinary Internal Medicine"},{"key":"10.1016\/j.tvjl.2013.06.022_b0115","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1177\/1040638711407896","article-title":"C-reactive protein concentrations in serum of dogs with naturally occurring renal disease","volume":"23","author":"Raila","year":"2011","journal-title":"Journal of Veterinary Diagnostic Investigation"},{"key":"10.1016\/j.tvjl.2013.06.022_b0120","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1373\/clinchem.2003.021634","article-title":"Facts and recommendations about total homocysteine determinations: An expert opinion","volume":"50","author":"Refsum","year":"2004","journal-title":"Clinical Chemistry"},{"key":"10.1016\/j.tvjl.2013.06.022_b0125","doi-asserted-by":"crossref","first-page":"779","DOI":"10.2460\/ajvr.73.6.779","article-title":"Evaluation of factors that affect analytic variability of urine protein-to-creatinine ratio determination in dogs","volume":"73","author":"Rossi","year":"2012","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2013.06.022_b0130","doi-asserted-by":"crossref","DOI":"10.1136\/vr.101171","article-title":"Association between hypocobalaminemia and hyperhomocysteinemia in dogs","author":"Rossi","year":"2013","journal-title":"Veterinary Record"},{"key":"10.1016\/j.tvjl.2013.06.022_b0135","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1177\/104063870802000520","article-title":"Homocysteine measurement by an enzymatic method and potential role of homocysteine as a biomarker in dogs","volume":"20","author":"Rossi","year":"2008","journal-title":"Journal of Veterinary Diagnostic Investigation"},{"key":"10.1016\/j.tvjl.2013.06.022_b0140","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tvjl.2007.07.002","article-title":"Analytical validation of commercial immunoassays for the measurement of cardiovascular peptides in the dog","volume":"178","author":"Schellenberg","year":"2008","journal-title":"The Veterinary Journal"},{"key":"10.1016\/j.tvjl.2013.06.022_b0145","first-page":"876","article-title":"Role of endothelin-1 in hypertension","volume":"34","author":"Schiffrin","year":"1999","journal-title":"Journal of the American Heart Association"},{"key":"10.1016\/j.tvjl.2013.06.022_b0150","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1172\/JCI113935","article-title":"Endothelin stimulates phospholipase C, Na\/H exchange c-Fos expression, and mitogenesis in rat mesangial cells","volume":"83","author":"Simonson","year":"1989","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.tvjl.2013.06.022_b0155","doi-asserted-by":"crossref","first-page":"F579","DOI":"10.1152\/ajprenal.00019.2003","article-title":"Physiology and pathology of endothelin-1 in renal mesangium","volume":"285","author":"Sorokin","year":"2003","journal-title":"American Journal of Renal Physiology"},{"key":"10.1016\/j.tvjl.2013.06.022_b0160","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1093\/ndt\/gfg080","article-title":"Impaired renal function is associated with markers of endothelial dysfunction and increased inflammatory activity","volume":"18","author":"Stam","year":"2003","journal-title":"Nephrology Dialysis Transplantation"},{"key":"10.1016\/j.tvjl.2013.06.022_b0165","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1515\/CCLM.2003.214","article-title":"DACH\u2013LIGA Homocystein (German, Austrian and Swiss Homocysteine Society): Consensus paper on the rational clinical use of homocysteine, folic acid and B-vitamins in cardiovascular and thrombotic diseases: Guidelines and recommendations","volume":"41","author":"Stanger","year":"2003","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"key":"10.1016\/j.tvjl.2013.06.022_b0170","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1515\/CCLM.2003.216","article-title":"Does homocysteine cause hypertension?","volume":"41","author":"Stehouwer","year":"2003","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"key":"10.1016\/j.tvjl.2013.06.022_b0175","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1161\/01.RES.71.5.1039","article-title":"Cellular mechanisms for synthesis and secretion of atrial natriuretic peptide and brain natriuretic peptide in cultured rat atrial cells","volume":"71","author":"Suzuki","year":"1992","journal-title":"Circulation Research"},{"key":"10.1016\/j.tvjl.2013.06.022_b0180","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1136\/vr.158.23.783","article-title":"Diagnostic and prognostic value of endothelin-1 plasma concentrations in dogs with heart and respiratory disorders","volume":"158","author":"Tessier-Vetzel","year":"2006","journal-title":"Veterinary Record"},{"key":"10.1016\/j.tvjl.2013.06.022_b0185","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1007\/s11745-001-0679-7","article-title":"The Hordaland homocysteine studies","volume":"36","author":"Ueland","year":"2001","journal-title":"Lipids"},{"key":"10.1016\/j.tvjl.2013.06.022_b0190","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1001\/jama.289.10.1251","article-title":"Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarction","volume":"289","author":"Vasan","year":"2003","journal-title":"Journal of the American Medical Association"},{"key":"10.1016\/j.tvjl.2013.06.022_b0195","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1053\/meta.2001.28079","article-title":"Hyperhomocysteinemia and related factors in 600 hospitalized elderly subjects","volume":"50","author":"Ventura","year":"2001","journal-title":"Metabolism"},{"key":"10.1016\/j.tvjl.2013.06.022_b0200","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/332411a0","article-title":"A novel potent vasoconstrictor peptide produced by vascular endothelial cells","volume":"332","author":"Yanagisawa","year":"1988","journal-title":"Nature"}],"container-title":["The Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023313003067?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023313003067?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T11:59:08Z","timestamp":1646222348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090023313003067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S1090023313003067"],"URL":"https:\/\/doi.org\/10.1016\/j.tvjl.2013.06.022","relation":{},"ISSN":["1090-0233"],"issn-type":[{"value":"1090-0233","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Big-endothelin 1 (big ET-1) and homocysteine in the serum of dogs with chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"The Veterinary Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tvjl.2013.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}