{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:20:02Z","timestamp":1792660802826,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Veterinary Journal"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.tvjl.2014.06.008","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T18:09:01Z","timestamp":1402423741000},"page":"207-214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Pradofloxacin: A novel veterinary fluoroquinolone for treatment of bacterial infections in cats"],"prefix":"10.1016","volume":"201","author":[{"given":"Jane E.","family":"Sykes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Blondeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tvjl.2014.06.008_bib0010","series-title":"42nd Interscience Conference on Antimicrobial Agents and Chemotherapy","first-page":"189","article-title":"Pradofloxacin: Comparative in vitro activity against selected pathogens from the US","author":"Abraham","year":"2002"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0015","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/jac\/dkp459","article-title":"Molecular mechanisms of Bartonella henselae resistance to azithromycin, pradofloxacin and enrofloxacin","volume":"65","author":"Biswas","year":"2010","journal-title":"The Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0020","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1128\/JCM.01287-09","article-title":"Comparative activity of pradofloxacin, enrofloxacin, and azithromycin against Bartonella henselae isolates collected from cats and a human","volume":"48","author":"Biswas","year":"2010","journal-title":"Journal of Clinical Microbiology"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0025","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1365-3164.2009.00856.x","article-title":"New concepts in antimicrobial susceptibility testing: The mutant prevention concentration and mutant selection window approach","volume":"20","author":"Blondeau","year":"2009","journal-title":"Veterinary Dermatology"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0030","series-title":"Proceedings of the 2nd International Veraflox Symposium","author":"Blondeau","year":"2012"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0035","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0924-8579(01)00334-X","article-title":"Susceptibility of Canadian isolates of Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae to oral antimicrobial agents","volume":"17","author":"Blondeau","year":"2001","journal-title":"International Journal of Antimicrobial Agents"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0040","series-title":"Novel Perspectives in Antibacterial Action","first-page":"15","article-title":"Optimal killing of Streptococcus pneumoniae by gemifloxacin, levofloxacin and moxifloxacin","author":"Blondeau","year":"2002"},{"issue":"Suppl. 3","key":"10.1016\/j.tvjl.2014.06.008_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/1120009X.2004.11782371","article-title":"The role of PK\/PD parameters to avoid selection and increase of resistance: Mutant prevention concentration","volume":"16","author":"Blondeau","year":"2004","journal-title":"Journal of Chemotherapy"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0050","first-page":"266","article-title":"Pharmacokinetic properties of pradofloxacin administered as an oral suspension to cats","volume":"29","author":"Daube","year":"2006","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0055","series-title":"4th Symposium on Antimicrobial Resistance in Animals and the Environment (ARAE)","first-page":"p23","article-title":"Pradofloxacin: In vitro activity against various canine and feline bacterial pathogens in four EU countries","author":"Doerner","year":"2011"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0060","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2460\/ajvr.70.1.105","article-title":"Use of pradofloxacin to treat experimentally induced Mycoplasma hemofelis infection in cats","volume":"70","author":"Dowers","year":"2009","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0065","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1086\/511642","article-title":"Mutant selection window hypothesis updated","volume":"44","author":"Drlica","year":"2007","journal-title":"Clinical Infectious Diseases"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0070","doi-asserted-by":"crossref","first-page":"190","DOI":"10.2460\/ajvr.68.2.190","article-title":"Ocular and systemic manifestations after oral administration of a high dose of enrofloxacin in cats","volume":"68","author":"Ford","year":"2007","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0075","series-title":"10th International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT)","first-page":"I26","article-title":"Serum pharmacokinetics of pradofloxacin after oral administration to cats","author":"Fraatz","year":"2003"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0080","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1046\/j.1463-5224.2001.00182.x","article-title":"Enrofloxacin-associated retinal degeneration in cats","volume":"4","author":"Gelatt","year":"2001","journal-title":"Veterinary Ophthalmology"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0085","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.vetmic.2009.11.031","article-title":"Identification of Qnr and AAC(6\u2019)-1b-cr plasmid-mediated fluoroquinolone resistance determinants in multidrug-resistant Enterobacter spp. isolated from extraintestinal infections in companion animals","volume":"143","author":"Gibson","year":"2010","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0090","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1099\/jmm.0.018002-0","article-title":"Characterization of multidrug-resistant Escherichia coli isolated from extraintestinal clinical infections in animals","volume":"59","author":"Gibson","year":"2010","journal-title":"Journal of Medical Microbiology"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0095","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.vetmic.2011.06.001","article-title":"Susceptibility of rapidly growing mycobacteria and Nocardia isolates from cats and dogs to pradofloxacin","volume":"153","author":"Govendir","year":"2011","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0100","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1128\/AAC.47.1.440-441.2003","article-title":"Mutant prevention concentration of gemifloxacin for clinical isolates of Streptococcus pneumoniae","volume":"47","author":"Hansen","year":"2003","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0105","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1365-2885.2007.00932.x","article-title":"Pharmacokinetics of pradofloxacin and doxycycline in serum, saliva, and tear fluid of cats after oral administration","volume":"31","author":"Hartmann","year":"2008","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0110","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1939-1676.2007.0012.x","article-title":"Efficacy of pradofloxacin in cats with feline upper respiratory tract disease due to Chlamydophila felis or Mycoplasma infections","volume":"22","author":"Hartmann","year":"2008","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0115","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1586\/17476348.1.1.7","article-title":"MICs, MPCs and PK\/PDs: A match (sometimes) made in hosts","volume":"1","author":"Hesje","year":"2007","journal-title":"Expert Review of Respiratory Medicine"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0120","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/jvp.12036","article-title":"Pharmacokinetics, pharmacodynamics and therapeutics of pradofloxacin in the dog and cat","volume":"36","author":"Lees","year":"2013","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0125","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/j.1939-1676.2007.tb03054.x","article-title":"Clinical efficacy and palatability of pradofloxacin 2.5% oral suspension for the treatment of bacterial lower urinary tract infections in cats","volume":"21","author":"Litster","year":"2007","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0130","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s11274-012-1188-x","article-title":"In vitro potency and efficacy favor later generation fluoroquinolones for treatment of canine and feline Escherichia coli uropathogens in the United States","volume":"29","author":"Liu","year":"2013","journal-title":"World Journal of Microbiology and Biotechnology"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0135","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1365-3164.2012.01104.x","article-title":"Ulcerated and nonulcerated nontuberculous cutaneous mycobacterial granulomas in cats and dogs","volume":"24","author":"Malik","year":"2013","journal-title":"Veterinary Dermatology"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0140","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10633-007-9081-x","article-title":"Retinal safety of a new fluoroquinolone, pradofloxacin, in cats: Assessment with electroretinography","volume":"116","author":"Messias","year":"2008","journal-title":"Documenta Ophthalmologca. Advances in Ophthalmology"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0145","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/jac\/dks461","article-title":"Minimal inhibitory and mutant prevention concentrations of azithromycin, clarithromycin and erythromycin for clinical isolates of Streptococcus pneumoniae","volume":"68","author":"Metzler","year":"2013","journal-title":"The Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0150","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1093\/jac\/dkl135","article-title":"Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: Relation between drug exposure and mutant prevention concentration","volume":"57","author":"Olofsson","year":"2006","journal-title":"The Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0155","series-title":"Proceedings of the American Society for Microbiology (ASM) 105th General Meeting","first-page":"p617","article-title":"In vitro activity of pradofloxacin against clinical isolates from European field studies","author":"Pridmore","year":"2005"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0160","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/FPC.0b013e3283425f44","article-title":"Molecular genetic basis for fluoroquinolone-induced retinal degeneration in cats","volume":"21","author":"Ramirez","year":"2011","journal-title":"Pharmacogenetics and Genomics"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0165","first-page":"51","article-title":"Why pharmacoeconomics are relevant in managing respiratory infections: How an antibiotic's AUIC can predict outcomes and costs","author":"Schentag","year":"2004","journal-title":"Consultant"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0170","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.vetmic.2012.08.001","article-title":"Susceptibility of canine and feline bacterial pathogens to pradofloxacin and comparison with other fluoroquinolones approved for companion animals","volume":"162","author":"Schink","year":"2013","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0175","doi-asserted-by":"crossref","first-page":"6434","DOI":"10.1128\/AAC.00872-12","volume":"56","author":"Schubert","year":"2012","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0180","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1093\/jac\/dkm346","article-title":"Comparative activity of pradofloxacin against anaerobic bacteria isolated from dogs and cats","volume":"60","author":"Silley","year":"2007","journal-title":"The Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0185","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.vetmic.2011.11.027","article-title":"Bactericidal properties of pradofloxacin against veterinary pathogens","volume":"157","author":"Silley","year":"2012","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0190","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jfms.2008.04.003","article-title":"Evaluation of pradofloxacin for the treatment of feline rhinitis","volume":"10","author":"Spindel","year":"2008","journal-title":"Journal of Feline Medicine and Surgery"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0195","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.vetmic.2007.01.003","article-title":"Mutant prevention concentration of pradofloxacin against Porphyromonas gingivalis","volume":"121","author":"Stephan","year":"2007","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0200","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1128\/CMR.00016-09","article-title":"Plasmid-mediated quinolone resistance: A multifaceted threat","volume":"22","author":"Strahilevitz","year":"2009","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0205","series-title":"Canine and Feline Infectious Diseases","first-page":"859","article-title":"Intra-abdominal infections","author":"Sykes","year":"2014"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0210","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jfms.2010.04.003","article-title":"Association between Bartonella species infection and disease in pet cats as determined using serology and culture","volume":"12","author":"Sykes","year":"2010","journal-title":"Journal of Feline Medicine and Surgery"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0215","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1128\/AAC.49.10.4166-4173.2005","article-title":"Comparative mutant prevention concentrations of pradofloxacin and other veterinary fluoroquinolones indicate differing potentials in preventing selection of resistance","volume":"49","author":"Wetzstein","year":"2005","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0220","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1093\/jac\/dkr372","article-title":"Tuning of antibacterial activity of a cyclopropyl fluoroquinolone by variation of the substituent at position C-8","volume":"66","author":"Wetzstein","year":"2011","journal-title":"The Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0225","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.2460\/javma.2002.221.1568","article-title":"Fluoroquinolone-induced retinal degeneration in cats","volume":"221","author":"Wiebe","year":"2002","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"10.1016\/j.tvjl.2014.06.008_bib0230","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1128\/AAC.43.3.661","article-title":"Fluoroquinolone action against clinical isolates of Mycobacterium tuberculosis: Effects of a C-8 methoxyl group on survival in liquid media and in human macrophages","volume":"43","author":"Zhao","year":"1999","journal-title":"Antimicrobial Agents and Chemotherapy"}],"container-title":["The Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023314002640?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023314002640?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T07:53:31Z","timestamp":1565510011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090023314002640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S1090023314002640"],"URL":"https:\/\/doi.org\/10.1016\/j.tvjl.2014.06.008","relation":{},"ISSN":["1090-0233"],"issn-type":[{"value":"1090-0233","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pradofloxacin: A novel veterinary fluoroquinolone for treatment of bacterial infections in cats","name":"articletitle","label":"Article Title"},{"value":"The Veterinary Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tvjl.2014.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}