{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T01:25:00Z","timestamp":1777080300538,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Veterinary Journal"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.tvjl.2015.01.028","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T14:52:36Z","timestamp":1423320756000},"page":"99-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of a new metamizole formulation and carprofen for extended post-operative analgesia in dogs undergoing ovariohysterectomy"],"prefix":"10.1016","volume":"204","author":[{"given":"K.S.","family":"Kalchofner Guerrero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Wuhrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Feldmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hartnack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bettschart-Wolfensberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tvjl.2015.01.028_bib0010","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S1056-8719(00)00046-0","article-title":"Evidence for a peripheral mechanism of action for the potentiation of the antinociceptive effect of morphine by dipyrone","volume":"42","author":"Aguirre-Banuelos","year":"1999","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0015","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2460\/javma.2002.220.313","article-title":"Challenges of pain assessment in domestic animals","volume":"220","author":"Anil","year":"2002","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0020","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1751-0813.1996.tb13774.x","article-title":"Owner compliance with short term antimicrobial medication in dogs","volume":"74","author":"Barter","year":"1996","journal-title":"Australian Veterinary Journal"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0025","series-title":"An\u00e4esthesiologie","first-page":"99","article-title":"Analgetika","author":"Brack","year":"2008"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0030","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1053\/bean.2002.0262","article-title":"Pharmacology of systemic analgesics","volume":"16","author":"Camu","year":"2002","journal-title":"Best Practice and Research. Clinical Anaesthesiology"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0035","doi-asserted-by":"crossref","first-page":"13926","DOI":"10.1073\/pnas.162468699","article-title":"COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic\/antipyretic drugs: Cloning, structure, and expression","volume":"99","author":"Chandrasekharan","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0040","first-page":"1760","article-title":"Biopharmaceutical and pharmacokinetic studies on metamizol-14C (Novalgin 14C) given to rats, dogs and men]","volume":"23","author":"Christ","year":"1973","journal-title":"Arzneimittel-Forschung"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0045","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.2460\/javma.1997.210.11.1619","article-title":"Correlation between subjective and objective measures used to determine severity of post-operative pain in dogs","volume":"210","author":"Conzemius","year":"1997","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0050","doi-asserted-by":"crossref","first-page":"298","DOI":"10.5326\/0410298","article-title":"Nonsteroidal antiinflammatory drugs: A review","volume":"41","author":"Curry","year":"2005","journal-title":"Journal of the American Animal Hospital Association"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0055","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s00520-007-0327-7","article-title":"Adjunct dipyrone in association with oral morphine for cancer-related pain: The sooner the better","volume":"15","author":"Duarte Souza","year":"2007","journal-title":"Supportive Care in Cancer"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0060","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1097\/00000539-200212000-00019","article-title":"Post-operative nausea and vomiting in children and adolescents undergoing radiofrequency catheter ablation: A randomized comparison of propofol- and isoflurane-based anesthetics","volume":"95","author":"Erb","year":"2002","journal-title":"Anesthesia and Analgesia"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0065","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/vaa.12023","article-title":"Tramadol plus metamizole combined or not with anti-inflammatory drugs is clinically effective for moderate to severe chronic pain treatment in cancer patients","volume":"40","author":"Flor","year":"2013","journal-title":"Veterinary Anaesthesia and Analgesia"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0070","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.2460\/javma.1997.210.10.1493","article-title":"Use of carprofen for the treatment of pain and inflammation in dogs","volume":"210","author":"Fox","year":"1997","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0075","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00228-002-0465-2","article-title":"Agranulocytosis and other blood dyscrasias associated with dipyrone (metamizole)","volume":"58","author":"Hedenmalm","year":"2002","journal-title":"European Journal of Clinical Pharmacology"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0080","first-page":"331","article-title":"Pyrazolones in the treatment of post-operative pain","volume":"19","author":"Hempel","year":"1986","journal-title":"Agents and Actions. Supplements"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0085","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.2042-3306.1984.tb01893.x","article-title":"The acute inflammatory process, arachidonic acid metabolism and the mode of action of anti-inflammatory drugs","volume":"16","author":"Higgins","year":"1984","journal-title":"Equine Veterinary Journal"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0090","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1748-5827.1998.tb03681.x","article-title":"Relationship between physiological factors and clinical pain in dogs scored using a numerical rating scale","volume":"39","author":"Holton","year":"1998","journal-title":"Journal of Small Animal Practice"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0095","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1467-2995.2011.00617.x","article-title":"The use of different doses of metamizol for post-operative analgesia in dogs","volume":"38","author":"Imagawa","year":"2011","journal-title":"Veterinary Anaesthesia and Analgesia"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0100","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/vaa.12157","article-title":"Alfaxalone or ketamine-medetomidine in cats undergoing ovariohysterectomy: A comparison of intra-operative parameters and post-operative pain","volume":"41","author":"Kalchofner Guerrero","year":"2014","journal-title":"Veterinary Anaesthesia and Analgesia"},{"issue":"Suppl. 2","key":"10.1016\/j.tvjl.2015.01.028_bib0105","doi-asserted-by":"crossref","first-page":"313S","DOI":"10.1111\/j.1365-2125.1980.tb01815.x","article-title":"Chronic toxicity of pyrazolones: The problem of nitrosation","volume":"10","author":"Kramer","year":"1980","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0110","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1136\/vr.155.21.667","article-title":"Comparison of the analgesic effects of meloxicam and carprofen administered preoperatively to dogs undergoing orthopaedic surgery","volume":"155","author":"Laredo","year":"2004","journal-title":"Veterinary Record"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0115","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1532-950X.1998.tb00533.x","article-title":"Efficacy and kinetics of carprofen, administered preoperatively or post-operatively, for the prevention of pain in dogs undergoing ovariohysterectomy","volume":"27","author":"Lascelles","year":"1998","journal-title":"Veterinary Surgery"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0120","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1467-2995.2005.00207.x","article-title":"Comparison of carprofen and meloxicam for 72 hours following ovariohysterectomy in dogs","volume":"32","author":"Leece","year":"2005","journal-title":"Veterinary Anaesthesia and Analgesia"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0125","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.2042-3306.1985.tb02056.x","article-title":"Clinical pharmacology and therapeutic uses of non-steroidal anti-inflammatory drugs in the horse","volume":"17","author":"Lees","year":"1985","journal-title":"Equine Veterinary Journal"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0130","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.2460\/javma.2002.221.1268","article-title":"Effects of preoperative administration of ketoprofen on anesthetic requirements and signs of post-operative pain in dogs undergoing elective ovariohysterectomy","volume":"221","author":"Lemke","year":"2002","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0135","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2165\/00003088-199528030-00004","article-title":"Clinical pharmacokinetics of dipyrone and its metabolites","volume":"28","author":"Levy","year":"1995","journal-title":"Clinical Pharmacokinetics"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0140","first-page":"124","article-title":"Experimental studies on the action of a pyrazolone derivative on smooth-muscled organs","volume":"6","author":"Lindner","year":"1956","journal-title":"Arzneimittel-Forschung"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0145","doi-asserted-by":"crossref","first-page":"258","DOI":"10.2460\/ajvr.68.3.258","article-title":"Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs","volume":"68","author":"Luna","year":"2007","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0150","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0304-3940(99)00721-1","article-title":"Antinociceptive effects of metamizol (dipyrone) in rat single motor units","volume":"274","author":"Mazario","year":"1999","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0155","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/jvim.12127","article-title":"Systematic review of nonsteroidal anti-inflammatory drug-induced adverse effects in dogs","volume":"27","author":"Monteiro-Steagall","year":"2013","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0160","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.5504\/BBEQ.2012.0135","article-title":"Metamizole: A review profile of a well-known \u2018forgotten\u2019 drug. Part II: Clinical profile","volume":"27","author":"Nikolova","year":"2013","journal-title":"Biotechnology and Biotechnological Equipment"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0165","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1136\/vr.133.10.240","article-title":"Comparison of the post-operative analgesic and sedative effects of carprofen and papaveretum in the dog","volume":"133","author":"Nolan","year":"1993","journal-title":"Veterinary Record"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0170","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/clpt.1988.191","article-title":"Use of a pharmacologic indicator to compare compliance with tablets prescribed to be taken once, twice, or three times daily","volume":"44","author":"Pullar","year":"1988","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0175","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1532-950X.2007.00276.x","article-title":"Evaluation of agreement between numerical rating scales, visual analogue scoring scales, and force plate gait analysis in dogs","volume":"36","author":"Quinn","year":"2007","journal-title":"Veterinary Surgery"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0180","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1017\/S096272860003178X","article-title":"Development of the short-form Glasgow Composite Measure Pain Scale (CMPS-SF) and derivation of an analgesic intervention score","volume":"16","author":"Reid","year":"2007","journal-title":"Animal Welfare"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0185","series-title":"Intraoperative analgesia in dogs with metamizole and\/or fentanyl for hip replacement","author":"Richter","year":"2007"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0190","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1136\/vr.129.17.378","article-title":"Analgesic and spasmolytic effects of dipyrone, hyoscine-N-butylbromide and a combination of the two in ponies","volume":"129","author":"Roelvink","year":"1991","journal-title":"Veterinary Record"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0195","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1023\/A:1021077810548","article-title":"Gastrointestinal tolerability of metamizol, acetaminophen, and diclofenac in subchronic treatment in rats","volume":"47","author":"Sanchez","year":"2002","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0200","first-page":"760","article-title":"Investigation of rociverine\u2009+\u2009dipyrone for antispasmodic and analgesic interactions","volume":"29","author":"Schiantarelli","year":"1979","journal-title":"Arzneimittel-Forschung"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0205","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1467-2995.2007.00352.x","article-title":"Comparison between analgesic effects of buprenorphine, carprofen, and buprenorphine with carprofen for canine ovariohysterectomy","volume":"35","author":"Shih","year":"2008","journal-title":"Veterinary Anaesthesia and Analgesia"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0210","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/00003643-199807000-00009","article-title":"A meta-analysis of nausea and vomiting following maintenance of anaesthesia with propofol or inhalational agents","volume":"15","author":"Sneyd","year":"1998","journal-title":"European Journal of Anaesthesiology"},{"issue":"K","key":"10.1016\/j.tvjl.2015.01.028_bib0215","first-page":"19","article-title":"Metamizol (dipyrone) for pain therapy. A literature review and own clinical experiences","volume":"36","author":"Tacke","year":"2008","journal-title":"Tierarztliche Praxis"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0220","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/vaa.12080","article-title":"Effects of tramadol alone, in combination with meloxicam or dipyrone, on post-operative pain and the analgesic requirement in dogs undergoing unilateral mastectomy with or without ovariohysterectomy","volume":"40","author":"Teixeira","year":"2013","journal-title":"Veterinary Anaesthesia and Analgesia"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0225","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.tvjl.2013.05.015","article-title":"Comparison of intrarectal ozone, ozone administered in acupoints and meloxicam for post-operative analgesia in bitches undergoing ovariohysterectomy","volume":"197","author":"Teixeira","year":"2013","journal-title":"The Veterinary Journal"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0230","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/BF01699225","article-title":"The opiate-sparing effect of dipyrone in post-operative pain therapy with morphine using a patient-controlled analgesic system","volume":"22","author":"Tempel","year":"1996","journal-title":"Intensive Care Medicine"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0235","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0006-8993(96)00196-5","article-title":"Naloxone partial reversal of the antinociception produced by dipyrone microinjected into the periaqueductal gray of rats. Possible involvement of medullary off- and on-cells","volume":"725","author":"Tortorici","year":"1996","journal-title":"Brain Research"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0240","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1399-6576.1998.tb05298.x","article-title":"Vomiting, retching, headache and restlessness after halothane-, isoflurane- and enflurane-based anaesthesia. An analysis of pooled data following ear, nose, throat and eye surgery","volume":"42","author":"van den Berg","year":"1998","journal-title":"Acta Anaesthesiologica Scandinavica"},{"key":"10.1016\/j.tvjl.2015.01.028_bib0245","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1460-9568.2007.05280.x","article-title":"A nonopioid analgesic acts upon the PAG-RVM axis to reverse inflammatory hyperalgesia","volume":"25","author":"Vazquez","year":"2007","journal-title":"European Journal of Neuroscience"}],"container-title":["The Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023315000489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023315000489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T02:20:22Z","timestamp":1717726822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090023315000489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S1090023315000489"],"URL":"https:\/\/doi.org\/10.1016\/j.tvjl.2015.01.028","relation":{},"ISSN":["1090-0233"],"issn-type":[{"value":"1090-0233","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of a new metamizole formulation and carprofen for extended post-operative analgesia in dogs undergoing ovariohysterectomy","name":"articletitle","label":"Article Title"},{"value":"The Veterinary Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tvjl.2015.01.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}