{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:25:09Z","timestamp":1793262309946,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Cavalier Kings Charles Club of England"},{"DOI":"10.13039\/501100000848","name":"University of Edinburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000848","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese Government State Scholarship","award":["2009635129"],"award-info":[{"award-number":["2009635129"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Veterinary Journal"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.tvjl.2015.02.021","type":"journal-article","created":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T17:12:46Z","timestamp":1425575566000},"page":"23-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Gene network and canonical pathway analysis in canine myxomatous mitral valve disease: A microarray study"],"prefix":"10.1016","volume":"204","author":[{"given":"C.-C.","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.-M.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Culshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Clinton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.J.","family":"Argyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.M.","family":"Corcoran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tvjl.2015.02.021_bib0010","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1161\/CIRCULATIONAHA.105.591768","article-title":"Human semilunar cardiac valve remodeling by activated cells from fetus to adult: Implications for postnatal adaptation, pathology, and tissue engineering","volume":"113","author":"Aikawa","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0015","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/01.RES.0000141146.95728.da","article-title":"Heart valve development: Endothelial cell signaling and differentiation","volume":"95","author":"Armstrong","year":"2004","journal-title":"Circulation Research"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0020","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jvc.2012.01.005","article-title":"Pathology, protein expression and signaling in myxomatous mitral valve degeneration: Comparison of dogs and humans","volume":"14","author":"Aupperle","year":"2012","journal-title":"Journal of Veterinary Cardiology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0025","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jcpa.2008.05.007","article-title":"Expression of transforming growth factor-beta1, -beta2 and -beta3 in normal and diseased canine mitral valves","volume":"139","author":"Aupperle","year":"2008","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0030","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.tvjl.2007.11.011","article-title":"An immunohistochemical study of the role of matrix metalloproteinases and their tissue inhibitors in chronic mitral valvular disease (valvular endocardiosis) in dogs","volume":"180","author":"Aupperle","year":"2009","journal-title":"The Veterinary Journal"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0035","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1242\/dev.00954","article-title":"Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation","volume":"131","author":"Bakkers","year":"2004","journal-title":"Development (Cambridge, England)"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0040","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.2460\/javma.1993.203.07.1023","article-title":"Chronic mitral valve disease in cavalier King Charles spaniels: 95 cases (1987\u20131991)","volume":"203","author":"Beardow","year":"1993","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0045","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.2460\/ajvr.2005.66.1408","article-title":"Ultrastructural morphologic evaluation of the phenotype of valvular interstitial cells in dogs with myxomatous degeneration of the mitral valve","volume":"66","author":"Black","year":"2005","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0050","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jvc.2012.01.011","article-title":"Historical review, epidemiology and natural history of degenerative mitral valve disease","volume":"14","author":"Borgarelli","year":"2012","journal-title":"Journal of Veterinary Cardiology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0055","first-page":"75","article-title":"Chronic valvular disease (endocardiosis) in dogs","volume":"21","author":"Buchanan","year":"1977","journal-title":"Advances in Veterinary Science and Comparative Medicine"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0060","first-page":"4","article-title":"Regulation of cardiac cushion development by hyaluronan","volume":"6","author":"Camenisch","year":"2001","journal-title":"Experimental and Clinical Cardiology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0065","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.exer.2011.12.007","article-title":"Focus on molecules: ADAMTSL4","volume":"104","author":"Chandra","year":"2012","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0070","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1152\/ajpheart.00995.2008","article-title":"Toll-like receptor signaling\u00a0: A critical modulator of cell survival and ischemic injury in the heart","volume":"296","author":"Chao","year":"2009","journal-title":"American Journal of Physiology \u2013 Heart and Circulatory Physiology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0075","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/nar\/gkp427","article-title":"ToppGene Suite for gene list enrichment analysis and candidate gene prioritization","volume":"37","author":"Chen","year":"2009","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0080","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/ar2053","article-title":"Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction","volume":"8","author":"Clements","year":"2006","journal-title":"Arthritis Research and Therapy"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0085","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2460\/ajvr.2004.65.198","article-title":"Identification of surface morphologic changes in the mitral valve leaflets and chordae tendineae of dogs with myxomatous degeneration","volume":"65","author":"Corcoran","year":"2004","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0090","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.diff.2012.04.001","article-title":"Atrioventricular valve development: New perspectives on an old theme","volume":"84","author":"de Vlaming","year":"2012","journal-title":"Differentiation; Research in Biological Diversity"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0095","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1242\/jcs.124529","article-title":"Endothelial adherens junctions at a glance","volume":"126","author":"Dejana","year":"2013","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0100","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/BOR.0b013e3283103d27","article-title":"Caveolin-1, TGF-\u03b2 receptor internalization, and the pathogenesis of systemic sclerosis","volume":"20","author":"Del Galdo","year":"2008","journal-title":"Current Opinion in Rheumatology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0105","first-page":"402","article-title":"Interstitial cells from dogs with naturally occurring myxomatous mitral valve disease undergo phenotype transformation","volume":"17","author":"Disatian","year":"2008","journal-title":"The Journal of Heart Valve Disease"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0110","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1161\/CIRCULATIONAHA.111.082610","article-title":"Modulation of transforming growth factor-\u03b2 signaling and extracellular matrix production in myxomatous mitral valves by angiotensin II receptor blockers","volume":"126","author":"Geirsson","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0115","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.carpath.2008.05.001","article-title":"Abundance and location of proteoglycans and hyaluronan within normal and myxomatous mitral valves","volume":"18","author":"Gupta","year":"2009","journal-title":"Cardiovascular Pathology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0120","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.carpath.2009.05.001","article-title":"Molecular changes in fibrillar collagen in myxomatous mitral valve disease","volume":"19","author":"Hadian","year":"2010","journal-title":"Cardiovascular Pathology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0125","doi-asserted-by":"crossref","first-page":"763","DOI":"10.2460\/ajvr.69.6.763","article-title":"Distribution of myofibroblasts, smooth muscle-like cells, mcrophages, and mast cells in mitral valve leaflets of dogs with myxomatous mitral valve disease","volume":"69","author":"Han","year":"2008","journal-title":"Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0130","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.tvjl.2013.01.032","article-title":"Cell maceration scanning electron microscopy and computer-derived porosity measurements in assessment of connective tissue microstructure changes in the canine myxomatous mitral valve","volume":"197","author":"Han","year":"2013","journal-title":"The Veterinary Journal"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0135","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1111\/j.1748-5827.2009.00800.x","article-title":"An update on treatment and prognostic indicators in canine myxomatous mitral valve disease","volume":"50","author":"H\u00e4ggstr\u00f6m","year":"2009","journal-title":"The Journal of Small Animal Practice"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0140","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/cb7d7b4c-624f-46e6-957e-13b355ca8e02","article-title":"The skeletal phenotype of chondroadherin deficient mice","volume":"8","author":"Hessle","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0145","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev-physiol-012110-142145","article-title":"Heart valve structure and function in development and disease","volume":"73","author":"Hinton","year":"2011","journal-title":"Annual Review of Physiology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang","year":"2009","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0155","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/cvr\/cvr337","article-title":"Metallothionein-dependent up-regulation of TGF-\u03b22 participates in the remodelling of the myxomatous mitral valve","volume":"93","author":"Hulin","year":"2012","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0160","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.yexcr.2003.09.030","article-title":"Cell adhesion molecule T-cadherin regulates vascular cell adhesion, phenotype and motility","volume":"293","author":"Ivanov","year":"2004","journal-title":"Experimental Cell Research"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0165","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.matbio.2010.01.005","article-title":"Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies","volume":"29","author":"Kern","year":"2010","journal-title":"Matrix Biology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0170","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/(SICI)1097-0177(199803)211:3<248::AID-AJA6>3.0.CO;2-H","article-title":"Expression of type VI collagen in the developing mouse heart","volume":"211","author":"Klewer","year":"1998","journal-title":"Developmental Dynamics"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0175","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ydbio.2006.09.024","article-title":"Atrioventricular valve development during late embryonic and postnatal stages involves condensation and extracellular matrix remodeling","volume":"302","author":"Kruithof","year":"2007","journal-title":"Developmental Biology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0180","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1002\/prca.200900066","article-title":"Differential protein expression between normal, early-stage, and late-stage myxomatous mitral valves from dogs","volume":"3","author":"Lacerda","year":"2009","journal-title":"Proteomics \u2013 Clinical Applications"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0185","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1152\/ajpheart.00987.2011","article-title":"Local serotonin mediates cyclic strain-induced phenotype transformation, matrix degradation, and glycosaminoglycan synthesis in cultured sheep mitral valves","volume":"302","author":"Lacerda","year":"2012","journal-title":"American Journal of Physiology, Heart and Circulatory Physiology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0190","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.tcm.2012.10.002","article-title":"Hyaluronan: A critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation","volume":"23","author":"Lagendijk","year":"2013","journal-title":"Trends in Cardiovascular Medicine"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0195","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/01.CIR.0000048892.83521.58","article-title":"Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises: Part I: Aging arteries: A \u201cset up\u201d for vascular disease","volume":"107","author":"Lakatta","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0200","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1440-1797.2010.01319.x","article-title":"Review: Endothelial-myofibroblast transition, a new player in diabetic renal fibrosis","volume":"15","author":"Li","year":"2010","journal-title":"Nephrology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0205","doi-asserted-by":"crossref","first-page":"21672","DOI":"10.1074\/jbc.M301169200","article-title":"Keratocan-deficient mice display alterations in corneal structure","volume":"278","author":"Liu","year":"2003","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0210","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1161\/ATVBAHA.112.300504","article-title":"Inflammatory cytokines promote mesenchymal transformation in embryonic and adult valve endothelial cells","volume":"33","author":"Mahler","year":"2013","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0215","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/00005344-199908000-00011","article-title":"Increased endothelin-receptor density in myxomatous canine mitral valve leaflets","volume":"34","author":"Mow","year":"1999","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0220","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/(SICI)1096-9896(200005)191:1<54::AID-PATH568>3.0.CO;2-Y","article-title":"Expression of endothelial cell adhesion molecules on heart valves: Up-regulation in degeneration as well as acute endocarditis","volume":"191","author":"M\u00fcller","year":"2000","journal-title":"The Journal of Pathology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0225","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.atherosclerosis.2013.12.038","article-title":"Decorin and biglycan retain LDL in disease-prone valvular and aortic subendothelial intimal matrix","volume":"233","author":"Neufeld","year":"2014","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0230","first-page":"70","article-title":"The variability in the canine lipid profile values and its possible relationship with the measurement method used","volume":"3","author":"Osorio","year":"2009","journal-title":"Veterinarija ir Zootechnika"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0235","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.2460\/ajvr.67.8.1307","article-title":"Genomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease","volume":"67","author":"Oyama","year":"2006","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0240","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1161\/hc4601.099489","article-title":"Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves","volume":"104","author":"Rabkin","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0245","first-page":"841","article-title":"Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves","volume":"13","author":"Rabkin-Aikawa","year":"2004","journal-title":"The Journal of Heart Valve Disease"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0250","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S1569-9293(03)00107-5","article-title":"Increased mRNA expression of decorin in the prolapsing posterior leaflet of the mitral valve","volume":"2","author":"Radermecker","year":"2003","journal-title":"Interactive Cardiovascular and Thoracic Surgery"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0255","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jvc.2012.01.002","article-title":"The mechanobiology of mitral valve function, degeneration, and repair","volume":"14","author":"Richards","year":"2012","journal-title":"Journal of Veterinary Cardiology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0260","doi-asserted-by":"crossref","first-page":"e43494","DOI":"10.1371\/journal.pone.0043494","article-title":"Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners","volume":"7","author":"Sage","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0265","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1002\/jcp.22999","article-title":"Human myxomatous mitral valve prolapse: Role of bone morphogenetic protein 4 in valvular interstitial cell activation","volume":"227","author":"Sainger","year":"2012","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0270","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/j.1582-4934.2007.00109.x","article-title":"Integrin regulation of caveolin function","volume":"11","author":"Salanueva","year":"2007","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0275","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fphys.2011.00120","article-title":"Caveolae, caveolins, cavins, and endothelial cell function: New insights","volume":"2","author":"Sowa","year":"2012","journal-title":"Frontiers in Physiology"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0280","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbapap.2011.10.002","article-title":"Cysteine cathepsins: From structure, function and regulation to new frontiers","volume":"1824","author":"Turk","year":"2012","journal-title":"Biochimica et Biophysica Acta \u2013 Proteins and Proteomics"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0285","doi-asserted-by":"crossref","first-page":"17058","DOI":"10.1074\/jbc.M100754200","article-title":"Identification of novel TGF-\u03b2\/Smad gene targets in dermal fibroblasts using a combined cDNA microarray\/promoter transactivation approach","volume":"276","author":"Verrecchia","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.tvjl.2015.02.021_bib0290","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1161\/01.RES.0000136520.07995.aa","article-title":"Valvular myofibroblast activation by transforming growth factor-beta: Implications for pathological extracellular matrix remodeling in heart valve disease","volume":"95","author":"Walker","year":"2004","journal-title":"Circulation Research"}],"container-title":["The Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023315000957?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023315000957?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T17:06:56Z","timestamp":1717780016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090023315000957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S1090023315000957"],"URL":"https:\/\/doi.org\/10.1016\/j.tvjl.2015.02.021","relation":{},"ISSN":["1090-0233"],"issn-type":[{"value":"1090-0233","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene network and canonical pathway analysis in canine myxomatous mitral valve disease: A microarray study","name":"articletitle","label":"Article Title"},{"value":"The Veterinary Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tvjl.2015.02.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}