{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:31:27Z","timestamp":1791973887601,"version":"4.4.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Portuguese Science and Technology Foundation","doi-asserted-by":"publisher","award":["SFRH\/BPD\/85462\/2012"],"award-info":[{"award-number":["SFRH\/BPD\/85462\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Veterinary Journal"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.tvjl.2015.05.002","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T16:22:18Z","timestamp":1430929338000},"page":"5-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["C-kit as a prognostic and therapeutic marker in canine cutaneous mast cell tumours: From laboratory to clinic"],"prefix":"10.1016","volume":"205","author":[{"given":"Rui M.","family":"Gil da Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tvjl.2015.05.002_bib0010","series-title":"Immunohistochemical detection of the oncoprotein KIT as a prognostic marker in canine and feline mast cell tumor","author":"Abadie","year":"2005"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0015","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.rvsc.2013.10.014","article-title":"Production of stem cell factor in canine mast cell tumors","volume":"96","author":"Amagai","year":"2013","journal-title":"Research in Veterinary Science"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0020","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1177\/030098589202900503","article-title":"Correlation of DNA ploidy, to tumor histologic grade, clinical variables and survival in dogs with mast cell tumors","volume":"29","author":"Ayl","year":"1992","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0025","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/1746-6148-9-190","article-title":"Evaluation of the adverse event profile and pharmacodynamics of toceranib phosphate administered to dogs with solid tumors at doses below the maximum tolerated dose","volume":"9","author":"Barnabe","year":"2013","journal-title":"BMC Veterinary Research"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0030","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0021-9975(03)00046-X","article-title":"Gastrointestinal spindle cell tumours of the dog, histological and immunohistochemical study","volume":"129","author":"Bettini","year":"2003","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0035","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1111\/j.1476-5829.2012.00341.x","article-title":"European consensus document on mast cell tumours in dogs and cats","volume":"10","author":"Blackwood","year":"2012","journal-title":"Veterinary and Comparative Oncology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0040","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1939-1676.2011.00851.x","article-title":"Multicenter prospective trial of hypofractionated radiation treatment, toceranib and prednisone for measurable canine mast cell tumors","volume":"26","author":"Carlsten","year":"2012","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0045","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.2460\/ajvr.2002.63.1718","article-title":"Prevalence and importance of internal tandem duplications in exons 11 and 12 of c-KIT in mast cell tumors of dogs","volume":"63","author":"Downing","year":"2002","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0050","doi-asserted-by":"crossref","first-page":"e7258","DOI":"10.1371\/journal.pone.0007258","article-title":"Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT","volume":"4","author":"Dubreuil","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0055","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1471-2407-14-84","article-title":"Overexpression of miR-9 in mast cells in associated with invasive behavior and spontaneous metastasis","volume":"14","author":"Fenger","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0060","article-title":"The use of COLD-PCR, DHPLC and GeneScanning for the highly sensitive detection of c-KIT somatic mutations in canine mast cell tumours","author":"Gentilini","year":"2013","journal-title":"Veterinary and Comparative Oncology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0065","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jcpa.2012.01.011","article-title":"Expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases and vascular endothelial growth factor in canine mast cell tumours","volume":"147","author":"Giantin","year":"2012","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0070","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1177\/1040638711425945","article-title":"C-KIT messenger RNA and protein expression in canine cutaneous mast cell tumors, correlations with post-surgical prognosis","volume":"24","author":"Giantin","year":"2012","journal-title":"Journal of Veterinary Diagnostic Investigation"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0075","doi-asserted-by":"crossref","first-page":"e95481","DOI":"10.1371\/journal.pone.0095481","article-title":"Global gene expression analysis of canine cutaneous mast cell tumor, could molecular profiling be useful for subtype classification and prognostication?","volume":"9","author":"Giantin","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0080","series-title":"Immunohistochemical evaluation of a multicentric lymphoma and an intestinal carcinoid in a dog","author":"Gil da Costa","year":"2006"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0085","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1746-6148-3-19","article-title":"CD117 immunoexpression in canine mast cell tumours, correlations with pathological variables and proliferation markers","volume":"3","author":"Gil da Costa","year":"2007","journal-title":"BMC Veterinary Research"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0090","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1177\/0300985810381909","article-title":"Immunohistochemical characterization of 13 canine renal cell carcinomas","volume":"48","author":"Gil da Costa","year":"2010","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0095","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1365-3164.2009.00768.x","article-title":"Two canine Merkel cell tumours, immunoexpression of c-KIT, E-cadherin, \u03b2-catenin and S100 protein","volume":"21","author":"Gil da Costa","year":"2010","journal-title":"Veterinary Dermatology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0100","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1354\/vp.37-1-33","article-title":"Immunohistochemical detection of p53 tumor-suppressor protein is a poor indicator of prognosis for canine cutaneous mast cell tumors","volume":"37","author":"Ginn","year":"2000","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0105","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/CMR.0b013e32835273f9","article-title":"Study of c-kit immunoexpression in canine cutaneous melanocytic tumors","volume":"22","author":"Gomes","year":"2012","journal-title":"Melanoma Research"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0110","series-title":"Skin Diseases of the Dog and Cat. Clinical and Histopathological Diagnosis","author":"Gross","year":"2005"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0115","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/j.1939-1676.2008.0190.x","article-title":"Masitinib is safe and effective for the treatment of canine mast cell tumors","volume":"22","author":"Hahn","year":"2008","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0120","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.2460\/ajvr.71.11.1354","article-title":"Evaluation of 12- and 24-month survival rates after treatment with masitinib in dogs with nonresectable mast cell tumors","volume":"71","author":"Hahn","year":"2010","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0125","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1746-6148-10-105","article-title":"Development of an in vitro model of acquired resistance to toceranib phosphate (Palladia) in canine mast cell tumor","volume":"10","author":"Halsey","year":"2014","journal-title":"BMC Veterinary Research"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0130","first-page":"3273","article-title":"An improved system for quantifying AgNOR and PCNA in canine tumors","volume":"20","author":"Hung","year":"2000","journal-title":"Anticancer Research"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0135","doi-asserted-by":"crossref","first-page":"e73555","DOI":"10.1371\/journal.pone.0073555","article-title":"Oncolytic reovirus in canine mast cell tumor","volume":"8","author":"Hwang","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0140","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/j.1939-1676.2008.00132.x","article-title":"Effect of tyrosine kinase inhibition by imatinib mesylate on mast cell tumors in dogs","volume":"22","author":"Isotani","year":"2008","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0145","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1354\/vp.37-1-40","article-title":"Immunohistochemical and clinical evaluation of p53 in canine cutaneous mast cell tumors","volume":"37","author":"Jaffe","year":"2000","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0150","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1354\/vp.41-4-371","article-title":"The use of KIT and tryptase expression patterns as prognostic tools for canine cutaneous mast cell tumors","volume":"41","author":"Kiupel","year":"2004","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0155","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/0300985810386469","article-title":"Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior","volume":"48","author":"Kiupel","year":"2011","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0160","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1746-6148-8-96","article-title":"Transcriptome and proteome analysis of tyrosine kinase inhibitor treated canine mast cell tumour cells identifies potentially kit signalling-dependent genes","volume":"8","author":"Klopfleisch","year":"2012","journal-title":"BMC Veterinary Research"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0165","first-page":"55","article-title":"Electrochemotherapy compared to surgery for treatment of canine mast cell tumours","volume":"23","author":"Kodre","year":"2009","journal-title":"In Vivo (Athens, Greece)"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0170","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1939-1676.2000.tb02280.x","article-title":"Identification of matrix metalloproteinases in canine cutaneous mast cell tumors","volume":"14","author":"Leibman","year":"2000","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0175","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1152\/physrev.00046.2011","article-title":"Stem cell factor receptor\/c-KIT, from basic science to clinical implications","volume":"92","author":"Lennartsson","year":"2012","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0180","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1158\/1541-7786.MCR-08-0067","article-title":"Gain-of-function mutations in the extracellular domain of KIT are common in canine mast cell tumors","volume":"6","author":"Letard","year":"2008","journal-title":"Molecular Cancer Research"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0185","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-3164.2012.01081.x","article-title":"Kinase dysfunction and kinase inhibitors","volume":"24","author":"London","year":"2013","journal-title":"Veterinary Dermatology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0190","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0021-9975(96)80074-0","article-title":"Expression of stem cell factor receptor c-kit. by the malignant mast cells from spontaneous mast cell tumours","volume":"115","author":"London","year":"1996","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0195","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0301-472X(98)00075-7","article-title":"Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit","volume":"27","author":"London","year":"1999","journal-title":"Experimental Hematology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0200","first-page":"2755","article-title":"Phase I dose-escalating study of SU11654, a small molecule receptor tyrosine kinase inhibitor, in dogs with spontaneous malignancies","volume":"9","author":"London","year":"2003","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0205","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1158\/1078-0432.CCR-08-1860","article-title":"Multi-center, placebo controlled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision","volume":"15","author":"London","year":"2009","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0210","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1046\/j.1523-1747.1999.00488.x","article-title":"Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms","volume":"112","author":"Ma","year":"1999","journal-title":"Journal of Investigative Dermatology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0215","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jcpa.2005.02.002","article-title":"Nucleomorphometric analysis of canine cutaneous mast cell tumours","volume":"133","author":"Maiolino","year":"2005","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0220","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1111\/j.1939-1676.2008.0128.x","article-title":"Clinicopathological features and outcome for dogs with mast cell tumors and bone marrow involvement","volume":"22","author":"Marconato","year":"2008","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0225","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/jvim.12266","article-title":"Concordance of c-kit mutational status in matched primary and metastatic cutaneous canine mast cell tumors at baseline","volume":"28","author":"Marconato","year":"2014","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0230","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.critrevonc.2013.12.011","article-title":"Masitinib (AB1010) from canine tumor model to human clinical development, where are we?","volume":"91","author":"Marech","year":"2014","journal-title":"Critical Reviews in Oncology\/Hematology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0235","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1177\/0300985812439215","article-title":"CD25 is expressed by canine cutaneous mast cell tumors but not by cutaneous connective tissue mast cells","volume":"49","author":"Meyer","year":"2012","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0240","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jcpa.2012.11.232","article-title":"All subunits of the interleukin-2 receptor are expressed by canine cutaneous mast cell tumours","volume":"149","author":"Meyer","year":"2013","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0245","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1177\/002215540405200515","article-title":"C-kit gene product (CD117) immunoreactivity in canine and feline paraffin sections","volume":"52","author":"Morini","year":"2004","journal-title":"Journal of Histochemistry and Cytochemistry"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0250","first-page":"545","article-title":"Imatinib responsiveness in canine mast cell tumors carrying novel mutations of c-KIT exon 11","volume":"76","author":"Nakano","year":"2014","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0255","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1476-5829.2011.00301.x","article-title":"Evaluation of prognostic indicators in dogs with multiple, simultaneously occurring cutaneous mast cell tumours, 63 cases","volume":"11","author":"O'Connell","year":"2011","journal-title":"Veterinary and Comparative Oncology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0260","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1177\/030098588402100503","article-title":"Canine cutaneous mast cell tumor, morphologic grading and survival time in 83 dogs","volume":"21","author":"Patnaik","year":"1984","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0265","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/730246","article-title":"C-kit expression, angiogenesis, and grading in canine mast cell tumour, a unique model to study c-kit driven human malignancies","author":"Patruno","year":"2014","journal-title":"BioMed Research International"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0270","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1177\/104063879801000303","article-title":"Immunohistochemical detection of Ki67 and PCNA in canine mammary tumours, relationship to clinical and pathologic variables","volume":"10","author":"Pe\u00f1a","year":"1998","journal-title":"Journal of Veterinary Diagnostic Investigation"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0275","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jcpa.2011.09.007","article-title":"Evaluation of cyclooxygenase-2 expression in canine mast cell tumours","volume":"147","author":"Prada","year":"2012","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0280","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1177\/104063870401600610","article-title":"Expression of the KIT protein (CD117) in primary cutaneous mast cell tumors of the dog","volume":"16","author":"Preziosi","year":"2004","journal-title":"Journal of Veterinary Diagnostic Investigation"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0285","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jcpa.2003.10.003","article-title":"Prognostic value of intratumoral vessel density in cutaneous mast cell tumors of the dog","volume":"130","author":"Preziosi","year":"2004","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0290","first-page":"5729","article-title":"Proof of target for SU11654, inhibition of KIT phosphorylation in canine mast cell tumors","volume":"9","author":"Pryer","year":"2003","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0295","first-page":"1189","article-title":"The dog mast cell tumour as a model to study the relationship between angiogenesis, mast cell density and tumour malignancy","volume":"10","author":"Ranieri","year":"2003","journal-title":"Oncology Reports"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0300","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00000372-200002000-00010","article-title":"Canine mast cell tumors express stem cell factor receptor","volume":"22","author":"Reguera","year":"2000","journal-title":"American Journal of Dermatopathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0305","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jcpa.2003.09.010","article-title":"Bilateral gonadoblastomas in a dog with mixed gonadal dysgenesis","volume":"130","author":"Reis-Filho","year":"2004","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0310","article-title":"p62\/sequestosome-1, mapping sites of protein-handling stress in canine cutaneous mast cell tumors","author":"Rich","year":"2014","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0315","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1476-5829.2011.00261.x","article-title":"Safety evaluation of combination vinblastine and toceranib phosphate (Palladia) in dogs, a phase I dose-finding study","volume":"10","author":"Robat","year":"2012","journal-title":"Veterinary and Comparative Oncology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0320","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1053\/jcpa.1998.0291","article-title":"PCNA and Ki67 proliferation markers as criteria for prediction of clinical behaviour of melanocytic tumours in cats and dogs","volume":"121","author":"Roels","year":"1999","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0325","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1354\/vp.44-3-335","article-title":"Mitotic index is predictive for survival for canine cutaneous mast cell tumours","volume":"44","author":"Romansik","year":"2007","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0330","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/0300985814521638","article-title":"Histologic grading of canine mast cell tumors, is 2 better than 3?","volume":"52","author":"Sabattini","year":"2015","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0335","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1053\/jcpa.2002.0586","article-title":"Proliferative activity of canine mast cell tumours evaluated by bromodeoxyuridine incorporation and Ki-67 expression","volume":"127","author":"Sakai","year":"2002","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0340","article-title":"Cytological grading of canine cutaneous mast cell tumours","author":"Scarpa","year":"2014","journal-title":"Veterinary and Comparative Oncology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0345","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1939-1676.2006.tb02835.x","article-title":"Canine mast cell tumours, correlation of apoptosis and proliferation markers with prognosis","volume":"20","author":"Scase","year":"2006","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0350","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.tvjl.2012.04.002","article-title":"Differences in the proteome of high-grade versus low-grade canine cutaneous mast cell tumours","volume":"194","author":"Schlieben","year":"2012","journal-title":"The Veterinary Journal"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0355","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jcpa.2012.07.006","article-title":"Tandem duplication of KIT exon 11 influences the proteome of canine mast cell tumours","volume":"148","author":"Schlieben","year":"2013","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0360","article-title":"Masitinib mesylate for metastatic and non-resectable canine cutaneous mast cell tumours","author":"Smrkovski","year":"2013","journal-title":"Veterinary and Comparative Oncology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0365","first-page":"2483","article-title":"Evaluation of local antitumour effectiveness of cisplatin in dogs and cats","volume":"21","author":"Spugnini","year":"2011","journal-title":"Anticancer Research"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0370","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1354\/vp.40-3-268","article-title":"Morphometry of canine cutaneous mast cell tumours","volume":"40","author":"Strefezzi Rde","year":"2003","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0375","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jcpa.2011.07.005","article-title":"The value of immunohistochemical expression of BAX in formulating a prognosis for canine mast cell tumours","volume":"146","author":"Strefezzi Rde","year":"2012","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0380","article-title":"Numerical model of dog mast cell tumor treated by electrochemotherapy","author":"Suzuki","year":"2014","journal-title":"Artificial Organs"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0385","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1248\/bpb.34.1774","article-title":"Receptor tyrosine kinases and targeted cancer therapeutics","volume":"34","author":"Takeuchi","year":"2011","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0390","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-2885.2011.01296.x","article-title":"Biological effects of tyrosine kinase inhibitors on three canine mast cell tumor cell lines with various KIT statuses","volume":"35","author":"Takeuchi","year":"2011","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0395","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1292\/jvms.11-0093","article-title":"Screening of therapeutic targets for canine mast cell tumors from a variety of kinase molecules","volume":"73","author":"Takeuchi","year":"2011","journal-title":"Journal of Veterinary Medical Science"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0400","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.tvjl.2012.11.018","article-title":"Validation of the prognostic value of histopathological grading or c-kit mutation in canine cutaneous mast cell tumours, a retrospective cohort study","volume":"196","author":"Takeuchi","year":"2013","journal-title":"The Veterinary Journal"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0405","series-title":"Small Animal Clinical Oncology","first-page":"402","article-title":"Mast cell tumors","author":"Thamm","year":"2007"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0410","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1177\/0300985810390716","article-title":"Canine subcutaneous mast cell tumours, cellular proliferation and KIT expression as prognostic indices","volume":"48","author":"Thompson","year":"2011","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0415","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1177\/0300985812447829","article-title":"Expression of Ki67, BCL-2, and COX-2 in canine cutaneous mast cell tumors, association with grading and prognosis","volume":"50","author":"Vascellari","year":"2012","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0420","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1593\/neo.05622","article-title":"The role of c-KIT in tumorigenesis, evaluation in canine cutaneous mast cell tumors","volume":"8","author":"Webster","year":"2006","journal-title":"Neoplasia (New York, N.Y.)"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0425","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1354\/vp.44-3-298","article-title":"Cellular proliferation in canine cutaneous mast cell tumors, associations with c-KIT and its role in prognostication","volume":"44","author":"Webster","year":"2007","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0430","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1354\/vp.41-3-296","article-title":"Immunohistochemical expression of p27 and p21 in canine cutaneous mast cell tumors and histiocytomas","volume":"41","author":"Wu","year":"2004","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0435","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.vetimm.2011.04.002","article-title":"Imatinib elicited a favorable response in a dog with a mast cell tumor carrying a c-kit c.1523A>T mutation via suppression of constitutive KIT activation","volume":"142","author":"Yamada","year":"2011","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0440","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1354\/vp.39-5-529","article-title":"Mutations in the juxtamembrane domain of c-KIT are associated with higher grade mast cell tumors in dogs","volume":"39","author":"Zemke","year":"2002","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2015.05.002_bib0445","first-page":"161","article-title":"Intratumoural interleukin-2 therapy can induce regression of non-resectable mastocytoma in dogs","volume":"33","author":"Ziekman","year":"2013","journal-title":"Anticancer Research"}],"container-title":["The Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023315001823?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023315001823?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T21:21:25Z","timestamp":1537651285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090023315001823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":88,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1090023315001823"],"URL":"https:\/\/doi.org\/10.1016\/j.tvjl.2015.05.002","relation":{},"ISSN":["1090-0233"],"issn-type":[{"value":"1090-0233","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"C-kit as a prognostic and therapeutic marker in canine cutaneous mast cell tumours: From laboratory to clinic","name":"articletitle","label":"Article Title"},{"value":"The Veterinary Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tvjl.2015.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}