{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:03:47Z","timestamp":1785499427430,"version":"3.56.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Progetto Operativo Nazionale","award":["PON01_02512"],"award-info":[{"award-number":["PON01_02512"]}]},{"name":"PO FESR","award":["2007\/20013"],"award-info":[{"award-number":["2007\/20013"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Veterinary Journal"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.tvjl.2015.10.060","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T10:48:14Z","timestamp":1447152494000},"page":"85-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Adelmidrol increases the endogenous concentrations of palmitoylethanolamide in canine keratinocytes and down-regulates an inflammatory reaction in an in vitro model of contact allergic dermatitis"],"prefix":"10.1016","volume":"207","author":[{"given":"S.","family":"Petrosino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Puigdemont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.F.","family":"della Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fusco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Verde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Allar\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Aveta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Orlando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Di Marzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tvjl.2015.10.060_bib0010","first-page":"352","article-title":"Aliamides in veterinary dermatology: An update on mechanism of action and clinical use in dogs and cats","volume":"17","author":"Abramo","year":"2006","journal-title":"Veterinary Dermatology"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0015","first-page":"149","article-title":"Mast cell morphometry and densitometry in experimental skin wounds treated with a gel containing adelmidrol: A placebo controlled study","volume":"20","author":"Abramo","year":"2008","journal-title":"Wounds"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1746-6148-10-21","article-title":"Increased levels of palmitoylethanolamide and other lipid mediators and enhanced local mast cell proliferation in canine atopic dermatitis","volume":"10","author":"Abramo","year":"2014","journal-title":"BMC Veterinary Research"},{"issue":"Spec No","key":"10.1016\/j.tvjl.2015.10.060_bib0025","doi-asserted-by":"crossref","first-page":"C145","DOI":"10.1007\/BF01972748","article-title":"A proposed autacoid mechanism controlling mastocyte behaviour","volume":"39","author":"Aloe","year":"1993","journal-title":"Agents and Actions"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0030","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.tips.2009.05.004","article-title":"The endocannabinoid system of the skin in health and disease: Novel perspectives and therapeutic opportunities","volume":"30","author":"Biro","year":"2009","journal-title":"Trends in Pharmacological Sciences"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0035","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1042\/bj3220671","article-title":"Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells","volume":"322","author":"Bisogno","year":"1997","journal-title":"The Biochemical Journal"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0040","doi-asserted-by":"crossref","first-page":"988","DOI":"10.2460\/ajvr.73.7.988","article-title":"Cannabinoid receptor type 1 and 2 expression in the skin of healthy dogs and dogs with atopic dermatitis","volume":"73","author":"Campora","year":"2012","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0045","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.tvjl.2011.04.002","article-title":"Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogs","volume":"191","author":"Cerrato","year":"2012","journal-title":"The Veterinary Journal"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0050","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/1746-6148-8-230","article-title":"Inhibitory effect of topical adelmidrol on antigen-induced skin wheal and mast cell behavior in a canine model of allergic dermatitis","volume":"8","author":"Cerrato","year":"2012","journal-title":"BMC Veterinary Research"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0055","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/sj.bjp.0704466","article-title":"Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat","volume":"135","author":"Conti","year":"2002","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0060","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/384083a0","article-title":"Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides","volume":"384","author":"Cravatt","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0065","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1111\/j.1582-4934.2008.00353.x","article-title":"Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats","volume":"13","author":"De Filippis","year":"2009","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0070","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/bj3580249","article-title":"Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells","volume":"358","author":"Di Marzo","year":"2001","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0075","first-page":"237","article-title":"Palmitoylethanolamide is a new possible pharmacological treatment for the inflammation associated with trauma","volume":"13","author":"Esposito","year":"2013","journal-title":"Mini Reviews in Medicinal Chemistry"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0080","first-page":"27","article-title":"Applicazione topica di adelmidrol (2%) per la gestione del prurito associato a dermatite atopica del cane: Studio osservazionale","volume":"27","author":"Fabbrini","year":"2013","journal-title":"Veterinaria"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0085","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1097\/00000542-200312000-00024","article-title":"A novel neuroimmune mechanism in cannabinoid-mediated attenuation of nerve growth factor-induced hyperalgesia","volume":"99","author":"Farquhar-Smith","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0090","series-title":"Cannabinoids","article-title":"Endocannabinoid biochemistry: What do we know after 50 years","author":"Fezza","year":"2014"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0095","doi-asserted-by":"crossref","first-page":"11131","DOI":"10.1073\/pnas.0812789106","article-title":"The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis","volume":"106","author":"Grimaldi","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0100","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1136\/vr.158.16.533","article-title":"Survey of the prevalence, diagnosis and treatment of dermatological conditions in small animals in general practice","volume":"158","author":"Hill","year":"2006","journal-title":"Veterinary Record"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0105","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1126\/science.1142265","article-title":"Attenuation of allergic contact dermatitis through the endocannabinoid system","volume":"316","author":"Karsak","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0110","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.plipres.2012.10.003","article-title":"Bioactive lipid mediators in skin inflammation and immunity","volume":"52","author":"Kendall","year":"2013","journal-title":"Progress in Lipid Research"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0115","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1600-0625.2009.00923.x","article-title":"Cannabinoid system in the skin \u2013 a possible target for future therapies in dermatology","volume":"18","author":"Kupczyk","year":"2009","journal-title":"Experimental Dermatology"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0120","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/cmdc.200700168","article-title":"Allergic contact dermatitis and the endocannabinoid system: From mechanisms to skin care","volume":"2","author":"Lambert","year":"2007","journal-title":"ChemMedChem"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0125","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0166-2236(96)10058-8","article-title":"Nerve growth factor: From neurotrophin to neurokine","volume":"19","author":"Levi-Montalcini","year":"1996","journal-title":"Trends in Neurosciences"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0130","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1124\/mol.104.006353","article-title":"The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide","volume":"67","author":"Lo Verme","year":"2005","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0135","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0165-2427(02)00232-5","article-title":"Expression of CC chemokine receptor 4 (CCR4) mRNA in canine atopic skin lesion","volume":"90","author":"Maeda","year":"2002","journal-title":"Veterinary Immunology and Immunopathology"},{"issue":"Suppl. 1","key":"10.1016\/j.tvjl.2015.10.060_bib0140","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.pain.2013.03.023","article-title":"Endocannabinoids: A unique opportunity to develop multi-target analgesics","volume":"154","author":"Maione","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0145","first-page":"113","article-title":"Assessment of the effect of an aliamide-containing topical gel by evaluation of the reduction of wound volume measured by high resolution ultrasound biomicroscopy","volume":"19","author":"Mantis","year":"2007","journal-title":"Wounds"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0150","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nature00839","article-title":"The endogenous cannabinoid system controls extinction of aversive memories","volume":"418","author":"Marsicano","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0155","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1600-0625.2010.01107.x","article-title":"Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPARgamma activation","volume":"19","author":"Mastrofrancesco","year":"2010","journal-title":"Experimental Dermatology"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0160","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0014-2999(96)00015-5","article-title":"N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation","volume":"300","author":"Mazzari","year":"1996","journal-title":"European Journal of Pharmacology"},{"issue":"Suppl. 1","key":"10.1016\/j.tvjl.2015.10.060_bib0165","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1365-2885.2006.00765_4.x","article-title":"Aliamides modulate skin mast cell degranulation in dogs and cats","volume":"29","author":"Miolo","year":"2006","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0170","doi-asserted-by":"crossref","first-page":"269541","DOI":"10.1155\/2009\/269541","article-title":"The imbalance in serum concentration of Th-1- and Th-2-derived chemokines as one of the factors involved in pathogenesis of atopic dermatitis","volume":"2009","author":"Narbutt","year":"2009","journal-title":"Mediators of Inflammation"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0175","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0190-9622(87)70294-1","article-title":"Azelaic acid","volume":"17","author":"Nazzaro-Porro","year":"1987","journal-title":"Journal of the American Academy of Dermatology"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0180","first-page":"390","article-title":"Efficacy of oral administration of ultra-micronized palmitoylethanolamide in canine non-seasonal atopic dermatitis: An open label multicentric field study","volume":"25","author":"Noli","year":"2014","journal-title":"Veterinary Dermatology"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0185","doi-asserted-by":"crossref","first-page":"5298","DOI":"10.1074\/jbc.M306642200","article-title":"Molecular characterization of a phospholipase D generating anandamide and its congeners","volume":"279","author":"Okamoto","year":"2004","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0190","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1365-3164.2010.00889.x","article-title":"Treatment of canine atopic dermatitis: 2010 clinical practice guidelines from the International Task Force on Canine Atopic Dermatitis","volume":"21","author":"Olivry","year":"2010","journal-title":"Veterinary Dermatology"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0195","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.biochi.2010.01.006","article-title":"N-palmitoyl-ethanolamine: Biochemistry and new therapeutic opportunities","volume":"92","author":"Petrosino","year":"2010","journal-title":"Biochimie"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0200","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/j.1398-9995.2009.02254.x","article-title":"Protective role of palmitoylethanolamide in contact allergic dermatitis","volume":"65","author":"Petrosino","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0205","article-title":"The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at transient receptor potential vanilloid type-1 channels","author":"Petrosino","year":"2015","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0210","first-page":"80","article-title":"Topical adelmidrol 2% emulsion, a novel aliamide, in the treatment of mild atopic dermatitis in pediatric subjects: A pilot study","volume":"15","author":"Pulvirenti","year":"2007","journal-title":"Acta Dermatovenerologica Croatica"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0215","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.tvjl.2005.10.003","article-title":"Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: Potential use in companion animals","volume":"173","author":"Re","year":"2007","journal-title":"The Veterinary Journal"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0220","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.bmcl.2009.11.134","article-title":"Synthesis and biological evaluation of new potential inhibitors of N-acylethanolamine hydrolyzing acid amidase","volume":"20","author":"Saturnino","year":"2010","journal-title":"Bioorganic and Medicinal Chemistry Letters"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0225","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1365-3164.2001.00214.x","article-title":"Clinical and histological evaluation of an analogue of palmitoylethanolamide, PLR 120 (comicronized Palmidrol INN) in cats with eosinophilic granuloma and eosinophilic plaque: A pilot study","volume":"12","author":"Scarampella","year":"2001","journal-title":"Veterinary Dermatology"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0230","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/imm.12170","article-title":"Mast cells, glia and neuroinflammation: Partners in crime?","volume":"141","author":"Skaper","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0235","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10787-013-0191-7","article-title":"Palmitoylethanolamide, a naturally occurring disease-modifying agent in neuropathic pain","volume":"22","author":"Skaper","year":"2014","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.tvjl.2015.10.060_bib0240","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0014-5793(99)00820-0","article-title":"An acid amidase hydrolyzing anandamide as an endogenous ligand for cannabinoid receptors","volume":"454","author":"Ueda","year":"1999","journal-title":"FEBS Letters"}],"container-title":["The Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023315004712?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023315004712?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T21:28:40Z","timestamp":1537219720000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090023315004712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":47,"alternative-id":["S1090023315004712"],"URL":"https:\/\/doi.org\/10.1016\/j.tvjl.2015.10.060","relation":{},"ISSN":["1090-0233"],"issn-type":[{"value":"1090-0233","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adelmidrol increases the endogenous concentrations of palmitoylethanolamide in canine keratinocytes and down-regulates an inflammatory reaction in an in vitro model of contact allergic dermatitis","name":"articletitle","label":"Article Title"},{"value":"The Veterinary Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tvjl.2015.10.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}