{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:43:00Z","timestamp":1792784580000,"version":"4.5.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Council of Technological and Scientific Development (CNPq)","award":["2011\/23483-1"],"award-info":[{"award-number":["2011\/23483-1"]}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2011\/14763-0"],"award-info":[{"award-number":["2011\/14763-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Veterinary Journal"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.tvjl.2016.05.006","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T17:59:27Z","timestamp":1463162367000},"page":"40-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Experimental infection of chickens by a flagellated motile strain of Salmonella enterica serovar Gallinarum biovar Gallinarum"],"prefix":"10.1016","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9121-8205","authenticated-orcid":false,"given":"P.D.","family":"Lopes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.C.","family":"Freitas Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.F.A.","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Denadai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.F.F.","family":"Alarcon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.O.","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Setta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.A.","family":"Barrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Junior","given":"A.","family":"Berchieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tvjl.2016.05.006_bib0010","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nature Reviews. Immunology"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0015","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/03079450120054631","article-title":"Observations on the persistence and vertical transmission of Salmonella enterica serovars Pullorum and Gallinarum in chickens: Effect of bacterial and host genetic background","volume":"30","author":"Berchieri","year":"2001","journal-title":"Avian Pathology"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0020","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1016\/j.vaccine.2008.07.088","article-title":"Effects of Salmonella enterica serovar Enteritidis on cellular recruitment and cytokine gene expression in caecum of vaccinated chickens","volume":"26","author":"Carvajal","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0025","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.vetimm.2008.10.295","article-title":"The immunobiology of avian systemic salmonellosis","volume":"128","author":"Chappell","year":"2009","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0030","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.pathol.4.110807.092239","article-title":"NOD-like receptors: Role in innate immunity and inflammatory disease","volume":"4","author":"Chen","year":"2009","journal-title":"Annual Review of Pathology"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0035","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1128\/IAI.01375-10","article-title":"Immune response of chicken gut to natural colonization by gut microflora and to Salmonella enterica serovar Enteritidis infection","volume":"79","author":"Crhanova","year":"2011","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0040","series-title":"Biostatistics: A Foundation for Analysis in the Health Sciences","first-page":"944","author":"Daniel","year":"1991"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0045","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.vetimm.2007.12.002","article-title":"Identification and validation of housekeeping genes as internal control for gene expression in an intravenous LPS inflammation model in chickens","volume":"122","author":"De Boever","year":"2008","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0050","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S1286-4579(01)01479-4","article-title":"Cytokines in host defense against Salmonella","volume":"3","author":"Eckmann","year":"2001","journal-title":"Microbes and Infection"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0055","first-page":"1","article-title":"In vitro intestinal mucosal epithelial responses to wild-type Salmonella Typhi and attenuated typhoid vaccines","volume":"12","author":"Fiorentino","year":"2013","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0060","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.vetmic.2013.04.015","article-title":"A flagellated motile Salmonella Gallinarum mutant (SG Fla+) elicits a pro-inflammatory response from avian epithelial cells and macrophages and is less virulent to chickens","volume":"165","author":"Freitas Neto","year":"2013","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0065","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.4049\/jimmunol.1100092","article-title":"The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria","volume":"187","author":"Ghose","year":"2011","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0070","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1128\/IAI.73.4.2344-2350.2005","article-title":"Identification and functional characterization of chicken Toll-like receptor 5 reveals a fundamental role in the biology of infection with Salmonella enterica serovar Typhimurium","volume":"73","author":"Iqbal","year":"2005","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0075","series-title":"Avian Immunology","first-page":"203","article-title":"Avian cytokines and chemokines","author":"Kaiser","year":"2008"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0080","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1099\/00221287-146-12-3217","article-title":"Differential cytokine expression in avian cells in response to invasion by Salmonella Typhimurium, Salmonella Enteritidis and Salmonella Gallinarum","volume":"12","author":"Kaiser","year":"2000","journal-title":"Microbiology (Reading, England)"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0085","doi-asserted-by":"crossref","first-page":"986","DOI":"10.4049\/jimmunol.164.2.986","article-title":"Characterization of CD4+ T cell responses during natural infection with Salmonella Typhimurium","volume":"164","author":"McSorley","year":"2000","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0090","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.4049\/jimmunol.169.7.3914","article-title":"Bacterial flagellin is an effective adjuvant for CD4+ T cells in vivo","volume":"169","author":"McSorley","year":"2002","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0095","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/35100529","article-title":"Toll-like receptors and innate immunity","volume":"1","author":"Medzhitov","year":"2001","journal-title":"Nature Reviews. Immunology"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0100","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00281-007-0078-z","article-title":"TLR5 and Ipaf: Dual sensors of bacterial flagellin in the innate immune system","volume":"29","author":"Miao","year":"2007","journal-title":"Seminars in Immunopathology"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0105","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1128\/CVI.05569-11","article-title":"Flagellin from recombinant attenuated Salmonella enterica serovar Typhimurium reveals a fundamental role in chicken innate immunity","volume":"19","author":"Pan","year":"2012","journal-title":"Clinical & Vaccine Immunology"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0110","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1128\/IAI.00417-06","article-title":"Caspase-1-mediated activation of interleukin-1\u03b2 (IL-1\u03b2) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection","volume":"74","author":"Raupach","year":"2006","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0115","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/1471-2180-9-268","article-title":"Virulence potential of five major pathogenicity islands (SPI-1 to SPI-5) of Salmonella enterica serovar Enteritidis for chickens","volume":"9","author":"Rychlik","year":"2009","journal-title":"BMC Microbiology"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0120","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.imlet.2005.05.004","article-title":"Salmonella flagellin, a microbial target of the innate and adaptive immune system","volume":"101","author":"Salazar-Gonzalez","year":"2005","journal-title":"Immunology Letters"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0125","series-title":"Diseases of Poultry","first-page":"620","article-title":"Pullorum disease and fowl typhoid","author":"Shivaprasad","year":"2008"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0130","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/ni1336","article-title":"Lysophospholipid sensing triggers secretion of flagellin from pathogenic Salmonella","volume":"7","author":"Subramanian","year":"2006","journal-title":"Nature Immunology"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0135","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1101\/gr.077404.108","article-title":"Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287\/91 provides insights into evolutionary and host adaptation pathways","volume":"18","author":"Thomson","year":"2008","journal-title":"Genome Research"},{"key":"10.1016\/j.tvjl.2016.05.006_bib0140","first-page":"247","article-title":"The Salmonella enterica serotype Typhi regulator TviA reduces interleukin-8 production in intestinal epithelial cells by repressing flagellin secretion","volume":"10","author":"Winter","year":"2008","journal-title":"Cellular Microbiology"}],"container-title":["The Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023316300442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023316300442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T22:20:23Z","timestamp":1536704423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090023316300442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":27,"alternative-id":["S1090023316300442"],"URL":"https:\/\/doi.org\/10.1016\/j.tvjl.2016.05.006","relation":{},"ISSN":["1090-0233"],"issn-type":[{"value":"1090-0233","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Experimental infection of chickens by a flagellated motile strain of Salmonella enterica serovar Gallinarum biovar Gallinarum","name":"articletitle","label":"Article Title"},{"value":"The Veterinary Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tvjl.2016.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}