{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:10:05Z","timestamp":1791360605850,"version":"4.3.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Veterinary Journal"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.tvjl.2018.04.015","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T08:36:09Z","timestamp":1524731769000},"page":"56-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["The role of infectious agents in the development of porcine gastric ulceration"],"prefix":"10.1016","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7632-105X","authenticated-orcid":false,"given":"C.","family":"De Witte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ducatelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1709-933X","authenticated-orcid":false,"given":"F.","family":"Haesebrouck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tvjl.2018.04.015_bib0005","series-title":"Proceedings of the 16th International Pig Veterinary Society Congress","article-title":"Links between diet, spiral bacteria in the gastric mucosa and ulceration in the stomach","author":"Accioly","year":"2000"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0010","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1556\/AVet.54.2006.4.9","article-title":"Detection of Helicobacter candidatus suis by PCR in oesophagogastric ulcers of swine in Italy","volume":"54","author":"Appino","year":"2006","journal-title":"Acta Veterinaria Hungarica"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0015","doi-asserted-by":"crossref","first-page":"564","DOI":"10.2460\/ajvr.1996.57.04.564","article-title":"Mechanisms of acid injury in porcine gastroesophageal mucosa","volume":"57","author":"Argenzio","year":"1996","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0020","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.2042-3306.1999.tb05163.x","article-title":"Comparative pathophysiology of nonglandular ulcer disease: a review of experimental studies","volume":"29","author":"Argenzio","year":"1999","journal-title":"Equine Veterinary Journal Supplement"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0025","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1099\/ijs.0.65133-0","article-title":"Isolation and characterization of Helicobacter suis sp. nov. from pig stomachs","volume":"58","author":"Baele","year":"2008","journal-title":"International Journal of Systematic and Evolutionary Microbiology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0030","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1023\/A:1027368311808","article-title":"Survey of gastric lesions and blood pepsinogen levels in pigs in Burkina Faso","volume":"27","author":"Banga-Mboko","year":"2003","journal-title":"Veterinary Research Communications"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0035","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/030098589503200206","article-title":"Higher incidence of Gastrospirillum sp. in swine with gastric ulcer of the pars oesophagea","volume":"32","author":"Barbosa","year":"1995","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0040","article-title":"Comparative virulence of in vitro-cultured primate- and pig-associated Helicobacter suis strains in a BALB\/c mouse and a Mongolian gerbil model","volume":"22","author":"Bosschem","year":"2016","journal-title":"Helicobacter"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0045","doi-asserted-by":"crossref","DOI":"10.1111\/hel.12375","article-title":"Species-specific immunity to Helicobacter suis","volume":"22","author":"Bosschem","year":"2017","journal-title":"Helicobacter"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0050","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0034-5288(18)32562-1","article-title":"Observations on plasma gastrin and plasma pepsinogen in relation to weaning and gastric (pars oesophagea) ulceration in pigs","volume":"30","author":"Bunn","year":"1981","journal-title":"Research in Veterinary Science"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0055","series-title":"Proceedings of the 24th International Pig Veterinary Society Congress","article-title":"Herd level risk factors for stomach ulcers in finishing pigs","author":"Busch","year":"2016"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0060","first-page":"195","article-title":"Helicobacter pylori modulation of gastric acid","volume":"72","author":"Calam","year":"1999","journal-title":"Yale Journal of Biology and Medicine"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0065","doi-asserted-by":"crossref","first-page":"4672","DOI":"10.1128\/AEM.65.10.4672-4676.1999","article-title":"Helicobacter species colonizing pig stomach: molecular characterization and determination of prevalence","volume":"65","author":"Cantet","year":"1999","journal-title":"Applied and Environmental Microbiology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0070","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4142\/jvs.2010.11.3.221","article-title":"Detection of Helicobacter spp. in gastric, fecal and saliva samples from swine affected by gastric ulceration","volume":"11","author":"Casagrande Proietti","year":"2010","journal-title":"Journal of Veterinary Science"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0075","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1128\/JCM.39.9.3311-3315.2001","article-title":"Identification of novel Helicobacter species in pig stomachs by PCR and partial sequencing","volume":"39","author":"Choi","year":"2001","journal-title":"Journal of Clinical Microbiology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0080","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1590\/S0100-736X2008001200007","article-title":"Gastric ulcers in pigs affected with postweaning multisystemic wasting syndrome","volume":"28","author":"Corr\u00eaa","year":"2008","journal-title":"Pesquisa Veterin\u00e1ria Brasileira"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0085","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.vetmic.2012.06.031","article-title":"An experimental Helicobacter suis infection causes gastritis and reduced daily weight gain in pigs","volume":"160","author":"De Bruyne","year":"2012","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0090","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.syapm.2016.10.001","article-title":"Detection, isolation and characterization of Fusobacterium gastrosuis sp. nov. colonizing the stomach of pigs","volume":"40","author":"De Witte","year":"2016","journal-title":"Systematic and Applied Microbiology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0095","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13567-017-0441-6","article-title":"Helicobacter suis induces changes in gastric inflammation and acid secretion markers in pigs of different ages","volume":"48","author":"De Witte","year":"2017","journal-title":"Veterinary Research"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0100","series-title":"Animal Influenza","first-page":"439","article-title":"The clinical features, pathobiology, and epidemiology of influenza infections in pigs","author":"Detmer","year":"2016"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0105","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4141\/A00-020","article-title":"Effect of health management strategy during rearing on grower-finisher pig performance and selected indicators of immune system stimulation","volume":"81","author":"Dionissopoulos","year":"2001","journal-title":"Canadian Journal of Animal Science"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0110","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/00480169.1960.33391","article-title":"Hyostrongylosis and gastric ulceration in the pig","volume":"8","author":"Dodd","year":"1960","journal-title":"New Zealand Veterinary Journal"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0115","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/0016-5085(91)90260-R","article-title":"Gastric injury and invasion of parietal cells by spiral bacteria in rhesus monkeys. Are gastritis and hyperchlorhydria infectious diseases?","volume":"100","author":"Dubois","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0120","first-page":"1","article-title":"Helicobacter suis causes severe gastric pathology in mouse and Mongolian gerbil models of human gastric disease","volume":"5","author":"Flahou","year":"2010","journal-title":"Public Library of Science One"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0125","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1111\/j.1462-5822.2011.01682.x","article-title":"Gastric epithelial cell death caused by Helicobacter suis and Helicobacter pylori \u03b3-glutamyl transpeptidase is mainly glutathione degradation-dependent","volume":"13","author":"Flahou","year":"2011","journal-title":"Cellular Microbiology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0130","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1017\/S1751731117000799","article-title":"Prevalence and risk factors for gastric ulceration in pigs slaughtered at 170kg","volume":"11","author":"Gottardo","year":"2017","journal-title":"Animal"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0135","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0147-9571(96)00007-0","article-title":"Prevalence of Helicobacter-like organisms in porcine gastric mucosa: a study of swine slaughtered in Italy","volume":"19","author":"Grasso","year":"1996","journal-title":"Comparative Immunology, Microbiology and Infectious Diseases"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0140","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1128\/CMR.00041-08","article-title":"Gastric helicobacters in domestic animals and nonhuman primates and their significance for human health","volume":"22","author":"Haesebrouck","year":"2009","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0145","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1177\/030098587901600517","article-title":"Esophagogastric ulcers in swine infected with Ascaris suum","volume":"16","author":"H\u00e4ni","year":"1979","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0150","first-page":"189","article-title":"Prevalence of \u2018Candidatus Helicobacter suis\u2019 in pigs of different ages","volume":"161","author":"Hellemans","year":"2007","journal-title":"Veterinary Research Communications"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0155","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s11259-006-3448-4","article-title":"Experimental infection of pigs with \u2018Candidatus Helicobacter suis\u2019","volume":"31","author":"Hellemans","year":"2007","journal-title":"Veterinary Research Communication"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0160","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3346\/jkms.2007.22.1.63","article-title":"Helicobacter heilmannii-associated gastritis: Clinicopathologic findings and comparison with Helicobacter pylori-associated gastritis","volume":"22","author":"Joo","year":"2007","journal-title":"Journal of Korean Medical Science"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0165","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1177\/030098589803500406","article-title":"Production of gastroesophageal erosions and ulcers (GEU) in gnotobiotic swine monoinfected with fermentative commensal bacteria and fed high-carbohydrate diet","volume":"35","author":"Krakowka","year":"1998","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0170","doi-asserted-by":"crossref","first-page":"938","DOI":"10.2460\/ajvr.2005.66.938","article-title":"Isolation and preliminary characterization of a novel Helicobacter species from swine","volume":"66","author":"Krakowka","year":"2005","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0175","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1354\/vp.43-6-956","article-title":"Reproduction of severe gastroesophageal ulcers (GEU) in gnotobiotic swine infected with porcine Helicobacter pylori-like bacteria","volume":"43","author":"Krakowka","year":"2006","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0180","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00595-004-2850-1","article-title":"The relationship of a Helicobacter heilmannii infection to the mucosal changes in abattoir and laboratory pig stomach","volume":"34","author":"Mall","year":"2004","journal-title":"Surgery Today"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0185","first-page":"201","article-title":"Helicobacter-like organisms in the stomach of pigs with and without gastric ulceration","volume":"7","author":"Melnichouk","year":"1999","journal-title":"Swine Health and Production"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0190","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1292\/jvms.62.725","article-title":"Association of tightly spiraled bacterial infection and gastritis in pigs","volume":"62","author":"Park","year":"2000","journal-title":"Journal of Veterinary Medicine and Science"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0195","series-title":"Proceedings of the 16th International Pig Veterinary Society Congress","article-title":"PCR-based identification of spiral bacteria in healthy and ulcerated swine stomachs","author":"Phillips","year":"2000"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0200","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1053\/gast.1996.v111.pm8698198","article-title":"Association between Helicobacter and gastric ulcer disease of the pars esophagea in swine","volume":"111","author":"Queiroz","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0205","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1177\/030098587801500310","article-title":"Esophagogastric ulcers associated with Ascaris suum infestation in swine","volume":"15","author":"Qureshi","year":"1978","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0210","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0304-4017(76)90063-7","article-title":"Sequential development of esophagogastric ulcers induced in swine by infections with Ascaris suum","volume":"2","author":"Rivera","year":"1976","journal-title":"Veterinary Parasitology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0215","first-page":"134","article-title":"Slaughter pigs are commonly infected by closely related but distinct gastric ulcerative lesion-inducing Gastrospirilla","volume":"39","author":"Roosendaal","year":"2002","journal-title":"Journal of Animal Science"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0220","first-page":"65","article-title":"Effect of Helicobacter sp. infection on the number of antral gastric endocrine cells in swine","volume":"10","author":"Sapierzynski","year":"2007","journal-title":"Polish Journal of Veterinary Sciences"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0225","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1053\/jcpa.2001.0541","article-title":"Gastrinaemia, tissue gastrin concentration and G cell density in the antral mucosa of swine with and without gastric ulcer of the pars oesophagea","volume":"126","author":"Silva","year":"2002","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0230","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1556\/AVet.53.2005.3.10","article-title":"Study on the role of gastric Helicobacter infection in gross pathological and histological lesions of the stomach in finishing pigs","volume":"53","author":"Szeredi","year":"2005","journal-title":"Acta Veterinaria Hungarica"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0235","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0021-9975(70)90066-6","article-title":"The microflora of the pig stomach and its possible relationship to ulceration of the pars oesophagea","volume":"80","author":"Tannock","year":"1970","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0240","series-title":"Diseases of Swine","first-page":"208","article-title":"The stomach: gastric ulceration","author":"Thomson","year":"2012"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0245","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1099\/jmm.0.017541-0","article-title":"Butyric acid-producing anaerobic bacteria as a novel probiotic treatment approach for inflammatory bowel disease","volume":"59","author":"Van Immerseel","year":"2010","journal-title":"Journal of Medical Microbiology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0250","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1297-9716-42-51","article-title":"Genome sequence of Helicobacter suis supports its role in gastric pathology","volume":"42","author":"Vermoote","year":"2011","journal-title":"Veterinary Research"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0255","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1590\/S0102-09352009000300005","article-title":"Altera\u00e7\u00f5es histol\u00f3gicas da pars esophagea de su\u00ednos e sua rela\u00e7\u00e3o com Helicobacter spp","volume":"61","author":"Yamasaki","year":"2009","journal-title":"Arquivo Brasileiro de Medicina Veterin\u00e1ria e Zootecnia"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0260","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1053\/gast.1996.v111.agast961110244","article-title":"Helicobacter heilmannii (formerly Gastrospirillum): association with pig and human gastric pathology","volume":"111","author":"Yeomans","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tvjl.2018.04.015_bib0265","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13567-016-0386-1","article-title":"Helicobacter suis affects the health and function of porcine gastric parietal cells","volume":"47","author":"Zhang","year":"2016","journal-title":"Veterinary Research"}],"container-title":["The Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023318301333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023318301333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T09:29:40Z","timestamp":1720258180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090023318301333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":53,"alternative-id":["S1090023318301333"],"URL":"https:\/\/doi.org\/10.1016\/j.tvjl.2018.04.015","relation":{},"ISSN":["1090-0233"],"issn-type":[{"value":"1090-0233","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of infectious agents in the development of porcine gastric ulceration","name":"articletitle","label":"Article Title"},{"value":"The Veterinary Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tvjl.2018.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}