{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:31:35Z","timestamp":1791973895668,"version":"4.4.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Veterinary Journal"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.tvjl.2018.10.004","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T14:02:08Z","timestamp":1539352928000},"page":"15-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Utility of flow cytometry in canine primary cutaneous and matched nodal mast cell tumor"],"prefix":"10.1016","volume":"242","author":[{"given":"M.","family":"Sulce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-615X","authenticated-orcid":false,"given":"L.","family":"Marconato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Martano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Iussich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0640-536X","authenticated-orcid":false,"given":"M.","family":"Melega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Miniscalco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4814-2273","authenticated-orcid":false,"given":"F.","family":"Riondato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tvjl.2018.10.004_bib0005","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/cyto.a.22995","article-title":"Elimination of erroneous results in flow cytometry caused by antibody binding to Fc receptors on human monocytes and macrophages","volume":"89","author":"Andersen","year":"2016","journal-title":"Cytometry A"},{"key":"10.1016\/j.tvjl.2018.10.004_bib0010","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/leu.2010.312","article-title":"Immunophenotyping of acute leukemia and lymphoproliferative disorders: a consensus proposal of the European Leukemia Net Work Package 10","volume":"25","author":"Be\u2019ne","year":"2011","journal-title":"Leukemia"},{"key":"10.1016\/j.tvjl.2018.10.004_bib0015","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1111\/j.1476-5829.2012.00341.x","article-title":"European consensus document on mast cell tumors in dogs and cats","volume":"10","author":"Blackwood","year":"2012","journal-title":"Vet. Comp. Oncol."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0020","first-page":"309","article-title":"Canine and feline neoplasia","volume":"14","author":"Brodey","year":"1970","journal-title":"Adv. Vet. Sci. Comp. Med."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0025","doi-asserted-by":"crossref","first-page":"763","DOI":"10.2460\/ajvr.2002.63.763","article-title":"Evaluation of cell-surface IgE receptor on the canine mastocytoma cell line C2 maintained in continues culture","volume":"63","author":"Brazis","year":"2002","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0030","series-title":"Immunology a Short Course","first-page":"221","article-title":"Hypersensitivity: type I","author":"Coico","year":"2009"},{"key":"10.1016\/j.tvjl.2018.10.004_bib0035","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.molimm.2014.01.018","article-title":"Mast cell progenitors: origin, development and migration to tissues","volume":"63","author":"Dahlin","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0040","series-title":"Veterinary Immunology Principles and Practice","first-page":"139","article-title":"Hypersensitivity mechanisms","author":"Day","year":"2014"},{"key":"10.1016\/j.tvjl.2018.10.004_bib0045","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1182\/blood.V91.8.2731.2731_2731_2736","article-title":"Indolent systemic mast cell disease in adults: immunophenotypic characterization of bone marrow mast cells and its diagnostic implications","volume":"91","author":"Escribano","year":"1998","journal-title":"Blood J."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cyto.b.10072","article-title":"Immunophenotypic analysis of mast cells in mastocytosis: when and how to do it. Proposal of the Spanish Network on Mastocytosis (REMA)","volume":"58","author":"Escribano","year":"2004","journal-title":"Cytometry B Clin. Cytom."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0055","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1751-0813.1979.tb07068.x","article-title":"Skin neoplasia in dogs","volume":"55","author":"Finnie","year":"1979","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0060","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1182\/blood-2012-07-442400","article-title":"Mast cell leukemia","volume":"121","author":"Georgin-Lavialle","year":"2013","journal-title":"Blood J."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0065","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.5858\/arpa.2013-0537-OA","article-title":"Flow cytometric immunophenotypic analysis of systemic mastocytosis involving bone marrow","volume":"138","author":"Jabbar","year":"2014","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0070","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1292\/jvms.09-0281","article-title":"Cultivation and characterization of canine skin-derived mast cells","volume":"72","author":"Kawarai","year":"2010","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0075","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/(SICI)1097-0320(19981215)34:6<280::AID-CYTO6>3.0.CO;2-H","article-title":"Isotype controls in the analysis of lymphocytes and CD34+ stem and progenitor cells by flow cytometry\u2014time to let go!","volume":"34","author":"Keeney","year":"1998","journal-title":"Cytometry"},{"key":"10.1016\/j.tvjl.2018.10.004_bib0080","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1354\/vp.41-4-371","article-title":"The use of KIT and tryptase expression patterns as prognostic tools for canine cutaneous mast cell tumors","volume":"41","author":"Kiupel","year":"2004","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0085","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/0300985810386469","article-title":"Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior","volume":"48","author":"Kiupel","year":"2011","journal-title":"Vet. Pathol."},{"issue":"2","key":"10.1016\/j.tvjl.2018.10.004_bib0090","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1476-5829.2009.00185.x","article-title":"Cytological lymph node evaluation in dogs with mast cell tumours: association with grade and survival","volume":"7","author":"Krick","year":"2009","journal-title":"Vet. Comp. Oncol."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0095","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.vetimm.2006.03.024","article-title":"Generation and characterization of bone marrow-derived cultured canine mast cells","volume":"113","author":"Lin","year":"2006","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0100","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.vetimm.2008.09.027","article-title":"Generation and characterization of novel canine malignant mast cell line CL1","volume":"127","author":"Lin","year":"2009","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0105","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/cyto.a.20333","article-title":"Flow cytometry controls, instrument setup, and the determination of positivity","volume":"69","author":"Maecker","year":"2006","journal-title":"Cytometry A"},{"key":"10.1016\/j.tvjl.2018.10.004_bib0110","series-title":"Clinical Immunology","first-page":"284","article-title":"Mast cells, basophils, and mastocytosis","author":"Metz","year":"2013"},{"key":"10.1016\/j.tvjl.2018.10.004_bib0115","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1177\/0300985812439215","article-title":"CD25 is expressed by canine cutaneous mast cell tumors but not by cutaneous connective tissue mast cells","volume":"49","author":"Meyer","year":"2012","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0120","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1080\/01652176.2004.9695178","article-title":"Mast cells and canine mast cell tumours","volume":"26","author":"Misdrop","year":"2004","journal-title":"Vet. Q."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0125","first-page":"1493","article-title":"Flow cytometric analysis of mast cells from normal and pathological human bone marrow samples. Identification and enumeration","volume":"149","author":"Orfao","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0130","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1177\/030098588402100503","article-title":"Canine cutaneous mast cell tumour: morphologic grading and survival time in 83 dogs","volume":"21","author":"Patnaik","year":"1984","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0135","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/cyto.b.20606","article-title":"Primary role of multiparametric flow cytometry in the diagnostic work-up of indolent clonal mast cell disorders","volume":"80","author":"Perbellini","year":"2011","journal-title":"Cytometry 2 (Clin. Cytom.)"},{"key":"10.1016\/j.tvjl.2018.10.004_bib0140","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.3109\/10428194.2014.970546","article-title":"High-sensitivity flow cytometric analysis of mast cell clustering in systemic mastocytosis: a quantitative and statistical analysis","volume":"56","author":"Pozdnyakova","year":"2015","journal-title":"Leuk. Lymphoma J."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0145","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1177\/104063870401600610","article-title":"Expression of the KIT protein in the primary cutaneous mast cell tumors of the dog","volume":"16","author":"Preziosi","year":"2004","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0150","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/jnci\/50.2.457","article-title":"Skin tumors in domestic animals, data from 12 United States and Canadian colleges of veterinary medicine","volume":"50","author":"Priester","year":"1973","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0155","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/cyto.b.21353","article-title":"Analytical and diagnostic validation of a flow cytometric strategy to quantify blood and marrow infiltration in dogs with large B-cell lymphoma","volume":"90","author":"Riondato","year":"2016","journal-title":"Cytometry B Clin. Cytom."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0160","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1751-0813.1987.tb09673.x","article-title":"Skin neoplasms of dogs in Sydney","volume":"64","author":"Rothwell","year":"1987","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0165","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1939-1676.2006.tb02835.x","article-title":"Canine mast cell tumors: correlation of apoptosis and proliferation markers with prognosis","volume":"20","author":"Scase","year":"2006","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0170","doi-asserted-by":"crossref","first-page":"765","DOI":"10.2460\/javma.246.7.765","article-title":"Comparison of 2- and 3-category histologic grading systems for predicting the presence of metastasis at the time of initial evaluation in dogs with cutaneous mast cell tumors: 386 cases (2009\u20132014)","volume":"246","author":"Stefanello","year":"2015","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0175","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/(SICI)1097-0320(19971015)30:5<214::AID-CYTO2>3.0.CO;2-H","article-title":"U.S.\u2013Canadian Consensus recommendations on the immunophenotypic analysis of hematologic neoplasia by flow cytometry: standardization and validation of laboratory procedures","volume":"30","author":"Stelzer","year":"1997","journal-title":"Cytometry"},{"key":"10.1016\/j.tvjl.2018.10.004_bib0180","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1046\/j.1365-2567.2003.01559.x","article-title":"Functional and phenotypic studies of two variants of a human mast cell line with a distinct set of mutations in the c-kit proto-oncogene","volume":"108","author":"Sundstr\u00f6m","year":"2003","journal-title":"Immunology"},{"key":"10.1016\/j.tvjl.2018.10.004_bib0185","first-page":"44","article-title":"The immunophenotype of mast cells and its utility in the diagnostic work up of systemic mastocytosis","volume":"97","author":"Teodosio","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0190","series-title":"Veterinary Immunology an Introduction","first-page":"308","article-title":"Type I hypersensitivity","author":"Tizard","year":"2004"},{"key":"10.1016\/j.tvjl.2018.10.004_bib0195","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1177\/0300985810387446","article-title":"Canine subcutaneous mast cell tumor: characterization and prognostic indices","volume":"48","author":"Thompson","year":"2011","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0200","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0165-2427(99)00051-3","article-title":"An immunophenotypic study of canine leukemias and preliminary assessment of clonality by polymerase chain reaction","volume":"69","author":"Vernau","year":"1999","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0205","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1182\/blood-2013-11-537571","article-title":"Stable long-term mixed chimerism achieved in a canine model of allogeneic in utero hematopoietic cell transplantation","volume":"124","author":"Vrecenak","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.tvjl.2018.10.004_bib0210","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jcpa.2014.07.004","article-title":"Correlation of nodal mast cells with clinical outcome in dogs with mast cell tumour and a proposed classification system for the evaluation of node metastasis","volume":"151","author":"Weishaar","year":"2014","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.tvjl.2018.10.004_bib0215","first-page":"7987","article-title":"Fluorouracil may enrich cancer stem cells in canine mammary tumor cells in vitro","volume":"15","author":"Zhou","year":"2018","journal-title":"Oncol. Lett."}],"container-title":["The Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023318306336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023318306336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T11:03:15Z","timestamp":1572087795000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090023318306336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":43,"alternative-id":["S1090023318306336"],"URL":"https:\/\/doi.org\/10.1016\/j.tvjl.2018.10.004","relation":{},"ISSN":["1090-0233"],"issn-type":[{"value":"1090-0233","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Utility of flow cytometry in canine primary cutaneous and matched nodal mast cell tumor","name":"articletitle","label":"Article Title"},{"value":"The Veterinary Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tvjl.2018.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}