{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:44:24Z","timestamp":1782553464780,"version":"3.54.5"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Veterinary Journal"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.tvjl.2024.106182","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T16:09:36Z","timestamp":1718640576000},"page":"106182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Enhancement of systemic virus-specific T lymphocyte responses in pigs supplemented with algae-derived \u03b2-glucan"],"prefix":"10.1016","volume":"306","author":[{"given":"SH.B.","family":"Chuaychu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Sirisereewan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Techakriengkrai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Tummaruk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Thanawongnuwech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nedumpun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tvjl.2024.106182_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens10091073","article-title":"Reappraisal of PRRS immune control strategies: the way forward","volume":"10","author":"Amadori","year":"2021","journal-title":"Pathogens"},{"key":"10.1016\/j.tvjl.2024.106182_bib2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.dci.2014.10.005","article-title":"Cell type-specific differences in beta-glucan recognition and signalling in porcine innate immune cells","volume":"48","author":"Baert","year":"2015","journal-title":"Development and Comparative Immunology"},{"key":"10.1016\/j.tvjl.2024.106182_bib3","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1177\/003591577306601202","article-title":"Cellular immunology in the pig","volume":"66","author":"Binns","year":"1973","journal-title":"Proceedings of the Royal Society of Medicine"},{"key":"10.1016\/j.tvjl.2024.106182_bib4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1462-5822.2005.00505.x","article-title":"Immune recognition of fungal \u03b2-glucans","volume":"7","author":"Brown","year":"2005","journal-title":"Cellular Microbiology"},{"key":"10.1016\/j.tvjl.2024.106182_bib5","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1177\/1753425920951607","article-title":"Differential induction of innate memory in porcine monocytes by beta-glucan or bacillus Calmette-Guerin","volume":"27","author":"Byrne","year":"2021","journal-title":"Innate Immunity"},{"key":"10.1016\/j.tvjl.2024.106182_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/v15071442","article-title":"Progress in PRRSV infection and adaptive immune response mechanisms","volume":"15","author":"Cai","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.tvjl.2024.106182_bib7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2049-1891-4-19","article-title":"The biological stress of early weaned piglets","volume":"4","author":"Campbell","year":"2013","journal-title":"Journal of Animal Science and Biotechnology"},{"key":"10.1016\/j.tvjl.2024.106182_bib8","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.dci.2016.07.006","article-title":"Lipopolysaccharide- and beta-1,3-glucan-binding protein from Fenneropenaeus merguiensis functions as a pattern recognition receptor with a broad specificity for diverse pathogens in the defense against microorganisms","volume":"67","author":"Chaosomboon","year":"2017","journal-title":"Development and Comparative Immunology"},{"key":"10.1016\/j.tvjl.2024.106182_bib9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5501\/wjv.v1.i1.23","article-title":"Porcine reproductive and respiratory syndrome virus vaccines: Immunogenicity, efficacy and safety aspects","volume":"1","author":"Charerntantanakul","year":"2012","journal-title":"World Journal of Virology"},{"key":"10.1016\/j.tvjl.2024.106182_bib10","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.5713\/ajas.2004.1145","article-title":"Effects of \u03b2-glucan supplementation on lymphocyte proliferation, macrophage chemotaxis and specific immune responses in broilers","volume":"17","author":"Cheng","year":"2004","journal-title":"Asian-Australasian Journal of Animal Sciences"},{"key":"10.1016\/j.tvjl.2024.106182_bib11","article-title":"Characterization of beta-glucans from cereal and microbial sources and their roles in feeds for intestinal health and growth of nursery pigs","volume":"13","author":"Choi","year":"2023","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.tvjl.2024.106182_bib12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1051\/vetres\/2009029","article-title":"Functional impairment of PRRSV-specific peripheral CD3+CD8high cells","volume":"40","author":"Costers","year":"2009","journal-title":"Veterinary Research"},{"key":"10.1016\/j.tvjl.2024.106182_bib13","article-title":"Euglena gracilis beta-Glucans (1,3): enriching colostrum of sow for enhanced piglet immunity","volume":"13","author":"de Carvalho","year":"2023","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.tvjl.2024.106182_bib14","first-page":"27","article-title":"A review of evidence for immunosuppression due to porcine reproductive and respiratory syndrome virus","volume":"31","author":"Drew","year":"2000","journal-title":"Veterinary Research"},{"key":"10.1016\/j.tvjl.2024.106182_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0166-0934(01)00358-5","article-title":"Quantitative TaqMan RT-PCR for the detection and differentiation of European and North American strains of porcine reproductive and respiratory syndrome virus","volume":"98","author":"Egli","year":"2001","journal-title":"Journal of Virological Methods"},{"key":"10.1016\/j.tvjl.2024.106182_bib16","doi-asserted-by":"crossref","first-page":"658","DOI":"10.3389\/fimmu.2020.00658","article-title":"Structure-functional activity relationship of beta-glucans from the perspective of immunomodulation: a mini-review","volume":"11","author":"Han","year":"2020","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.tvjl.2024.106182_bib17","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.3382\/ps\/pey523","article-title":"Effects of beta-1, 3-glucan (AletaTM) on vaccination response in broiler chickens","volume":"98","author":"Horst","year":"2019","journal-title":"Poultry Science"},{"key":"10.1016\/j.tvjl.2024.106182_bib18","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2527\/jas.2010-3470","article-title":"Effects of stress associated with weaning on the adaptive immune system in pigs.","volume":"90","author":"Kick","year":"2012","journal-title":"Journal of Animal Science"},{"key":"10.1016\/j.tvjl.2024.106182_bib19","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.anifeedsci.2018.12.004","article-title":"Algae-derived \u03b2-glucan enhanced gut health and immune responses of weaned pigs experimentally infected with a pathogenic E. coli","volume":"248","author":"Kim","year":"2019","journal-title":"Animal Feed Science and Technology"},{"key":"10.1016\/j.tvjl.2024.106182_bib20","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.3389\/fimmu.2019.02258","article-title":"Porcine anti-viral immunity: how important is it?","volume":"10","author":"Lager","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.tvjl.2024.106182_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/IntJMedMushr.v16.i1.10","article-title":"Innate immunity induced by fungal beta-glucans via dectin-1 signaling pathway","volume":"16","author":"Lee","year":"2014","journal-title":"International Journal of Medicinal Mushrooms"},{"key":"10.1016\/j.tvjl.2024.106182_bib22","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.3382\/ps\/pey227","article-title":"Evaluation of the effects of feeding dried algae containing beta-1,3-glucan on broilers challenged with Eimeria","volume":"97","author":"Levine","year":"2018","journal-title":"Poultry Science"},{"key":"10.1016\/j.tvjl.2024.106182_bib23","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1158\/1078-0432.CCR-10-0820","article-title":"Orally administered particulate beta-glucan modulates tumor-capturing dendritic cells and improves antitumor T-cell responses in cancer","volume":"16","author":"Li","year":"2010","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.tvjl.2024.106182_bib24","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.2527\/jas.2004-541","article-title":"Effects of beta-glucan extracted from Saccharomyces cerevisiae on growth performance, and immunological and somatotropic responses of pigs challenged with Escherichia coli lipopolysaccharide","volume":"84","author":"Li","year":"2006","journal-title":"Journal of Animal Science"},{"key":"10.1016\/j.tvjl.2024.106182_bib25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.aninu.2018.01.007","article-title":"Non-antibiotic feed additives in diets for pigs: a review","volume":"4","author":"Liu","year":"2018","journal-title":"Animal Nutrition"},{"key":"10.1016\/j.tvjl.2024.106182_bib26","article-title":"Purified beta-glucans of different molecular weights enhance growth performance of LPS-challenged piglets via improved gut barrier function and microbiota","volume":"9","author":"Luo","year":"2019","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.tvjl.2024.106182_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.691145","article-title":"The ability of porcine reproductive and respiratory syndrome virus isolates to induce broadly reactive neutralizing antibodies correlates with in vivo protection","volume":"12","author":"Martinez-Lobo","year":"2021","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.tvjl.2024.106182_bib28","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1128\/CVI.00434-15","volume":"22","author":"Niederwerder","year":"2015","journal-title":"Clinical and Vaccine Immunology"},{"key":"10.1016\/j.tvjl.2024.106182_bib29","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.vetmic.2018.08.024","article-title":"Detection of classical swine fever virus (CSFV) E2 and E(rns) antibody (IgG, IgA) in oral fluid specimens from inoculated (ALD strain) or vaccinated (LOM strain) pigs","volume":"224","author":"Panyasing","year":"2018","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2024.106182_bib30","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1080\/09712119.2018.1481855","article-title":"Effect of dietary \u03b2-glucan supplementation on growth performance, nutrient digestibility, and characteristics of feces in weaned pigs","volume":"46","author":"Park","year":"2018","journal-title":"Journal of Applied Animal Research"},{"key":"10.1016\/j.tvjl.2024.106182_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/v9060148","article-title":"Mechanisms of adaptive immunity to porcine reproductive and respiratory syndrome virus","volume":"9","author":"Rahe","year":"2017","journal-title":"Viruses"},{"key":"10.1016\/j.tvjl.2024.106182_bib32","doi-asserted-by":"crossref","first-page":"7998","DOI":"10.3168\/jds.2022-21838","article-title":"Effect of supplementation with algae beta-glucans on performance, health, and blood metabolites of Holstein dairy calves","volume":"105","author":"Reis","year":"2022","journal-title":"Journal of Dairy Science"},{"key":"10.1016\/j.tvjl.2024.106182_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1143682","article-title":"beta-glucans: a potential source for maintaining gut microbiota and the immune system","volume":"10","author":"Singh","year":"2023","journal-title":"Frontiers in Nutrition"},{"key":"10.1016\/j.tvjl.2024.106182_bib34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.vetimm.2009.11.014","article-title":"The effect of beta-glucans on porcine leukocytes","volume":"135","author":"Sonck","year":"2010","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"10.1016\/j.tvjl.2024.106182_bib35","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fvets.2015.00010","article-title":"Immune responses against classical swine fever virus: between ignorance and lunacy","volume":"2","author":"Summerfield","year":"2015","journal-title":"Frontiers in Veterinary Science"},{"key":"10.1016\/j.tvjl.2024.106182_bib36","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1016\/j.vaccine.2005.12.010","article-title":"Negative impact of porcine reproductive and respiratory syndrome virus infection on the efficacy of classical swine fever vaccine","volume":"24","author":"Suradhat","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.tvjl.2024.106182_bib37","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1016\/j.vaccine.2015.06.020","article-title":"A novel DNA vaccine for reduction of PRRSV-induced negative immunomodulatory effects: a proof of concept","volume":"33","author":"Suradhat","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.tvjl.2024.106182_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1042778","article-title":"Weaning stress and intestinal health of piglets: a review","volume":"13","author":"Tang","year":"2022","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.tvjl.2024.106182_bib39","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0378-1135(98)00245-4","article-title":"Influence of pig age on virus titer and bactericidal activity of porcine reproductive and respiratory syndrome virus (PRRSV)-infected pulmonary intravascular macrophages (PIMs)","volume":"63","author":"Thanawongnuwech","year":"1998","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.tvjl.2024.106182_bib40","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2174\/1874091X01408010089","article-title":"The effects of beta-glucan on pig growth and immunity","author":"Vetvicka","year":"2014","journal-title":"Open Biochemistry Journal 8"},{"key":"10.1016\/j.tvjl.2024.106182_bib41","article-title":"Glucan supplementation enhances the immune response against an influenza challenge in mice","volume":"3","author":"Vetvicka","year":"2015","journal-title":"Annals of Translational Medicine"},{"key":"10.1016\/j.tvjl.2024.106182_bib42","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.biopha.2007.05.011","article-title":"Enhancing effects of new biological response modifier \u03b2-1, 3 glucan sulfate PS3 on immune reactions","volume":"62","author":"Vetvicka","year":"2008","journal-title":"Biomedicine Pharmacotherapy"},{"key":"10.1016\/j.tvjl.2024.106182_bib43","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1865-1682.2008.01049.x","article-title":"Enhancement of peripheral blood CD8+ T cells and classical swine fever antibodies by dietary \u03b2-1, 3\/1, 6-glucan supplementation in weaned piglets","volume":"55","author":"Wang","year":"2008","journal-title":"Transboundary and Emerging Diseases"},{"key":"10.1016\/j.tvjl.2024.106182_bib44","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1039\/C7FO01980G","article-title":"Effects of dietary beta-glucan supplementation on growth performance and immunological and metabolic parameters of weaned pigs administered with Escherichia coli lipopolysaccharide","volume":"9","author":"Wu","year":"2018","journal-title":"Food Function"},{"key":"10.1016\/j.tvjl.2024.106182_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrep.2022.101256","article-title":"Immune-enhancing effect of water-soluble beta-glucan derived from enzymatic hydrolysis of yeast glucan","volume":"30","author":"Xin","year":"2022","journal-title":"Biochemistry and Biophysics Reports"},{"key":"10.1016\/j.tvjl.2024.106182_bib46","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.fsi.2018.04.003","article-title":"\u03b2-1, 3 glucan derived from Euglena gracilis and Algamune\u2122 enhances innate immune responses of red drum (Sciaenops ocellatus L.)","volume":"77","author":"Yamamoto","year":"2018","journal-title":"Fish Shellfish Immunology"},{"key":"10.1016\/j.tvjl.2024.106182_bib47","article-title":"Porcine reproductive and respiratory syndrome modified live virus vaccine: a \"Leaky\" vaccine with debatable efficacy and safety","volume":"9","author":"Zhou","year":"2021","journal-title":"Vaccines (Basel)"}],"container-title":["The Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023324001217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1090023324001217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T11:26:09Z","timestamp":1723634769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1090023324001217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":47,"alternative-id":["S1090023324001217"],"URL":"https:\/\/doi.org\/10.1016\/j.tvjl.2024.106182","relation":{},"ISSN":["1090-0233"],"issn-type":[{"value":"1090-0233","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhancement of systemic virus-specific T lymphocyte responses in pigs supplemented with algae-derived \u03b2-glucan","name":"articletitle","label":"Article Title"},{"value":"The Veterinary Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tvjl.2024.106182","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106182"}}