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Biol."},{"key":"10.1016\/j.tvr.2021.200225_bib166","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.tvr.2021.200225_bib167","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1158\/0008-5472.CAN-18-1326","article-title":"Antagonism of glycolysis and reductive carboxylation of glutamine potentiates activity of oncolytic adenoviruses in cancer cells","volume":"79","author":"Dyer","year":"2019","journal-title":"Canc. Res."},{"key":"10.1016\/j.tvr.2021.200225_bib168","first-page":"367","article-title":"Functions of adenovirus E1A","volume":"5","author":"Berk","year":"1986","journal-title":"Canc. Surv."},{"key":"10.1016\/j.tvr.2021.200225_bib169","doi-asserted-by":"crossref","first-page":"7936","DOI":"10.1128\/JVI.77.14.7936-7944.2003","article-title":"Mutual interference of adenovirus infection and myc expression","volume":"77","author":"L\u00f6hr","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.tvr.2021.200225_bib170","doi-asserted-by":"crossref","first-page":"752","DOI":"10.18632\/genesandcancer.160","article-title":"Enhanced MYC association with the NuA4 histone acetyltransferase complex mediated by the adenovirus E1A N-terminal domain activates a subset of MYC target genes highly expressed in cancer cells","volume":"8","author":"Zhao","year":"2017","journal-title":"Genes Canc."},{"key":"10.1016\/j.tvr.2021.200225_bib171","doi-asserted-by":"crossref","first-page":"6103","DOI":"10.1073\/pnas.0802095105","article-title":"Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc","volume":"105","author":"Tworkowski","year":"2008","journal-title":"Proc. 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Natl. Acad. Sci. U. S. A."},{"issue":"Pt 6","key":"10.1016\/j.tvr.2021.200225_bib181","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1099\/0022-1317-72-6-1467","article-title":"Individual adenovirus E1B proteins induce transformation independently but by additive pathways","volume":"72","author":"McLorie","year":"1991","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.tvr.2021.200225_bib182","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1128\/jvi.61.2.426-435.1987","article-title":"Expression of adenovirus E1B mutant phenotypes is dependent on the host cell and on synthesis of E1A proteins","volume":"61","author":"White","year":"1987","journal-title":"J. Virol."},{"key":"10.1016\/j.tvr.2021.200225_bib183","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1128\/JVI.80.4.2000-2012.2006","article-title":"Genetic identification of adenovirus type 5 genes that influence viral spread","volume":"80","author":"Subramanian","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.tvr.2021.200225_bib184","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1128\/jvi.62.9.3265-3273.1988","article-title":"Adenovirus type 12 E1B 19-kilodalton protein is not required for oncogenic transformation in rats","volume":"62","author":"Edbauer","year":"1988","journal-title":"J. Virol."},{"issue":"Pt 8","key":"10.1016\/j.tvr.2021.200225_bib185","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1099\/0022-1317-70-8-1975","article-title":"Role of adenovirus type 2 early region 1B 19K protein stability in expression of the cyt and deg phenotypes","volume":"70","author":"Kumai","year":"1989","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.tvr.2021.200225_bib186","first-page":"287","article-title":"Regulation of mRNA production by the adenoviral E1B 55-kDa and E4 Orf6 proteins","volume":"272","author":"Flint","year":"2003","journal-title":"Curr. Top. Microbiol. 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Virol."},{"key":"10.1016\/j.tvr.2021.200225_bib198","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1101\/gad.926401","article-title":"Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex","volume":"15","author":"Querido","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.tvr.2021.200225_bib199","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1073\/pnas.94.4.1206","article-title":"The adenovirus E4orf6 protein can promote E1A\/E1B-induced focus formation by interfering with p53 tumor suppressor function","volume":"94","author":"Nevels","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tvr.2021.200225_bib200","first-page":"3084","article-title":"Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells","volume":"5","author":"Zantema","year":"1985","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.tvr.2021.200225_bib201","doi-asserted-by":"crossref","first-page":"12210","DOI":"10.1128\/JVI.01442-10","article-title":"Adenovirus E1B 55-kilodalton protein is a p53-SUMO1 E3 ligase that represses p53 and stimulates its nuclear export through interactions with promyelocytic leukemia nuclear bodies","volume":"84","author":"Pennella","year":"2010","journal-title":"J. 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Virol."},{"key":"10.1016\/j.tvr.2021.200225_bib208","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2217\/fmb.11.153","article-title":"Adenovirus degradation of cellular proteins","volume":"7","author":"Schreiner","year":"2012","journal-title":"Future Microbiol."},{"key":"10.1016\/j.tvr.2021.200225_bib209","doi-asserted-by":"crossref","first-page":"9194","DOI":"10.1128\/JVI.76.18.9194-9206.2002","article-title":"Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery","volume":"76","author":"Harada","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.tvr.2021.200225_bib210","doi-asserted-by":"crossref","first-page":"7034","DOI":"10.1128\/JVI.00029-07","article-title":"Adenovirus E4 34k and E1b 55k oncoproteins target host DNA ligase IV for proteasomal degradation","volume":"81","author":"Baker","year":"2007","journal-title":"J. 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Virol."},{"key":"10.1016\/j.tvr.2021.200225_bib224","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s11658-020-00230-z","article-title":"Effects of HPV16 E6 protein on Daxx-induced apoptosis in C33A cells","volume":"25","author":"Tang","year":"2020","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.tvr.2021.200225_bib225","doi-asserted-by":"crossref","first-page":"14075","DOI":"10.1073\/pnas.1008850107","article-title":"Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres","volume":"107","author":"Lewis","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tvr.2021.200225_bib226","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1093\/nar\/gkt064","article-title":"Control of human adenovirus type 5 gene expression by cellular Daxx\/ATRX chromatin-associated complexes","volume":"41","author":"Schreiner","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tvr.2021.200225_bib227","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.2217\/epi.15.82","article-title":"Emerging roles of ATRX in cancer","volume":"7","author":"Watson","year":"2015","journal-title":"Epigenomics"},{"key":"10.1016\/j.tvr.2021.200225_bib228","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s13238-017-0462-y","article-title":"Structural basis for DAXX interaction with ATRX","volume":"8","author":"Wang","year":"2017","journal-title":"Protein Cell"},{"key":"10.1016\/j.tvr.2021.200225_bib229","first-page":"2570","article-title":"The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha","volume":"12","author":"White","year":"1992","journal-title":"Mol. 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Cell Biol."},{"key":"10.1016\/j.tvr.2021.200225_bib232","doi-asserted-by":"crossref","first-page":"6553","DOI":"10.1128\/jvi.68.10.6553-6566.1994","article-title":"Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells","volume":"68","author":"Chiou","year":"1994","journal-title":"J. Virol."},{"key":"10.1016\/j.tvr.2021.200225_bib233","doi-asserted-by":"crossref","first-page":"8479","DOI":"10.1073\/pnas.90.18.8479","article-title":"Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death","volume":"90","author":"Henderson","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tvr.2021.200225_bib234","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1128\/jvi.67.7.4391-4394.1993","article-title":"An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstein-Barr virus gene BHRF1","volume":"67","author":"Neilan","year":"1993","journal-title":"J. Virol."},{"key":"10.1016\/j.tvr.2021.200225_bib235","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/335440a0","article-title":"Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells","volume":"335","author":"Vaux","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.tvr.2021.200225_bib236","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0092-8674(94)90202-X","article-title":"Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins","volume":"79","author":"Boyd","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.tvr.2021.200225_bib237","doi-asserted-by":"crossref","first-page":"7742","DOI":"10.1073\/pnas.89.16.7742","article-title":"The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins","volume":"89","author":"Rao","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tvr.2021.200225_bib238","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1101\/gad.1012702","article-title":"Viral homologs of BCL-2: role of apoptosis in the regulation of virus infection","volume":"16","author":"Cuconati","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.tvr.2021.200225_bib239","first-page":"6","article-title":"BNIP-2 retards breast cancer cell migration by coupling microtubule-mediated GEF-H1 and RhoA activation","author":"Pan","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tvr.2021.200225_bib240","doi-asserted-by":"crossref","first-page":"33123","DOI":"10.1074\/jbc.274.46.33123","article-title":"Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42","volume":"274","author":"Low","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tvr.2021.200225_bib241","first-page":"120","article-title":"Role of adenovirus E1B proteins in transformation: altered organization of intermediate filaments in transformed cells that express the 19-kilodalton protein","volume":"10","author":"White","year":"1990","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.tvr.2021.200225_bib242","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1101\/gad.10.4.461","article-title":"The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein","volume":"10","author":"Han","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.tvr.2021.200225_bib243","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/374731a0","article-title":"Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K","volume":"374","author":"Farrow","year":"1995","journal-title":"Nature"},{"issue":"Pt 6","key":"10.1016\/j.tvr.2021.200225_bib244","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1099\/0022-1317-80-6-1513","article-title":"Human papillomavirus (HPV) E6 interactions with Bak are conserved amongst E6 proteins from high and low risk HPV types","volume":"80","author":"Thomas","year":"1999","journal-title":"J. Gen. 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Virol."},{"issue":"Pt 3","key":"10.1016\/j.tvr.2021.200225_bib248","first-page":"149","article-title":"Assessing the role of E1A in the differential oncogenicity of group A and group C human adenoviruses","volume":"199","author":"Williams","year":"1995","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.tvr.2021.200225_bib249","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1128\/jvi.66.4.2302-2309.1992","article-title":"Overexpression of the E1B 55-kilodalton (482R) protein of human adenovirus type 12 appears to permit efficient transformation of primary baby rat kidney cells in the absence of the E1B 19-kilodalton protein","volume":"66","author":"Zhang","year":"1992","journal-title":"J. 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Neurosci."},{"key":"10.1016\/j.tvr.2021.200225_bib253","doi-asserted-by":"crossref","first-page":"9680","DOI":"10.1128\/JVI.74.20.9680-9693.2000","article-title":"Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins","volume":"74","author":"Lee","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.tvr.2021.200225_bib254","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1073\/pnas.94.13.6670","article-title":"Binding of human virus oncoproteins to hDlg\/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein","volume":"94","author":"Lee","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tvr.2021.200225_bib255","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.1038\/sj.onc.1203906","article-title":"Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins","volume":"19","author":"Glaunsinger","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.tvr.2021.200225_bib256","doi-asserted-by":"crossref","first-page":"5578","DOI":"10.1093\/emboj\/20.20.5578","article-title":"Link of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2","volume":"20","author":"Glaunsinger","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.tvr.2021.200225_bib257","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/sj.onc.1201567","article-title":"The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins","volume":"16","author":"Rousset","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.tvr.2021.200225_bib258","doi-asserted-by":"crossref","first-page":"11612","DOI":"10.1073\/pnas.94.21.11612","article-title":"Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein","volume":"94","author":"Kiyono","year":"1997","journal-title":"Proc. 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Virol."},{"key":"10.1016\/j.tvr.2021.200225_bib261","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004102","article-title":"The human adenovirus E4-ORF1 protein subverts discs large 1 to mediate membrane recruitment and dysregulation of phosphatidylinositol 3-kinase","volume":"10","author":"Kong","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tvr.2021.200225_bib262","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/sj.emboj.7601030","article-title":"Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor","volume":"25","author":"Frese","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.tvr.2021.200225_bib263","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1111\/j.1742-4658.2012.08729.x","article-title":"The PDZ protein discs-large (DLG): the \u201cJekyll and Hyde\u201d of the epithelial polarity proteins","volume":"279","author":"Roberts","year":"2012","journal-title":"FEBS J."},{"key":"10.1016\/j.tvr.2021.200225_bib264","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002543","article-title":"The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF\/RhoG activity","volume":"8","author":"Krishna Subbaiah","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tvr.2021.200225_bib265","doi-asserted-by":"crossref","first-page":"8873","DOI":"10.1038\/ncomms9873","article-title":"MYC-induced reprogramming of glutamine catabolism supports optimal virus replication","volume":"6","author":"Thai","year":"2015","journal-title":"Nat. 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Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tvr.2021.200225_bib278","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1083\/jcb.138.1.5","article-title":"Human cytomegalovirus immediate early interaction with host nuclear structures: definition of an immediate transcript environment","volume":"138","author":"Ishov","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tvr.2021.200225_bib279","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1083\/jcb.131.1.45","article-title":"Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies","volume":"131","author":"Carvalho","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tvr.2021.200225_bib280","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1101\/gad.10.2.196","article-title":"Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure","volume":"10","author":"Doucas","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.tvr.2021.200225_bib281","doi-asserted-by":"crossref","first-page":"5295","DOI":"10.1128\/JVI.77.9.5295-5304.2003","article-title":"Distinct roles of the Adenovirus E4 ORF3 protein in viral DNA replication and inhibition of genome concatenation","volume":"77","author":"Evans","year":"2003","journal-title":"J. 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