{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T03:47:51Z","timestamp":1782532071495,"version":"3.54.5"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Tumour Virus Research"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.tvr.2026.200337","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T19:13:33Z","timestamp":1769714013000},"page":"200337","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Ad-VT oncolytic adenovirus suppresses bladder cancer via cAMP-dependent AMPK-Raptor activation and G2\/M arrest"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8402-6461","authenticated-orcid":false,"given":"Dapeng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhe","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tvr.2026.200337_bib1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-076743","article-title":"Advances in diagnosis and treatment of bladder cancer","author":"Lopez-Beltran","year":"2024","journal-title":"Br. Med. J."},{"key":"10.1016\/j.tvr.2026.200337_bib2","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1001\/jama.2020.17598","article-title":"Bladder cancer: a review","volume":"324","author":"Lenis","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.tvr.2026.200337_bib3","volume":"6","year":"2016","journal-title":"Cancer Discov."},{"key":"10.1016\/j.tvr.2026.200337_bib4","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1111\/jcmm.17549","article-title":"A comparative study of the ability of recombinant oncolytic adenovirus, doxorubicin and tamoxifen to inhibit the proliferation of breast cancer cells","volume":"26","author":"Li","year":"2022","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.tvr.2026.200337_bib5","article-title":"Anti-tumor synergistic effect of a dual cancer-specific recombinant adenovirus and Paclitaxel on breast cancer","volume":"10","author":"Wang","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.tvr.2026.200337_bib6","article-title":"Recombinant adenoviruses expressing apoptin suppress the growth of MCF-7 breast cancer cells and affect cell autophagy","author":"Chen","year":"2019","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.tvr.2026.200337_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens9040294","article-title":"The role of apoptin in chicken anemia virus replication","volume":"9","author":"Feng","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.tvr.2026.200337_bib8","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.drup.2006.02.003","article-title":"Tumor-specific nuclear targeting: promises for anti-cancer therapy?","volume":"9","author":"Alvisi","year":"2006","journal-title":"Drug Resist. Updates : reviews and commentaries in antimicrobial and anticancer chemotherapy"},{"key":"10.1016\/j.tvr.2026.200337_bib9","first-page":"11334","article-title":"Antitumor effects of apoptin expressed by the dual cancer-specific oncolytic adenovirus - a review","volume":"24","author":"Fang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.tvr.2026.200337_bib10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1476-4598-9-10","article-title":"Potent anti-tumor effects of a dual specific oncolytic adenovirus expressing apoptin in vitro and in vivo","volume":"9","author":"Li","year":"2010","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tvr.2026.200337_bib11","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s10637-021-01073-x","article-title":"Autophagy promotes oncolysis of an adenovirus expressing apoptin in human bladder cancer models","volume":"39","author":"Shang","year":"2021","journal-title":"Invest. N. Drugs"},{"key":"10.1016\/j.tvr.2026.200337_bib12","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/mt.2015.172","article-title":"Activation of Cyclic Adenosine Monophosphate pathway increases the sensitivity of cancer cells to the oncolytic virus M1","volume":"24","author":"Li","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.tvr.2026.200337_bib13","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.4161\/cc.8.20.9832","article-title":"Alphavirus M1 induces apoptosis of malignant glioma cells via downregulation and nucleolar translocation of p21WAF1\/CIP1 protein","volume":"8","author":"Hu","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.tvr.2026.200337_bib14","doi-asserted-by":"crossref","DOI":"10.1186\/s13058-024-01880-z","article-title":"CAR expression in invasive breast carcinoma and its effect on adenovirus transduction efficiency","volume":"26","author":"Phung","year":"2024","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.tvr.2026.200337_bib15","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3389\/fcell.2020.00524","article-title":"Apoptin as a tumor-specific therapeutic agent: current perspective on mechanism of action and delivery systems","volume":"8","author":"Malla","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tvr.2026.200337_bib16","doi-asserted-by":"crossref","first-page":"560","DOI":"10.4161\/cc.4.4.1606","article-title":"The anaphase promoting complex - a critical target for viral proteins and anti-cancer drugs","volume":"4","author":"Heilman","year":"2005","journal-title":"Cell Cycle"},{"key":"10.1016\/j.tvr.2026.200337_bib17","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.bbamcr.2009.04.002","article-title":"Apoptin, a tumor-selective killer","volume":"1793","author":"Los","year":"2009","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.tvr.2026.200337_bib18","doi-asserted-by":"crossref","first-page":"5843","DOI":"10.1073\/pnas.94.11.5843","article-title":"Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells","volume":"94","author":"Oorschot","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.tvr.2026.200337_bib19","doi-asserted-by":"crossref","first-page":"26581","DOI":"10.1074\/jbc.M203571200","article-title":"Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP","volume":"277","author":"Qiao","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tvr.2026.200337_bib20","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3390\/cells11020308","article-title":"Emerging role of cAMP\/AMPK signaling","volume":"11","author":"Aslam","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.tvr.2026.200337_bib21","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-3-319-43589-3_9","article-title":"AMPK and cancer","volume":"107","author":"Wang","year":"2016","journal-title":"Experientia Suppl."},{"key":"10.1016\/j.tvr.2026.200337_bib22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.semcancer.2021.04.006","article-title":"AMPK signaling and its targeting in cancer progression and treatment","volume":"85","author":"Hsu","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.tvr.2026.200337_bib23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3892\/etm.2014.2086","article-title":"Antitumor effects of a dual cancer-specific oncolytic adenovirus on colorectal cancer in vitro and in vivo","volume":"9","author":"Yang","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.tvr.2026.200337_bib24","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.2174\/0929867325666180309112023","article-title":"A Versatile protein with selective antitumor activity","volume":"25","author":"Castro","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.tvr.2026.200337_bib25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12929-018-0422-8","article-title":"Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer","volume":"25","author":"Le\u00e3o","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.tvr.2026.200337_bib26","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.canlet.2015.01.044","article-title":"miR-1182 attenuates gastric cancer proliferation and metastasis by targeting the open reading frame of hTERT","volume":"360","author":"Zhang","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.tvr.2026.200337_bib27","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s00432-021-03899-7","article-title":"In vivo and in vitro inhibition of SCLC by combining dual cancer-specific recombinant adenovirus with Etoposide","volume":"148","author":"Li","year":"2022","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.tvr.2026.200337_bib28","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.3892\/ijo.2013.1783","article-title":"Potent growth-inhibitory effect of a dual cancer-specific oncolytic adenovirus expressing apoptin on prostate carcinoma","volume":"42","author":"Zhang","year":"2013","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.tvr.2026.200337_bib29","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ygyno.2015.05.022","article-title":"Ovarian and cervical cancer patient derived xenografts: the past, present, and future","volume":"138","author":"Boone","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.tvr.2026.200337_bib30","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1101\/gad.1198404","article-title":"The viral protein Apoptin associates with the anaphase-promoting complex to induce G2\/M arrest and apoptosis in the absence of p53","volume":"18","author":"Teodoro","year":"2004","journal-title":"Gene Dev."},{"key":"10.1016\/j.tvr.2026.200337_bib31","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1083\/jcb.200104104","article-title":"Adenovirus E4orf 4 protein induces PP2A-dependent growth arrest in Saccharomyces cerevisiae and interacts with the anaphase-promoting complex\/cyclosome","volume":"154","author":"Kornitzer","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tvr.2026.200337_bib32","doi-asserted-by":"crossref","first-page":"7144","DOI":"10.1128\/JVI.72.9.7144-7153.1998","article-title":"The early region 4 orf 4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis","volume":"72","author":"Marcellus","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.tvr.2026.200337_bib33","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ygyno.2004.05.041","article-title":"A phase I study of Adp 53 (INGN 201; ADVEXIN) for patients with platinum- and paclitaxel-resistant epithelial ovarian cancer","volume":"94","author":"Wolf","year":"2004","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.tvr.2026.200337_bib34","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1128\/JVI.73.3.2074-2083.1999","article-title":"The replicative Capacities of Large E1B-Null Group A and Group C adenoviruses are independent of host cell p53 status","volume":"73","author":"Turnell","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.tvr.2026.200337_bib35","article-title":"Adenovirus E1B-55K regulates p53-dependent and -independent gene expression during infection","volume":"21","author":"Smith","year":"2025","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.tvr.2026.200337_bib36","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2310770120","article-title":"The human adenovirus E1B-55K oncoprotein coordinates cell transformation through regulation of DNA-bound host transcription factors","volume":"120","author":"von Stromberg","year":"2023","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.tvr.2026.200337_bib37","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.3390\/v7112905","article-title":"Oncolytic replication of E1b-Deleted adenoviruses","volume":"7","author":"Cheng","year":"2015","journal-title":"Viruses"},{"key":"10.1016\/j.tvr.2026.200337_bib38","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/S1471-4914(02)02309-2","article-title":"Therapeutic exploitation of the p53 pathway","volume":"8","author":"Lane","year":"2002","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.tvr.2026.200337_bib39","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1158\/1940-6207.CAPR-08-0165","article-title":"Effects of the Kava Chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53","volume":"1","author":"Tang","year":"2008","journal-title":"Cancer Prev. Res."},{"key":"10.1016\/j.tvr.2026.200337_bib40","doi-asserted-by":"crossref","first-page":"5309","DOI":"10.1158\/0008-5472.CAN-08-0504","article-title":"ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells","volume":"68","author":"Stohr","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.tvr.2026.200337_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/cells11020308","article-title":"Emerging role of cAMP\/AMPK signaling","volume":"11","author":"Aslam","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.tvr.2026.200337_bib42","doi-asserted-by":"crossref","first-page":"8911","DOI":"10.1074\/jbc.275.12.8911","article-title":"cAMP-independent activation of the adenovirus type 12 E2 promoter correlates with the recruitment of CREB-1\/ATF-1, E1A12S, and CBP to the E2-CRE","volume":"275","author":"Fax","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tvr.2026.200337_bib43","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1101\/gad.2.12a.1517","article-title":"cAMP acts in synergy with E1A protein to activate transcription of the adenovirus early genes E4 and E1A","volume":"2","author":"Engel","year":"1988","journal-title":"Gene Dev."},{"key":"10.1016\/j.tvr.2026.200337_bib44","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13046-018-0731-5","article-title":"Metformin induces autophagy and G0\/G1 phase cell cycle arrest in myeloma by targeting the AMPK\/mTORC1 and mTORC2 pathways","volume":"37","author":"Wang","year":"2018","journal-title":"J. Exp. Clin. Cancer Res. : CR"},{"key":"10.1016\/j.tvr.2026.200337_bib45","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tvr.2026.200337_bib46","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ceb.2017.01.005","article-title":"AMPK signalling in health and disease","volume":"45","author":"Carling","year":"2017","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.tvr.2026.200337_bib47","first-page":"1","article-title":"Resistance to oncolytic virotherapy: multidimensional mechanisms and therapeutic breakthroughs","volume":"56","author":"Xu","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.tvr.2026.200337_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1308890","article-title":"Oncolytic virotherapy in cancer treatment: challenges and optimization prospects","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tvr.2026.200337_bib49","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/j.ymthe.2025.03.035","article-title":"Oncolytic viruses as cancer therapeutics: from mechanistic insights to clinical translation","volume":"33","author":"Alwithenani","year":"2025","journal-title":"Mol. Ther."},{"key":"10.1016\/j.tvr.2026.200337_bib50","article-title":"Chemovirotherapy of lung squamous cell carcinoma by combining oncolytic adenovirus with gemcitabine","volume":"10","author":"Liu","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.tvr.2026.200337_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112185","article-title":"Anti-tumor effect of a dual cancer-specific recombinant adenovirus on ovarian cancer cells","volume":"396","author":"Cui","year":"2020","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.tvr.2026.200337_bib52","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/jmv.10382","article-title":"Rapid and quantitative detection of human adenovirus DNA by real\u2010time PCR","volume":"70","author":"Heim","year":"2003","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.tvr.2026.200337_bib53","doi-asserted-by":"crossref","DOI":"10.1128\/aem.01033-22","article-title":"Risk of gastroenteritis from swimming at a wastewater-impacted tropical beach varies across localized scales","volume":"89","author":"Gonz\u00e1lez-Fern\u00e1ndez","year":"2023","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.tvr.2026.200337_bib54","doi-asserted-by":"crossref","DOI":"10.1101\/683227","article-title":"Dissociation of solid tumor tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase-associated stress responses","volume":"20","author":"O'Flanagan","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.tvr.2026.200337_bib55","doi-asserted-by":"crossref","DOI":"10.3791\/66766","article-title":"Dissociation of Human and Mouse tumor tissue samples for single-cell RNA sequencing","author":"Fang","year":"2024","journal-title":"JoVE J."}],"container-title":["Tumour Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666679026000017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666679026000017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T03:42:51Z","timestamp":1782531771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666679026000017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":55,"alternative-id":["S2666679026000017"],"URL":"https:\/\/doi.org\/10.1016\/j.tvr.2026.200337","relation":{},"ISSN":["2666-6790"],"issn-type":[{"value":"2666-6790","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ad-VT oncolytic adenovirus suppresses bladder cancer via cAMP-dependent AMPK-Raptor activation and G2\/M arrest","name":"articletitle","label":"Article Title"},{"value":"Tumour Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tvr.2026.200337","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"200337"}}